Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1

Neuroscience Letters

Volumn 318, Issue 1, 2002, Pages 29-33

  Boutajangout, A ^a   Leroy, K ^a   Touchet, N ^b   Authelet, M ^a   Blanchard, V ^b   Tremp, G ^b   Pradier, L ^b   Brion, J P ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b SANOFI   (France)

Author keywords

Catenin; Glycogen synthase kinase 3 ; Microtubule associated protein; Phosphorylation; Presenilin 1; Tau protein; Transgenesis

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; ISOPROTEIN; MUTANT PROTEIN; PRESENILIN 1; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN NERVE CELL; CONTROLLED STUDY; HUMAN; IMMUNOPRECIPITATION; MOUSE; MOUSE STRAIN; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; BETA CATENIN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CYTOSKELETAL PROTEINS; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; HUMANS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; NEUROFIBRILLARY TANGLES; NEURONS; PHOSPHORYLATION; PRESENILIN-1; TAU PROTEINS; TRANS-ACTIVATORS;

EID: 0037126952     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)02461-2     Document Type: Article

References (21)

1. Alzheimer's disease: Clues from flies and worms
2. The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region
3. Synaptophysin and chromogranin A immunoreactivities in senile plaques of Alzheimer's disease
4. Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer disease
5. Characterization of human presenilin 1 transgenic rats: Increased sensitivity to apoptosis in primary neuronal cultures
6. Presenilins and Alzheimer's disease: Biological functions and pathogenic mechanisms
7. Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: Identification of phosphorylation sites in tau protein
8. Immunoreactivity of presenilin-1 and tau in Alzheimer's disease brain
9. Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation
10. Tau phosphorylation in cells transfected with wild-type or an Alzheimer's disease mutant Presenilin 1
11. No influence of presenilin 1 I143Tand G384A mutations on endogenous tau phosphorylation in human and mouse neuroblastoma cells
12. Presenilin 1 facilitates the constitutive turnover of β-catenin: Differential activity of Alzheimer's disease-linked PS1 mutants in the β-catenin-signaling pathway
13. Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
14. Developmental expression and localization of glycogen synthase-kinase 3β in rat brain
15. Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations
16. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
17. Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404
18. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
19. Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau
20. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin
21. Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis