-
1
-
-
69449106873
-
Autophagy is required for extension of yeast chronological life span by rapamycin
-
Alvers A. L., Wood M. S., Hu D., Kaywell A. C., Dunn W. Jr.A., and, Aris J. P., (2009) Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy 5, 847-849.
-
(2009)
Autophagy
, vol.5
, pp. 847-849
-
-
Alvers, A.L.1
Wood, M.S.2
Hu, D.3
Kaywell, A.C.4
Dunn Jr., W.A.5
Aris, J.P.6
-
2
-
-
77952083662
-
Rapamycin extends maximal lifespan in cancer-prone mice
-
Anisimov V. N., Zabezhinski M. A., Popovich I. G., Piskunova T. S., Semenchenko A. V., Tyndyk M. L., Yurova M. N., Antoch M. P., and, Blagosklonny M. V., (2010) Rapamycin extends maximal lifespan in cancer-prone mice. Am. J. Pathol. 176, 2092-2097.
-
(2010)
Am. J. Pathol.
, vol.176
, pp. 2092-2097
-
-
Anisimov, V.N.1
Zabezhinski, M.A.2
Popovich, I.G.3
Piskunova, T.S.4
Semenchenko, A.V.5
Tyndyk, M.L.6
Yurova, M.N.7
Antoch, M.P.8
Blagosklonny, M.V.9
-
3
-
-
65649128580
-
Amino acid regulation of TOR complex 1
-
Avruch J., Long X., Ortiz-Vega S., Rapley J., Papageorgiou A., and, Dai N., (2009) Amino acid regulation of TOR complex 1. Am. J. Physiol. Endocrinol. Metab. 296, E592-E602.
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.296
-
-
Avruch, J.1
Long, X.2
Ortiz-Vega, S.3
Rapley, J.4
Papageorgiou, A.5
Dai, N.6
-
4
-
-
16844385435
-
Characterization of the FKBP.rapamycin.FRB ternary complex
-
Banaszynski L. A., Liu C. W., and, Wandless T. J., (2005) Characterization of the FKBP.rapamycin.FRB ternary complex. J. Am. Chem. Soc. 127, 4715-4721.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 4715-4721
-
-
Banaszynski, L.A.1
Liu, C.W.2
Wandless, T.J.3
-
5
-
-
67649356581
-
DSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster
-
Bauer J. H., Morris S. N., Chang C., Flatt T., Wood J. G., and, Helfand S. L., (2009) dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster. Aging (Albany NY) 1, 38-48.
-
(2009)
Aging (Albany NY)
, vol.1
, pp. 38-48
-
-
Bauer, J.H.1
Morris, S.N.2
Chang, C.3
Flatt, T.4
Wood, J.G.5
Helfand, S.L.6
-
6
-
-
31544454404
-
Rapamycin alleviates toxicity of different aggregate-prone proteins
-
DOI 10.1093/hmg/ddi458
-
Berger Z., Ravikumar B., Menzies F. M., et al. (2006) Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum. Mol. Genet. 15, 433-442. (Pubitemid 43159895)
-
(2006)
Human Molecular Genetics
, vol.15
, Issue.3
, pp. 433-442
-
-
Berger, Z.1
Ravikumar, B.2
Menzies, F.M.3
Oroz, L.G.4
Underwood, B.R.5
Pangalos, M.N.6
Schmitt, I.7
Wullner, U.8
Evert, B.O.9
O'Kane, C.J.10
Rubinsztein, D.C.11
-
7
-
-
63849230729
-
The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events
-
Bhaskar K., Miller M., Chludzinski A., Herrup K., Zagorski M., and, Lamb B. T., (2009) The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Mol. Neurodegener. 4, 14.
-
(2009)
Mol. Neurodegener.
, vol.4
, pp. 14
-
-
Bhaskar, K.1
Miller, M.2
Chludzinski, A.3
Herrup, K.4
Zagorski, M.5
Lamb, B.T.6
-
8
-
-
77950229880
-
Neural mechanisms of ageing and cognitive decline
-
Bishop N. A., Lu T., and, Yankner B. A., (2010) Neural mechanisms of ageing and cognitive decline. Nature 464, 529-535.
-
(2010)
Nature
, vol.464
, pp. 529-535
-
-
Bishop, N.A.1
Lu, T.2
Yankner, B.A.3
-
9
-
-
72649091698
-
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
-
Bjedov I., Toivonen J. M., Kerr F., Slack C., Jacobson J., Foley A., and, Partridge L., (2010) Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 11, 35-46.
-
(2010)
Cell Metab.
, vol.11
, pp. 35-46
-
-
Bjedov, I.1
Toivonen, J.M.2
Kerr, F.3
Slack, C.4
Jacobson, J.5
Foley, A.6
Partridge, L.7
-
10
-
-
33947574775
-
Reduced TOR Signaling Extends Chronological Life Span via Increased Respiration and Upregulation of Mitochondrial Gene Expression
-
DOI 10.1016/j.cmet.2007.02.009, PII S1550413107000617
-
Bonawitz N. D., Chatenay-Lapointe M., Pan Y., and, Shadel G. S., (2007) Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab. 5, 265-277. (Pubitemid 46477854)
-
(2007)
Cell Metabolism
, vol.5
, Issue.4
, pp. 265-277
-
-
Bonawitz, N.D.1
Chatenay-Lapointe, M.2
Pan, Y.3
Shadel, G.S.4
-
11
-
-
77956850682
-
Pathological implications of cell cycle re-entry in Alzheimer disease
-
Bonda D. J., Lee H. P., Kudo W., Zhu X., Smith M. A., and, Lee H. G., (2010) Pathological implications of cell cycle re-entry in Alzheimer disease. Expert Rev. Mol. Med. 12, e19.
-
(2010)
Expert Rev. Mol. Med.
, vol.12
-
-
Bonda, D.J.1
Lee, H.P.2
Kudo, W.3
Zhu, X.4
Smith, M.A.5
Lee, H.G.6
-
12
-
-
79951686964
-
The sirtuin pathway in ageing and Alzheimer disease: Mechanistic and therapeutic considerations
-
Bonda D. J., Lee H. G., Camins A., Pallàs M., Casadesus G., Smith M. A., and, Zhu X., (2011) The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. Lancet Neurol. 10, 275-279.
-
(2011)
Lancet Neurol.
, vol.10
, pp. 275-279
-
-
Bonda, D.J.1
Lee, H.G.2
Camins, A.3
Pallàs, M.4
Casadesus, G.5
Smith, M.A.6
Zhu, X.7
-
13
-
-
56549084442
-
Local protein synthesis, actin dynamics, and LTP consolidation
-
Bramham C. R., (2008) Local protein synthesis, actin dynamics, and LTP consolidation. Curr. Opin. Neurobiol. 18, 524-531.
-
(2008)
Curr. Opin. Neurobiol.
, vol.18
, pp. 524-531
-
-
Bramham, C.R.1
-
14
-
-
77951227122
-
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: Effects on cognitive impairments
-
Caccamo A., Majumder S., Richardson A., Strong R., and, Oddo S., (2010) Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J. Biol. Chem. 285, 13107-13120.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 13107-13120
-
-
Caccamo, A.1
Majumder, S.2
Richardson, A.3
Strong, R.4
Oddo, S.5
-
15
-
-
0033796250
-
Mitochondrial free radical generation, oxidative stress, and aging
-
Cadenas E., and, Davies K. J., (2000) Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 29, 222-230.
-
(2000)
Free Radic. Biol. Med.
, vol.29
, pp. 222-230
-
-
Cadenas, E.1
Davies, K.J.2
-
16
-
-
77956470750
-
Alzheimer disease
-
Castellani R. J., Rolston R. K., and, Smith M. A., (2010) Alzheimer disease. Dis. Mon. 56, 484-546.
-
(2010)
Dis. Mon.
, vol.56
, pp. 484-546
-
-
Castellani, R.J.1
Rolston, R.K.2
Smith, M.A.3
-
17
-
-
59749098315
-
Nutrient-dependent regulation of autophagy through the target of rapamycin pathway
-
Chang Y. Y., Juhasz G., Goraksha-Hicks P., Arsham A. M., Mallin D. R., Muller L. K., and, Neufeld T. P., (2009) Nutrient-dependent regulation of autophagy through the target of rapamycin pathway. Biochem. Soc. Trans. 37, 232-236.
-
(2009)
Biochem. Soc. Trans.
, vol.37
, pp. 232-236
-
-
Chang, Y.Y.1
Juhasz, G.2
Goraksha-Hicks, P.3
Arsham, A.M.4
Mallin, D.R.5
Muller, L.K.6
Neufeld, T.P.7
-
18
-
-
0029055145
-
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
-
Chen J., Zheng X. F., Brown E. J., and, Schreiber S. L., (1995) Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc. Natl Acad. Sci. USA 92, 4947-4951.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 4947-4951
-
-
Chen, J.1
Zheng, X.F.2
Brown, E.J.3
Schreiber, S.L.4
-
19
-
-
0035040549
-
The inflammation hypothesis of aging: Molecular modulation by calorie restriction
-
Chung H. Y., Kim H. J., Kim J. W., and, Yu B. P., (2001) The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann. N Y Acad. Sci. 928, 327-335.
-
(2001)
Ann. N y Acad. Sci.
, vol.928
, pp. 327-335
-
-
Chung, H.Y.1
Kim, H.J.2
Kim, J.W.3
Yu, B.P.4
-
20
-
-
67650439330
-
Caloric restriction delays disease onset and mortality in rhesus monkeys
-
Colman R. J., Anderson R. M., Johnson S. C., et al. (2009) Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325, 201-204.
-
(2009)
Science
, vol.325
, pp. 201-204
-
-
Colman, R.J.1
Anderson, R.M.2
Johnson, S.C.3
-
21
-
-
70449900928
-
TOR complex 2: A signaling pathway of its own
-
Cybulski N., and, Hall M. N., (2009) TOR complex 2: a signaling pathway of its own. Trends Biochem. Sci. 34, 620-627.
-
(2009)
Trends Biochem. Sci.
, vol.34
, pp. 620-627
-
-
Cybulski, N.1
Hall, M.N.2
-
22
-
-
37549032568
-
Raptor-rictor axis in TGFbeta-induced protein synthesis
-
Das F., Ghosh-Choudhury N., Mahimainathan L., Venkatesan B., Feliers D., Riley D. J., Kasinath B. S., and, Choudhury G. G., (2008) Raptor-rictor axis in TGFbeta-induced protein synthesis. Cell. Signal. 20, 409-423.
-
(2008)
Cell. Signal.
, vol.20
, pp. 409-423
-
-
Das, F.1
Ghosh-Choudhury, N.2
Mahimainathan, L.3
Venkatesan, B.4
Feliers, D.5
Riley, D.J.6
Kasinath, B.S.7
Choudhury, G.G.8
-
23
-
-
67649316033
-
Rapamycin decelerates cellular senescence
-
Demidenko Z. N., Zubova S. G., Bukreeva E. I., Pospelov V. A., Pospelova T. V., and, Blagosklonny M. V., (2009) Rapamycin decelerates cellular senescence. Cell Cycle 8, 1888-1895.
-
(2009)
Cell Cycle
, vol.8
, pp. 1888-1895
-
-
Demidenko, Z.N.1
Zubova, S.G.2
Bukreeva, E.I.3
Pospelov, V.A.4
Pospelova, T.V.5
Blagosklonny, M.V.6
-
24
-
-
77955046461
-
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
-
Donmez G., Wang D., Cohen D. E., and, Guarente L., (2010) SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 142, 320-332.
-
(2010)
Cell
, vol.142
, pp. 320-332
-
-
Donmez, G.1
Wang, D.2
Cohen, D.E.3
Guarente, L.4
-
25
-
-
34249104544
-
Oxidative stress and aberrant signaling in aging and cognitive decline
-
DOI 10.1111/j.1474-9726.2007.00294.x
-
Droge W., and, Schipper H. M., (2007) Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell 6, 361-370. (Pubitemid 46785141)
-
(2007)
Aging Cell
, vol.6
, Issue.3
, pp. 361-370
-
-
Droge, W.1
Schipper, H.M.2
-
26
-
-
62749096589
-
Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms
-
Dunlop E. A., and, Tee A. R., (2009) Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms. Cell. Signal. 21, 827-835.
-
(2009)
Cell. Signal.
, vol.21
, pp. 827-835
-
-
Dunlop, E.A.1
Tee, A.R.2
-
27
-
-
49149088555
-
Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis
-
Ehninger D., Han S., Shilyansky C., Zhou Y., Li W., Kwiatkowski D. J., Ramesh V., and, Silva A. J., (2008) Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat. Med. 14, 843-848.
-
(2008)
Nat. Med.
, vol.14
, pp. 843-848
-
-
Ehninger, D.1
Han, S.2
Shilyansky, C.3
Zhou, Y.4
Li, W.5
Kwiatkowski, D.J.6
Ramesh, V.7
Silva, A.J.8
-
28
-
-
0035853552
-
Regulation of longevity and stress resistance by Sch9 in yeast
-
DOI 10.1126/science.1059497
-
Fabrizio P., Pozza F., Pletcher S. D., Gendron C. M., and, Longo V. D., (2001) Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-290. (Pubitemid 32295387)
-
(2001)
Science
, vol.292
, Issue.5515
, pp. 288-290
-
-
Fabrizio, P.1
Pozza, F.2
Pletcher, S.D.3
Gendron, C.M.4
Longo, V.D.5
-
29
-
-
34548812551
-
The role of amyloid β peptide 42 in Alzheimer's disease
-
DOI 10.1016/j.pharmthera.2007.06.006, PII S016372580700143X
-
Findeis M. A., (2007) The role of amyloid beta peptide 42 in Alzheimer's disease. Pharmacol. Ther. 116, 266-286. (Pubitemid 47451506)
-
(2007)
Pharmacology and Therapeutics
, vol.116
, Issue.2
, pp. 266-286
-
-
Findeis, M.A.1
-
30
-
-
77952007543
-
Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony
-
Foster K. G., and, Fingar D. C., (2010) Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J. Biol. Chem. 285, 14071-14077.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 14071-14077
-
-
Foster, K.G.1
Fingar, D.C.2
-
31
-
-
0033911488
-
Inflamm-aging. An evolutionary perspective on immunosenescence
-
Franceschi C., Bonafe M., Valensin S., Olivieri F., De Luca M., Ottaviani E., and, De Benedictis G., (2000) Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N Y Acad. Sci. 908, 244-254. (Pubitemid 30462008)
-
(2000)
Annals of the New York Academy of Sciences
, vol.908
, pp. 244-254
-
-
Franceschi, C.1
Bonafe, M.2
Valensin, S.3
Olivieri, F.4
De Luca, M.5
Ottaviani, E.6
De Benedictis, G.7
-
32
-
-
33748471980
-
MSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s
-
DOI 10.1016/j.cub.2006.08.001, PII S0960982206019749
-
Frias M. A., Thoreen C. C., Jaffe J. D., Schroder W., Sculley T., Carr S. A., and, Sabatini D. M., (2006) mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr. Biol. 16, 1865-1870. (Pubitemid 44354144)
-
(2006)
Current Biology
, vol.16
, Issue.18
, pp. 1865-1870
-
-
Frias, M.A.1
Thoreen, C.C.2
Jaffe, J.D.3
Schroder, W.4
Sculley, T.5
Carr, S.A.6
Sabatini, D.M.7
-
33
-
-
66449083078
-
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
-
Ganley I. G., Lam du H., Wang J., Ding X., Chen S., and, Jiang X., (2009) ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J. Biol. Chem. 284, 12297-12305.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 12297-12305
-
-
Ganley, I.G.1
Lam Du, H.2
Wang, J.3
Ding, X.4
Chen, S.5
Jiang, X.6
-
34
-
-
58649092475
-
MTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
-
García-Martínez J. M., and, Alessi D. R., (2008) mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem. J. 416, 375-385.
-
(2008)
Biochem. J.
, vol.416
, pp. 375-385
-
-
García-Martínez, J.M.1
Alessi, D.R.2
-
35
-
-
0043258253
-
Loss of perforated synapses in the dentate gyrus: Morphological substrate of memory deficit in aged rats
-
Geinisman Y., de Toledo-Morrell L., and, Morrell F., (1986) Loss of perforated synapses in the dentate gyrus: morphological substrate of memory deficit in aged rats. Proc. Natl Acad. Sci. USA 83, 3027-3031. (Pubitemid 16041794)
-
(1986)
Proceedings of the National Academy of Sciences of the United States of America
, vol.83
, Issue.9
, pp. 3027-3031
-
-
Geinisman, Y.1
De Toledo-Morrell, L.2
Morrell, F.3
-
36
-
-
77950127881
-
SIRT1 negatively regulates the mammalian target of rapamycin
-
Ghosh H. S., McBurney M., and, Robbins P. D., (2010) SIRT1 negatively regulates the mammalian target of rapamycin. PLoS ONE 5, e9199.
-
(2010)
PLoS ONE
, vol.5
-
-
Ghosh, H.S.1
McBurney, M.2
Robbins, P.D.3
-
37
-
-
33644861975
-
Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis
-
PII 0000611420060124100013
-
Glabe C. G., and, Kayed R., (2006) Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis. Neurology 66, S74-S78. (Pubitemid 43739989)
-
(2006)
Neurology
, vol.66
, Issue.2 SUPPL. 1
-
-
Glabe, C.G.1
Kayed, R.2
-
38
-
-
0033632219
-
Cellular and molecular basis of beta-amyloid precursor protein metabolism
-
Greenfield J. P., Gross R. S., Gouras G. K., and, Xu H., (2000) Cellular and molecular basis of beta-amyloid precursor protein metabolism. Front. Biosci. 5, D72-D83.
-
(2000)
Front. Biosci.
, vol.5
-
-
Greenfield, J.P.1
Gross, R.S.2
Gouras, G.K.3
Xu, H.4
-
39
-
-
23144467910
-
An expanding role for mTOR in cancer
-
DOI 10.1016/j.molmed.2005.06.007, PII S1471491405001371
-
Guertin D. A., and, Sabatini D. M., (2005) An expanding role for mTOR in cancer. Trends Mol. Med. 11, 353-361. (Pubitemid 41080576)
-
(2005)
Trends in Molecular Medicine
, vol.11
, Issue.8
, pp. 353-361
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
40
-
-
68149096799
-
The pharmacology of mTOR inhibition
-
Guertin D. A., and, Sabatini D. M., (2009) The pharmacology of mTOR inhibition. Sci. Signal. 2, pe24.
-
(2009)
Sci. Signal.
, vol.2
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
41
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
-
DOI 10.1038/nrm2101, PII NRM2101
-
Haass C., and, Selkoe D. J., (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 8, 101-112. (Pubitemid 46432529)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.2
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
42
-
-
33846423520
-
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
-
DOI 10.1111/j.1474-9726.2006.00267.x
-
Hansen M., Taubert S., Crawford D., Libina N., Lee S. J., and, Kenyon C., (2007) Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6, 95-110. (Pubitemid 46140143)
-
(2007)
Aging Cell
, vol.6
, Issue.1
, pp. 95-110
-
-
Hansen, M.1
Taubert, S.2
Crawford, D.3
Libina, N.4
Lee, S.-J.5
Kenyon, C.6
-
43
-
-
40149105890
-
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
-
Hansen M., Chandra A., Mitic L. L., Onken B., Driscoll M., and, Kenyon C., (2008) A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet. 4, e24.
-
(2008)
PLoS Genet.
, vol.4
-
-
Hansen, M.1
Chandra, A.2
Mitic, L.L.3
Onken, B.4
Driscoll, M.5
Kenyon, C.6
-
44
-
-
0142213542
-
The Free Radical Theory of Aging
-
Harman D., (2003) The free radical theory of aging. Antioxid. Redox Signal. 5, 557-561. (Pubitemid 37315142)
-
(2003)
Antioxidants and Redox Signaling
, vol.5
, Issue.5
, pp. 557-561
-
-
Harman, D.1
-
45
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison D. E., Strong R., Sharp Z. D., et al. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392-395.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
-
46
-
-
0035341254
-
Mitochondrial abnormalities in Alzheimer's disease
-
Hirai K., Aliev G., Nunomura A., et al. (2001) Mitochondrial abnormalities in Alzheimer's disease. J. Neurosci. 21, 3017-3023. (Pubitemid 32323483)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.9
, pp. 3017-3023
-
-
Hirai, K.1
Aliev, G.2
Nunomura, A.3
Fujioka, H.4
Russell, R.L.5
Atwood, C.S.6
Johnson, A.B.7
Kress, Y.8
Vinters, H.V.9
Tabaton, M.10
Shimohama, S.11
Cash, A.D.12
Siedlak, S.L.13
Harris, P.L.R.14
Jones, P.K.15
Petersen, R.B.16
Perry, G.17
Smith, M.A.18
-
47
-
-
75749114797
-
MTOR signaling: At the crossroads of plasticity, memory and disease
-
Hoeffer C. A., and, Klann E., (2010) mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci. 33, 67-75.
-
(2010)
Trends Neurosci.
, vol.33
, pp. 67-75
-
-
Hoeffer, C.A.1
Klann, E.2
-
48
-
-
20444383489
-
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron
-
DOI 10.1074/jbc.M500526200
-
Honda K., Smith M. A., Zhu X., et al. (2005) Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J. Biol. Chem. 280, 20978-20986. (Pubitemid 40805655)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.22
, pp. 20978-20986
-
-
Honda, K.1
Smithi, M.A.2
Zhu, X.3
Baus, D.4
Merrick, W.C.5
Tartakoff, A.M.6
Hattier, T.7
Harris, P.L.8
Siedlak, S.L.9
Fujioka, H.10
Liu, Q.11
Moreira, P.I.12
Miller, F.P.13
Nunomura, A.14
Shimohama, S.15
Perry, G.16
-
49
-
-
65249119430
-
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
-
Hosokawa N., Hara T., Kaizuka T., et al. (2009) Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol. Biol. Cell 20, 1981-1991.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
Hara, T.2
Kaizuka, T.3
-
50
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
DOI 10.1038/nature01960
-
Howitz K. T., Bitterman K. J., Cohen H. Y., et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196. (Pubitemid 37150899)
-
(2003)
Nature
, vol.425
, Issue.6954
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
Zipkin, R.E.7
Chung, P.8
Kisielewski, A.9
Zhang, L.-L.10
Scherer, B.11
Sinclair, D.A.12
-
51
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
DOI 10.1038/35001622
-
Imai S., Armstrong C. M., Kaeberlein M., and, Guarente L., (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800. (Pubitemid 30111843)
-
(2000)
Nature
, vol.403
, Issue.6771
, pp. 795-800
-
-
Imai, S.-I.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
52
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
DOI 10.1038/ncb1183
-
Jacinto E., Loewith R., Schmidt A., Lin S., Ruegg M. A., Hall A., and, Hall M. N., (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128. (Pubitemid 39468014)
-
(2004)
Nature Cell Biology
, vol.6
, Issue.11
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
53
-
-
33847038824
-
The growing role of mTOR in neuronal development and plasticity
-
Jaworski J., and, Sheng M., (2006) The growing role of mTOR in neuronal development and plasticity. Mol. Neurobiol. 34, 205-219.
-
(2006)
Mol. Neurobiol.
, vol.34
, pp. 205-219
-
-
Jaworski, J.1
Sheng, M.2
-
54
-
-
64049092736
-
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease
-
Julien C., Tremblay C., Emond V., Lebbadi M., Salem Jr.N., Bennett D. A., and, Calon F., (2009) Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J. Neuropathol. Exp. Neurol. 68, 48-58.
