Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: Implications for lewy body formation

Journal of Neuroscience

Volumn 25, Issue 8, 2005, Pages 2002-2009

  Kah, Leong Lim ^a,b,c   Chew, Katherine C M ^b,c   Tan, Jeanne M M ^b   Wang, Cheng ^b,c   Chung, Kenny K K ^a   Zhang, Yi ^a   Tanaka, Yuji ^a,e   Smith, Wanli ^a   Engelender, Simone ^d   Ross, Christopher A ^a   Dawson, Valina L ^a   Dawson, Ted M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^e OKAYAMA UNIVERSITY   (Japan)

Author keywords

Dopamine; Lewy body; Parkin; Parkinson's disease; Synphilin 1; Ubiquitin

Indexed keywords

ALPHA SYNUCLEIN; LYSINE; PARKIN; POLYUBIQUITIN; PROTEASOME; PROTEIN; SYNPHILIN 1; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL STRAIN HEK293; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEWY BODY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION;

ALPHA-SYNUCLEIN; CARRIER PROTEINS; CATALYSIS; CELL LINE; GENE EXPRESSION; HUMANS; KIDNEY; LEWY BODIES; LYSINE; NERVE TISSUE PROTEINS; PARKINSON DISEASE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT FUSION PROTEINS; SYNUCLEINS; TRANSFECTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 20044386298     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4474-04.2005     Document Type: Article

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