Rapamycin increases the p53/MDM2 protein ratio and p53-dependent apoptosis by translational inhibition of mdm2 in cancer cells

Cancer Letters

Volumn 286, Issue 2, 2009, Pages 250-259

  Kao, Chia Li ^a   Hsu, Han Shui ^a   Chen, Hsin Wu ^a   Cheng, Tzu Hao ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

eIF4E; MDM2; p53; Rapamycin; Translational control

Indexed keywords

INITIATION FACTOR 4E BINDING PROTEIN 1; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN MDM2; PROTEIN P53; PUMA PROTEIN; RAPAMYCIN; SMALL INTERFERING RNA;

5' UNTRANSLATED REGION; APOPTOSIS; ARTICLE; CANCER CELL; CELL STIMULATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; TRANSLATION REGULATION;

5' UNTRANSLATED REGIONS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; EUKARYOTIC INITIATION FACTOR-4E; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; NEOPLASMS; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS C-MDM2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIROLIMUS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 71549134278     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.05.031     Document Type: Article

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