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Volumn 97, Issue 1, 2006, Pages 265-279

Amino acid sequence motifs and mechanistic features of the membrane translocation of α-synuclein

Author keywords

synuclein; Membrane translocation; Parkinson's disease; Protein transduction domain; Repeat sequence

Indexed keywords

ALPHA SYNUCLEIN; BETA SYNUCLEIN; GAMMA SYNUCLEIN;

EID: 33644954146     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03731.x     Document Type: Article
Times cited : (106)

References (59)
  • 1
    • 0034077041 scopus 로고    scopus 로고
    • Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system
    • Abeliovich A. Schmitz Y. Farinas I. et al. 2000 Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system Neuron 25 239 252
    • (2000) Neuron , vol.25 , pp. 239-252
    • Abeliovich, A.1    Schmitz, Y.2    Farinas, I.3
  • 3
    • 0038054286 scopus 로고    scopus 로고
    • A structural and functional role for 11-mer repeats in α-synuclein and other exchangeable lipid binding proteins
    • Bussel R. Jr. Eliezer D. 2003 A structural and functional role for 11-mer repeats in α-synuclein and other exchangeable lipid binding proteins JMolBiol 329 763 778
    • (2003) JMolBiol , vol.329 , pp. 763-778
    • Bussel Jr., R.1    Eliezer, D.2
  • 4
    • 0038341134 scopus 로고    scopus 로고
    • A broken alpha-helix in folded alpha-synucleinq14
    • Chandra S. Chen X. Rizo J. Jahn R. Sudhof TC. 2003 A broken alpha-helix in folded alpha-synucleinq14 JBiolChem 278 15313 15318
    • (2003) JBiolChem , vol.278 , pp. 15313-15318
    • Chandra, S.1    Chen, X.2    Rizo, J.3    Jahn, R.4    Sudhof, T.C.5
  • 5
    • 0032102455 scopus 로고    scopus 로고
    • The synucleins: A family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
    • Clayton DF. George JM. 1998 The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease Trends Neurosci 21 249 254
    • (1998) Trends Neurosci , vol.21 , pp. 249-254
    • Clayton, D.F.1    George, J.M.2
  • 6
    • 0037155197 scopus 로고    scopus 로고
    • Lipid droplet binding and oligomerization properties of the Parkinson's disease protein α-synuclein
    • Cole NB. Murphy DD. Grider T. Ruter S. Brasaemle D. Nussbaum RI. 2002 Lipid droplet binding and oligomerization properties of the Parkinson's disease protein α-synuclein JBiolChem 277 6344 6352
    • (2002) JBiolChem , vol.277 , pp. 6344-6352
    • Cole, N.B.1    Murphy, D.D.2    Grider, T.3    Ruter, S.4    Brasaemle, D.5    Nussbaum, R.I.6
  • 7
    • 0034604583 scopus 로고    scopus 로고
    • Wild-type but not Parkinson's disease-related ala-53 → Thr mutant α-synuclein protects neuronal cells from apoptotic stimuli
    • da Costa CA. Ancolio K. Checler F. 2000 Wild-type but not Parkinson's disease-related ala-53 → Thr mutant α-synuclein protects neuronal cells from apoptotic stimuli JBiolChem 275 24065 24069
    • (2000) JBiolChem , vol.275 , pp. 24065-24069
    • Da Costa, C.A.1    Ancolio, K.2    Checler, F.3
  • 8
    • 0032540327 scopus 로고    scopus 로고
    • Stabilization of α-synuclein secondary structure upon binding to synthetic membranes
    • Davidson WS. Jonas A. Clayton DF. George JM. 1998 Stabilization of α-synuclein secondary structure upon binding to synthetic membranes JBiolChem 273 9443 9449
    • (1998) JBiolChem , vol.273 , pp. 9443-9449
    • Davidson, W.S.1    Jonas, A.2    Clayton, D.F.3    George, J.M.4
  • 9
    • 0037072284 scopus 로고    scopus 로고
    • Annular α-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes
    • Ding TT. Lee SJ. Rochet JC. Lansbury PT. Jr. 2002 Annular α-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes Biochemistry 41 10209 10207
