-
1
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos, M.H., Lavedan, C., Leroy, E., Ide, S.E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R. et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science, 276, 2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
-
2
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
Spillantini, M.G., Schmidt, M.L., Lee, V.M., Trojanowski, J.Q., Jakes, R. and Goedert, M. (1997) Alpha-synuclein in Lewy bodies. Nature, 388, 839-840.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
3
-
-
69149089036
-
Molecular pathogenesis of Parkinson disease: insights from genetic studies
-
Gasser, T. (2009) Molecular pathogenesis of Parkinson disease: insights from genetic studies. Expert Rev. Mol. Med., 11, e22.
-
(2009)
Expert Rev. Mol. Med.
, vol.11
-
-
Gasser, T.1
-
4
-
-
68649097307
-
The genetics of Parkinson's syndromes: a critical review
-
Hardy, J., Lewis, P., Revesz, T., Lees, A. and Paisan-Ruiz, C. (2009) The genetics of Parkinson's syndromes: a critical review. Curr. Opin. Genet. Dev., 19, 254-265.
-
(2009)
Curr. Opin. Genet. Dev.
, vol.19
, pp. 254-265
-
-
Hardy, J.1
Lewis, P.2
Revesz, T.3
Lees, A.4
Paisan-Ruiz, C.5
-
5
-
-
70350759686
-
Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease
-
Hatano, T., Kubo, S., Sato, S. and Hattori, N. (2009) Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease. J. Neurochem., 111, 1075-1093.
-
(2009)
J. Neurochem.
, vol.111
, pp. 1075-1093
-
-
Hatano, T.1
Kubo, S.2
Sato, S.3
Hattori, N.4
-
6
-
-
63149090431
-
Parkinson's disease: from monogenic forms to genetic susceptibility factors
-
Lesage, S. and Brice, A. (2009) Parkinson's disease: from monogenic forms to genetic susceptibility factors. Hum. Mol. Genet., 18, R48-R59.
-
(2009)
Hum. Mol. Genet.
, vol.18
-
-
Lesage, S.1
Brice, A.2
-
7
-
-
70549084415
-
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
-
Satake, W., Nakabayashi, Y., Mizuta, I., Hirota, Y., Ito, C., Kubo, M., Kawaguchi, T., Tsunoda, T., Watanabe, M., Takeda, A. et al. (2009) Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat. Genet., 41, 1303-1307.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1303-1307
-
-
Satake, W.1
Nakabayashi, Y.2
Mizuta, I.3
Hirota, Y.4
Ito, C.5
Kubo, M.6
Kawaguchi, T.7
Tsunoda, T.8
Watanabe, M.9
Takeda, A.10
-
8
-
-
70549088602
-
Genome-wide association study reveals genetic risk underlying Parkinson's disease
-
Simon-Sanchez, J., Schulte, C., Bras, J.M., Sharma, M., Gibbs, J.R., Berg, D., Paisan-Ruiz, C., Lichtner, P., Scholz, S.W., Hernandez, D.G. et al. (2009) Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet., 41, 1308-1312.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1308-1312
-
-
Simon-Sanchez, J.1
Schulte, C.2
Bras, J.M.3
Sharma, M.4
Gibbs, J.R.5
Berg, D.6
Paisan-Ruiz, C.7
Lichtner, P.8
Scholz, S.W.9
Hernandez, D.G.10
-
9
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y. and Shimizu, N. (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature, 392, 605-608.
-
(1998)
Nature
, vol.392
, pp. 605-608
-
-
Kitada, T.1
Asakawa, S.2
Hattori, N.3
Matsumine, H.4
Yamamura, Y.5
Minoshima, S.6
Yokochi, M.7
Mizuno, Y.8
Shimizu, N.9
-
10
-
-
0037428241
-
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
-
Bonifati, V., Rizzu, P., van Baren, M.J., Schaap, O., Breedveld, G.J., Krieger, E., Dekker, M.C., Squitieri, F., Ibanez, P., Joosse, M. et al. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science, 299, 256-259.
-
(2003)
Science
, vol.299
, pp. 256-259
-
-
Bonifati, V.1
Rizzu, P.2
van Baren, M.J.3
Schaap, O.4
Breedveld, G.J.5
Krieger, E.6
Dekker, M.C.7
Squitieri, F.8
Ibanez, P.9
Joosse, M.10
-
11
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
Valente, E.M., Abou-Sleiman, P.M., Caputo, V., Muqit, M.M., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A.R., Healy, D.G. et al. (2004) Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science, 304, 1158-1160.
-
(2004)
Science
, vol.304
, pp. 1158-1160
-
-
Valente, E.M.1
Abou-Sleiman, P.M.2
Caputo, V.3
Muqit, M.M.4
Harvey, K.5
Gispert, S.6
Ali, Z.7
Del Turco, D.8
Bentivoglio, A.R.9
Healy, D.G.10
-
12
-
-
24644462201
-
Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers
-
Pramstaller, P.P., Schlossmacher, M.G., Jacques, T.S., Scaravilli, F., Eskelson, C., Pepivani, I., Hedrich, K., Adel, S., Gonzales-McNeal, M., Hilker, R. et al. (2005) Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers. Ann. Neurol., 58, 411-422.