-
(2009)
J. Neuropathol. Exp. Neurol.
, vol.68
, pp. 48-58
-
-
Julien, C.1
Tremblay, C.2
Emond, V.3
Lebbadi, M.4
Salem Jr., N.5
Bennett, D.A.6
Calon, F.7
-
55
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
Jung C. H., Jun C. B., Ro S. H., Kim Y. M., Otto N. M., Cao J., Kundu M., and, Kim D. H., (2009) ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 20, 1992-2003.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
Kim, Y.M.4
Otto, N.M.5
Cao, J.6
Kundu, M.7
Kim, D.H.8
-
56
-
-
27744511769
-
Cell biology: Regulation of yeast replicative life span by TOR and Sch9 response to nutrients
-
DOI 10.1126/science.1115535
-
Kaeberlein M., Powers R. W. 3rd, Steffen K. K., et al. (2005) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196. (Pubitemid 41681747)
-
(2005)
Science
, vol.310
, Issue.5751
, pp. 1193-1196
-
-
Kaeberlein, M.1
Powers III, R.W.2
Steffen, K.K.3
Westman, E.A.4
Hu, D.5
Dang, N.6
Kerr, E.O.7
Kirkland, K.T.8
Fields, S.9
Kennedy, B.K.10
-
57
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
DOI 10.1016/j.cub.2004.03.059, PII S0960982204002386
-
Kapahi P., Zid B. M., Harper T., Koslover D., Sapin V., and, Benzer S., (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14, 885-890. (Pubitemid 38800910)
-
(2004)
Current Biology
, vol.14
, Issue.10
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
Benzer, S.6
-
58
-
-
77955747346
-
With TOR, less is more: A key role for the conserved nutrient-sensing TOR pathway in aging
-
Kapahi P., Chen D., Rogers A. N., Katewa S. D., Li P. W., Thomas E. L., and, Kockel L., (2010) With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab. 11, 453-465.
-
(2010)
Cell Metab.
, vol.11
, pp. 453-465
-
-
Kapahi, P.1
Chen, D.2
Rogers, A.N.3
Katewa, S.D.4
Li, P.W.5
Thomas, E.L.6
Kockel, L.7
-
59
-
-
0032831936
-
Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae
-
Kim S., Benguria A., Lai C. Y., and, Jazwinski S. M., (1999) Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Mol. Biol. Cell 10, 3125-3136. (Pubitemid 29489550)
-
(1999)
Molecular Biology of the Cell
, vol.10
, Issue.10
, pp. 3125-3136
-
-
Kim, S.1
Benguria, A.2
Lai, C.-Y.3
Jazwinski, S.M.4
-
60
-
-
0027311858
-
1 progression
-
DOI 10.1016/0092-8674(93)90144-F
-
Kunz J., Henriquez R., Schneider U., Deuter-Reinhard M., Movva N. R., and, Hall M. N., (1993) Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 73, 585-596. (Pubitemid 23143356)
-
(1993)
Cell
, vol.73
, Issue.3
, pp. 585-596
-
-
Kunz, J.1
Henriquez, R.2
Schneider, U.3
Deuter-Reinhard, M.4
Movva, N.R.5
Hall, M.N.6
-
61
-
-
21344459656
-
MTOR/p70S6k signalling alteration by Aβ exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease
-
DOI 10.1111/j.1471-4159.2005.03187.x
-
Lafay-Chebassier C., Paccalin M., Page G., Barc-Pain S., Perault-Pochat M. C., Gil R., Pradier L., and, Hugon J., (2005) mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease. J. Neurochem. 94, 215-225. (Pubitemid 40911407)
-
(2005)
Journal of Neurochemistry
, vol.94
, Issue.1
, pp. 215-225
-
-
Lafay-Chebassier, C.1
Paccalin, M.2
Page, G.3
Barc-Pain, S.4
Perault-Pochat, M.C.5
Gil, R.6
Pradier, L.7
Hugon, J.8
-
62
-
-
33750482915
-
The immunosuppressant rapamycin exacerbates neurotoxicity of Aβ peptide
-
DOI 10.1002/jnr.21039
-
Lafay-Chebassier C., Perault-Pochat M. C., Page G., Rioux Bilan A., Damjanac M., Pain S., Houeto J. L., Gil R., and, Hugon J., (2006) The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide. J. Neurosci. Res. 84, 1323-1334. (Pubitemid 44654455)
-
(2006)
Journal of Neuroscience Research
, vol.84
, Issue.6
, pp. 1323-1334
-
-
Lafay-Chebassier, C.1
Perault-Pochat, M.C.2
Page, G.3
Bilan, A.R.4
Damjanac, M.5
Pain, S.6
Houeto, J.-L.7
Gil, R.8
Hugon, J.9
-
63
-
-
33751203889
-
Dietary deprivation extends lifespan in Caenorhabditis elegans
-
DOI 10.1111/j.1474-9726.2006.00241.x
-
Lee G. D., Wilson M. A., Zhu M., Wolkow C. A., de Cabo R., Ingram D. K., and, Zou S., (2006) Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell 5, 515-524. (Pubitemid 44782620)
-
(2006)
Aging Cell
, vol.5
, Issue.6
, pp. 515-524
-
-
Lee, G.D.1
Wilson, M.A.2
Zhu, M.3
Wolkow, C.A.4
De Cabo, R.5
Ingram, D.K.6
Zou, S.7
-
64
-
-
23844457609
-
Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain
-
DOI 10.1111/j.1742-4658.2005.04833.x
-
Li X., Alafuzoff I., Soininen H., Winblad B., and, Pei J. J., (2005) Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain. FEBS J. 272, 4211-4220. (Pubitemid 41160927)
-
(2005)
FEBS Journal
, vol.272
, Issue.16
, pp. 4211-4220
-
-
Li, X.1
Alafuzoff, I.2
Soininen, H.3
Winblad, B.4
Pei, J.-J.5
-
65
-
-
33748304113
-
Sir2 represses endogenous polymerase II transcription units in the ribosomal DNA nontranscribed spacer
-
DOI 10.1091/mbc.E06-03-0205
-
Li C., Mueller J. E., and, Bryk M., (2006) Sir2 represses endogenous polymerase II transcription units in the ribosomal DNA nontranscribed spacer. Mol. Biol. Cell 17, 3848-3859. (Pubitemid 44330870)
-
(2006)
Molecular Biology of the Cell
, vol.17
, Issue.9
, pp. 3848-3859
-
-
Li, C.1
Mueller, J.E.2
Bryk, M.3
-
66
-
-
0037130175
-
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
-
DOI 10.1038/nature00829
-
Lin S. J., Kaeberlein M., Andalis A. A., Sturtz L. A., Defossez P. A., Culotta V. C., Fink G. R., and, Guarente L., (2002) Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418, 344-348. (Pubitemid 34790687)
-
(2002)
Nature
, vol.418
, Issue.6895
, pp. 344-348
-
-
Lin, S.-J.1
Kaeberlein, M.2
Andalis, A.A.3
Sturtz, L.A.4
Defossez, P.-A.5
Culotta, V.C.6
Fink, G.R.7
Guarente, L.8
-
67
-
-
33749324414
-
The intracellular domain of amyloid precursor protein interacts with FKBP12
-
Liu F. L., Liu P. H., Shao H. W., and, Kung F. L., (2006) The intracellular domain of amyloid precursor protein interacts with FKBP12. Biochem. Biophys. Res. Commun. 350, 472-477.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.350
, pp. 472-477
-
-
Liu, F.L.1
Liu, P.H.2
Shao, H.W.3
Kung, F.L.4
-
68
-
-
77958465822
-
Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease
-
Ma T., Hoeffer C. A., Capetillo-Zarate E., et al. (2010) Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS ONE 5, e12845.
-
(2010)
PLoS ONE
, vol.5
-
-
Ma, T.1
Hoeffer, C.A.2
Capetillo-Zarate, E.3
-
69
-
-
77956420489
-
Can autophagy promote longevity?
