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Volumn 128, Issue 8, 1999, Pages 1733-1738

Bepridil differentially inhibits two delayed rectifier K+ currents, I(Kr) and I(Ks), in guinea-pig ventricular myocytes

Author keywords

Antiarrhythmic drug; Bepridil; I(Kr); I(Ks); Ventricular myocytes

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; BEPRIDIL; NITRENDIPINE; POTASSIUM ION;

EID: 0033408458     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702959     Document Type: Article
Times cited : (71)

References (25)
  • 2
    • 0024308972 scopus 로고
    • Effects of the Ca entry blocker bepridil on repolarizing and pacemaker currents in sheep cardiac Purkinje fibres
    • BERGER, F., BORCHARD, U. & HAFNER, D. (1989). Effects of the Ca entry blocker bepridil on repolarizing and pacemaker currents in sheep cardiac Purkinje fibres. Naunyn-Schmiedeberg's Arch. Pharmacol., 339, 638-646.
    • (1989) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.339 , pp. 638-646
    • Berger, F.1    Borchard, U.2    Hafner, D.3
  • 4
    • 0026706518 scopus 로고
    • Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists
    • COHEN, C.J., SPIRES, S. & VAN SKIVER, D. (1992). Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists. J. Gen. Physiol., 100, 703-728.
    • (1992) J. Gen. Physiol. , vol.100 , pp. 703-728
    • Cohen, C.J.1    Spires, S.2    Van Skiver, D.3
  • 5
    • 0017338477 scopus 로고
    • Cardiovascular pharmacology of bepridil, (1[3 isobutoxy 2 (benzylphenyl) amino] propyl pyrrolidine hydrochloride) a new potential anti-anginal compound
    • COSNIER, D., DUCHENNE-MARULLAZ, P., RISPAT, G. & STREICHENBERGER, G. (1977). Cardiovascular pharmacology of bepridil, (1[3 isobutoxy 2 (benzylphenyl) amino] propyl pyrrolidine hydrochloride) a new potential anti-anginal compound. Arch. Int. Pharmacodyn. Ther., 225, 133-151.
    • (1977) Arch. Int. Pharmacodyn. Ther. , vol.225 , pp. 133-151
    • Cosnier, D.1    Duchenne-Marullaz, P.2    Rispat, G.3    Streichenberger, G.4
  • 6
    • 0020615240 scopus 로고
    • Effects of bepridil, a new antianginal agent, on ambulatory electrocardiography in human volunteers
    • DUCHENE-MARULLAZ, P., KANTELIP, J.-P. & TROLESE, J.-F. (1983). Effects of bepridil, a new antianginal agent, on ambulatory electrocardiography in human volunteers. J. Cardiovasc. Pharmacol., 5, 506-510.
    • (1983) J. Cardiovasc. Pharmacol. , vol.5 , pp. 506-510
    • Duchene-Marullaz, P.1    Kantelip, J.-P.2    Trolese, J.-F.3
  • 8
    • 0026496477 scopus 로고
    • Bepridil. A review of its pharmacological properties and therapeutic use in stable angina pectoris
    • HOLLINGSHEAD, L.M., FAULDS, D. & FITTON, A. (1992). Bepridil. A review of its pharmacological properties and therapeutic use in stable angina pectoris. Drugs, 44, 835-837.
    • (1992) Drugs , vol.44 , pp. 835-837
    • Hollingshead, L.M.1    Faulds, D.2    Fitton, A.3
  • 9
    • 0022620878 scopus 로고
    • Effects of bepridil on the electrophysiological properties of isolated canine and rabbit myocardial fibers
    • KATO, R. & SINGH, B.N. (1986). Effects of bepridil on the electrophysiological properties of isolated canine and rabbit myocardial fibers. Am. Heart. J., 111, 271-279.
    • (1986) Am. Heart. J. , vol.111 , pp. 271-279
    • Kato, R.1    Singh, B.N.2
  • 10
    • 0020691851 scopus 로고
    • Effects of antiarrhythmic drugs on ventricular fibrillation thresholds of normal and ischemic myocardium in the anesthetized rat
