Chlorthalidone inhibits the KvLQT1 potassium current in guinea-pig ventricular myocytes and oocytes from Xenopus laevis

British Journal of Pharmacology

Volumn 153, Issue 3, 2008, Pages 448-458

  Mancilla Simbro, C ^a   Lopez A ^a   Martinez Morales, E ^a   Soto Perez De Celis, E ^a   Millan PerezPena L ^a   Tsushima, R ^b   Salinas Stefanon, E M ^a  

^a BENEMÉRITA UNIVERSIDAD AUTÓNOMA DE PUEBLA   (Mexico)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cardiac potassium currents; Chlorthalidone; IK; Isolated cardiac myocytes; KvLQT1 current; Oocytes; Patch clamp; Thiazide diuretics

Indexed keywords

CHLORTALIDONE; ION CHANNEL; POTASSIUM CHANNEL; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KCNE1; POTASSIUM LONG QT CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG POTENCY; FEMALE; GENETIC TRANSFECTION; GUINEA PIG; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; NONHUMAN; OOCYTE; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; XENOPUS LAEVIS;

ACTION POTENTIALS; ANIMALS; ANTIHYPERTENSIVE AGENTS; CHLORTHALIDONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; GUINEA PIGS; HEART VENTRICLES; HUMANS; KCNQ1 POTASSIUM CHANNEL; MYOCYTES, CARDIAC; OOCYTES; POTASSIUM CHANNELS, VOLTAGE-GATED; XENOPUS LAEVIS;

EID: 38849187304     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707579     Document Type: Article

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