Phosphatidylinositol-4, 5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: A functional homology between voltage-gated and inward rectifier K+ channels

EMBO Journal

Volumn 22, Issue 20, 2003, Pages 5412-5421

  Loussouarn, G ^a   Park, K H ^a   Bellocq, C ^a   Baro I ^a   Charpentier, F ^a   Escande, D ^a  

^a HÔTEL DIEU   (France)

Author keywords

KCNE1 KCNQ1; MgATP; Phosphatidylinositol 4, 5 bisphosphate

Indexed keywords

ADENOSINE TRIPHOSPHATE MAGNESIUM; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSOL; GUINEA PIG; KINETICS; MEMBRANE POTENTIAL; MOLECULAR STABILITY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CERCOPITHECUS AETHIOPS; COS CELLS; GUINEA PIGS; HEART; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; KCNQ2 POTASSIUM CHANNEL; KINETICS; MAGNESIUM; MOLECULAR SEQUENCE DATA; PATCH-CLAMP TECHNIQUES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, SECONDARY; TRANSFECTION;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0142105405     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg526     Document Type: Article

References (46)

1. Barhanin, J., Lesage, F., Guillemare, E., Fink, M., Lazdunski, M. and Romey, G. (1996) K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature, 384, 78-80.
2. 2+-activated outward current in guinea-pig atrial myocytes. Pflugers Arch., 415, 63-71.
3. Baukrowitz, T. and Fakler, B. (2000) K(ATP) channels: linker between phospholipid metabolism and excitability. Biochem. Pharmacol., 60, 735-740.
4. ATP channels. Science, 282, 1141-1144.
5. Becq, F. (1996) Ionic channel rundown in excised membrane patches. Biochim. Biophys Acta, 1286, 53-63.
6. + channel activity is regulated by changes in phosphatidyl inositol 4, 5-bisphosphate. Circ. Res., 89, 1168-1176.
7. Cukras, C.A., Jeliaskova, I. and Nichols, C.G. (2002) Structural and functional determinants of conserved lipid interaction domains of inward rectifying Kir6.2 channels. J. Gen. Physiol., 119, 581-591.
8. Enkvetchakul, D., Loussouarn, G., Makhina, E., Shyng, S.L. and Nichols, C.G. (2000) The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding. Biophys. J., 78, 2334-2348.
9. + channels in the heart. Pflugers Arch., 414, S93-S98.
10. + channel to the actin cytoskeleton. Pflugers Arch., 431, 504-512.
11. Grunnet, M., Jespersen, T., MacAulay, N., Jorgensen, N.K., Schmitt, N., Pongs, O., Olesen, S.P. and Klaerke, D.A. (2003) KCNQ1 channels sense small changes in cell volume. J. Physiol., 549, 419-427.
12. Haruna, T., Yoshida, H., Nakamura, T.Y., Xie, L.H., Otani, H., Ninomiya, T., Takano, M., Coetzee, W.A. and Horie, M. (2002) Alpha1-adrenoceptor-mediated breakdown of phosphatidylinositol 4, 5-bisphosphate inhibits pinacidil-activated ATP-sensitive K+ currents in rat ventricular myocytes. Circ. Res., 91, 232-239.
13. Hilgemann, D.W. (1997) Cytoplasmic ATP-dependent regulation of ion transporters and channels: mechanisms and messengers. Annu. Rev. Physiol., 59, 193-220.
14. 2 with ion channels and transporters. Sci. STKE, 111, RE19.
15. Hille, B. (2001) Ion Channels of Excitable Membranes. Sinauer, Sunderland, MA.
16. + current in guinea pig ventricular myocytes. Jpn. J. Physiol., 48, 81-89.
17. Huang, C.L., Feng, S. and Hilgemann, D.W. (1998) Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ. Nature, 391, 803-806.
18. Inagaki, N., Gonoi, T., Clement, J.P., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S. and Bryan, J. (1995) Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science, 270, 1166-1170.
19. Larsson, O., Barker, C.J. and Berggren, P.O. (2000) Phosphatidylinositol 4, 5-bisphosphate and ATP-sensitive potassium channel regulation: a word of caution. Diabetes, 49, 1409-1412.
20. + channels to ATP. J. Biol. Chem., 276, 29098-29103.
21. Loussouarn, G., Rose, T. and Nichols, C.G. (2002) Structural basis of inward rectifying potassium channel gating. Trends Cardiovasc. Med., 12, 253-258.