    • MARSHALL, R.J, MUIR, A.W. & WINSLOW, E. (1983). Effects of antiarrhythmic drugs on ventricular fibrillation thresholds of normal and ischemic myocardium in the anesthetized rat. Br. J. Pharmacol., 78, 165-171.
    • (1983) Br. J. Pharmacol. , vol.78 , pp. 165-171
    • Marshall, R.J.1    Muir, A.W.2    Winslow, E.3
  • 11
    • 0001865942 scopus 로고
    • Tight-seal whole-cell recording
    • ed. Sackmann B. Neher E., New York: Plenum
    • MARTY, A. & NEHER, E. (1983). Tight-seal whole-cell recording. In: Single-Channel Recording, ed. Sackmann B. Neher E., pp. 107-122, New York: Plenum.
    • (1983) Single-Channel Recording , pp. 107-122
    • Marty, A.1    Neher, E.2
  • 13
    • 0030905460 scopus 로고    scopus 로고
    • Emerging class 3 antiarrhythmic agents: Mechanism of action and proarrhythmic potential
    • NAIR, L.A. & GRANT, A.O. (1997). Emerging class 3 antiarrhythmic agents: mechanism of action and proarrhythmic potential. Cardiovasc. Drug. Ther., 11, 149-167.
    • (1997) Cardiovasc. Drug. Ther. , vol.11 , pp. 149-167
    • Nair, L.A.1    Grant, A.O.2
  • 15
    • 0027264734 scopus 로고
    • Bepridil prolongs the action potential duration of guinea pig ventricular muscle only at rapid rates of stimulation
    • NOBE, S., AOMINE, M. & ARITA, M. (1993). Bepridil prolongs the action potential duration of guinea pig ventricular muscle only at rapid rates of stimulation. Gen. Pharmac., 24, 1187-1196.
    • (1993) Gen. Pharmac. , vol.24 , pp. 1187-1196
    • Nobe, S.1    Aomine, M.2    Arita, M.3
  • 16
    • 0014438985 scopus 로고
    • Outward membrane currents activated in the plateau range of potential in cardiac Purkinje fibres
    • NOBLE, D. & TSIEN, R.W. (1969). Outward membrane currents activated in the plateau range of potential in cardiac Purkinje fibres. J. Physiol (Lond.), 200, 205-231.
    • (1969) J. Physiol (Lond.) , vol.200 , pp. 205-231
    • Noble, D.1    Tsien, R.W.2
  • 17
    • 0033065152 scopus 로고    scopus 로고
    • Effect of bepridil on intracellular calcium concentration and contraction in cultured rat ventricular myocytes
    • OZAKI, M., ZAIZEN, H., KIYOSUE, T., NASU, M. & ARITA, M. (1999). Effect of bepridil on intracellular calcium concentration and contraction in cultured rat ventricular myocytes. J. Cardiovasc. Pharmacol., 33, 492-499.
    • (1999) J. Cardiovasc. Pharmacol. , vol.33 , pp. 492-499
    • Ozaki, M.1    Zaizen, H.2    Kiyosue, T.3    Nasu, M.4    Arita, M.5
  • 18
    • 0021883105 scopus 로고
    • Effect of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart
    • PELLEG, A., PARDO, Y., BELHASSEN, B., SHARGORDSKY, B., CHAGNAC, A. & LANIADO, S. (1985). Effect of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart. Cardiology, 72, 193-201.
    • (1985) Cardiology , vol.72 , pp. 193-201
    • Pelleg, A.1    Pardo, Y.2    Belhassen, B.3    Shargordsky, B.4    Chagnac, A.5    Laniado, S.6
  • 19
    • 0025351245 scopus 로고
    • - current: Differential sensitivity to block by class III antiarrhythmic agents
    • - current: differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol., 96, 195-215.
    • (1990) J. Gen. Physiol. , vol.96 , pp. 195-215
    • Sanguinetti, M.C.1    Jurkiewicz, N.K.2
  • 25
    • 0022637607 scopus 로고
    • Bepridil block of cardiac calcium and sodium channels
    • YATANI, A., BROWN, A.M. & SCHWARTZ, A. (1986). Bepridil block of cardiac calcium and sodium channels. J. Pharmacol. Exp. Ther., 237, 9-17.
    • (1986) J. Pharmacol. Exp. Ther. , vol.237 , pp. 9-17
    • Yatani, A.1    Brown, A.M.2    Schwartz, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.