-
(2005)
Ann. Neurol.
, vol.58
, pp. 411-422
-
-
Pramstaller, P.P.1
Schlossmacher, M.G.2
Jacques, T.S.3
Scaravilli, F.4
Eskelson, C.5
Pepivani, I.6
Hedrich, K.7
Adel, S.8
Gonzales-McNeal, M.9
Hilker, R.10
-
13
-
-
37349129281
-
The parkin protein as a therapeutic target in Parkinson's disease
-
Winklhofer, K.F. (2007) The parkin protein as a therapeutic target in Parkinson's disease. Expert Opin. Ther. Targets, 11, 1543-1552.
-
(2007)
Expert Opin. Ther. Targets
, vol.11
, pp. 1543-1552
-
-
Winklhofer, K.F.1
-
14
-
-
41149114560
-
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)
-
Mills, R.D., Sim, C.H., Mok, S.S., Mulhern, T.D., Culvenor, J.G. and Cheng, H.C. (2008) Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1). J. Neurochem., 105, 18-33.
-
(2008)
J. Neurochem.
, vol.105
, pp. 18-33
-
-
Mills, R.D.1
Sim, C.H.2
Mok, S.S.3
Mulhern, T.D.4
Culvenor, J.G.5
Cheng, H.C.6
-
15
-
-
50149121528
-
The kinase domain of mitochondrial PINK1 faces the cytoplasm
-
Zhou, C., Huang, Y., Shao, Y., May, J., Prou, D., Perier, C., Dauer, W., Schon, E.A. and Przedborski, S. (2008) The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc. Natl Acad. Sci. USA, 105, 12022-12027.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 12022-12027
-
-
Zhou, C.1
Huang, Y.2
Shao, Y.3
May, J.4
Prou, D.5
Perier, C.6
Dauer, W.7
Schon, E.A.8
Przedborski, S.9
-
16
-
-
70350002152
-
DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders
-
Kahle, P.J., Waak, J. and Gasser, T. (2009) DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. Free Radic. Biol. Med., 47, 1354-1361.
-
(2009)
Free Radic. Biol. Med.
, vol.47
, pp. 1354-1361
-
-
Kahle, P.J.1
Waak, J.2
Gasser, T.3
-
17
-
-
0037386532
-
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
-
Greene, J.C., Whitworth, A.J., Kuo, I., Andrews, L.A., Feany, M.B. and Pallanck, L.J. (2003) Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc. Natl Acad. Sci. USA, 100, 4078-4083.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 4078-4083
-
-
Greene, J.C.1
Whitworth, A.J.2
Kuo, I.3
Andrews, L.A.4
Feany, M.B.5
Pallanck, L.J.6
-
18
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
Clark, I.E., Dodson, M.W., Jiang, C., Cao, J.H., Huh, J.R., Seol, J.H., Yoo, S.J., Hay, B.A. and Guo, M. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature, 441, 1162-1166.
-
(2006)
Nature
, vol.441
, pp. 1162-1166
-
-
Clark, I.E.1
Dodson, M.W.2
Jiang, C.3
Cao, J.H.4
Huh, J.R.5
Seol, J.H.6
Yoo, S.J.7
Hay, B.A.8
Guo, M.9
-
19
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park, J., Lee, S.B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.M. et al. (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature, 441, 1157-1161.
-
(2006)
Nature
, vol.441
, pp. 1157-1161
-
-
Park, J.1
Lee, S.B.2
Lee, S.3
Kim, Y.4
Song, S.5
Kim, S.6
Bae, E.7
Kim, J.8
Shong, M.9
Kim, J.M.10
-
20
-
-
67649399288
-
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission
-
Dagda, R.K., Cherra, S.J. 3rd, Kulich, S.M., Tandon, A., Park, D. and Chu, C.T. (2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem., 284, 13843-13855.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 13843-13855
-
-
Dagda, R.K.1
Cherra S.J. 3rd2
Kulich, S.M.3
Tandon, A.4
Park, D.5
Chu, C.T.6
-
21
-
-
36049038504
-
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
-
Exner, N., Treske, B., Paquet, D., Holmstrom, K., Schiesling, C., Gispert, S., Carballo-Carbajal, I., Berg, D., Hoepken, H.H., Gasser, T. et al. (2007) Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J. Neurosci., 27, 12413-12418.
