KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 22, 2011, Pages 9095-9100

  Li, Yang ^a   Zaydman, Mark A ^a   Wu, Dick ^a,b   Shi, Jingyi ^a   Guan, Michael ^a   Virgin Downey, Brett ^a   Cui, Jianmin ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; PROTEIN SUBUNIT;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BIOLOGICAL ACTIVITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; LONG QT SYNDROME; LOSS OF FUNCTION MUTATION; MEMBRANE CHANNEL; MEMBRANE CURRENT; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; VOLTAGE CLAMP; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; IONS; KCNQ1 POTASSIUM CHANNEL; LIPIDS; LONG QT SYNDROME; MOLECULAR SEQUENCE DATA; MUTATION; PATCH-CLAMP TECHNIQUES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 79959352977     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100872108     Document Type: Article

References (53)

1. Ks potassium channel. Nature 384:80-83.
2. Ks cardiac potassium current. Nature 384:78-80.
3. Rudy Y, Silva JR (2006) Computational biology in the study of cardiac ion channels and cell electrophysiology. Q Rev Biophys 39:57-116. (Pubitemid 44566374)
4. Suh BC, Hille B (2008) PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys 37:175-195.
5. Park KH, et al. (2005) Impaired KCNQ1-KCNE1 and phosphatidylinositol-4,5- bisphosphate interaction underlies the long QT syndrome. Circ Res 96:730-739.
6. 2, controls KCNQ1/KCNE1 voltage-gated potassium channels: A functional homology between voltage-gated and inward rectifier K+ channels. EMBO J 22:5412-5421.
7. Lai LP, et al. (2005) Denaturing high-performance liquid chromatography screening of the long QT syndrome-related cardiac sodium and potassium channel genes and identification of novel mutations and single nucleotide polymorphisms. J Hum Genet 50:490-496.
8. Hedley PL, et al. (2009) The genetic basis of long QT and short QT syndromes: A mutation update. Hum Mutat 30:1486-1511.
9. Kapplinger JD, et al. (2009) Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test. Heart Rhythm 6:1297-1303.
10. Murata Y, Iwasaki H, Sasaki M, Inaba K, Okamura Y (2005) Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature 435:1239-1243. (Pubitemid 40943089)
11. sK expressed in Xenopus oocytes depends on the amount of mRNA injected. J Gen Physiol 104:87-105.
12. sK channel. J Biol Chem 273:34069-34074.
13. Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY (2010) Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. Proc Natl Acad Sci USA 107:18862-18867.
14. Rosenhouse-Dantsker A, Logothetis DE (2007) Molecular characteristics of phosphoinositide binding. Pflugers Arch 455:45-53. (Pubitemid 47403985)
15. Kang CB, et al. (2008) Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Biochemistry 47:7999-8006.
16. Rocheleau JM, Gage SD, Kobertz WR (2006) Secondary structure of a KCNE cytoplasmic domain. J Gen Physiol 128:721-729. (Pubitemid 44833382)
17. Romey G, et al. (1997) Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity. J Biol Chem 272:16713-16716. (Pubitemid 27289761)
18. Ks channels and channels formed with two MinK mutants that cause long QT syndrome. J Gen Physiol 112:651-663.
19. Ks potassium channels. J Gen Physiol 112:665-678.
20. Tapper AR, George AL, Jr (2000) MinK subdomains that mediate modulation of and association with KvLQT1. J Gen Physiol 116:379-390.
21. Takumi T, et al. (1991) Alteration of channel activities and gating by mutations of slow IsK potassium channel. J Biol Chem 266:22192-22198. (Pubitemid 21908634)
22. Lvov A, Gage SD, Berrios VM, Kobertz WR (2010) Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1. J Gen Physiol 135:607-618.
23. Thomas AM, Harmer SC, Khambra T, Tinker A (2010) Characterization of a binding site for anionic phospholipids on KCNQ1. J Biol Chem 286:2088-2100.
