Zeroing in on the pathogenic form of α-Synuclein and its mechanism of neurotoxicity in Parkinson's disease

Biochemistry

Volumn 42, Issue 26, 2003, Pages 7871-7878

  Volles, Michael J ^a   Lansbury Jr , Peter T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTOXICITY;

AGGLOMERATION; DISEASES; PATHOLOGY; TOXICITY;

BIOCHEMISTRY;

ALPHA SYNUCLEIN; AMYLOID;

ANIMAL MODEL; ARTICLE; BETA SHEET; HUMAN; LEWY BODY; MEMBRANE PERMEABILITY; MUTATION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FOLDING;

ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; AMYLOID; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NERVE TISSUE PROTEINS; PARKINSON DISEASE; SYNUCLEINS;

ANIMALIA;

EID: 0038386274     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi030086j     Document Type: Article

References (119)

1. Parkinson, J. (1817) An Essay on the Shaking Palsy, Whittingham and Rowland, London.
2. Lansbury, P. T., Jr., and Brice, A. (2002) Curr. Opin. Genet. Dev. 12, 299-306.
3. Polymeropoulos, M. H., Higgins, J. J., Golbe, L. I., Johnson, W. G., Ide, S. E., Di Iorio, G., Sanges, G., Stenroos, E. S., Pho, L. T., Schaffer, A. A., Lazzarini, A. M., Nussbaum, R. L., and Duvoisin, R. C. (1996) Science 274, 1197-1199.
4. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Science 276, 2045-2047.
5. Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schols, L., and Riess, O. (1998) Nat. Genet. 18, 106-108.
6. Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., and Shimizu, N. (1998) Nature 392, 605-608.
7. Leroy, E., Boyer, R., Auburger, G., Leube, B., Ulm, G., Mezey, E., Harta, G., Brownstein, M. J., Jonnalagada, S., Chemova, T., Dehejia, A., Lavedan, C., Gasser, T., Steinbach, P. J., Wilkinson, K. D., and Polymeropoulos, M. H. (1998) Nature 395, 451-452.
8. Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C., Squitieri, F., Ibanez, P., Joosse, M., van Dongen, J. W., Vanacore, N., van Swieten, J. C., Brice, A., Meco, G., van Duijn, C. M., Oostra, B. A., and Heutink, P. (2003) Science 299, 256-259.
9. Liu, Y., Fallon, L., Lashuel, H. A., Liu, Z., and Lansbury, P. T., Jr. (2002) Cell 111, 209-218.
10. Shimura, H., Schlossmacher, M. G., Hattori, N., Frosch, M. P., Trockenbacher, A., Schneider, R., Mizuno, Y., Kosik, K. S., and Selkoe, D. J. (2001) Science 293, 263-269.
11. Petrucelli, L., O'Farrell, C., Lockhart, P. J., Baptista, M., Kehoe, K., Vink, L., Choi, P., Wolozin, B., Farrer, M., Hardy, J., and Cookson, M. R. (2002) Neuron 36, 1007-1019.
12. Lewy, F. H. (1912) in Handbuch der Neurologie (Lewandowsky, M., and Abelsdorff, G., Eds.) pp 920-933, Springer-Verlag, Berlin.
13. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Nature 388, 839-840.
14. Forno, L. S. (1996) J. Neuropathol. Exp. Neurol. 55, 259-272.
15. Forno, L. S. (1990) in Parkinson's Disease (Stern, G. M., Ed.) pp 185-238, The Johns Hopkins University Press, Baltimore.
16. Gertz, H. J., Siegers, A., and Kuchinke, J. (1994) Brain Res. 637, 339-341.
17. Kastner, A., Hirsch, E. C., Herrero, M. T., Javoy-Agid, F., and Agid, Y. (1993) J. Neurochem. 61, 1024-1034.
18. Hill, W. D. (1996) Am. J. Pathol. 149, 728-729.
19. Bergeron, C., Petrunka, C., Weyer, L., and Pollanen, M. S. (1996) Am. J. Pathol. 148, 267-272.
20. Tompkins, M. M., and Hill, W. D. (1997) Brain Res. 775, 24-29.
21. Farrer, M., Chan, P., Chen, R., Tan, L., Lincoln, S., Hernandez, D., Forno, L., Gwinn-Hardy, K., Petrucelli, L., Hussey, J., Singleton, A., Tanner, C., Hardy, J., and Langston, J. W. (2001) Ann. Neurol. 50, 293-300.
22. Abeliovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W. H., Castillo, P. E., Shinsky, N., Verdugo, J. M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., and Rosenthal, A. (2000) Neuron 25, 239-252.
23. Cabin, D. E., Shimazu, K., Murphy, D., Cole, N. B., Gottschalk, W., McIlwain, K. L., Orrison, B., Chen, A., Ellis, C. E., Paylor, R., Lu, B., and Nussbaum, R. L. (2002) J. Neurosci. 22, 8797-8807.
24. Clayton, D. F., and George, J. M. (1998) Trends Neurosci. 21, 249-254.
25. Maroteaux, L., Campanelli, J. T., and Scheller, R. H. (1988) J. Neurosci. 8, 2804-2815.
26. Ueda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A., Kondo, J., Ihara, Y., and Saitoh, T. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 11282-11286.
27. George, J. M., Jin, H., Woods, W. S., and Clayton, D. F. (1995) Neuron 15, 361-372.
28. Maroteaux, L., and Scheller, R. H. (1991) Brain Res. Mol. Brain Res. 11, 335-343.
29. Lavedan, C., Leroy, E., Dehejia, A., Buchholtz, S., Dutra, A., Nussbaum, R. L., and Polymeropoulos, M. H. (1998) Hum. Genet. 103, 106-112.
30. Jakes, R., Spillantini, M. G., and Goedert, M. (1994) FEBS Lett. 345, 27-32.
31. Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., Flanagan, L., de Silva, H. A., Kittel, A., and Saitoh, T. (1995) Neuron 14, 467-475.
32. Rockenstein, E., Hansen, L. A., Mallory, M., Trojanowski, J. Q., Galasko, D., and Masliah, E. (2001) Brain Res. 914, 48-56.
33. Buchman, V. L., Hunter, H. J., Pinon, L. G., Thompson, J., Privalova, E. M., Ninkina, N. N., and Davies, A. M. (1998) J. Neurosci. 18, 9335-9341.
34. Solano, S. M., Miller, D. W., Augood, S. J., Young, A. B., and Penney, J. B., Jr. (2000) Ann. Neurol. 47, 201-210.
35. Nakajo, S., Tsukada, K., Omata, K., Nakamura, Y., and Nakaya, K. (1993) Eur. J. Biochem. 217, 1057-1063.
36. Pronin, A. N., Morris, A. J., Surguchov, A., and Benovic, J. L. (2000) J. Biol. Chem. 275, 26515-26522.
37. Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., and Iwatsubo, T. (2002) Nat. Cell Biol. 4, 160-164.
38. Takahashi, M., Kanuka, H., Fujiwara, H., Koyama, A., Hasegawa, M., Miura, M., and Iwatsubo, T. (2003) Neurosci. Lett. 336, 155-158.
39. Masliah, E., Rockenstein, E., Veinbergs, I., Mallory, M., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., and Mucke, L. (2000) Science 287, 1265-1269.
40. Hashimoto, M., Rockenstein, E., Mante, M., Mallory, M., and Masliah, E. (2001) Neuron 32, 213-223.
41. van der Putten, H., Wiederhold, K. H., Probst, A., Barbieri, S., Mistl, C., Danner, S., Kauffmann, S., Hofele, K., Spooren, W. P., Ruegg, M. A., Lin, S., Caroni, P., Sommer, B., Tolnay, M., and Bilbe, G. (2000) J. Neurosci. 20, 6021-6029.
42. Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q., and Lee, V. M. (2002) Neuron 34, 521-533.
43. Lee, M. K., Stirling, W., Xu, Y., Xu, X., Qui, D., Mandir, A. S., Dawson, T. M., Copeland, N. G., Jenkins, N. A., and Price, D. L. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 8968-8973.
44. Gomez-Isla, T., Irizarry, M. C., Mariash, A., Cheung, B., Soto, O., Schrump, S., Sondel, J., Kotilinek, L., Day, J., Schwarzschild, M. A., Cha, J. H., Newell, K., Miller, D. W., Ueda, K., Young, A. B., Hyman, B. T., and Ashe, K. H. (2003) Neurobiol. Aging 24, 245-258.
45. Auluck, P. K., Chan, H. Y., Trojanowski, J. Q., Lee, V. M., and Bonini, N. M. (2002) Science 295, 865-868.
46. Feany, M. B., and Bender, W. W. (2000) Nature 404, 394-398.
47. Auluck, P. K., and Bonini, N. M. (2002) Nat. Med. 8, 1185-1186.
48. Lo Bianco, C., Ridet, J. L., Schneider, B. L., Deglon, N., and Aebischer, P. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 10813-10818.
49. Kirik, D., Rosenblad, C., Burger, C., Lundberg, C., Johansen, T. E., Muzyczka, N., Mandel, R. J., and Bjorklund, A. (2002) J. Neurosci. 22, 2780-2791.
50. Kirik, D., Annett, L. E., Burger, C., Muzyczka, N., Mandel, R. J., and Bjorklund, A. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 2884-2889.
51. Betarbet, R., Sherer, T. B., MacKenzie, G., Garcia-Osuna, M., Panov, A. V., and Greenamyre, J. T. (2000) Nat. Neurosci. 3, 1301-1306.
52. Dauer, W., Kholodilov, N., Vila, M., Trillat, A. C., Goodchild, R., Larsen, K. E., Staal, R., Tieu, K., Schmitz, Y., Yuan, C. A., Rocha, M., Jackson-Lewis, V., Hersch, S., Sulzer, D., Przedborski, S., Burke, R., and Hen, R. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 14524-14529.
53. Goldberg, M. S., and Lansbury, P. T., Jr. (2000) Nat. Cell Biol. 2, E115-E119.
54. Zhou, W., Hurlbert, M. S., Schaack, J., Prasad, K. N., and Freed, C. R. (2000) Brain Res. 866, 33-43.
55. Zhou, W., Schaack, J., Zawada, W. M., and Freed, C. R. (2002) Brain Res. 926, 42-50.
56. Xu, J., Kao, S. Y., Lee, F. J., Song, W., Jin, L. W., and Yankner, B. A. (2002) Nat. Med. 8, 600-606.
57. Conway, K. A., Rochet, J.-C., Bieganski, R. M., and Lansbury, P. T., Jr. (2001) Science 294, 1346-1349.
58. Gosavi, N., Lee, H. J., Lee, J. S., Patel, S., and Lee, S. J. (2002) J. Biol. Chem. 277, 48984-48992.
59. Ding, T. T., Lee, S. J., Rochet, J. C., and Lansbury, P. T., Jr. (2002) Biochemistry 41, 10209-10217.
60. Conway, K. A., Harper, J. D., and Lansbury, P. T., Jr. (1998) Nat. Med. 4, 1318-1320.
61. Conway, K. A., Harper, J. D., and Lansbury, P. T., Jr. (2000) Biochemistry 39, 2552-2563.
62. Conway, K. A., Lee, S. J., Rochet, J.-C., Ding, T. T., Williamson, R. E., and Lansbury, P. T., Jr. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 571-576.