    • (2002) Biochemistry , vol.41 , pp. 10209-10207
    • Ding, T.T.1    Lee, S.J.2    Rochet, J.C.3    Lansbury Jr., P.T.4
  • 10
    • 20444372698 scopus 로고    scopus 로고
    • α-Synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast
    • Dixon C. Mathias N. Zweig RM. Davis DA. Gross DS. 2005 α-Synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast Genetics 170 47 59
    • (2005) Genetics , vol.170 , pp. 47-59
    • Dixon, C.1    Mathias, N.2    Zweig, R.M.3    Davis, D.A.4    Gross, D.S.5
  • 11
    • 85109083933 scopus 로고    scopus 로고
    • α-Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
    • El-Aganaf OM. Salem SA. Paleologou KE. et al. 2003 α-Synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma FASEB J 17 1945 1947
    • (2003) FASEB J , vol.17 , pp. 1945-1947
    • El-Aganaf, O.M.1    Salem, S.A.2    Paleologou, K.E.3
  • 12
    • 0032573597 scopus 로고    scopus 로고
    • Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments
    • El-Agnaf OM. Jakes R. Curran MD. Middleton D. Ingenito R. Bianchi E. Pessi A. Neill D. Wallace A. 1998 Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments FEBS Lett 440 71 75
    • (1998) FEBS Lett , vol.440 , pp. 71-75
    • El-Agnaf, O.M.1    Jakes, R.2    Curran, M.D.3    Middleton, D.4    Ingenito, R.5    Bianchi, E.6    Pessi, A.7    Neill, D.8    Wallace, A.9
  • 13
    • 0031471203 scopus 로고    scopus 로고
    • Intercellular trafficking and protein delivery by a herpes virus structural protein
    • Elliott G. O'Hare P. 1997 Intercellular trafficking and protein delivery by a herpes virus structural protein Cell 88 223 233
    • (1997) Cell , vol.88 , pp. 223-233
    • Elliott, G.1    O'Hare, P.2
  • 14
    • 0345119026 scopus 로고    scopus 로고
    • Caught in the act: α-synuclein is the culprit in Parkinson's disease
    • Ericksen JL. Dawson TM. Dickson DW. Petrucelli L. 2003 Caught in the act: α-synuclein is the culprit in Parkinson's disease Neuron 40 453 456
    • (2003) Neuron , vol.40 , pp. 453-456
    • Ericksen, J.L.1    Dawson, T.M.2    Dickson, D.W.3    Petrucelli, L.4
  • 15
    • 0034017710 scopus 로고    scopus 로고
    • α-Synuclein and Parkinson's disease: Selective neurodegenerative effect of α-synuclein fragment on dopaminergic neurons in vitro and in vivo
    • Forloni G. Bertani I. Calella AM. Thaler F. Invernizzi R. 2004 α-Synuclein and Parkinson's disease: selective neurodegenerative effect of α-synuclein fragment on dopaminergic neurons in vitro and in vivo AnnNeurol 47 632 640
    • (2004) AnnNeurol , vol.47 , pp. 632-640
    • Forloni, G.1    Bertani, I.2    Calella, A.M.3    Thaler, F.4    Invernizzi, R.5
  • 17
    • 0036804013 scopus 로고    scopus 로고
    • Arginine-rich peptides: Potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms
    • Futaki S. 2002 Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms IntJPharm 245 1 7
    • (2002) IntJPharm , vol.245 , pp. 1-7
    • Futaki, S.1
  • 18
    • 0029127954 scopus 로고
    • Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
    • George JM. Jin H. Woods WS. Clayton DF. 1995 Characterization of a novel protein regulated during the critical period for song learning in the zebra finch Neuron 2 361 372
    • (1995) Neuron , vol.2 , pp. 361-372
    • George, J.M.1    Jin, H.2    Woods, W.S.3    Clayton, D.F.4
  • 19
    • 0032888789 scopus 로고    scopus 로고
    • α-Synuclein in Lewy body disease and Alzheimer's disease
    • Hashimoto M. Masliah E. 1999 α-Synuclein in Lewy body disease and Alzheimer's disease Brain Pathol 9 707 720
    • (1999) Brain Pathol , vol.9 , pp. 707-720
    • Hashimoto, M.1    Masliah, E.2
  • 22
    • 0029820770 scopus 로고    scopus 로고
