메뉴 건너뛰기




Volumn 2, Issue 67, 2009, Pages

Immune regulation by rapamycin: Moving beyond T cells

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RAPAMYCIN; TOLL LIKE RECEPTOR; IMMUNOSUPPRESSIVE AGENT; INTERFERON;

EID: 70349257680     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.267pe25     Document Type: Short Survey
Times cited : (40)

References (26)
  • 1
    • 0016724057 scopus 로고
    • Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • C. Vezina, A. Kudelski, S. N. Sehgal, Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. (Tokyo) 28, 721-726 (1975).
    • (1975) J. Antibiot. (Tokyo) , vol.28 , pp. 721-726
    • Vezina, C.1    Kudelski, A.2    Sehgal S.N3
  • 3
    • 24644445998 scopus 로고    scopus 로고
    • Rapamycin: An anti-cancer immunosuppressant?
    • B. K. Law, Rapamycin: An anti-cancer immunosuppressant? Crit. Rev. Oncol. Hematol. 56, 47-60 (2005).
    • (2005) Crit. Rev. Oncol. Hematol. , vol.56 , pp. 47-60
    • Law B.K1
  • 4
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • S. Wullschleger, R. Loewith, M. N. Hall, TOR signaling in growth and metabolism. Cell 124, 471-484 (2006). (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 5
    • 52549127241 scopus 로고    scopus 로고
    • Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycinsensitive PI(3)K-mTOR-p70S6K pathway
    • W. Cao, S. Manicassamy, H. Tang, S. P. Kasturi, A. Pirani, N. Murthy, B. Pulendran, Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycinsensitive PI(3)K-mTOR-p70S6K pathway. Nat. Immunol. 9, 1157-1164 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1157-1164
    • Cao, W.1    Manicassamy, S.2    Tang, H.3    Kasturi, S.P.4    Pirani, A.5    Murthy, N.6    Pulendran, B.7
  • 7
    • 50949130076 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
    • M. Ohtani, S. Nagai, S. Kondo, S. Mizuno, K. Nakamura, M. Tanabe, T. Takeuchi, S. Matsuda, S. Koyasu, Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 112, 635-643 (2008).
    • (2008) Blood , vol.112 , pp. 635-643
    • Ohtani, M.1    Nagai, S.2    Kondo, S.3    Mizuno, S.4    Nakamura, K.5    Tanabe, M.6    Takeuchi, T.7    Matsuda, S.8    Koyasu, S.9
  • 9
    • 77953669713 scopus 로고    scopus 로고
    • Toll-Like Receptor Pathway
    • Connections Map in the Database of Cell Signaling
    • G. B. Barton, R. Medzhitov, Toll-Like Receptor Pathway. Sci. Signal. (Connections Map in the Database of Cell Signaling), http://stke. sciencemag.org/cgi/cm/stkecm;CMP-8643.
    • Sci. Signal.
    • Barton, G.B.1    Medzhitov, R.2
  • 11
    • 0037199972 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • DOI 10.1074/jbc.M203298200
    • M. Guha, N. Mackman, The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277, 32124-32132 (2002). (Pubitemid 34969025)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.35 , pp. 32124-32132
    • Guha, M.1    Mackman, N.2
  • 12
    • 0038446051 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide
    • M. Martin, R. E. Schifferle, N. Cuesta, S. N. Vogel, J. Katz, S. M. Michalek, Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J. Immunol. 171, 717-725 (2003). (Pubitemid 36871381)
    • (2003) Journal of Immunology , vol.171 , Issue.2 , pp. 717-725
    • Martin, M.1    Schifferle, R.E.2    Cuesta, N.3    Vogel, S.N.4    Katz, J.5    Michalek, S.M.6
  • 13
    • 39549116503 scopus 로고    scopus 로고
    • PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation
    • DOI 10.1084/jem.20070763
    • C. Guiducci, C. Ghirelli, M. A. Marloie-Provost, T. Matray, R. L. Coffman, Y. J. Liu, F. J. Barrat, V. Soumelis, PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J. Exp. Med. 205, 315-322 (2008). (Pubitemid 351281597)
    • (2008) Journal of Experimental Medicine , vol.205 , Issue.2 , pp. 315-322
    • Guiducci, C.1    Ghirelli, C.2    Marloie-Provost, M.-A.3    Matray, T.4    Coffman, R.L.5    Liu, Y.-J.6    Barrat, F.J.7    Soumelis, V.8
  • 14
    • 56749156696 scopus 로고    scopus 로고
    • The PI3K/Akt/mTOR pathway in innate immune cells: Emerging therapeutic applications
    • T. Weichhart, M. D. Saemann, The PI3K/Akt/mTOR pathway in innate immune cells: Emerging therapeutic applications. Ann. Rheum. Dis. 67 (suppl. 3), iii70-iii74 (2008).
    • (2008) Ann. Rheum. Dis. , vol.67 , Issue.SUPPL. 3
    • Weichhart, T.1    Saemann M.D2
  • 18
    • 60549107773 scopus 로고    scopus 로고
    • Use of rapamycin in the induction of tolerogenic dendritic cells
    • R. Fischer, H. R. Turnquist, T. Taner, A. W. Thomson, Use of rapamycin in the induction of tolerogenic dendritic cells. Handb. Exp. Pharmacol. 188, 215-232 (2009).
    • (2009) Handb. Exp. Pharmacol. , vol.188 , pp. 215-232
    • Fischer, R.1    Turnquist, H.R.2    Taner, T.3    Thomson A.W4
  • 19
    • 37349068519 scopus 로고    scopus 로고
    • Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion
    • DOI 10.1016/j.trim.2007.10.007, PII S0966327407001724
    • E. K. Horibe, J. Sacks, J. Unadkat, G. Raimondi, Z. Wang, R. Ikeguchi, D. Marsteller, L. M. Ferreira, A. W. Thomson, W. P. Lee, M. Feili-Hariri, Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion. Transpl. Immunol. 18, 307-318 (2008). (Pubitemid 350297967)
    • (2008) Transplant Immunology , vol.18 , Issue.4 , pp. 307-318
    • Horibe, E.K.1    Sacks, J.2    Unadkat, J.3    Raimondi, G.4    Wang, Z.5    Ikeguchi, R.6    Marsteller, D.7    Ferreira, L.M.8    Thomson, A.W.9    Lee, W.P.A.10    Feili-Hariri, M.11
  • 20
    • 58149292274 scopus 로고    scopus 로고
    • Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation
    • W. Reichardt, C. Durr, D. von Elverfeldt, E. Juttner, U. V. Gerlach, M. Yamada, B. Smith, R. S. Negrin, R. Zeiser, Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation. J. Immunol. 181, 4770-4779 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 4770-4779
    • Reichardt, W.1    Durr, C.2    Von Elverfeldt, D.3    Juttner, E.4    Gerlach, U.V.5    Yamada, M.6    Smith, B.7    Negrin, R.S.8    Zeiser, R.9
  • 22
    • 56249147509 scopus 로고    scopus 로고
    • Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    • A. Y. Choo, S. O. Yoon, S. G. Kim, P. P. Roux, J. Blenis, Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc. Natl. Acad. Sci. U.S.A. 105, 17414-17419 (2008).
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 17414-17419
    • Choo, A.Y.1    Yoon, S.O.2    Kim, S.G.3    Roux, P.P.4    Blenis, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.