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Volumn 12, Issue 6B, 2008, Pages 2525-2532

mTOR-dependent signalling in Alzheimer's disease

Author keywords

Alzheimer's disease; mTOR; Neurodegeneration; Neurofibrillary degeneration

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE; TAU PROTEIN;

EID: 58149463424     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00509.x     Document Type: Review
Times cited : (163)

References (69)
  • 1
    • 24044442298 scopus 로고    scopus 로고
    • Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1
    • Tee AR, Blenis J, Proud CG. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett. 2005 579 : 4763 8.
    • (2005) FEBS Lett. , vol.579 , pp. 4763-8
    • Tee, A.R.1    Blenis, J.2    Proud, C.G.3
  • 2
    • 0024442393 scopus 로고
    • A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
    • Siekierka JJ, Hung SH, Poe M, Lin CS, Sigal NH. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature. 1989 341 : 755 7.
    • (1989) Nature. , vol.341 , pp. 755-7
    • Siekierka, J.J.1    Hung, S.H.2    Poe, M.3    Lin, C.S.4    Sigal, N.H.5
  • 3
    • 38149062059 scopus 로고    scopus 로고
    • Role of mTOR in physiology and pathology of the nervous system
    • Swiech L, Perycz M, Malik A, Jaworski J. Role of mTOR in physiology and pathology of the nervous system. Biochim Biophys Acta. 2008 1784 : 116 32.
    • (2008) Biochim Biophys Acta. , vol.1784 , pp. 116-32
    • Swiech, L.1    Perycz, M.2    Malik, A.3    Jaworski, J.4
  • 4
    • 34047095297 scopus 로고    scopus 로고
    • The two TORCs and Akt
    • Bhaskar PT, Hay N. The two TORCs and Akt. Dev Cell. 2007 12 : 487 502.
    • (2007) Dev Cell. , vol.12 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 6
  • 7
    • 40649120732 scopus 로고    scopus 로고
    • Increased mTORC1 signaling UPRegulates stress
    • Reiling JH, Sabatini DM. Increased mTORC1 signaling UPRegulates stress. Mol Cell. 2008 29 : 533 5.
    • (2008) Mol Cell. , vol.29 , pp. 533-5
    • Reiling, J.H.1    Sabatini, D.M.2
  • 9
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006 124 : 471 84.
    • (2006) Cell. , vol.124 , pp. 471-84
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 10
    • 0037312507 scopus 로고    scopus 로고
    • Tor signalling in bugs, brain and brawn
    • Jacinto E, Hall MN. Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol. 2003 4 : 117 26.
    • (2003) Nat Rev Mol Cell Biol. , vol.4 , pp. 117-26
    • Jacinto, E.1    Hall, M.N.2
  • 11
    • 0242268407 scopus 로고    scopus 로고
    • MTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
    • Kwon CH, Zhu X, Zhang J, Baker SJ. mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc Natl Acad Sci USA. 2003 100 : 12923 8.
    • (2003) Proc Natl Acad Sci USA. , vol.100 , pp. 12923-8
    • Kwon, C.H.1    Zhu, X.2    Zhang, J.3    Baker, S.J.4
  • 12
    • 33847038824 scopus 로고    scopus 로고
    • The growing role of mTOR in neuronal development and plasticity
    • Jaworski J, Sheng M. The growing role of mTOR in neuronal development and plasticity. Mol Neurobiol. 2006 34 : 205 19.
    • (2006) Mol Neurobiol. , vol.34 , pp. 205-19
    • Jaworski, J.1    Sheng, M.2
  • 13
    • 33744818219 scopus 로고    scopus 로고
    • Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
    • Zhou XW, Li X, Bjorkdahl C, Sjogren MJ, Alafuzoff I, Soininen H, Grundke-Iqbal I, Iqbal K, Winblad B, Pei JJ. Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains. Neurobiol Dis. 2006 22 : 657 68.
    • (2006) Neurobiol Dis. , vol.22 , pp. 657-68
    • Zhou, X.W.1    Li, X.2    Bjorkdahl, C.3    Sjogren, M.J.4    Alafuzoff, I.5    Soininen, H.6    Grundke-Iqbal, I.7    Iqbal, K.8    Winblad, B.9    Pei, J.J.10
  • 14
    • 85047693458 scopus 로고    scopus 로고
    • Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: Cause or effect?
    • Dickson DW. Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? J Clin Invest. 2004 114 : 23 7.