-
(2007)
J. Neurosci.
, vol.27
, pp. 12413-12418
-
-
Exner, N.1
Treske, B.2
Paquet, D.3
Holmstrom, K.4
Schiesling, C.5
Gispert, S.6
Carballo-Carbajal, I.7
Berg, D.8
Hoepken, H.H.9
Gasser, T.10
-
22
-
-
55749090654
-
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
-
Deng, H., Dodson, M.W., Huang, H. and Guo, M. (2008) The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. Natl Acad. Sci. USA, 105, 14503-14508.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 14503-14508
-
-
Deng, H.1
Dodson, M.W.2
Huang, H.3
Guo, M.4
-
23
-
-
39449088321
-
The PINK1/Parkin pathway regulates mitochondrial morphology
-
Poole, A.C., Thomas, R.E., Andrews, L.A., McBride, H.M., Whitworth, A.J. and Pallanck, L.J. (2008) The PINK1/Parkin pathway regulates mitochondrial morphology. Proc. Natl Acad. Sci. USA, 105, 1638-1643.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 1638-1643
-
-
Poole, A.C.1
Thomas, R.E.2
Andrews, L.A.3
McBride, H.M.4
Whitworth, A.J.5
Pallanck, L.J.6
-
24
-
-
44349195101
-
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
-
Yang, Y., Ouyang, Y., Yang, L., Beal, M.F., McQuibban, A., Vogel, H. and Lu, B. (2008) Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc. Natl Acad. Sci. USA, 105, 7070-7075.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 7070-7075
-
-
Yang, Y.1
Ouyang, Y.2
Yang, L.3
Beal, M.F.4
McQuibban, A.5
Vogel, H.6
Lu, B.7
-
25
-
-
77951235489
-
Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1
-
Cui, M., Tang, X., Christian, W.V., Yoon, Y. and Tieu, K. (2010) Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. J. Biol. Chem, 285, 11740-11752.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 11740-11752
-
-
Cui, M.1
Tang, X.2
Christian, W.V.3
Yoon, Y.4
Tieu, K.5
-
26
-
-
69249096578
-
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation
-
Lutz, A.K., Exner, N., Fett, M.E., Schlehe, J.S., Kloos, K., Lammermann, K., Brunner, B., Kurz-Drexler, A., Vogel, F., Reichert, A.S. et al. (2009) Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J. Biol. Chem., 284, 22938-22951.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 22938-22951
-
-
Lutz, A.K.1
Exner, N.2
Fett, M.E.3
Schlehe, J.S.4
Kloos, K.5
Lammermann, K.6
Brunner, B.7
Kurz-Drexler, A.8
Vogel, F.9
Reichert, A.S.10
-
27
-
-
66349123690
-
Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1
-
Sandebring, A., Thomas, K.J., Beilina, A., van der Brug, M., Cleland, M.M., Ahmad, R., Miller, D.W., Zambrano, I., Cowburn, R.F., Behbahani, H. et al. (2009) Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. PLoS One, 4, e5701.
-
(2009)
PLoS One
, vol.4
-
-
Sandebring, A.1
Thomas, K.J.2
Beilina, A.3
van der Brug, M.4
Cleland, M.M.5
Ahmad, R.6
Miller, D.W.7
Zambrano, I.8
Cowburn, R.F.9
Behbahani, H.10
-
28
-
-
49349087497
-
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons
-
Wood-Kaczmar, A., Gandhi, S., Yao, Z., Abramov, A.Y., Miljan, E.A., Keen, G., Stanyer, L., Hargreaves, I., Klupsch, K., Deas, E. et al. (2008) PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One, 3, e2455.
-
(2008)
PLoS One
, vol.3
-
-
Wood-Kaczmar, A.1
Gandhi, S.2
Yao, Z.3
Abramov, A.Y.4
Miljan, E.A.5
Keen, G.6
Stanyer, L.7
Hargreaves, I.8
Klupsch, K.9
Deas, E.10
-
29
-
-
49649097747
-
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
-
Gautier, C.A., Kitada, T. and Shen, J. (2008) Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc. Natl Acad. Sci. USA, 105, 11364-11369.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 11364-11369
-
-
Gautier, C.A.1
Kitada, T.2
Shen, J.3
-
30
-
-
62749113469
-
Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells
-
Gegg, M.E., Cooper, J.M., Schapira, A.H. and Taanman, J.W. (2009) Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells. PLoS One, 4, e4756.
-
(2009)
PLoS One
, vol.4
-
-
Gegg, M.E.1
Cooper, J.M.2
Schapira, A.H.3
Taanman, J.W.4
-
31
-
-
77953666757
-
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
-
Morais, V.A., Verstreken, P., Roethig, A., Smet, J., Snellinx, A., Vanbrabant, M., Haddad, D., Frezza, C., Mandemakers, W., Vogt-Weisenhorn, D. et al. (2009) Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol. Med., 1, 99-111.
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 99-111
-
-
Morais, V.A.1
Verstreken, P.2
Roethig, A.3
Smet, J.4
Snellinx, A.5
Vanbrabant, M.6
Haddad, D.7
Frezza, C.8
Mandemakers, W.9
Vogt-Weisenhorn, D.10
-
32
-
-
67649413521
-
Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio)
-
Flinn, L., Mortiboys, H., Volkmann, K., Koster, R.W., Ingham, P.W. and Bandmann, O. (2009) Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio). Brain, 132, 1613-1623.
-
(2009)
Brain
, vol.132
, pp. 1613-1623
-
-
Flinn, L.1
Mortiboys, H.2
Volkmann, K.3
Koster, R.W.4
Ingham, P.W.5
Bandmann, O.6
-
33
-
-
57749100375
-
Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts
-
Mortiboys, H., Thomas, K.J., Koopman, W.J., Klaffke, S., Abou-Sleiman, P., Olpin, S., Wood, N.W., Willems, P.H., Smeitink, J.A., Cookson, M.R. et al. (2008) Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann. Neurol., 64, 555-565.
