Retromer disruption promotes amyloidogenic APP processing

Neurobiology of Disease

Volumn 43, Issue 2, 2011, Pages 338-345

  Sullivan, Christopher P ^a,b   Jay, Anthony G ^a,b   Stack, Edward C ^a,b   Pakaluk, Maria ^a,b   Wadlinger, Erin ^a,b   Fine, Richard E ^a,b   Wells, John M ^a,b   Morin, Peter J ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

A ; APP; Endosome; Exosome; Retromer; Vps35

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; MEMBRANE PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN VPS35; RETROMER; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN TARGETING; PROTEIN TRANSPORT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOIDOSIS; EXOSOMES; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; MUTATION; NEURONS; UP-REGULATION; VESICULAR TRANSPORT PROTEINS;

EID: 79958188530     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.04.002     Document Type: Article

References (36)

1. Aharon A., et al. Monocyte-derived microparticles and exosomes induce procoagulant and apoptotic effects on endothelial cells. Thromb. Haemost. 2008, 100:878-885.
2. Andersen O.M., et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. USA 2005, 102:13461-13466.
3. Arighi C.N., et al. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J. Cell Biol. 2004, 165:123-133.
4. Belenkaya T.Y., et al. The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev. Cell 2008, 14:120-131.
5. Bonifacino J.S., Hurley J.H. Retromer. Curr. Opin. Cell Biol. 2008, 20:427-436.
6. Borchelt D.R., et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 1996, 17:1005-1013.
7. Canuel M., et al. AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes. Biochem. Biophys. Res. Commun. 2008, 366:724-730.
8. Garcia-Alloza M., et al. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol. Dis. 2006, 24:516-524.
9. He X., et al. GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J. Biol. Chem. 2005, 280:11696-11703.
10. Hierro A., et al. Functional architecture of the retromer cargo-recognition complex. Nature 2007, 449:1063-1067.
11. Hu X., et al. Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc. Natl. Acad. Sci. USA 2009, 106:20324-20329.
12. Jacobsen L., et al. Activation and functional characterization of the mosaic receptor SorLA/LR11. J. Biol. Chem. 2001, 276:22788-22796.
13. Jacobsen L., et al. The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding. FEBS Lett. 2002, 511:155-158.
14. Jiang Y., et al. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc. Natl. Acad. Sci. USA 2009, 107:1630-1635.
15. Korkut C., et al. Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless. Cell 2009, 139:393-404.
16. Mathias R.A., et al. Isolation of extracellular membranous vesicles for proteomic analysis. Methods Mol. Biol. 2009, 528:227-242.
17. Muhammad A., et al. Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc. Natl. Acad. Sci. USA 2008, 105:7327-7332.
18. Nielsen M.S., et al. Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol. Cell. Biol. 2007, 27:6842-6851.
19. Offe K., et al. The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J. Neurosci. 2006, 26:1596-1603.
20. Okada H., et al. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J. 2010, 24:2783-2794.
21. Rajendran L., et al. Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc. Natl. Acad. Sci. USA 2006, 103:11172-11177.
22. Reitz C., et al. SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk. Ann. Neurol. 2011, 69:47-64.
23. Rogaeva E., et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat. Genet. 2007, 39:168-177.
24. Sharples R.A., et al. Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes. FASEB J. 2008, 22:1469-1478.
25. Small S.A., Gandy S. Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron 2006, 52:15-31.
26. Small S.A., et al. Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann. Neurol. 2005, 58:909-919.
27. Stahl P.D., Barbieri M.A. Multivesicular bodies and multivesicular endosomes: the "ins and outs" of endosomal traffic. Sci. STKE 2002, pe32.
28. Sullivan C.P., et al. Secretory phospholipase A2, group IIA is a novel serum amyloid a target gene; Activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism. J. Biol. Chem. 2009.
29. Takahashi R.H., et al. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am. J. Pathol. 2002, 161:1869-1879.
30. Thery C., et al. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J. Immunol. 2001, 166:7309-7318.
31. Troncoso J.C., et al. Neuropathology of preclinical and clinical late-onset Alzheimer's disease. Ann. Neurol. 1998, 43:673-676.
32. Vella L.J., et al. The role of exosomes in the processing of proteins associated with neurodegenerative diseases. Eur. Biophys. J. 2008, 37:323-332.
33. Vieira S.I., et al. Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Mol. Neurodegener. 2010, 5:40.
34. Vingtdeux V., et al. Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies. J. Biol. Chem. 2007, 282:18197-18205.
35. Williams N.S., et al. Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference. Clin. Cancer Res. 2003, 9:931-946.
36. Wolfe M.S. When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease. EMBO Rep. 2007, 8:136-140.