    • (2004) J Clin Invest. , vol.114 , pp. 23-7
    • Dickson, D.W.1
  • 19
    • 0021238760 scopus 로고
    • Alzheimer's disease brain: Alterations in RNA levels and in a ribonuclease-inhibitor complex
    • Sajdel-Sulkowska EM, Marotta CA. Alzheimer's disease brain: alterations in RNA levels and in a ribonuclease-inhibitor complex. Science. 1984 225 : 947 9.
    • (1984) Science. , vol.225 , pp. 947-9
    • Sajdel-Sulkowska, E.M.1    Marotta, C.A.2
  • 20
    • 1842562209 scopus 로고    scopus 로고
    • An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease
    • Onuki R, Bando Y, Suyama E, Katayama T, Kawasaki H, Baba T, Tohyama M, Taira K. An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. EMBO J. 2004 23 : 959 68.
    • (2004) EMBO J. , vol.23 , pp. 959-68
    • Onuki, R.1    Bando, Y.2    Suyama, E.3    Katayama, T.4    Kawasaki, H.5    Baba, T.6    Tohyama, M.7    Taira, K.8
  • 21
    • 0041833464 scopus 로고    scopus 로고
    • Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice
    • Peel AL, Bredesen DE. Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice. Neurobiol Dis. 2003 14 : 52 62.
    • (2003) Neurobiol Dis. , vol.14 , pp. 52-62
    • Peel, A.L.1    Bredesen, D.E.2
  • 22
    • 0037147666 scopus 로고    scopus 로고
    • Phosphorylation of eukaryotic initiation factor-2alpha {eIF2alpha} is associated with neuronal degeneration in Alzheimer's disease
    • Chang RC, Wong AK, Ng HK, Hugon J. Phosphorylation of eukaryotic initiation factor-2alpha {eIF2alpha} is associated with neuronal degeneration in Alzheimer's disease. Neuroreport. 2002 13 : 2429 32.
    • (2002) Neuroreport. , vol.13 , pp. 2429-32
    • Chang, R.C.1    Wong, A.K.2    Ng, H.K.3    Hugon, J.4
  • 23
    • 0041343303 scopus 로고    scopus 로고
    • Up-regulation of phos-phorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
    • An WL, Cowburn RF, Li L, Braak H, Alafuzoff I, Iqbal K, Grundke-Iqbal I, Winblad B, Pei JJ. Up-regulation of phos-phorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am J Pathol. 2003 163 : 591 607.
    • (2003) Am J Pathol. , vol.163 , pp. 591-607
    • An, W.L.1    Cowburn, R.F.2    Li, L.3    Braak, H.4    Alafuzoff, I.5    Iqbal, K.6    Grundke-Iqbal, I.7    Winblad, B.8    Pei, J.J.9
  • 24
    • 0036892618 scopus 로고    scopus 로고
    • Involvement of double- stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration
    • Chang RC, Suen KC, Ma CH, Elyaman W, Ng HK, Hugon J. Involvement of double- stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration. J Neurochem. 2002 83 : 1215 25.
    • (2002) J Neurochem. , vol.83 , pp. 1215-25
    • Chang, R.C.1    Suen, K.C.2    Ma, C.H.3    Elyaman, W.4    Ng, H.K.5    Hugon, J.6
  • 25
    • 0348010382 scopus 로고    scopus 로고
    • Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity
    • Suen KC, Yu MS, So KF, Chang RC, Hugon J. Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity. J Biol Chem. 2003 278 : 49819 27.
    • (2003) J Biol Chem. , vol.278 , pp. 49819-27
    • Suen, K.C.1    Yu, M.S.2    So, K.F.3    Chang, R.C.4    Hugon, J.5
  • 27
    • 6344269168 scopus 로고    scopus 로고
    • Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain
    • Li X, An WL, Alafuzoff I, Soininen H, Winblad B, Pei JJ. Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain. Neuroreport. 2004 15 : 2237 40.
    • (2004) Neuroreport. , vol.15 , pp. 2237-40
    • Li, X.1    An, W.L.2    Alafuzoff, I.3    Soininen, H.4    Winblad, B.5    Pei, J.J.6
  • 28
    • 23844457609 scopus 로고    scopus 로고
    • Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain
    • Li X, Alafuzoff I, Soininen H, Winblad B, Pei JJ. Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain. FEBS J. 2005 272 : 4211 20.
    • (2005) FEBS J. , vol.272 , pp. 4211-20
    • Li, X.1    Alafuzoff, I.2    Soininen, H.3    Winblad, B.4    Pei, J.J.5
  • 30
    • 0023141084 scopus 로고
    • Lactate and pH in the brain: Association and dissociation in different pathophysiological states
    • Paschen W, Djuricic B, Mies G, Schmidt-Kastner R, Linn F. Lactate and pH in the brain: association and dissociation in different pathophysiological states. J Neurochem. 1987 48 : 154 9.
