Density and kinetics of IKr and IKs in guinea pig and rabbit ventricular myocytes explain different efficacy of IKs blockade at high heart rate in guinea pig and rabbit: Implications for arrhythmogenesis in humans

Circulation

Volumn 104, Issue 8, 2001, Pages 951-956

  Lu, Zhibo ^a   Kamiya, Kaichiro ^a   Opthof, Tobias ^b   Yasui, Kenji ^a   Kodama, Itsuo ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Action potentials; Antiarrhythmia agents; Ion channels; Potassium

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 4 CHROMANONE DERIVATIVE; ANTIARRHYTHMIC AGENT; CHROMANOL 293B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; GUINEA PIG; HEART ARRHYTHMIA; HEART MUSCLE POTENTIAL; HEART RATE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RABBIT; TRANSPORT KINETICS;

EID: 0035928757     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc3401.093151     Document Type: Article

References (30)

1. + current: Differential sensitivity to block by class III antiarrhythmic agents
2. Ks in guinea pig isolated ventricular myocytes
3. + current by dofetilide
4. QTU-prolongation and torsades de points induced by putative class III antiarrhythmic agents in the rabbit: Etiology and interventions
5. Class III antiarrhythmic agents have a lot of potential but a long way to go: Reduced effectiveness and dangers of reverse use-dependence
6. + current, on repolarization in human and guinea pig ventricular myocytes
7. Ks contributes to the longer action potential in the M cell
8. Ks are larger in right than left canine ventricular midmyocardium
9. Ks) in myocytes isolated from apex and base of rabbit ventricle: An underlying mechanism of the proarrhythmic effects of class III antiarrhythmic agents
10. + channel
11. Rate-dependent class III antiarrhythmic action, negative chronotropy, and positive inotropy of a novel iK blocking drug, UK-68,798: Potent in guinea pig but no effect in rat myocardium
12. Ks play a role in the reverse rate dependence of class III agents?
13. + current
14. + current in human ventricular myocytes
15. The effect of amiodarone, a new anti-anginal drug, on cardiac muscle
16. + currents
17. Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytes
18. Amiodarone blocks the inward rectifier potassium channel in isolated guinea pig ventricular cells
19. Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone
20. Amiodarone: Ionic cellular mechanisms of action of the most promising class III agents
21. Differential effect of β-adrenergic stimulation on the frequency-dependent electrophysiologic actions of the new class III antiarrhythmics dofetilide, ambasilide and chromanol 293B
22. Ks) fails to lengthen rabbit ventricular muscle QTc and action potential
23. Ks in dog ventricular muscle and Purkinje fibre repolarization
24. + current in rabbit ventricular myocytes
25. + current in isolated human ventricular myocytes from patients with terminal heart failure
26. Delayed rectifier channels in human ventricular myocytes
27. The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes
28. Ks absent from undiseased human ventricular myocardium?
29. Kr blockade
30. ca contributes to rate-dependent changes of action potentials in human ventricular myocytes