    • Characterization of the precursor protein of the non-Aβ component of senile plaques (NACP) in the human central nervous system
    • Irizarry MC. Kim TW. McNamara M. Tanzi RE. George JM. Clayton DF. Hyman BT. 1996 Characterization of the precursor protein of the non-Aβ component of senile plaques (NACP) in the human central nervous system JNeuropatholExpNeurol 55 889 895
    • (1996) JNeuropatholExpNeurol , vol.55 , pp. 889-895
    • Irizarry, M.C.1    Kim, T.W.2    McNamara, M.3    Tanzi, R.E.4    George, J.M.5    Clayton, D.F.6    Hyman, B.T.7
  • 23
    • 0034718160 scopus 로고    scopus 로고
    • Properties of NACP/α-synuclein and its role in Alzheimer's disease
    • Iwai A. 2000 Properties of NACP/α-synuclein and its role in Alzheimer's disease BiochimBiophysActa 1502 95 109
    • (2000) BiochimBiophysActa , vol.1502 , pp. 95-109
    • Iwai, A.1
  • 24
    • 0028277520 scopus 로고
    • Identification of two distinct synucleins from human brain
    • Jakes R. Spillantini MG. Goedert M. 1994 Identification of two distinct synucleins from human brain FEBS Lett 345 27 32
    • (1994) FEBS Lett , vol.345 , pp. 27-32
    • Jakes, R.1    Spillantini, M.G.2    Goedert, M.3
  • 25
    • 2942555022 scopus 로고    scopus 로고
    • Structure of membrane-bound α-synuclein studied by site-directed spin labeling
    • Jao CC. Der-Sarkissian A. Chen J. Langen R. 2004 Structure of membrane-bound α-synuclein studied by site-directed spin labeling ProcNatl AcadSciUSA 101 8331 8336
    • (2004) ProcNatl AcadSciUSA , vol.101 , pp. 8331-8336
    • Jao, C.C.1    Der-Sarkissian, A.2    Chen, J.3    Langen, R.4
  • 26
    • 0032500599 scopus 로고    scopus 로고
    • Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
    • Jensen PH. Nielsen MS. Jakes R. Dotti CG. Goedert M. 1998 Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation JBiolChem 273 26292 26294
    • (1998) JBiolChem , vol.273 , pp. 26292-26294
    • Jensen, P.H.1    Nielsen, M.S.2    Jakes, R.3    Dotti, C.G.4    Goedert, M.5
  • 27
    • 0031045589 scopus 로고    scopus 로고
    • Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing
    • Ji H. Liu YE. Jia T. Wang M. Liu J. Xiao G. Joseph BK. Rosen C. Shi YE. 1997 Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing Cancer Res 57 759 764
    • (1997) Cancer Res , vol.57 , pp. 759-764
    • Ji, H.1    Liu, Y.E.2    Jia, T.3    Wang, M.4    Liu, J.5    Xiao, G.6    Joseph, B.K.7    Rosen, C.8    Shi, Y.E.9
  • 29
    • 0032707654 scopus 로고    scopus 로고
    • Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury
    • Kholodilov NG. Neystat M. Oo TF. Lo SE. Larsen KE. Sulzer D. Burke RE. 1999 Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury JNeurochem 73 2586 2599
    • (1999) JNeurochem , vol.73 , pp. 2586-2599
    • Kholodilov, N.G.1    Neystat, M.2    Oo, T.F.3    Lo, S.E.4    Larsen, K.E.5    Sulzer, D.6    Burke, R.E.7
  • 30
    • 0027439173 scopus 로고
    • Unusual routes of protein secretion: The easy way out
    • Kuchler K. 1993 Unusual routes of protein secretion: the easy way out Trends CellBiol 3 421 426
    • (1993) Trends CellBiol , vol.3 , pp. 421-426
    • Kuchler, K.1
  • 31
    • 0031763264 scopus 로고    scopus 로고
    • The synuclein family
    • Lavedan C. 1998 The synuclein family Genome Res 8 871 880
    • (1998) Genome Res , vol.8 , pp. 871-880
    • Lavedan, C.1
  • 32
    • 21344456506 scopus 로고    scopus 로고
    • A broken α-helix in folded α-synuclein
    • Lee HJ. Patel S. Lee SJ. 2005 A broken α-helix in folded α-synuclein JNeurosci 25 6016 6024
    • (2005) JNeurosci , vol.25 , pp. 6016-6024
    • Lee, H.J.1    Patel, S.2    Lee, S.J.3
  • 33
