Autophagy dysfunction in Alzheimer's disease

Neurodegenerative Diseases

Volumn 7, Issue 4, 2010, Pages 265-271

  Li, Liang ^a,b,c   Zhang, Xiaojie ^a,b   Le, Weidong ^a,b  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Alzheimer's disease; APP; Autophagy; Lysosome; Tau

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; BECLIN 1; BETA SECRETASE; CATHEPSIN B; LIPOFUSCIN; NICOTINE; RAPAMYCIN; TAU PROTEIN;

ALZHEIMER DISEASE; AUTOPHAGY; BRAIN MITOCHONDRION; DISEASE COURSE; HUMAN; HUNTINGTON CHOREA; LYSOSOME; MOLECULAR DYNAMICS; NEUROFIBRILLARY TANGLE; NEUROMODULATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TARGETING; REVIEW; SENILE PLAQUE; SIGNAL TRANSDUCTION; TURNOVER TIME;

ALZHEIMER DISEASE; ANIMALS; AUTOPHAGY; HUMANS; NEURAL PATHWAYS; NEURONS;

EID: 77953777070     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000276710     Document Type: Review

References (48)

1. Klionsky DJ, Emr SD: Autophagy as a regulated pathway of cellular degradation. Science 2000; 290: 1717-1721.
2. Massey AC, Zhang C, Cuervo AM: Chaperone- mediated autophagy in aging and disease. Curr Top Dev Biol 2006; 73: 205-235.
3. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y: In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15: 1101-1111.
4. Meijer AJ, Codogno P: Regulation and role of autophagy in mammalian cells. Int J Biochem Cell Biol 2004; 36: 2445-2462.
5. Gordon PB, Seglen PO: Prelysosomal convergence of autophagic and endocytic pathways. Biochem Biophys Res Commun 1988; 151: 40-47.
6. Yamamoto M, Suzuki SO, Himeno M: The effects of dynein inhibition on the autophagic pathway in glioma cells. Neuropathology 2010; 30: 1-6.
7. Kochl R, Hu XW, Chan EY, Tooze SA: Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Traffic 2006; 7: 129-145.
8. Glickman MH, Ciechanover A: The ubiquitin- proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 2002; 82: 373-428.
9. Reggiori F, Klionsky DJ: Autophagosomes: biogenesis from scratch? Curr Opin Cell Biol 2005; 17: 415-422.
10. Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T: Impairment of starvation-induced and constitutive autophagy in atg7- deficient mice. J Cell Biol 2005; 169: 425-434.
11. Ventruti A, Cuervo AM: Autophagy and neurodegeneration. Curr Neurol Neurosci Rep 2007; 7: 443-451.
12. Mori E, Hirono N, Yamashita H, Imamura T, Ikejiri Y, Ikeda M, Kitagaki H, Shimomura T, Yoneda Y: Premorbid brain size as a determinant of reserve capacity against intellectual decline in Alzheimer's disease. Am J Psychiatry 1997; 154: 18-24.
13. Lunemann JD, Schmidt J, Dalakas MC, Munz C: Macroautophagy as a pathomechanism in sporadic inclusion body myositis. Autophagy 2007; 3: 384-386. (Pubitemid 46986351)
14. Pacheco CD, Elrick MJ, Lieberman AP: Tau deletion exacerbates the phenotype of Niemann- Pick type c mice and implicates autophagy in pathogenesis. Hum Mol Genet 2009; 18: 956-965.
15. Li L, Zhang X, Yang D, Luo G, Chen S, Le W: Hypoxia increases abeta generation by altering beta- and gamma-cleavage of app. Neurobiol Aging 2009; 30: 1091-1098.
16. Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Naslund J, Mathews PM, Cataldo AM, Nixon RA: Macroautophagy - a novel beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol 2005; 171: 87-98.
17. Yu WH, Kumar A, Peterhoff C, Shapiro Kulnane L, Uchiyama Y, Lamb BT, Cuervo AM, Nixon RA: Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. Int J Biochem Cell Biol 2004; 36: 2531-2540.
18. Nixon RA: Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci 2007; 120: 4081-4091.
19. Sahara N, Maeda S, Takashima A: Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration. Curr Alzheimer Res 2008; 5: 591-598.
20. Zhang CE, Tian Q, Wei W, Peng JH, Liu GP, Zhou XW, Wang Q, Wang DW, Wang JZ: Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2a in rat hippocampus. Neurobiol Aging 2008; 29: 1654-1665.
21. Iqbal K, Liu F, Gong CX, Alonso Adel C, Grundke-Iqbal I: Mechanisms of tau-induced neurodegeneration. Acta Neuropathol 2009; 118: 53-69.
22. Williams A, Jahreiss L, Sarkar S, Saiki S, Menzies FM, Ravikumar B, Rubinsztein DC: Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications. Curr Top Dev Biol 2006; 76: 89-101.