-
Madeo F., Tavernarakis N., and, Kroemer G., (2010) Can autophagy promote longevity? Nat. Cell Biol. 12, 842-846.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 842-846
-
-
Madeo, F.1
Tavernarakis, N.2
Kroemer, G.3
-
70
-
-
0141766912
-
Demography of dietary restriction and death in Drosophila
-
DOI 10.1126/science.1086016
-
Mair W., Goymer P., Pletcher S. D., and, Partridge L., (2003) Demography of dietary restriction and death in Drosophila. Science 301, 1731-1733. (Pubitemid 37174368)
-
(2003)
Science
, vol.301
, Issue.5640
, pp. 1731-1733
-
-
Mair, W.1
Goymer, P.2
Pletcher, S.D.3
Partridge, L.4
-
71
-
-
0023891743
-
The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy
-
Mann D. M., Marcyniuk B., Yates P. O., Neary D., and, Snowden J. S., (1988) The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy. Neuropathol. Appl. Neurobiol. 14, 177-195.
-
(1988)
Neuropathol. Appl. Neurobiol.
, vol.14
, pp. 177-195
-
-
Mann, D.M.1
Marcyniuk, B.2
Yates, P.O.3
Neary, D.4
Snowden, J.S.5
-
72
-
-
0347716759
-
Rheb fills a GAP between TSC and TOR
-
DOI 10.1016/j.tibs.2003.09.003, PII S0968000403002275
-
Manning B. D., and, Cantley L. C., (2003) Rheb fills a GAP between TSC and TOR. Trends Biochem. Sci. 28, 573-576. (Pubitemid 38352801)
-
(2003)
Trends in Biochemical Sciences
, vol.28
, Issue.11
, pp. 573-576
-
-
Manning, B.D.1
Cantley, L.C.2
-
73
-
-
15044350668
-
The expanding TOR signaling network
-
DOI 10.1016/j.ceb.2005.02.008, Cell Regulation
-
Martin D. E., and, Hall M. N., (2005) The expanding TOR signaling network. Curr. Opin. Cell Biol. 17, 158-166. (Pubitemid 40380939)
-
(2005)
Current Opinion in Cell Biology
, vol.17
, Issue.2
, pp. 158-166
-
-
Martin, D.E.1
Hall, M.N.2
-
74
-
-
0024364877
-
Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease
-
DOI 10.1016/0304-3940(89)90582-X
-
Masliah E., Terry R. D., DeTeresa R. M., and, Hansen L. A., (1989) Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neurosci. Lett. 103, 234-239. (Pubitemid 19201259)
-
(1989)
Neuroscience Letters
, vol.103
, Issue.2
, pp. 234-239
-
-
Masliah, E.1
Terry, R.D.2
DeTeresa, R.M.3
Hansen, L.A.4
-
75
-
-
0025330775
-
Quantitative immunohistochemistry of synaptophysin in human neocortex: An alternative method to estimate density of presynaptic terminals in paraffin sections
-
Masliah E., Terry R. D., Alford M., and, DeTeresa R., (1990) Quantitative immunohistochemistry of synaptophysin in human neocortex: an alternative method to estimate density of presynaptic terminals in paraffin sections. J. Histochem. Cytochem. 38, 837-844. (Pubitemid 20177851)
-
(1990)
Journal of Histochemistry and Cytochemistry
, vol.38
, Issue.6
, pp. 837-844
-
-
Masliah, E.1
Terry, R.D.2
Alford, M.3
DeTeresa, R.4
-
76
-
-
0141611988
-
Subfield history: Caloric restriction, slowing aging, and extending life
-
2003, RE2
-
Masoro E. J., (2003) Subfield history: caloric restriction, slowing aging, and extending life. Sci. Aging Knowledge Environ. 2003, RE2.
-
(2003)
Sci. Aging Knowledge Environ.
-
-
Masoro, E.J.1
-
77
-
-
0037314445
-
Meal size and frequency affect neuronal plasticity and vulnerability to disease: Cellular and molecular mechanisms
-
DOI 10.1046/j.1471-4159.2003.01586.x
-
Mattson M. P., Duan W., and, Guo Z., (2003) Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms. J. Neurochem. 84, 417-431. (Pubitemid 36182240)
-
(2003)
Journal of Neurochemistry
, vol.84
, Issue.3
, pp. 417-431
-
-
Mattson, M.P.1
Duan, W.2
Guo, Z.3
-
78
-
-
35648995939
-
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae
-
Medvedik O., Lamming D. W., Kim K. D., and, Sinclair D. A., (2007) MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol. 5, e261.
-
(2007)
PLoS Biol.
, vol.5
-
-
Medvedik, O.1
Lamming, D.W.2
Kim, K.D.3
Sinclair, D.A.4
-
79
-
-
38049170722
-
Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau
-
Meske V., Albert F., and, Ohm T. G., (2008) Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau. J. Biol. Chem. 283, 100-109.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 100-109
-
-
Meske, V.1
Albert, F.2
Ohm, T.G.3
-
80
-
-
13644270565
-
Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients
-
DOI 10.1016/j.neurobiolaging.2004.07.016
-
Migliore L., Fontana I., Trippi F., Colognato R., Coppedè F., Tognoni G., Nucciarone B., and, Siciliano G., (2005) Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients. Neurobiol. Aging 26, 567-573. (Pubitemid 40228745)
-
(2005)
Neurobiology of Aging
, vol.26
, Issue.5
, pp. 567-573
-
-
Migliore, L.1
Fontana, I.2
Trippi, F.3
Colognato, R.4
Coppede, F.5
Tognoni, G.6
Nucciarone, B.7
Siciliano, G.8
-
81
-
-
33644850568
-
Brain and brawn: Parallels in oxidative strength
-
PII 0000611420060124100017
-
Moreira P. I., Honda K., Zhu X., Nunomura A., Casadesus G., Smith M. A., and, Perry G., (2006) Brain and brawn: parallels in oxidative strength. Neurology 66, S97-S101. (Pubitemid 43739993)
-
(2006)
Neurology
, vol.66
, Issue.2 SUPPL. 1
-
-
Moreira, P.I.1
Honda, K.2
Zhu, X.3
Nunomura, A.4
Casadesus, G.5
Smith, M.A.6
Perry, G.7
-
82
-
-
34648831384
-
Alzheimer's disease: A lesson from mitochondrial dysfunction
-
DOI 10.1089/ars.2007.1703
-
Moreira P. I., Santos M. S., and, Oliveira C. R., (2007a) Alzheimer's disease: a lesson from mitochondrial dysfunction. Antioxid. Redox Signal. 9, 1621-1630. (Pubitemid 47462966)
-
(2007)
Antioxidants and Redox Signaling
, vol.9
, Issue.10
, pp. 1621-1630
-
-
Moreira, P.I.1
Santos, M.S.2
Oliveira, C.R.3
-
83
-
-
34848890388
-
Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts
-
Mini-Forum "Mitochondria in Alzheimer Disease"
-
Moreira P. I., Harris P. L., Zhu X., Santos M. S., Oliveira C. R., Smith M. A., and, Perry G., (2007b) Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J. Alzheimer Dis. 12, 195-206. (Pubitemid 47509369)
-
(2007)
Journal of Alzheimer's Disease
, vol.12
, Issue.2
, pp. 195-206
-
-
Moreira, P.I.1
Harris, P.L.R.2
Zhu, X.3
Santos, M.S.4
Oliveira, C.R.5
Smith, M.A.6
Perry, G.7
-
84
-
-
34249881080
-
Autophagocytosis of mitochondria is prominent in Alzheimer disease
-
DOI 10.1097/01.jnen.0000240476.73532.b0, PII 0000507220070600000007
-
Moreira P. I., Siedlak S. L., Wang X., et al. (2007c) Autophagocytosis of mitochondria is prominent in Alzheimer disease. J. Neuropathol. Exp. Neurol. 66, 525-532. (Pubitemid 46869694)
-
(2007)
Journal of Neuropathology and Experimental Neurology
, vol.66
, Issue.6
, pp. 525-532
-
-
Moreira, P.I.1
Siedlak, S.L.2
Wang, X.3
Santos, M.S.4
Oliveira, C.R.5
Tabaton, M.6
Nunomura, A.7
Szweda, L.I.8
Aliev, G.9
Smith, M.A.10
Zhu, X.11
Perry, G.12
-
85
-
-
71749121998
-
Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
-
Moreira P. I., Carvalho C., Zhu X., Smith M. A., and, Perry G., (2010) Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. Biochim. Biophys. Acta 1802, 2-10.