-
(2008)
Ann. Neurol.
, vol.64
, pp. 555-565
-
-
Mortiboys, H.1
Thomas, K.J.2
Koopman, W.J.3
Klaffke, S.4
Abou-Sleiman, P.5
Olpin, S.6
Wood, N.W.7
Willems, P.H.8
Smeitink, J.A.9
Cookson, M.R.10
-
34
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra, D., Tanaka, A., Suen, D.F. and Youle, R.J. (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol., 183, 795-803.
-
(2008)
J. Cell Biol.
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.F.3
Youle, R.J.4
-
35
-
-
75949130828
-
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
-
Geisler, S., Holmstrom, K.M., Skujat, D., Fiesel, F.C., Rothfuss, O.C., Kahle, P.J. and Springer, W. (2010) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol., 12, 119-131.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 119-131
-
-
Geisler, S.1
Holmstrom, K.M.2
Skujat, D.3
Fiesel, F.C.4
Rothfuss, O.C.5
Kahle, P.J.6
Springer, W.7
-
36
-
-
75749156257
-
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
-
Narendra, D.P., Jin, S.M., Tanaka, A., Suen, D.F., Gautier, C.A., Shen, J., Cookson, M.R. and Youle, R.J. (2010) PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol., 8, e1000298.
-
(2010)
PLoS Biol.
, vol.8
-
-
Narendra, D.P.1
Jin, S.M.2
Tanaka, A.3
Suen, D.F.4
Gautier, C.A.5
Shen, J.6
Cookson, M.R.7
Youle, R.J.8
-
37
-
-
75949098487
-
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
-
Vives-Bauza, C., Zhou, C., Huang, Y., Cui, M., de Vries, R.L., Kim, J., May, J., Tocilescu, M.A., Liu, W., Ko, H.S. et al. (2010) PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc. Natl Acad. Sci. USA, 107, 378-383.
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 378-383
-
-
Vives-Bauza, C.1
Zhou, C.2
Huang, Y.3
Cui, M.4
de Vries, R.L.5
Kim, J.6
May, J.7
Tocilescu, M.A.8
Liu, W.9
Ko, H.S.10
-
38
-
-
73449111577
-
Mitochondrial autophagy as a compensatory response to PINK1 deficiency
-
Cherra, S.J. 3rd, Dagda, R.K., Tandon, A. and Chu, C.T. (2009) Mitochondrial autophagy as a compensatory response to PINK1 deficiency. Autophagy, 5, 1213-1214.
-
(2009)
Autophagy
, vol.5
, pp. 1213-1214
-
-
Cherra S.J. 3rd1
Dagda, R.K.2
Tandon, A.3
Chu, C.T.4
-
39
-
-
35548972027
-
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
-
Andres-Mateos, E., Perier, C., Zhang, L., Blanchard-Fillion, B., Greco, T.M., Thomas, B., Ko, H.S., Sasaki, M., Ischiropoulos, H., Przedborski, S. et al. (2007) DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc. Natl Acad. Sci. USA, 104, 14807-14812.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 14807-14812
-
-
Andres-Mateos, E.1
Perier, C.2
Zhang, L.3
Blanchard-Fillion, B.4
Greco, T.M.5
Thomas, B.6
Ko, H.S.7
Sasaki, M.8
Ischiropoulos, H.9
Przedborski, S.10
-
40
-
-
2942684871
-
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
-
Canet-Aviles, R.M., Wilson, M.A., Miller, D.W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M.J., Ringe, D., Petsko, G.A. and Cookson, M.R. (2004) The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc. Natl Acad. Sci. USA, 101, 9103-9108.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 9103-9108
-
-
Canet-Aviles, R.M.1
Wilson, M.A.2
Miller, D.W.3
Ahmad, R.4
McLendon, C.5
Bandyopadhyay, S.6
Baptista, M.J.7
Ringe, D.8
Petsko, G.A.9
Cookson, M.R.10
-
41
-
-
65249159732
-
Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1
-
Blackinton, J., Lakshminarasimhan, M., Thomas, K.J., Ahmad, R., Greggio, E., Raza, A.S., Cookson, M.R. and Wilson, M.A. (2009) Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1. J. Biol. Chem., 284, 6476-6485.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 6476-6485
-
-
Blackinton, J.1
Lakshminarasimhan, M.2
Thomas, K.J.3
Ahmad, R.4
Greggio, E.5
Raza, A.S.6
Cookson, M.R.7
Wilson, M.A.8
-
42
-
-
63049138430
-
Mitochondrial localization of DJ-1 leads to enhanced neuroprotection
-
Junn, E., Jang, W.H., Zhao, X., Jeong, B.S. and Mouradian, M.M. (2009) Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. J. Neurosci. Res., 87, 123-129.
