Tanshinone IIA: A new activator of human cardiac KCNQ1/KCNE1 (IKs) potassium channels

European Journal of Pharmacology

Volumn 590, Issue 1-3, 2008, Pages 317-321

  Sun, Dong Dong ^a   Wang, Hai Chang ^a   Wang, Xiao Bin ^a   Luo, Ying ^a   Jin, Zhen Xiao ^a   Li, Zhi Chao ^a   Li, Gui Rong ^b   Dong, Ming Qing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

HEK 293 cell; hERG; hKCNQ1 hKCNE1; Human; IK1; IKs; Ion channel; Kv1.5; Patch clamp; Potassium channel; Tanshinone IIA

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; GUANYLATE CYCLASE INHIBITOR; INWARDLY RECTIFYING POTASSIUM CHANNEL; ISOPRENALINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; POTASSIUM CHANNEL KV1.5; TANSHINONE; TANSHINONE IIA; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CHINA; CHINESE HERB; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PATCH CLAMP; PRIORITY JOURNAL; SALVIA MILTIORRHIZA;

CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ETHER-A-GO-GO POTASSIUM CHANNELS; GUANYLATE CYCLASE; HEART; HUMANS; KCNQ1 POTASSIUM CHANNEL; KV1.5 POTASSIUM CHANNEL; NITRIC OXIDE DONORS; OXADIAZOLES; PHENANTHRENES; POTASSIUM CHANNELS, VOLTAGE-GATED; QUINOXALINES;

EID: 48049120166     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.005     Document Type: Article

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