-
(2010)
Biochim. Biophys. Acta
, vol.1802
, pp. 2-10
-
-
Moreira, P.I.1
Carvalho, C.2
Zhu, X.3
Smith, M.A.4
Perry, G.5
-
86
-
-
79953043473
-
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
-
Morselli E., Maiuri M. C., Markaki M., et al. (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death & Disease 1, e10.
-
(2010)
Cell Death & Disease
, vol.1
-
-
Morselli, E.1
Maiuri, M.C.2
Markaki, M.3
-
87
-
-
0034923434
-
Oxidative damage is the earliest event in Alzheimer disease
-
Nunomura A., Perry G., Aliev G., et al. (2001) Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60, 759-767. (Pubitemid 32678256)
-
(2001)
Journal of Neuropathology and Experimental Neurology
, vol.60
, Issue.8
, pp. 759-767
-
-
Nunomura, A.1
Perry, G.2
Aliev, G.3
Hirai, K.4
Takeda, A.5
Balraj, E.K.6
Jones, P.K.7
Ghanbari, H.8
Wataya, T.9
Shimohama, S.10
Chiba, S.11
Atwood, C.S.12
Petersen, R.B.13
Smith, M.A.14
-
88
-
-
33846015514
-
Reduction of soluble Aβ and tau, but not soluble Aβ alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
-
DOI 10.1074/jbc.M608485200
-
Oddo S., Vasilevko V., Caccamo A., Kitazawa M., Cribbs D. H., and, LaFerla F. M., (2006) Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J. Biol. Chem. 281, 39413-39423. (Pubitemid 46041901)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.51
, pp. 39413-39423
-
-
Oddo, S.1
Vasilevko, V.2
Caccamo, A.3
Kitazawa, M.4
Cribbs, D.H.5
LaFerla, F.M.6
-
89
-
-
1942487890
-
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
-
DOI 10.1111/j.1356-9597.2004.00727.x
-
Oshiro N., Yoshino K., Hidayat S., Tokunaga C., Hara K., Eguchi S., Avruch J., and, Yonezawa K., (2004) Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function Genes. Cells 9, 359-366. (Pubitemid 38514871)
-
(2004)
Genes to Cells
, vol.9
, Issue.4
, pp. 359-366
-
-
Oshiro, N.1
Yoshino, K.-I.2
Hidayat, S.3
Tokunaga, C.4
Hara, K.5
Eguchi, S.6
Avruch, J.7
Yonezawa, K.8
-
90
-
-
33846418352
-
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
-
DOI 10.1111/j.1474-9726.2006.00266.x
-
Pan K. Z., Palter J. E., Rogers A. N., Olsen A., Chen D., Lithgow G. J., and, Kapahi P., (2007) Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6, 111-119. (Pubitemid 46140144)
-
(2007)
Aging Cell
, vol.6
, Issue.1
, pp. 111-119
-
-
Pan, K.Z.1
Palter, J.E.2
Rogers, A.N.3
Olsen, A.4
Chen, D.5
Lithgow, G.J.6
Kapahi, P.7
-
91
-
-
55849108858
-
Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
-
Park K. K., Liu K., Hu Y., et al. (2008) Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science 322, 963-966.
-
(2008)
Science
, vol.322
, pp. 963-966
-
-
Park, K.K.1
Liu, K.2
Hu, Y.3
-
92
-
-
30944458446
-
Extension of chronological life span in yeast by decreased TOR pathway signaling
-
DOI 10.1101/gad.1381406
-
Powers R. W. 3rd, Kaeberlein M., Caldwell S. D., Kennedy B. K., and, Fields S., (2006) Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 20, 174-184. (Pubitemid 43112936)
-
(2006)
Genes and Development
, vol.20
, Issue.2
, pp. 174-184
-
-
Powers III, R.W.1
Kaeberlein, M.2
Caldwell, S.D.3
Kennedy, B.K.4
Fields, S.5
-
93
-
-
69449095814
-
Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling
-
Puighermanal E., Marsicano G., Busquets-Garcia A., Lutz B., Maldonado R., and, Ozaita A., (2009) Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nat. Neurosci. 12, 1152-1158.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 1152-1158
-
-
Puighermanal, E.1
Marsicano, G.2
Busquets-Garcia, A.3
Lutz, B.4
Maldonado, R.5
Ozaita, A.6
-
95
-
-
76049099052
-
Direct control of mitochondrial function by mTOR
-
Ramanathan A., and, Schreiber S. L., (2009) Direct control of mitochondrial function by mTOR. Proc. Natl Acad. Sci. USA 106, 22229-22232.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 22229-22232
-
-
Ramanathan, A.1
Schreiber, S.L.2
-
96
-
-
0035912780
-
The target of rapamycin (TOR) proteins
-
DOI 10.1073/pnas.121145898
-
Raught B., Gingras A. C., and, Sonenberg N., (2001) The target of rapamycin (TOR) proteins. Proc. Natl Acad. Sci. USA 98, 7037-7044. (Pubitemid 32567899)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.13
, pp. 7037-7044
-
-
Raught, B.1
Gingras, A.-C.2
Sonenberg, N.3
-
98
-
-
0032766181
-
Calorie restriction in primates: Will it work and how will we know?
-
Roth G. S., Ingram D. K., and, Lane M. A., (1999) Calorie restriction in primates: will it work and how will we know? J. Am. Geriatr. Soc. 47, 896-903. (Pubitemid 29326024)
-
(1999)
Journal of the American Geriatrics Society
, vol.47
, Issue.7
, pp. 896-903
-
-
Roth, G.S.1
Ingram, D.K.2
Lane, M.A.3
-
99
-
-
33846841155
-
A link between protein translation and body weight
-
DOI 10.1172/JCI31289
-
Rui L., (2007) A link between protein translation and body weight. J. Clin. Invest. 117, 310-313. (Pubitemid 46203959)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.2
, pp. 310-313
-
-
Rui, L.1
-
100
-
-
0029102357
-
The rapamycin and FKBP12 target (RAFT) displays phosphatidylinositol 4-kinase activity
-
Sabatini D. M., Pierchala B. A., Barrow R. K., Schell M. J., and, Snyder S. H., (1995) The rapamycin and FKBP12 target (RAFT) displays phosphatidylinositol 4-kinase activity. J. Biol. Chem. 270, 20875-20878.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 20875-20878
-
-
Sabatini, D.M.1
Pierchala, B.A.2
Barrow, R.K.3
Schell, M.J.4
Snyder, S.H.5
-
101
-
-
22344438508
-
Medicine: Tau suppression in a neurodegenerative mouse model improves memory function
-
DOI 10.1126/science.1113694
-
Santacruz K., Lewis J., Spires T., et al. (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Science 309, 476-481. (Pubitemid 40994688)
-
(2005)
Science
, vol.309
, Issue.5733
, pp. 476-481
-
-
Santacruz, K.1
Lewis, J.2
Spires, T.3
Paulson, J.4
Kotilinek, L.5
Ingelsson, M.6
Guimaraes, A.7
DeTure, M.8
Ramsden, M.9
McCowan, E.10
Forster, C.11
Yue, M.12
Orne, J.13
Janus, C.14
Mariash, A.15
Kuskowski, M.16
Hyman, B.17
Hutton, M.18
Ashe, K.H.19
-
102
-
-
77953681716
-
Targeting autophagy in the brain: A promising approach?
-
Santos R. X., Cardoso S., Correia S., Carvalho C., Santos M. S., and, Moreira P. I., (2010a) Targeting autophagy in the brain: a promising approach? Cent. Nerv. Syst. Agents. Med. Chem. 10, 158-168.
-
(2010)
Cent. Nerv. Syst. Agents. Med. Chem.