22. Lu, Z., Klem, A.M. and Ramu, Y. (2001) Ion conduction pore is conserved among potassium channels. Nature, 413, 809-813.
23. Marcus, D.C., Sunose, H. Liu, J., Shen, Z. and Scofield, M.A. (1997) P2U purinergic receptor inhibits apical IsK/KvLQT1 channel via protein kinase C in vestibular dark cells. Am. J. Physiol., 273, C2022-C2029.
24. Marx, S.O., Kurokawa, J., Reiken, S., Motoike, H., D'Armiento, J., Marks, A.R. and Kass, R.S. (2002) Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science, 295, 496-499.
25. Nishida, M. and MacKinnon, R. (2002) Structural basis of inward rectification. Cytoplasomic pore of the G protein-gated inward rectifier GIRK1 at 1.8 Å resolution. Cell, 111, 957-965.
26. Potet, F., Scott, J.D., Mohammad-Panah, R., Escande, D. and Baro, I. (2001) AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex. Am. J. Physiol., 280, H2038-H2045.
27. Sanguinetti, M.C., Curran, M.E., Zou, A., Shen, J., Spector, P.S., Atkinson, D.L. and Keating, M.T. (1996) Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature, 384, 80-83.
28. Sansom, S.C., Stockand, J.D., Hall, D. and Williams, B. (1997) Regulation of large calcium-activated potassium channels by protein phosphatase 2A. J. Biol. Chem., 272, 9902-9906.
29. 2+/calmodulin. EMBO J., 19, 3263-3271.
30. Schoppa, N.E. and Sigworth, F.J. (1998) Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J. Gen. Physiol., 111, 313-342.
31. Shen, Z. and Marcus. D.C. (1998) Divalent cations inhibit IsK/KvLQT1 channels in excised membrane patches of strial marginal cells. Hear. Res., 123, 157-167.
32. Shyng, S.L. and Nichols, C.G. (1998) Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science, 282, 1138-1141.
33. Shyng, S.L., Cukras, C.A., Harwood, J. and Nichols, C.G. (2000) Structural determinants of PIP2 regulation of inward rectifier KATP channels. J. Gen. Physiol., 116, 599-607.
34. Sippel, C.J., Dawson P.A., Shen T. and Perlmutter D.H. (1997) Reconstitution of bile acid transport in a heterologous cell by cotransfection of transporters for bile acid uptake and efflux. J. Biol. Chem., 272, 18290-18297.
35. Suh, B.C. and Hille, B. (2002) Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4, 5-bisphosphate synthesis. Neuron, 35, 507-520.
36. Szokodi, I. et al. (2002) Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ. Res., 91, 434-440.
37. Towbin, J.A. and Vatta, M. (2001) Molecular biology and the prolonged QT syndromes. Am. J. Med., 110, 385-398.
38. + channel (minK) subunits. J. Physiol., 510, 37-45.
39. Vetter, D.E. et al. (1996) Inner ear defects induced by null mutation of the isk gene. Neuron, 17, 1251-1264.
40. Wen, H. and Levitan, I.B. (2002) Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels. J. Neurosci., 22, 7991-8001.
41. Wu, L., Bauer, C.S., Zhen, X.G., Xie, C. and Yang, J. (2002) Dual regulation of voltage-gated calcium channels by Ptdlns(4, 5)P2. Nature, 419, 947-952.
42. Yang, Y. and Sigworth, F.J. (1998) Single-channel properties of IKs potassium channels. J. Gen. Physiol., 112, 665-678.
43. Yin, H.L. and Janmey, P.A. (2003) Phosphoinositide regulation of the actin cytoskeleton. Annu. Rev. Physiol., 65, 761-789.
44. Yus-Najera, E., Santana-Castro, I. and Villarroel, A. (2002). The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. J. Biol. Chem., 277, 28545-28553.
45. Zhang, H., Craciun, L.C., Mirshahi, T., Rohacs, T., Lopes, C.M., Jin, T. and Logothetis, D.E. (2003) PIP2 activates KCNQ channels and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron, 37, 963-975.
46. Zicha, S., Moss, I., Allen, B., Varro, A., Papp, J., Dumaine, R., Antzelevitch, C. and Nattel, S. (2003) Molecular basis of species-specific expression of repolarizing potassium currents in the heart. Am. J. Physiol., 285, H1641-H1649.