-
(2009)
J. Neurosci. Res.
, vol.87
, pp. 123-129
-
-
Junn, E.1
Jang, W.H.2
Zhao, X.3
Jeong, B.S.4
Mouradian, M.M.5
-
43
-
-
30044434872
-
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
-
Ved, R., Saha, S., Westlund, B., Perier, C., Burnam, L., Sluder, A., Hoener, M., Rodrigues, C.M., Alfonso, A., Steer, C. et al. (2005) Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J. Biol. Chem., 280, 42655-42668.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 42655-42668
-
-
Ved, R.1
Saha, S.2
Westlund, B.3
Perier, C.4
Burnam, L.5
Sluder, A.6
Hoener, M.7
Rodrigues, C.M.8
Alfonso, A.9
Steer, C.10
-
44
-
-
70449729372
-
DJ-1 binds to mitochondrial complex I and maintains its activity
-
Hayashi, T., Ishimori, C., Takahashi-Niki, K., Taira, T., Kim, Y.C., Maita, H., Maita, C., Ariga, H. and Iguchi-Ariga, S.M. (2009) DJ-1 binds to mitochondrial complex I and maintains its activity. Biochem. Biophys. Res. Commun., 390, 667-672.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.390
, pp. 667-672
-
-
Hayashi, T.1
Ishimori, C.2
Takahashi-Niki, K.3
Taira, T.4
Kim, Y.C.5
Maita, H.6
Maita, C.7
Ariga, H.8
Iguchi-Ariga, S.M.9
-
45
-
-
64149091391
-
Silencing DJ-1 reveals its contribution in paraquat-induced autophagy
-
Gonzalez-Polo, R., Niso-Santano, M., Moran, J.M., Ortiz-Ortiz, M.A., Bravo-San Pedro, J.M., Soler, G. and Fuentes, J.M. (2009) Silencing DJ-1 reveals its contribution in paraquat-induced autophagy. J. Neurochem., 109, 889-898.
-
(2009)
J. Neurochem.
, vol.109
, pp. 889-898
-
-
Gonzalez-Polo, R.1
Niso-Santano, M.2
Moran, J.M.3
Ortiz-Ortiz, M.A.4
Bravo-San Pedro, J.M.5
Soler, G.6
Fuentes, J.M.7
-
46
-
-
77949623516
-
Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1
-
Krebiehl, G., Ruckerbauer, S., Burbulla, L.F., Kieper, N., Maurer, B., Waak, J., Wolburg, H., Gizatullina, Z., Gellerich, F.N., Woitalla, D. et al. (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One, 5, e9367.
-
(2010)
PLoS One
, vol.5
-
-
Krebiehl, G.1
Ruckerbauer, S.2
Burbulla, L.F.3
Kieper, N.4
Maurer, B.5
Waak, J.6
Wolburg, H.7
Gizatullina, Z.8
Gellerich, F.N.9
Woitalla, D.10
-
47
-
-
56049091236
-
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
-
Kim, Y., Park, J., Kim, S., Song, S., Kwon, S.K., Lee, S.H., Kitada, T., Kim, J.M. and Chung, J. (2008) PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem. Biophys. Res. Commun., 377, 975-980.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.377
, pp. 975-980
-
-
Kim, Y.1
Park, J.2
Kim, S.3
Song, S.4
Kwon, S.K.5
Lee, S.H.6
Kitada, T.7
Kim, J.M.8
Chung, J.9
-
48
-
-
77949478474
-
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
-
Sha, D., Chin, L.S. and Li, L. (2010) Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum. Mol. Genet., 19, 352-363.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 352-363
-
-
Sha, D.1
Chin, L.S.2
Li, L.3
-
49
-
-
70349923087
-
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice
-
Kitada, T., Tong, Y., Gautier, C.A. and Shen, J. (2009) Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. J. Neurochem., 111, 696-702.
-
(2009)
J. Neurochem.
, vol.111
, pp. 696-702
-
-
Kitada, T.1
Tong, Y.2
Gautier, C.A.3
Shen, J.4
-
50
-
-
26444445118
-
Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene
-
Yamaguchi, K., Cochran, E.J., Murrell, J.R., Polymeropoulos, M.H., Shannon, K.M., Crowther, R.A., Goedert, M. and Ghetti, B. (2005) Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene. Acta Neuropathol., 110, 298-305.
-
(2005)
Acta Neuropathol.
, vol.110
, pp. 298-305
-
-
Yamaguchi, K.1
Cochran, E.J.2
Murrell, J.R.3
Polymeropoulos, M.H.4
Shannon, K.M.5
Crowther, R.A.6
Goedert, M.7
Ghetti, B.8
-
51
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
Zarranz, J.J., Alegre, J., Gomez-Esteban, J.C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atares, B. et al. (2004) The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol., 55, 164-173.
-
(2004)
Ann. Neurol.
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gomez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atares, B.10
-
52
-
-
4644290985
-
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier-Harlin, M.C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M. et al. (2004) Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet, 364, 1167-1169.
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Larvor, L.8
Andrieux, J.9
Hulihan, M.10
-
53
-
-
4644236043
-
Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease
-
Ibanez, P., Bonnet, A.M., Debarges, B., Lohmann, E., Tison, F., Pollak, P., Agid, Y., Durr, A. and Brice, A. (2004) Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet, 364, 1169-1171.