    • (1987) J Neurochem. , vol.48 , pp. 154-9
    • Paschen, W.1    Djuricic, B.2    Mies, G.3    Schmidt-Kastner, R.4    Linn, F.5
  • 31
    • 0027509140 scopus 로고
    • Regulation of serine protease activity by aluminum: Implications for Alzheimer disease
    • Clauberg M, Joshi JG. Regulation of serine protease activity by aluminum: implications for Alzheimer disease. Proc Natl Acad Sci USA. 1993 90 : 1009 12.
    • (1993) Proc Natl Acad Sci USA. , vol.90 , pp. 1009-12
    • Clauberg, M.1    Joshi, J.G.2
  • 33
    • 24144440042 scopus 로고    scopus 로고
    • Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms
    • Liu R, Pei JJ, Wang XC, Zhou XW, Tian Q, Winblad B, Wang JZ. Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms. J Neurochem. 2005 94 : 1225 34.
    • (2005) J Neurochem. , vol.94 , pp. 1225-34
    • Liu, R.1    Pei, J.J.2    Wang, X.C.3    Zhou, X.W.4    Tian, Q.5    Winblad, B.6    Wang, J.Z.7
  • 34
    • 2542428253 scopus 로고    scopus 로고
    • Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats
    • Wen Y, Yang S, Liu R, Brun-Zinkernagel AM, Koulen P, Simpkins JW. Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats. J Biol Chem. 2004 279 : 22684 92.
    • (2004) J Biol Chem. , vol.279 , pp. 22684-92
    • Wen, Y.1    Yang, S.2    Liu, R.3    Brun-Zinkernagel, A.M.4    Koulen, P.5    Simpkins, J.W.6
  • 35
    • 0025011401 scopus 로고
    • Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias
    • Yates CM, Butterworth J, Tennant MC, Gordon A. Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias. J Neurochem. 1990 55 : 1624 30.
    • (1990) J Neurochem. , vol.55 , pp. 1624-30
    • Yates, C.M.1    Butterworth, J.2    Tennant, M.C.3    Gordon, A.4
  • 37
    • 27144494994 scopus 로고    scopus 로고
    • Ribosome dysfunction is an early event in Alzheimer's disease
    • Ding Q, Markesbery WR, Chen Q, Li F, Keller JN. Ribosome dysfunction is an early event in Alzheimer's disease. J Neurosci. 2005 25 : 9171 5.
    • (2005) J Neurosci. , vol.25 , pp. 9171-5
    • Ding, Q.1    Markesbery, W.R.2    Chen, Q.3    Li, F.4    Keller, J.N.5
  • 40
    • 27144465421 scopus 로고    scopus 로고
    • Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways
    • Smirnova JB, Selley JN, Sanchez-Cabo F, Carroll K, Eddy AA, McCarthy JE, Hubbard SJ, Pavitt GD, Grant CM, Ashe MP. Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways. Mol Cell Biol. 2005 25 : 9340 9.
    • (2005) Mol Cell Biol. , vol.25 , pp. 9340-9
    • Smirnova, J.B.1    Selley, J.N.2    Sanchez-Cabo, F.3    Carroll, K.4    Eddy, A.A.5    McCarthy, J.E.6    Hubbard, S.J.7    Pavitt, G.D.8    Grant, C.M.9    Ashe, M.P.10
  • 41
    • 0345602742 scopus 로고    scopus 로고
    • Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock
    • Preiss T, Baron-Benhamou J, Ansorge W, Hentze MW. Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock. Nat Struct Biol. 2003 10 : 1039 47.
    • (2003) Nat Struct Biol. , vol.10 , pp. 1039-47
    • Preiss, T.1    Baron-Benhamou, J.2    Ansorge, W.3    Hentze, M.W.4
  • 42
    • 31944434543 scopus 로고    scopus 로고
    • TOR-mediated cell-cycle activation causes neurode-generation in a Drosophila tauopathy model
    • Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB. TOR-mediated cell-cycle activation causes neurode-generation in a Drosophila tauopathy model. Curr Biol. 2006 16 : 230 41.
    • (2006) Curr Biol. , vol.16 , pp. 230-41
    • Khurana, V.1    Lu, Y.2    Steinhilb, M.L.3    Oldham, S.4    Shulman, J.M.5    Feany, M.B.6
  • 43
    • 84880186369 scopus 로고    scopus 로고
    • Genetic complexity of Alzheimer's disease: Successes and challenges
    • Rogaeva E, Kawarai T, George-Hyslop PS. Genetic complexity of Alzheimer's disease: successes and challenges. J Alzheimers Dis. 2006 9 : 381 7.