63. Uversky, V. N., Li, J., Souillac, P., Millett, I. S., Doniach, S., Jakes, R., Goedert, M., and Fink, A. L. (2002) J. Biol. Chem. 277, 11970-11978.
64. Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A., and Lansbury, P. T., Jr. (1996) Biochemistry 35, 13709-13715.
65. Eliezer, D., Kutluay, E., Bussell, R., Jr., and Browne, G. (2001) J. Mol. Biol. 307, 1061-1073.
66. Park, J. Y., and Lansbury, P. T., Jr. (2003) Biochemistry 42, 3696-3700.
67. Bussell, R., Jr., and Eliezer, D. (2001) J. Biol. Chem. 276, 45996-46003.
68. Jensen, P. H., Nielsen, M. S., Jakes, R., Dotti, C. G., and Goedert, M. (1998) J. Biol. Chem. 273, 26292-26294.
69. Jo, E., McLaurin, J., Yip, C. M., St George-Hyslop, P., and Fraser, P. E. (2000) J. Biol. Chem. 275, 34329-34334.
70. Davidson, W. S., Jonas, A., Clayton, D. F., and George, J. M. (1998) J. Biol. Chem. 273, 9443-9449.
71. Perrin, R. J., Woods, W. S., Clayton, D. F., and George, J. M. (2000) J. Biol. Chem. 275, 34393-34398.
72. Volles, M. J., Lee, S. J., Rochet, J.-C., Shtilerman, M. D., Ding, T. T., Kessler, J. C., and Lansbury, P. T., Jr. (2001) Biochemistry 40, 7812-7819.
73. Kessler, J. C., Rochet, J. C., and Lansbury, P. T., Jr. (2003) Biochemistry 42, 672-678.
74. Chandra, S., Chen, X., Rizo, J., Jahn, R., and Sudhof, T. C. (2003) J. Biol. Chem. 278, 15313-15318.
75. Volles, M. J., and Lansbury, P. T., Jr. (2002) Biochemistry 41, 4595-4602.
76. Jo, E., Fuller, N., Rand, R. P., St George-Hyslop, P., and Fraser, P. E. (2002) J. Mol. Biol. 315, 799-807.
77. Sharon, R., Bar-Joseph, I., Frosch, M. P., Walsh, D. M., Hamilton, J. A., and Selkoe, D. J. (2003) Neuron. 37, 583-595.
78. Perrin, R. J., Woods, W. S., Clayton, D. F., and George, J. M. (2001) J. Biol. Chem. 276, 41958-41962.
79. Leng, Y., Chase, T. N., and Bennett, M. C. (2001) J. Biol. Chem. 276, 28212-28218.
80. Perez, R. G., Waymire, J. C., Lin, E., Liu, J. J., Guo, F., and Zigmond, M. J. (2002) J. Neurosci. 22, 3090-3099.
81. Lee, F. J., Liu, F., Pristupa, Z. B., and Niznik, H. B. (2001) FASEB J. 15, 916-926.
82. Jenco, J. M., Rawlingson, A., Daniels, B., and Morris, A. J. (1998) Biochemistry 37, 4901-4909.
83. Okochi, M., Walter, J., Koyama, A., Nakajo, S., Baba, M., Iwatsubo, T., Meijer, L., Kahle, P. J., and Haass, C. (2000) J. Biol. Chem. 275, 390-397.
84. Ellis, C. E., Schwartzberg, P. L., Grider, T. L., Fink, D. W., and Nussbaum, R. L. (2001) J. Biol. Chem. 276, 3879-3884.
85. Narhi, L., Wood, S. J., Steavenson, S., Jiang, Y., Wu, G. M., Anafi, D., Kaufman, S. A., Martin, F., Sitney, K., Denis, P., Louis, J. C., Wypych, J., Biere, A. L., and Citron, M. (1999) J. Biol. Chem. 274, 9843-9846.
86. Rochet, J.-C., Conway, K. A., and Lansbury, P. T., Jr. (2000) Biochemistry 39, 10619-10626.
87. Li, J., Uversky, V. N., and Fink, A. L. (2001) Biochemistry 40, 11604-11613.