, vol.10
, pp. 158-168
-
-
Santos, R.X.1
Cardoso, S.2
Correia, S.3
Carvalho, C.4
Santos, M.S.5
Moreira, P.I.6
-
103
-
-
77956199031
-
A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease
-
Santos R. X., Correia S. C., Wang X., Perry G., Smith M. A., Moreira P. I., and, Zhu X., (2010b) A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease. J. Alzheimers Dis. 20 (Suppl 2), S401-S412.
-
(2010)
J. Alzheimers Dis.
, vol.20
, Issue.SUPPL. 2
-
-
Santos, R.X.1
Correia, S.C.2
Wang, X.3
Perry, G.4
Smith, M.A.5
Moreira, P.I.6
Zhu, X.7
-
104
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
DOI 10.1016/j.cub.2004.06.054, PII S0960982204004713
-
Sarbassov D. D., Ali S. M., Kim D. H., Guertin D. A., Latek R. R., Erdjument- Bromage H., Tempst P., and, Sabatini D. M., (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302. (Pubitemid 38991819)
-
(2004)
Current Biology
, vol.14
, Issue.14
, pp. 1296-1302
-
-
Dos D. Sarbassov1
Ali, S.M.2
Kim, D.-H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
105
-
-
27544500981
-
Growing roles for the mTOR pathway
-
DOI 10.1016/j.ceb.2005.09.009, PII S0955067405001481
-
Sarbassov D. D., Ali S. M., and, Sabatini D. M., (2005) Growing roles for the mTOR pathway. Curr. Opin. Cell Biol. 17, 596-603. (Pubitemid 41540408)
-
(2005)
Current Opinion in Cell Biology
, vol.17
, Issue.6
, pp. 596-603
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sabatini, D.M.3
-
106
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov D. D., Ali S. M., Sengupta S., Sheen J. H., Hsu P. P., Bagley A. F., Markhard A. L., and, Sabatini D. M., (2006) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22, 159-168.
-
(2006)
Mol. Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
107
-
-
33748752151
-
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
-
DOI 10.1074/jbc.M603536200
-
Schieke S. M., Phillips D., McCoy J. Jr.P., Aponte A. M., Shen R. F., Balaban R. S., and, Finkel T., (2006) The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J. Biol. Chem. 281, 27643-27652. (Pubitemid 44401789)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.37
, pp. 27643-27652
-
-
Schieke, S.M.1
Phillips, D.2
McCoy Jr., J.P.3
Aponte, A.M.4
Shen, R.-F.5
Balaban, R.S.6
Finkel, T.7
-
108
-
-
0038299000
-
Sirolimus: Its discovery, biological properties, and mechanism of action
-
DOI 10.1016/S0041-1345(03)00211-2
-
Sehgal S. N., (2003) Sirolimus: its discovery, biological properties, and mechanism of action. Transplant. Proc. 35, 7S-14S. (Pubitemid 36547910)
-
(2003)
Transplantation Proceedings
, vol.35
, Issue.3 SUPPL.
-
-
Sehgal, S.N.1
-
109
-
-
0016713286
-
Rapamycin (AY-22,989), a new antifungal antibiotic II. Fermentation, isolation and characterization
-
Sehgal S. N., Baker H., and, Vezina C., (1975) Rapamycin (AY-22,989), a new antifungal antibiotic II. Fermentation, isolation and characterization. J. Antibiot. (Tokyo) 28, 727-732.
-
(1975)
J. Antibiot. (Tokyo)
, vol.28
, pp. 727-732
-
-
Sehgal, S.N.1
Baker, H.2
Vezina, C.3
-
110
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
Selman C., Tullet J. M., Wieser D., et al. (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326, 140-144.
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
Tullet, J.M.2
Wieser, D.3
-
111
-
-
32044431845
-
Coronary-artery stents
-
DOI 10.1056/NEJMra051091
-
Serruys P. W., Kutryk M. J., and, Ong A. T., (2006) Coronary-artery stents. N. Engl. J. Med. 354, 483-495. (Pubitemid 43200299)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.5
, pp. 483-495
-
-
Serruys, P.W.1
Kutryk, M.J.B.2
Ong, A.T.L.3
-
112
-
-
33746237577
-
To be or not to be toxic: Aggregations in Huntington and Alzheimer disease
-
DOI 10.1016/j.tig.2006.05.008, PII S0168952506001685
-
Slow E. J., Graham R. K., and, Hayden M. R., (2006) To be or not to be toxic: aggregations in Huntington and Alzheimer disease. Trends Genet. 22, 408-411. (Pubitemid 44093764)
-
(2006)
Trends in Genetics
, vol.22
, Issue.8
, pp. 408-411
-
-
Slow, E.J.1
Graham, R.K.2
Hayden, M.R.3
-
113
-
-
77950900079
-
MTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action
-
Soliman G. A., Acosta-Jaquez H. A., Dunlop E. A., Ekim B., Maj N. E., Tee A. R., and, Fingar D. C., (2010) mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J. Biol. Chem. 285, 7866-7879.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 7866-7879
-
-
Soliman, G.A.1
Acosta-Jaquez, H.A.2
Dunlop, E.A.3
Ekim, B.4
Maj, N.E.5
Tee, A.R.6
Fingar, D.C.7
-
114
-
-
60149091189
-
Regulation of translation initiation in eukaryotes: Mechanisms and biological targets
-
Sonenberg N., and, Hinnebusch A. G., (2009) Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136, 731-745.
-
(2009)
Cell
, vol.136
, pp. 731-745
-
-
Sonenberg, N.1
Hinnebusch, A.G.2
-
115
-
-
61449244533
-
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
-
Soukas A. A., Kane E. A., Carr C. E., Melo J. A., and, Ruvkun G., (2009) Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 23, 496-511.
-
(2009)
Genes Dev.
, vol.23
, pp. 496-511
-
-
Soukas, A.A.1
Kane, E.A.2
Carr, C.E.3
Melo, J.A.4
Ruvkun, G.5
-
116
-
-
77954235821
-
Targeting mTOR: Prospects for mTOR complex 2 inhibitors in cancer therapy
-
Sparks C. A., and, Guertin D. A., (2010) Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy. Oncogene 29, 3733-3744.
-
(2010)
Oncogene
, vol.29
, pp. 3733-3744
-
-
Sparks, C.A.1
Guertin, D.A.2
-
117
-
-
77956305343
-
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
-
Spilman P., Podlutskaya N., Hart M. J., Debnath J., Gorostiza O., Bredesen D., Richardson A., Strong R., and, Galvan V., (2010) Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS ONE 5, e9979.
-
(2010)
PLoS ONE
, vol.5
-
-
Spilman, P.1
Podlutskaya, N.2
Hart, M.J.3
Debnath, J.4
Gorostiza, O.5
Bredesen, D.6
Richardson, A.7
Strong, R.8
Galvan, V.9
-
118
-
-
43449138491
-
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
-
DOI 10.1111/j.1474-9726.2008.00385.x
-
Steinkraus K. A., Smith E. D., Davis C., Carr D., Pendergrass W. R., Sutphin G. L., Kennedy B. K., and, Kaeberlein M., (2008) Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell 7, 394-404. (Pubitemid 351663908)
-
(2008)
Aging Cell
, vol.7
, Issue.3
, pp. 394-404
-
-
Steinkraus, K.A.1
Smith, E.D.2
Davis, C.3
Carr, D.4
Pendergrass, W.R.5
Sutphin, G.L.6
Kennedy, B.K.7
Kaeberlein, M.8
-
119
-
-
53549122987
-
The effects of p53 on whole organism longevity are mediated by autophagy
-
Tavernarakis N., Pasparaki A., Tasdemir E., Maiuri M. C., and, Kroemer G., (2008) The effects of p53 on whole organism longevity are mediated by autophagy. Autophagy 4, 870-873.