-
(2004)
Lancet
, vol.364
, pp. 1169-1171
-
-
Ibanez, P.1
Bonnet, A.M.2
Debarges, B.3
Lohmann, E.4
Tison, F.5
Pollak, P.6
Agid, Y.7
Durr, A.8
Brice, A.9
-
54
-
-
0242300619
-
Alpha-synuclein locus triplication causes Parkinson's disease
-
Singleton, A.B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R. et al. (2003) Alpha-synuclein locus triplication causes Parkinson's disease. Science, 302, 841.
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
-
55
-
-
34147109175
-
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication
-
Fuchs, J., Nilsson, C., Kachergus, J., Munz, M., Larsson, E.M., Schule, B., Langston, J.W., Middleton, F.A., Ross, O.A., Hulihan, M. et al. (2007) Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication. Neurology, 68, 916-922.
-
(2007)
Neurology
, vol.68
, pp. 916-922
-
-
Fuchs, J.1
Nilsson, C.2
Kachergus, J.3
Munz, M.4
Larsson, E.M.5
Schule, B.6
Langston, J.W.7
Middleton, F.A.8
Ross, O.A.9
Hulihan, M.10
-
56
-
-
43249120160
-
Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain
-
Fuchs, J., Tichopad, A., Golub, Y., Munz, M., Schweitzer, K.J., Wolf, B., Berg, D., Mueller, J.C. and Gasser, T. (2008) Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain. FASEB J., 22, 1327-1334.
-
(2008)
FASEB J.
, vol.22
, pp. 1327-1334
-
-
Fuchs, J.1
Tichopad, A.2
Golub, Y.3
Munz, M.4
Schweitzer, K.J.5
Wolf, B.6
Berg, D.7
Mueller, J.C.8
Gasser, T.9
-
57
-
-
70349503591
-
Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein
-
Uversky, V.N. and Eliezer, D. (2009) Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein. Curr. Protein Pept. Sci., 10, 483-499.
-
(2009)
Curr. Protein Pept. Sci.
, vol.10
, pp. 483-499
-
-
Uversky, V.N.1
Eliezer, D.2
-
58
-
-
37549030985
-
In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?
-
Chesselet, M.F. (2008) In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease? Exp. Neurol., 209, 22-27.
-
(2008)
Exp. Neurol.
, vol.209
, pp. 22-27
-
-
Chesselet, M.F.1
-
59
-
-
47049084912
-
Viral vectors, animal models and new therapies for Parkinson's disease
-
Schneider, B., Zufferey, R. and Aebischer, P. (2008) Viral vectors, animal models and new therapies for Parkinson's disease. Parkinsonism Relat. Disord., 14(Suppl. 2), S169-S171.
-
(2008)
Parkinsonism Relat. Disord.
, vol.14
, Issue.SUPPL. 2
-
-
Schneider, B.1
Zufferey, R.2
Aebischer, P.3
-
60
-
-
77953395313
-
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions
-
pii
-
Greggio, E. and Cookson, M.R. (2009) Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions. ASN Neuro, 1, pii: e00002.
-
(2009)
ASN Neuro
, vol.1
-
-
Greggio, E.1
Cookson, M.R.2
-
61
-
-
77649105209
-
Mechanisms in dominant parkinsonism: the toxic triangle of LRRK2, alpha-synuclein, and tau
-
Taymans, J.M. and Cookson, M.R. (2010) Mechanisms in dominant parkinsonism: the toxic triangle of LRRK2, alpha-synuclein, and tau. Bioessays, 32, 227-235.
-
(2010)
Bioessays
, vol.32
, pp. 227-235
-
-
Taymans, J.M.1
Cookson, M.R.2
-
62
-
-
33748621731
-
Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations
-
Ishihara, L., Warren, L., Gibson, R., Amouri, R., Lesage, S., Durr, A., Tazir, M., Wszolek, Z.K., Uitti, R.J., Nichols, W.C. et al. (2006) Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations. Arch. Neurol., 63, 1250-1254.
-
(2006)
Arch. Neurol.
, vol.63
, pp. 1250-1254
-
-
Ishihara, L.1
Warren, L.2
Gibson, R.3
Amouri, R.4
Lesage, S.5
Durr, A.6
Tazir, M.7
Wszolek, Z.K.8
Uitti, R.J.9
Nichols, W.C.10
-
63
-
-
67651171368
-
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans
-
Saha, S., Guillily, M.D., Ferree, A., Lanceta, J., Chan, D., Ghosh, J., Hsu, C.H., Segal, L., Raghavan, K., Matsumoto, K. et al. (2009) LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J. Neurosci., 29, 9210-9218.
-
(2009)
J. Neurosci.
, vol.29
, pp. 9210-9218
-
-
Saha, S.1
Guillily, M.D.2
Ferree, A.3
Lanceta, J.4
Chan, D.5
Ghosh, J.6
Hsu, C.H.7
Segal, L.8
Raghavan, K.9
Matsumoto, K.10
-
64
-
-
34248574535
-
Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila
-
Lee, S.B., Kim, W., Lee, S. and Chung, J. (2007) Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila. Biochem. Biophys. Res. Commun., 358, 534-539.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.358
, pp. 534-539
-
-
Lee, S.B.1
Kim, W.2
Lee, S.3
Chung, J.4
-
65
-
-
41549124987
-
Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
-
Wang, D., Tang, B., Zhao, G., Pan, Q., Xia, K., Bodmer, R. and Zhang, Z. (2008) Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons. Mol. Neurodegener., 3,3.