88. Biere, A. L., Wood, S. J., Wypych, J., Steavenson, S., Jiang, Y., Anafi, D., Jacobsen, F. W., Jarosinski, M. A., Wu, G. M., Louis, J. C., Martin, F., Narhi, L. O., and Citron, M. (2000) J. Biol. Chem. 275, 34574-34579.
89. Lashuel, H., Petre, B., Wall, J., Simon, M., Nowak, R., Walz, T., and Lansbury, P. (2002) J. Mol. Biol. 322, 1089.
90. Lashuel, H. A., Hartley, D., Petre, B. M., Walz, T., and Lansbury, P. T., Jr. (2002) Nature 418, 291.
91. Jarrett, J. T., and Lansbury, P. T., Jr. (1993) Cell 73, 1055-1058.
92. Caughey, B., and Lansbury, P. T., Jr. (2003) Annu. Rev. Neurosci. 26, 267-298.
93. Arispe, N., Pollard, H. B., and Rojas, E. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 10573-10577.
94. Arispe, N., Pollard, H. B., and Rojas, E. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 1710-1715.
95. Arispe, N., Rojas, E., and Pollard, H. B. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 567-571.
96. Rhee, S. K., Quist, A. P., and Lal, R. (1998) J. Biol. Chem. 273, 13379-13382.
97. McLaurin, J., and Chakrabartty, A. (1996) J. Biol. Chem. 271, 26482-26489.
98. Hirakura, Y., Lin, M. C., and Kagan, B. L. (1999) J. Neurosci. Res. 57, 458-466.
99. Lin, H., Zhu, Y. J., and Lal, R. (1999) Biochemistry 38, 11189-11196.
100. Kawahara, M., Arispe, N., Kuroda, Y., and Rojas, E. (1997) Biophys. J. 73, 67-75.
101. Kawahara, M., Kuroda, Y., Arispe, N., and Rojas, E. (2000) J. Biol. Chem. 275, 14077-14083.
102. Bhatia, R., Lin, H., and Lal, R. (2000) FASEB J. 14, 1233-1243.
103. Zhu, Y. J., Lin, H., and Lal, R. (2000) FASEB J. 14, 1244-1254.
104. Lin, H., Bhatia, R., and Lal, R. (2001) FASEB J. 15, 2433-2444.
105. Mirzabekov, T. A., Lin, M. C., and Kagan, B. L. (1996) J. Biol. Chem. 271, 1988-1992.
106. Janson, J., Ashley, R. H., Harrison, D., McIntyre, S., and Butler, P. C. (1999) Diabetes 48, 491-498.
107. Anguiano, M., Nowak, R. J., and Lansbury, P. T., Jr. (2002) Biochemistry 41, 11338-11343.
108. Lin, M. C., Mirzabekov, T., and Kagan, B. L. (1997) J. Biol. Chem. 272, 44-47.
109. Hirakura, Y., and Kagan, B. L. (2001) Amyloid 8, 94-100.
110. Hirakura, Y., Carreras, I., Sipe, J. D., and Kagan, B. L. (2002) Amyloid 9, 13-23.
111. Monoi, H., Futaki, S., Kugimiya, S., Minakata, H., and Yoshihara, K. (2000) Biophys. J. 78, 2892-2899.
112. Hirakura, Y., Azimov, R., Azimova, R., and Kagan, B. L. (2000) J. Neurosci. Res. 60, 490-494.
113. Ibrahim, H. R., Thomas, U., and Pellegrini, A. (2001) J. Biol. Chem. 276, 43767-43774.
114. Stipani, V., Gallucci, E., Micelli, S., Picciarelli, V., and Benz, R. (2001) Biophys. J. 81, 3332-3338.
115. Kourie, J. I., Hanna, E. A., and Henry, C. L. (2001) Can. J. Physiol. Pharmacol. 79, 654-664.
116. Shtilerman, M. D., Ding, T. T., and Lansbury, P. T., Jr. (2002) Biochemistry 41, 3855-3860.
117. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680.
118. Giasson, B. I., Murray, I. V., Trojanowski, J. Q., and Lee, V. M. (2001) J. Biol. Chem. 276, 2380-2386.
119. Nicholas, K. B., Nicholas, H. B., Jr., and Deerfield, D. W. II. (1997) http://www.psc.edu/biomed/genedoc.