    • (2006) J Alzheimers Dis. , vol.9 , pp. 381-7
    • Rogaeva, E.1    Kawarai, T.2    George-Hyslop, P.S.3
  • 44
    • 4944230199 scopus 로고    scopus 로고
    • Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease
    • Boutajangout A, Boom A, Leroy K, Brion J P. Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease. FEBS Lett. 2004 576 : 183 9.
    • (2004) FEBS Lett. , vol.576 , pp. 183-9
    • Boutajangout, A.1    Boom, A.2    Leroy, K.3    Brion, J.P.4
  • 45
    • 0032859650 scopus 로고    scopus 로고
    • Overexpression of four-repeat tau mRNA isoforms in progressive supranuclear palsy but not in Alzheimer's disease
    • Chambers CB, Lee JM, Troncoso JC, Reich S, Muma NA. Overexpression of four-repeat tau mRNA isoforms in progressive supranuclear palsy but not in Alzheimer's disease. Ann Neurol. 1999 46 : 325 32.
    • (1999) Ann Neurol. , vol.46 , pp. 325-32
    • Chambers, C.B.1    Lee, J.M.2    Troncoso, J.C.3    Reich, S.4    Muma, N.A.5
  • 46
    • 0026500429 scopus 로고
    • In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs; Species differences and relative preservation in Alzheimer's disease
    • Mah VH, Eskin TA, Kazee AM, Lapham L, Higgins GA. In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs; species differences and relative preservation in Alzheimer's disease. Brain Res Mol Brain Res. 1992 12 : 85 94.
    • (1992) Brain Res Mol Brain Res. , vol.12 , pp. 85-94
    • Mah, V.H.1    Eskin, T.A.2    Kazee, A.M.3    Lapham, L.4    Higgins, G.A.5
  • 47
    • 0028802451 scopus 로고
    • The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain
    • Pearson RB, Dennis PB, Han JW, Williamson NA, Kozma SC, Wettenhall RE, Thomas G. The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J. 1995 14 : 5279 87.
    • (1995) EMBO J. , vol.14 , pp. 5279-87
    • Pearson, R.B.1    Dennis, P.B.2    Han, J.W.3    Williamson, N.A.4    Kozma, S.C.5    Wettenhall, R.E.6    Thomas, G.7
  • 48
    • 14844299775 scopus 로고    scopus 로고
    • Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells
    • An WL, Bjorkdahl C, Liu R, Cowburn RF, Winblad B, Pei JJ. Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells. J Neurochem. 2005 92 : 1104 15.
    • (2005) J Neurochem. , vol.92 , pp. 1104-15
    • An, W.L.1    Bjorkdahl, C.2    Liu, R.3    Cowburn, R.F.4    Winblad, B.5    Pei, J.J.6
  • 49
  • 51
    • 0042679509 scopus 로고    scopus 로고
    • Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease
    • Pei JJ, Gong CX, An WL, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K. Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease. Am J Pathol. 2003 163 : 845 58.
    • (2003) Am J Pathol. , vol.163 , pp. 845-58
    • Pei, J.J.1    Gong, C.X.2    An, W.L.3    Winblad, B.4    Cowburn, R.F.5    Grundke-Iqbal, I.6    Iqbal, K.7
  • 53
    • 38049170722 scopus 로고    scopus 로고
    • Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A-and glycogen synthase kinase-3 -dependent phosphorylation of Tau
    • Meske V, Albert F, Ohm TG. Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A-and glycogen synthase kinase-3 -dependent phosphorylation of Tau. J Biol Chem. 2008 283 : 100 9.
    • (2008) J Biol Chem. , vol.283 , pp. 100-9
    • Meske, V.1    Albert, F.2    Ohm, T.G.3
  • 55
    • 34249738681 scopus 로고    scopus 로고
    • Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily
    • Virdee K, Yoshida H, Peak-Chew S, Goedert M. Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily. FEBS Lett. 2007 581 : 2657 62.
    • (2007) FEBS Lett. , vol.581 , pp. 2657-62
    • Virdee, K.1    Yoshida, H.2    Peak-Chew, S.3    Goedert, M.4
  • 56
    • 38049169106 scopus 로고    scopus 로고
    • Parallel increase in p70 kinase activation and tau phosphorylation {s262} with Abeta overproduction
    • Zhou XW, Tanila H, Pei JJ. Parallel increase in p70 kinase activation and tau phosphorylation {S262} with Abeta overproduction. FEBS Lett. 2008 582 : 159 64.