-
(2008)
Mol. Neurodegener.
, vol.3
, pp. 3
-
-
Wang, D.1
Tang, B.2
Zhao, G.3
Pan, Q.4
Xia, K.5
Bodmer, R.6
Zhang, Z.7
-
66
-
-
72449198522
-
Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine)
-
Andres-Mateos, E., Mejias, R., Sasaki, M., Li, X., Lin, B.M., Biskup, S., Zhang, L., Banerjee, R., Thomas, B., Yang, L. et al. (2009) Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine). J. Neurosci., 29, 15846-15850.
-
(2009)
J. Neurosci.
, vol.29
, pp. 15846-15850
-
-
Andres-Mateos, E.1
Mejias, R.2
Sasaki, M.3
Li, X.4
Lin, B.M.5
Biskup, S.6
Zhang, L.7
Banerjee, R.8
Thomas, B.9
Yang, L.10
-
67
-
-
68249104469
-
Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation
-
Milosevic, J., Schwarz, S.C., Ogunlade, V., Meyer, A.K., Storch, A. and Schwarz, J. (2009) Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation. Mol. Neurodegener., 4, 25.
-
(2009)
Mol. Neurodegener.
, vol.4
, pp. 25
-
-
Milosevic, J.1
Schwarz, S.C.2
Ogunlade, V.3
Meyer, A.K.4
Storch, A.5
Schwarz, J.6
-
68
-
-
67649813448
-
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease
-
Li, Y., Liu, W., Oo, T.F., Wang, L., Tang, Y., Jackson-Lewis, V., Zhou, C., Geghman, K., Bogdanov, M., Przedborski, S. et al. (2009) Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat. Neurosci., 12, 826-828.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 826-828
-
-
Li, Y.1
Liu, W.2
Oo, T.F.3
Wang, L.4
Tang, Y.5
Jackson-Lewis, V.6
Zhou, C.7
Geghman, K.8
Bogdanov, M.9
Przedborski, S.10
-
69
-
-
70149124508
-
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
-
Tong, Y., Pisani, A., Martella, G., Karouani, M., Yamaguchi, H., Pothos, E.N. and Shen, J. (2009) R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc. Natl Acad. Sci. USA, 106, 14622-14627.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 14622-14627
-
-
Tong, Y.1
Pisani, A.2
Martella, G.3
Karouani, M.4
Yamaguchi, H.5
Pothos, E.N.6
Shen, J.7
-
70
-
-
72149087091
-
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein
-
Lin, X., Parisiadou, L., Gu, X.L., Wang, L., Shim, H., Sun, L., Xie, C., Long, C.X., Yang, W.J., Ding, J. et al. (2009) Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron, 64, 807-827.
-
(2009)
Neuron
, vol.64
, pp. 807-827
-
-
Lin, X.1
Parisiadou, L.2
Gu, X.L.3
Wang, L.4
Shim, H.5
Sun, L.6
Xie, C.7
Long, C.X.8
Yang, W.J.9
Ding, J.10
-
71
-
-
67249165702
-
Genetic neuropathology of Parkinson's disease
-
Cookson, M.R., Hardy, J. and Lewis, P.A. (2008) Genetic neuropathology of Parkinson's disease. Int. J. Clin. Exp. Pathol., 1, 217-231.
-
(2008)
Int. J. Clin. Exp. Pathol.
, vol.1
, pp. 217-231
-
-
Cookson, M.R.1
Hardy, J.2
Lewis, P.A.3
-
72
-
-
70349103837
-
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila
-
Ng, C.H., Mok, S.Z., Koh, C., Ouyang, X., Fivaz, M.L., Tan, E.K., Dawson, V.L., Dawson, T.M., Yu, F. and Lim, K.L. (2009) Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. J. Neurosci., 29, 11257-11262.
-
(2009)
J. Neurosci.
, vol.29
, pp. 11257-11262
-
-
Ng, C.H.1
Mok, S.Z.2
Koh, C.3
Ouyang, X.4
Fivaz, M.L.5
Tan, E.K.6
Dawson, V.L.7
Dawson, T.M.8
Yu, F.9
Lim, K.L.10
-
73
-
-
10644281090
-
Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease
-
Lo Bianco, C., Schneider, B.L., Bauer, M., Sajadi, A., Brice, A., Iwatsubo, T. and Aebischer, P. (2004) Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proc. Natl Acad. Sci. USA, 101, 17510-17515.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 17510-17515
-
-
Lo Bianco, C.1
Schneider, B.L.2
Bauer, M.3
Sajadi, A.4
Brice, A.5
Iwatsubo, T.6
Aebischer, P.7
-
74
-
-
0037137702
-
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons
-
Petrucelli, L., O'Farrell, C., Lockhart, P.J., Baptista, M., Kehoe, K., Vink, L., Choi, P., Wolozin, B., Farrer, M., Hardy, J. et al. (2002) Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron, 36, 1007-1019.