    • 0041698459 scopus 로고    scopus 로고
    • 'Translocatory proteins' and 'protein transduction domains': A critical analysis of their biological effects and the underlying mechanisms
    • Leifert JA. Whitton JL. 2003 'Translocatory proteins' and 'protein transduction domains': a critical analysis of their biological effects and the underlying mechanisms MolTher 8 13 20
    • (2003) MolTher , vol.8 , pp. 13-20
    • Leifert, J.A.1    Whitton, J.L.2
  • 34
    • 0025232841 scopus 로고
    • Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin a suggests an ER recycling pathway
    • Lippincott Schwartz J. Donaldson JG. Schweizer A. Berger EG. Hauri HP. Yuan LC. Klausner RD. 1990 Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin A suggests an ER recycling pathway Cell 60 821 836
    • (1990) Cell , vol.60 , pp. 821-836
    • Lippincott Schwartz, J.1    Donaldson, J.G.2    Schweizer, A.3    Berger, E.G.4    Hauri, H.P.5    Yuan, L.C.6    Klausner, R.D.7
  • 35
    • 0034489853 scopus 로고    scopus 로고
    • α-Synuclein and Parkinson's disease
    • Lücking CB. Brice A. 2000 α-Synuclein and Parkinson's disease Cell MolLife Sci 57 1894 1908
    • (2000) Cell MolLife Sci , vol.57 , pp. 1894-1908
    • Lücking, C.B.1    Brice, A.2
  • 36
    • 0023722437 scopus 로고
    • Synuclein: A neuron-specific protein localized to the nucleus and presynaptic nerve terminal
    • Maroteaux L. Campanelli JT. Scheller RH. 1988 Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal JNeurosci 8 2804 2815
    • (1988) JNeurosci , vol.8 , pp. 2804-2815
    • Maroteaux, L.1    Campanelli, J.T.2    Scheller, R.H.3
  • 37
    • 0034708767 scopus 로고    scopus 로고
    • Membrane association and protein conformation of α-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations
    • McLean PJ. Kawamata H. Ribich S. Hyman BT. 2000 Membrane association and protein conformation of α-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations JBiolChem 275 8812 8816
    • (2000) JBiolChem , vol.275 , pp. 8812-8816
    • McLean, P.J.1    Kawamata, H.2    Ribich, S.3    Hyman, B.T.4
  • 39
    • 0038701886 scopus 로고    scopus 로고
    • The mystery of non-classical protein secretion. a current view on cargo proteins and potential export routes
    • Nickel W. 2003 The mystery of non-classical protein secretion. A current view on cargo proteins and potential export routes EurJBiochem 270 2109 2119
    • (2003) EurJBiochem , vol.270 , pp. 2109-2119
    • Nickel, W.1
  • 41
    • 0019859435 scopus 로고
    • Journey to the center of the cell: Role of the receptosome
    • Pastan IH. Willingham MC. 1981 Journey to the center of the cell: role of the receptosome Science 14 504 509
    • (1981) Science , vol.14 , pp. 504-509
    • Pastan, I.H.1    Willingham, M.C.2
  • 42
    • 0034602271 scopus 로고    scopus 로고
    • Interaction of human α-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis
    • Perrin RJ. Woods WS. Clayton DF. George JM. 2000 Interaction of human α-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis JBiolChem 275 34393 34398
    • (2000) JBiolChem , vol.275 , pp. 34393-34398
    • Perrin, R.J.1    Woods, W.S.2    Clayton, D.F.3    George, J.M.4
  • 43
    • 0034663176 scopus 로고    scopus 로고
    • Neuropathology in mice expressing human α-synuclein
    • van der Putten H. Wiederhold KH. Probst A. et al. 2000 Neuropathology in mice expressing human α-synuclein JNeurosci 20 6021 6029
    • (2000) JNeurosci , vol.20 , pp. 6021-6029
    • Van Der Putten, H.1    Wiederhold, K.H.2    Probst, A.3
  • 44
    • 0035975712 scopus 로고    scopus 로고
    • α-Synuclein aggregation: Is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease?