    • (2008) FEBS Lett. , vol.582 , pp. 159-64
    • Zhou, X.W.1    Tanila, H.2    Pei, J.J.3
  • 57
    • 27844530579 scopus 로고    scopus 로고
    • The relation between p70S6k expression in lymphocytes and the decline of cognitive test scores in patients with Alzheimer disease
    • Paccalin M, Pain-Barc S, Pluchon C, Paul C, Bazin H, Gil R, Hugon J. The relation between p70S6k expression in lymphocytes and the decline of cognitive test scores in patients with Alzheimer disease. Arch Intern Med. 2005 165 : 2428 9.
    • (2005) Arch Intern Med. , vol.165 , pp. 2428-9
    • Paccalin, M.1    Pain-Barc, S.2    Pluchon, C.3    Paul, C.4    Bazin, H.5    Gil, R.6    Hugon, J.7
  • 61
    • 33749166640 scopus 로고    scopus 로고
    • RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation
    • Malagelada C, Ryu EJ, Biswas SC, Jackson-Lewis V, Greene LA. RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. J Neurosci. 2006 26 : 9996 10005.
    • (2006) J Neurosci. , vol.26 , pp. 9996-10005
    • Malagelada, C.1    Ryu, E.J.2    Biswas, S.C.3    Jackson-Lewis, V.4    Greene, L.A.5
  • 63
    • 41149128223 scopus 로고    scopus 로고
    • MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis
    • Chen L, Liu L, Luo Y, Huang S. MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem. 2008 105 : 251 61.
    • (2008) J Neurochem. , vol.105 , pp. 251-61
    • Chen, L.1    Liu, L.2    Luo, Y.3    Huang, S.4
  • 65
    • 0025172064 scopus 로고
    • Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease
    • Vogt BA, Van Hoesen GW, Vogt LJ. Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease. Acta Neuropathol. 1990 80 : 581 9.
    • (1990) Acta Neuropathol. , vol.80 , pp. 581-9
    • Vogt, B.A.1    Van Hoesen, G.W.2    Vogt, L.J.3
  • 66
    • 0031127495 scopus 로고    scopus 로고
    • Cultured neurons expressing phosphorylated tau are more resistant to apoptosis induced by NMDA or serum deprivation
    • Lesort M, Blanchard C, Yardin C, Esclaire F, Hugon J. Cultured neurons expressing phosphorylated tau are more resistant to apoptosis induced by NMDA or serum deprivation. Brain Res Mol Brain Res. 1997 45 : 127 32.
    • (1997) Brain Res Mol Brain Res. , vol.45 , pp. 127-32
    • Lesort, M.1    Blanchard, C.2    Yardin, C.3    Esclaire, F.4    Hugon, J.5
  • 67
    • 0032557888 scopus 로고    scopus 로고
    • FK506 antagonizes apoptosis and c-jun protein expression in neuronal cultures
    • Yardin C, Terro F, Lesort M, Esclaire F, Hugon J. FK506 antagonizes apoptosis and c-jun protein expression in neuronal cultures. Neuroreport. 1998 9 : 2077 80.
    • (1998) Neuroreport. , vol.9 , pp. 2077-80
    • Yardin, C.1    Terro, F.2    Lesort, M.3    Esclaire, F.4    Hugon, J.5
  • 68
    • 12244288323 scopus 로고    scopus 로고
    • BAD and Bcl-2 reguation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis
    • Elyaman W, Terro F, Suen KC, Yardin C, Chang RC, Hugon J. BAD and Bcl-2 reguation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis. Brain Res Mol Brain Res. 2002 109 : 233 8.
    • (2002) Brain Res Mol Brain Res. , vol.109 , pp. 233-8
    • Elyaman, W.1    Terro, F.2    Suen, K.C.3    Yardin, C.4    Chang, R.C.5    Hugon, J.6
  • 69
    • 0031913730 scopus 로고    scopus 로고
    • Activation of a PP2A-like phosphatase and dephosphorylation of tau protein characterize onset of the execution phase of apoptosis
    • Mills JC, Lee VM, Pittman RN. Activation of a PP2A-like phosphatase and dephosphorylation of tau protein characterize onset of the execution phase of apoptosis. J Cell Sci. 1998 111 : 625 36.
    • (1998) J Cell Sci. , vol.111 , pp. 625-36
    • Mills, J.C.1    Lee, V.M.2    Pittman, R.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.