-
(2002)
Neuron
, vol.36
, pp. 1007-1019
-
-
Petrucelli, L.1
O'Farrell, C.2
Lockhart, P.J.3
Baptista, M.4
Kehoe, K.5
Vink, L.6
Choi, P.7
Wolozin, B.8
Farrer, M.9
Hardy, J.10
-
75
-
-
70350683754
-
Leucine-rich repeat kinase 2 interacts with Parkin
-
Venderova, K., Kabbach, G., Abdel-Messih, E., Zhang, Y., Parks, R.J., Imai, Y., Gehrke, S., Ngsee, J., Lavoie, M.J., Slack, R.S. et al. (2009) Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum. Mol. Genet., 18, 4390-4404.
-
(2009)
DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum. Mol. Genet.
, vol.18
, pp. 4390-4404
-
-
Venderova, K.1
Kabbach, G.2
Abdel-Messih, E.3
Zhang, Y.4
Parks, R.J.5
Imai, Y.6
Gehrke, S.7
Ngsee, J.8
Lavoie, M.J.9
Slack, R.S.10
-
76
-
-
33645558938
-
Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy
-
von Coelln, R., Thomas, B., Andrabi, S.A., Lim, K.L., Savitt, J.M., Saffary, R., Stirling, W., Bruno, K., Hess, E.J., Lee, M.K. et al. (2006) Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy. J. Neurosci., 26, 3685-3696.
-
(2006)
J. Neurosci.
, vol.26
, pp. 3685-3696
-
-
von Coelln, R.1
Thomas, B.2
Andrabi, S.A.3
Lim, K.L.4
Savitt, J.M.5
Saffary, R.6
Stirling, W.7
Bruno, K.8
Hess, E.J.9
Lee, M.K.10
-
77
-
-
60049091402
-
Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
-
Ludolph, A.C., Kassubek, J., Landwehrmeyer, B.G., Mandelkow, E., Mandelkow, E.M., Burn, D.J., Caparros-Lefebvre, D., Frey, K.A., de Yebenes, J.G., Gasser, T. et al. (2009) Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options. Eur. J. Neurol., 16, 297-309.
-
(2009)
Eur. J. Neurol.
, vol.16
, pp. 297-309
-
-
Ludolph, A.C.1
Kassubek, J.2
Landwehrmeyer, B.G.3
Mandelkow, E.4
Mandelkow, E.M.5
Burn, D.J.6
Caparros-Lefebvre, D.7
Frey, K.A.8
de Yebenes, J.G.9
Gasser, T.10
-
78
-
-
51949090816
-
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
-
Imai, Y., Gehrke, S., Wang, H.Q., Takahashi, R., Hasegawa, K., Oota, E. and Lu, B. (2008) Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J., 27, 2432-2443.
-
(2008)
EMBO J.
, vol.27
, pp. 2432-2443
-
-
Imai, Y.1
Gehrke, S.2
Wang, H.Q.3
Takahashi, R.4
Hasegawa, K.5
Oota, E.6
Lu, B.7
-
79
-
-
69449084089
-
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
-
Tain, L.S., Mortiboys, H., Tao, R.N., Ziviani, E., Bandmann, O. and Whitworth, A.J. (2009) Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat. Neurosci., 12, 1129-1135.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 1129-1135
-
-
Tain, L.S.1
Mortiboys, H.2
Tao, R.N.3
Ziviani, E.4
Bandmann, O.5
Whitworth, A.J.6
-
80
-
-
77649328234
-
The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation
-
Kumar, A., Greggio, E., Beilina, A., Kaganovich, A., Chan, D., Taymans, J.M., Wolozin, B. and Cookson, M.R. (2010) The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. PLoS One, 5, e8730.
-
(2010)
PLoS One
, vol.5
-
-
Kumar, A.1
Greggio, E.2
Beilina, A.3
Kaganovich, A.4
Chan, D.5
Taymans, J.M.6
Wolozin, B.7
Cookson, M.R.8
-
81
-
-
68649090472
-
p38(MAPK): stress responses from molecular mechanisms to therapeutics
-
Coulthard, L.R., White, D.E., Jones, D.L., McDermott, M.F. and Burchill, S.A. (2009) p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol. Med., 15, 369-379.
-
(2009)
Trends Mol. Med.
, vol.15
, pp. 369-379
-
-
Coulthard, L.R.1
White, D.E.2
Jones, D.L.3
McDermott, M.F.4
Burchill, S.A.5
-
82
-
-
73549085595
-
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
-
Nemani, V.M., Lu, W., Berge, V., Nakamura, K., Onoa, B., Lee, M.K., Chaudhry, F.A., Nicoll, R.A. and Edwards, R.H. (2010) Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron, 65, 66-79.
-
(2010)
Neuron
, vol.65
, pp. 66-79
-
-
Nemani, V.M.1
Lu, W.2
Berge, V.3
Nakamura, K.4
Onoa, B.5
Lee, M.K.6
Chaudhry, F.A.7
Nicoll, R.A.8
Edwards, R.H.9
|