-
(2008)
Autophagy
, vol.4
, pp. 870-873
-
-
Tavernarakis, N.1
Pasparaki, A.2
Tasdemir, E.3
Maiuri, M.C.4
Kroemer, G.5
-
120
-
-
33846569938
-
Targeting mammalian target of rapamycin (mTOR) for health and diseases
-
DOI 10.1016/j.drudis.2006.12.008, PII S1359644606004910
-
Tsang C. K., Qi H., Liu L. F., and, Zheng X. F., (2007) Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov. Today 12, 112-124. (Pubitemid 46176669)
-
(2007)
Drug Discovery Today
, vol.12
, Issue.3-4
, pp. 112-124
-
-
Tsang, C.K.1
Qi, H.2
Liu, L.F.3
Zheng, X.F.S.4
-
121
-
-
34249813098
-
Sch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae
-
DOI 10.1016/j.molcel.2007.04.020, PII S1097276507002560
-
Urban J., Soulard A., Huber A., et al. (2007) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol. Cell 26, 663-674. (Pubitemid 46856238)
-
(2007)
Molecular Cell
, vol.26
, Issue.5
, pp. 663-674
-
-
Urban, J.1
Soulard, A.2
Huber, A.3
Lippman, S.4
Mukhopadhyay, D.5
Deloche, O.6
Wanke, V.7
Anrather, D.8
Ammerer, G.9
Riezman, H.10
Broach, J.R.11
De Virgilio, C.12
Hall, M.N.13
Loewith, R.14
-
122
-
-
57649234905
-
Autophagy genes and ageing
-
Vellai T., (2009) Autophagy genes and ageing. Cell Death Differ. 16, 94-102.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 94-102
-
-
Vellai, T.1
-
123
-
-
0642367846
-
Influence of TOR kinase on lifespan in C. elegans
-
Vellai T., Takacs-Vellai K., Zhang Y., Kovacs A. L., Orosz L., and, Muller F., (2003) Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426, 620. (Pubitemid 38009359)
-
(2003)
Nature
, vol.426
, Issue.6967
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
124
-
-
0016724057
-
Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
-
Vezina C., Kudelski A., and, Sehgal S. N., (1975) Rapamycin (AY-22, 989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. (Tokyo) 28, 721-726.
-
(1975)
J. Antibiot. (Tokyo)
, vol.28
, pp. 721-726
-
-
Vezina, C.1
Kudelski, A.2
Sehgal, S.N.3
-
125
-
-
34248549251
-
Theories of ageing
-
DOI 10.1080/15216540601178067, PII 778717133
-
Vina J., Borras C., and, Miquel J., (2007) Theories of ageing. IUBMB Life 59, 249-254. (Pubitemid 46763767)
-
(2007)
IUBMB Life
, vol.59
, Issue.4-5
, pp. 249-254
-
-
Vina, J.1
Borras, C.2
Miquel, J.3
-
126
-
-
17144366976
-
Generation of superoxide-radical by the NADH: Ubiquinone oxidoreductase of heart mitochondria
-
DOI 10.1007/s10541-005-0090-7
-
Vinogradov A. D., and, Grivennikova V. G., (2005) Generation of superoxide-radical by the NADH:ubiquinone oxidoreductase of heart mitochondria. Biochemistry (Mosc) 70, 120-127. (Pubitemid 40512317)
-
(2005)
Biochemistry (Moscow)
, vol.70
, Issue.2
, pp. 120-127
-
-
Vinogradov, A.D.1
Grivennikova, V.G.2
-
127
-
-
79957528883
-
MTORC1 signaling: What we still don't know
-
(in press), doi
-
Wang X., and, Proud C. G., (2010) mTORC1 signaling: what we still don't know. J. Mol. Cell. Biol. (in press), doi:.
-
(2010)
J. Mol. Cell. Biol
-
-
Wang, X.1
Proud, C.G.2
-
128
-
-
0022517746
-
The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake
-
Weindruch R., Walford R. L., Fligiel S., and, Guthrie D., (1986) The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J. Nutr. 116, 641-654. (Pubitemid 16066430)
-
(1986)
Journal of Nutrition
, vol.116
, Issue.4
, pp. 641-654
-
-
Weindruch, R.1
Walford, R.L.2
Fligiel, S.3
Guthrie, D.4
-
129
-
-
70049103975
-
Systematic gene expression profile of hypothalamus in calorie-restricted mice implicates the involvement of mTOR signaling in neuroprotective activity. Mech
-
Wu P., Jiang C., Shen Q., and, Hu Y., (2009) Systematic gene expression profile of hypothalamus in calorie-restricted mice implicates the involvement of mTOR signaling in neuroprotective activity. Mech. Ageing Dev. 130, 602-610.
-
(2009)
Ageing Dev.
, vol.130
, pp. 602-610
-
-
Wu, P.1
Jiang, C.2
Shen, Q.3
Hu, Y.4
-
130
-
-
32044465506
-
TOR signaling in growth and metabolism
-
DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
-
Wullschleger S., Loewith R., and, Hall M. N., (2006) TOR signaling in growth and metabolism. Cell 124, 471-484. (Pubitemid 43199434)
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
131
-
-
33751079895
-
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
-
DOI 10.1101/gad.1461206
-
Yang Q., Inoki K., Ikenoue T., and, Guan K. L., (2006) Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 20, 2820-2832. (Pubitemid 44771744)
-
(2006)
Genes and Development
, vol.20
, Issue.20
, pp. 2820-2832
-
-
Yang, Q.1
Inoki, K.2
Ikenoue, T.3
Guan, K.-L.4
-
132
-
-
77953091045
-
Structure of the human mTOR complex i and its implications for rapamycin inhibition
-
Yip C. K., Murata K., Walz T., Sabatini D. M., and, Kang S. A., (2010) Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol. Cell 38, 768-774.
-
(2010)
Mol. Cell
, vol.38
, pp. 768-774
-
-
Yip, C.K.1
Murata, K.2
Walz, T.3
Sabatini, D.M.4
Kang, S.A.5
-
133
-
-
33846538660
-
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
-
DOI 10.1016/j.neuron.2007.01.010, PII S089662730700030X
-
Yoshiyama Y., Higuchi M., Zhang B., et al. (2007) Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53, 337-351. (Pubitemid 46161268)
-
(2007)
Neuron
, vol.53
, Issue.3
, pp. 337-351
-
-
Yoshiyama, Y.1
Higuchi, M.2
Zhang, B.3
Huang, S.-M.4
Iwata, N.5
Saido, TakaomiC.6
Maeda, J.7
Suhara, T.8
Trojanowski, J.Q.9
Lee, V.M.-Y.10
-
134
-
-
26444587508
-
Macroautophagy - A novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
-
DOI 10.1083/jcb.200505082
-
Yu W. H., Cuervo A. M., Kumar A., et al. (2005) Macroautophagy-a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J. Cell Biol. 171, 87-98. (Pubitemid 41434604)
-
(2005)
Journal of Cell Biology
, vol.171
, Issue.1
, pp. 87-98
-
-
Haung Yu, W.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
Lee, J.-H.6
Mohan, P.S.7
Mercken, M.8
Farmery, M.R.9
Tjernberg, L.O.10
Jiang, Y.11
Duff, K.12
Uchiyama, Y.13
Naslund, J.14
Mathews, P.M.15
Cataldo, A.M.16
Nixon, R.A.17
-
135
-
-
77955280344
-
Rapamycin promotes beta-amyloid production via ADAM-10 inhibition
-
Zhang S., Salemi J., Hou H., Zhu Y., Mori T., Giunta B., Obregon D., and, Tan J., (2010) Rapamycin promotes beta-amyloid production via ADAM-10 inhibition. Biochem. Biophys. Res. Commun. 398, 337-341.
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.398
, pp. 337-341
-
-
Zhang, S.1
Salemi, J.2
Hou, H.3
Zhu, Y.4
Mori, T.5
Giunta, B.6
Obregon, D.7
Tan, J.8
-
136
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
Zinzalla V., Stracka D., Oppliger W., and, Hall M. N., (2011) Activation of mTORC2 by association with the ribosome. Cell 144, 757-768.
-
(2011)
Cell
, vol.144
, pp. 757-768
-
-
Zinzalla, V.1
Stracka, D.2
Oppliger, W.3
Hall, M.N.4
|