23. Wyttenbach A, Hands S, King MA, Lipkow K, Tolkovsky AM: Amelioration of protein misfolding disease by rapamycin: translation or autophagy? Autophagy 2008; 4: 542-545.
24. Zhang JY, Peng C, Shi H, Wang S, Wang Q, Wang JZ: Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain. J Alzheimers Dis 2009; 16: 39-47.
25. Aplin A, Jasionowski T, Tuttle DL, Lenk SE, Dunn WA Jr: Cytoskeletal elements are required for the formation and maturation of AVs. J Cell Physiol 1992; 152: 458-466.
26. Yoon SY, Choi JE, Kweon HS, Choe H, Kim SW, Hwang O, Lee H, Lee JY, Kim DH: Okadaic acid increases autophagosomes in rat neurons: implications for Alzheimer's disease. J Neurosci Res 2008; 86: 3230-3239.
27. Tian Q, Lin ZQ, Wang XC, Chen J, Wang Q, Gong CX, Wang JZ: Injection of okadaic acid into the Meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit. Neuroscience 2004; 126: 277-284.
28. Ling D, Salvaterra PM: A central role for autophagy in Alzheimer-type neurodegeneration. Autophagy 2009; 5: 738-740.
29. Rubinsztein DC, DiFiglia M, Heintz N, Nixon RA, Qin ZH, Ravikumar B, Stefanis L, Tolkovsky A: Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy 2005; 1: 11-22.
30. Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM: Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol 2005; 64: 113-122.
31. Brunk UT, Terman A: The mitochondriallysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem 2002; 269: 1996-2002.
32. Brunk UT, Dalen H, Roberg K, Hellquist HB: Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radic Biol Med 1997; 23: 616-626.
33. Heikkinen T, Kalesnykas G, Rissanen A, Tapiola T, Iivonen S, Wang J, Chaudhuri J, Tanila H, Miettinen R, Puolivali J: Estrogen treatment improves spatial learning in app + ps1 mice but does not affect beta amyloid accumulation and plaque formation. Exp Neurol 2004; 187: 105-117.
34. Lai CS, Preisler J, Baum L, Lee DH, Ng HK, Hugon J, So KF, Chang RC: Low molecular weight abeta induces collapse of endoplasmic reticulum. Mol Cell Neurosci 2009; 41: 32-43.
35. Sanchez MP, Alvarez-Tallada V, Avila J: The microtubule-associated protein tau in neurodegenerative diseases. Tauopathies (in Spanish). Rev Neurol 2001; 33: 169-177.
36. Nixon RA, Cataldo AM, Mathews PM: The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review. Neurochem Res 2000; 25: 1161-1172.
37. Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA: Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci 2008; 28: 6926-6937.
38. Yang AJ, Chandswangbhuvana D, Margol L, Glabe CG: Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid abeta1-42 pathogenesis. J Neurosci Res 1998; 52: 691-698.
39. Koh YH, von Arnim CA, Hyman BT, Tanzi RE, Tesco G: BACE is degraded via the lysosomal pathway. J Biol Chem 2005; 280: 32499-32504.
40. Zhou W, Scott SA, Shelton SB, Crutcher KA: Cathepsin D-mediated proteolysis of apolipoprotein E: Possible role in Alzheimer's disease. Neuroscience 2006; 143: 689-701.
41. Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G: Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy 2007; 3: 614-615.
42. Selwood SP, Parvathy S, Cordell B, Ryan HS, Oshidari F, Vincent V, Yesavage J, Lazzeroni LC, Murphy GM Jr: Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without apolipoprotein E. Neurobiol Aging 2009; 30: 574-590.
43. Cardoso SM, Pereira CF, Moreira PI, Arduino DM, Esteves AR, Oliveira CR: Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease. Exp Neurol 2009, E-pub ahead of print.
44. Ravikumar B, Sarkar S, Rubinsztein DC: Clearance of mutant aggregate-prone proteins by autophagy. Methods Mol Biol 2008; 445: 195-211.
45. Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC: Trehalose, a novel mTORindependent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 2007; 282: 5641-5652.
46. Hung SY, Huang WP, Liou HC, Fu WM: Autophagy protects neuron from abeta-induced cytotoxicity. Autophagy 2009; 5: 502-510.
47. Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, Wyss-Coray T: The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 2008; 118: 2190-2199.
48. Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L: Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron 2006; 51: 703-714.