Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?

Journal of Neuroscience Research

Volumn 90, Issue 6, 2012, Pages 1105-1118

  Cai, Zhiyou ^a,b   Zhao, Bin ^a   Li, Keshen ^a   Zhang, Liangqing ^a   Li, Chunhua ^c   Quazi, Sohel H ^b   Tan, Yan ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid ; Autophagy; Mammalian target of rapamycin; Rapamycin; Tau

Indexed keywords

ADAM10 ENDOPEPTIDASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BECLIN 1; BETA SECRETASE; GAMMA SECRETASE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; TAU PROTEIN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; AUTOPHAGOSOME; AUTOPHAGY; COGNITIVE DEFECT; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; LYSOSOME; MOLECULAR PATHOLOGY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REVIEW;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; AUTOPHAGY; COGNITION DISORDERS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; NEUROFIBRILLARY TANGLES; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84862798401     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23011     Document Type: Review

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