Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel

Journal of Physiology

Volumn 576, Issue 3, 2006, Pages 755-767

  Bett, Glenna C L ^a   Morales, Michael J ^a   Beahm, Derek L ^a   Duffey, Michael E ^a   Rasmusson, Randall L ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMANOL 293B; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNE3; POTASSIUM CHANNEL KCNQ1; UNCLASSIFIED DRUG; THREONINE; VALINE; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SENSITIVITY; ELECTROSTIMULATION; FEMALE; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; XENOPUS; ANIMAL TISSUE; IC50; OOCYTE; POTASSIUM CURRENT; PROTEIN SUBUNIT; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; CHROMANS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; ION CHANNEL GATING; KCNQ1 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; MODELS, THEORETICAL; MOLECULAR SEQUENCE DATA; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; SULFONAMIDES; TIME FACTORS; XENOPUS LAEVIS;

EID: 33750419028     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.116012     Document Type: Article

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