    • Rajagopalan S. Andersen JK. 2001 α-Synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease? MechAgeing Dev 122 1499 1510
    • (2001) MechAgeing Dev , vol.122 , pp. 1499-1510
    • Rajagopalan, S.1    Andersen, J.K.2
  • 46
    • 0141841634 scopus 로고    scopus 로고
    • Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease
    • Scherzer CR. Jensen RV. Gullans SR. Feany MB. 2003 Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease HumMolGenet 12 2457 2466
    • (2003) HumMolGenet , vol.12 , pp. 2457-2466
    • Scherzer, C.R.1    Jensen, R.V.2    Gullans, S.R.3    Feany, M.B.4
  • 49
    • 0034728281 scopus 로고    scopus 로고
    • Expression patterns of α-synuclein in human hematopoietic cells and in Drosophila at different developmental stages
    • Shin EC. Cho SE. Lee DK. Hur MW. Paik SR. Park JH. Kim J. 2000 Expression patterns of α-synuclein in human hematopoietic cells and in Drosophila at different developmental stages MolCells 10 65 70
    • (2000) MolCells , vol.10 , pp. 65-70
    • Shin, E.C.1    Cho, S.E.2    Lee, D.K.3    Hur, M.W.4    Paik, S.R.5    Park, J.H.6    Kim, J.7
  • 51
    • 0032568534 scopus 로고    scopus 로고
    • α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    • Spillantini MG. Crowther RA. Jakes R. Hasegawa M. Goedert M. 1998 α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies ProcNatl AcadSciUSA 95 6469 6473
    • (1998) ProcNatl AcadSciUSA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 52
    • 0035109875 scopus 로고    scopus 로고
    • Synuclein-1 is selectively up-regulated in response to nerve growth factor treatment in PC12 cells
    • Stefanis L. Kholodilov N. Rideout HJ. Burke RE. Greene LA. 2001 Synuclein-1 is selectively up-regulated in response to nerve growth factor treatment in PC12 cells JNeurochem 76 1165 1176
    • (2001) JNeurochem , vol.76 , pp. 1165-1176
    • Stefanis, L.1    Kholodilov, N.2    Rideout, H.J.3    Burke, R.E.4    Greene, L.A.5
  • 53
    • 0035920226 scopus 로고    scopus 로고
    • Induction of neuronal cell death by Rab5A-dependent endocytosis of α-synuclein
    • Sung JY. Kim J. Paik SR. et al. 2001 Induction of neuronal cell death by Rab5A-dependent endocytosis of α-synuclein JBiolChem 276 27441 27448
    • (2001) JBiolChem , vol.276 , pp. 27441-27448
    • Sung, J.Y.1    Kim, J.2    Paik, S.R.3
  • 55
    • 0031907128 scopus 로고    scopus 로고
    • Abnormal accumulation of NACP/α-synuclein in neurodegenerative disorders
    • Takeda A. Mallory M. Sundsmo M. Honer W. Hansen L. Masliah E. 1998 Abnormal accumulation of NACP/α-synuclein in neurodegenerative disorders AmJPathol 152 367 372
    • (1998) AmJPathol , vol.152 , pp. 367-372
    • Takeda, A.1    Mallory, M.2    Sundsmo, M.3    Honer, W.4    Hansen, L.5    Masliah, E.6
  • 57
    • 0032546895 scopus 로고    scopus 로고
    • α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy
    • Wakabayashi K. Yoshimoto M. Tsuji S. Takahashi H. 1998 α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy NeurosciLett 249 180 182
    • (1998) NeurosciLett , vol.249 , pp. 180-182
    • Wakabayashi, K.1    Yoshimoto, M.2    Tsuji, S.3    Takahashi, H.4
  • 58
    • 0345189365 scopus 로고    scopus 로고
    • Yeast genes that enhance the toxicity of a mutant huntingtin fragment or α-synuclein
    • Willingham S. Outeiro TF. DeVit MJ. Lindquist SL. Muchowski PJ. 2003 Yeast genes that enhance the toxicity of a mutant huntingtin fragment or α-synuclein Science 302 1769 1772
    • (2003) Science , vol.302 , pp. 1769-1772
    • Willingham, S.1    Outeiro, T.F.2    Devit, M.J.3    Lindquist, S.L.4    Muchowski, P.J.5
  • 59
    • 0347511729 scopus 로고    scopus 로고
    • Intracellular cargo delivery using tat peptide and derivatives
    • Zhao M. Weissleder R. 2004 Intracellular cargo delivery using tat peptide and derivatives MedResRev 24 1 12
    • (2004) MedResRev , vol.24 , pp. 1-12
    • Zhao, M.1    Weissleder, R.2


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