Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

FASEB Journal

Volumn 25, Issue 1, 2011, Pages 326-336

  Danzer, Karin M ^a   Ruf, Wolfgang P ^a   Putcha, Preeti ^a   Joyner, Daniel ^a   Hashimoto, Tadafumi ^a   Glabe, Charles ^b   Hyman, Bradley T ^a   McLean, Pamela J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aggregation; Microfluidic culture system; Parkinson's disease; Protein complementation

Indexed keywords

ALPHA SYNUCLEIN; HEAT SHOCK PROTEIN 70; PARVOVIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISEASE COURSE; EMBRYO; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; MICROFLUIDICS; MOUSE; NERVE CELL; NERVE FIBER TRANSPORT; NEUROMODULATION; NEUROPATHOLOGY; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; OLIGOMERIZATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN SECRETION; PROTEIN TRANSPORT; SYNAPTIC TRANSMISSION;

ALPHA-SYNUCLEIN; ANIMALS; AXONS; BENZOQUINONES; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; DEPENDOVIRUS; EXTRACELLULAR SPACE; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; LUCIFERASES; MICE; NEURONS; PROTEIN MULTIMERIZATION; SYNAPTIC TRANSMISSION; TRANSFECTION;

EID: 79251565507     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-164624     Document Type: Article

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