Desensitization of chemical activation by auxiliary subunits: Convergence of molecular determinants critical for augmenting KCNQ1 potassium channels

Journal of Biological Chemistry

Volumn 283, Issue 33, 2008, Pages 22649-22658

  Gao, Zhaobing ^a   Xiong, Qiaojie ^a   Sun, Haiyan ^a   Li, Min ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; POTASSIUM; ZINC;

CARDIAC ACTION POTENTIALS; CARDIAC MYOCYTES; CHANNEL GATING; CURRENT AMPLITUDES; ISOFORMS; MOLECULAR DETERMINANTS; MOLECULAR SPECIFICITIES; PHARMACOLOGICAL DIFFERENCES; POTASSIUM CHANNELS; REPOLARIZATION; REVERSIBLE EFFECTS; ZINC PYRITHIONE;

CHEMICAL ACTIVATION;

POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ4; POTASSIUM CHANNEL KCNQ5; PYRITHIONE ZINC; PROTEIN SUBUNIT; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; ANIMAL; BINDING SITE; CHEMISTRY; CHO CELL; CRICETULUS; GENETIC TRANSFECTION; GENETICS; HAMSTER; KINETICS; METABOLISM; METHODOLOGY; PATCH CLAMP; PHYSIOLOGY; PROTEIN ENGINEERING;

MUSTELA;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; KCNQ1 POTASSIUM CHANNEL; KINETICS; PATCH-CLAMP TECHNIQUES; PROTEIN ENGINEERING; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 53049101647     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802426200     Document Type: Article

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