Brain aging and Aβ1-42 neurotoxicity converge via deterioration in autophagy-lysosomal system: A conditional Drosophila model linking Alzheimer's neurodegeneration with aging

Acta Neuropathologica

Volumn 121, Issue 2, 2011, Pages 183-191

  Ling, Daijun ^a   Salvaterra, Paul M ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Aging; Alzheimer's disease; Autophagy; Drosophila; Lysosome; Pathogenesis

Indexed keywords

AMYLOID BETA PROTEIN[1-42];

AGING; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN NERVE CELL; CELL ACTIVATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DROSOPHILA; LYSOSOME; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR;

AGE FACTORS; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTOPHAGY; BRAIN; DISEASE MODELS, ANIMAL; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HORMONE ANTAGONISTS; HUMANS; LYSOSOMES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MIFEPRISTONE; NEURONS; PEPTIDE FRAGMENTS;

EID: 79451471809     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-010-0772-0     Document Type: Article

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