The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure

Journal of Biological Chemistry

Volumn 286, Issue 1, 2011, Pages 717-725

  Labro, Alain J ^a   Boulet, Inge R ^a   Choveau, Frank S ^b,c,d   Mayeur, Evy ^a   Bruyns, Tine ^a   Loussouarn, Gildas ^b,c,d   Raes, Adam L ^a   Snyders, Dirk J ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b INSERM   (France)

^c CNRS   (France)

^d UNIVERSITÉ DE NANTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL GATES; CHANNEL GATING; DOUBLE MUTANTS; HIGH IMPACT; IN-CHANNELS; IN-VIVO; INTRACELLULAR CHANNEL; POTASSIUM CURRENTS; S4 SEGMENT; TRANSMEMBRANE HELICES;

AMINO ACIDS; ELECTROMECHANICAL DEVICES; POTASSIUM;

ELECTROMECHANICAL COUPLING;

ALANINE; LEUCINE; MOLECULAR SCAFFOLD; POTASSIUM CHANNEL KCNQ1; PROTEIN S6; TRYPTOPHAN; VALINE;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; CROSS COUPLING REACTION; EXCITATION CONTRACTION COUPLING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RESIDUE ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; ION CHANNEL GATING; KCNQ1 POTASSIUM CHANNEL; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; PROTEIN CONFORMATION;

EID: 78650959213     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.146977     Document Type: Article

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