24. + current by protein kinase C and protein kinase A. Circ Res 83:995-1002.
25. Ks channel gating and assembly - Impaired function in long-QT mutations. Circ Res 98:1055-1063.
26. Ks by Gq-coupled receptors. J Mol Cell Cardiol 46:704-712.
27. Habuchi Y, et al. (1992) Endothelin enhances delayed potassium current via phospholipase C in guinea pig ventricular myocytes. Am J Physiol 262:H345-354.
28. Ks potassium current by membrane phosphatidylinositol 4,5-bisphosphate. J Biol Chem 279:50726-50734.
29. + channel by extracellular ATP through membrane phosphatidylinositol 4,5-bisphosphate in guinea-pig atrial myocytes. Br J Pharmacol 145:156-165.
30. Marx SO, et al. (2002) Requirement of a macromolecular signaling complex for β adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 295:496-499. (Pubitemid 34101639)
31. + channels. Channels 1:124-134.
32. Kurokawa J, Chen L, Kass RS (2003) Requirement of subunit expression for cAMP-mediated regulation of a heart potassium channel. Proc Natl Acad Sci USA 100:2122-2127. (Pubitemid 36254584)
33. Kr. Nature 388:289-292.
34. Bian JS, Cui J, McDonald TV (2001) HERG K+ channel activity is regulated by changes in phosphatidylinositol 4,5-bisphosphate. Circ Res 89:1168-1176. (Pubitemid 34627875)
35. Deschenes I, Tomaselli GF (2002) Modulation of Kv4. 3 current by accessory subunits. FEBS Lett 528:183-188.
36. Tinel N, Diochot S, Borsotto M, Lazdunski M, Barhanin J (2000) KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J 19:6326-6330.
37. Heitzmann D, et al. (2004) Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells. J Physiol 561:547-557. (Pubitemid 39646542)
38. Tinel N, et al. (2000) M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit. FEBS Lett 480:137-141.
39. Winks JS, et al. (2005) Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels. J Neurosci 25:3400-3413. (Pubitemid 40471348)
40. Kr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97:175-187.
41. Yu H, et al. (2001) MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. Circ Res 88:e84-e87.
42. Pian P, Bucchi A, Robinson RB, Siegelbaum SA (2006) Regulation of Gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2. J Gen Physiol 128:593-604. (Pubitemid 44664636)
43. Zhang M, Jiang M, Tseng GN (2001) MinK-related peptide 1 associates with Kv4. 2 and modulates its gating function: Potential role as beta subunit of cardiac transient outward channel? Circ Res 88:1012-1019.
44. Schroeder BC, et al. (2000) A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403:196-199. (Pubitemid 30050962)
45. McCrossan ZA, et al. (2003) MinK-related peptide 2 modulates Kv2. 1 and Kv3.1 potassium channels in mammalian brain. J Neurosci 23:8077-8091. (Pubitemid 37082461)
46. Xie LH, John SA, Ribalet B, Weiss JN (2008) Phosphatidylinositol-4,5- bisphosphate (PIP2) regulation of strong inward rectifier Kir2.1 channels: Multilevel positive cooperativity. J Physiol 586:1833-1848. (Pubitemid 351997512)
47. Abbott GW, et al. (2001) MiRP2 forms potassium channels in skeletal musclewith Kv3.4 and is associated with periodic paralysis. Cell 104:217-231. (Pubitemid 32174838)
48. + channels by membrane lipids. Science 304:265-270.
49. Zhang H, et al. (2003) PIP2 activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron 37:963-975. (Pubitemid 36398301)
50. Grunnet M, et al. (2002) KCNE4 is an inhibitory subunit to the KCNQ1 channel. J Physiol 542:119-130. (Pubitemid 35203234)
51. Grunnet M, et al. (2003) KCNQ1 channels sense small changes in cell volume. J Physiol 549:419-427. (Pubitemid 36701755)
52. Angelo K, et al. (2002) KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current. Biophys J 83:1997-2006.
53. Abbott GW, Goldstein SA (2002) Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. FASEB J 16:390-400. (Pubitemid 34195300)