Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for α-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT

Brain

Volumn 128, Issue 1, 2005, Pages 126-137

  Stiasny Kolster, Karin ^a,c   Doerr, Y ^a   Moller J C ^a   Hoffken H ^a   Behr, T M ^a   Oertel, W H ^a   Mayer, G ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b Hephata Klinik   (Germany)

^c Center of Nervous Diseases   (Germany)

Author keywords

Dopamine transporter; Olfactory dysfunction; Parkinson's disease; REM sleep behaviour disorder (RBD); synucleinopathy

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE TRANSPORTER;

ADULT; AGED; ALPHA SYNUCLEINOPATHY; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; DOPAMINERGIC NERVE CELL; FEMALE; GLOSSOPHARYNGEAL NERVE; HUMAN; IDIOPATHIC DISEASE; MALE; MEDULLA OBLONGATA; MESENCEPHALON; MOTONEURON NUCLEUS; NARCOLEPSY; NERVE CELL DEGENERATION; NEUROIMAGING; NEUROLOGIC DISEASE; NEUROLOGIC EXAMINATION; OLFACTORY BULB; OLFACTORY DISCRIMINATION; OLFACTORY NUCLEUS; PARASOMNIA; PARKINSON DISEASE; PARKINSONISM; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; RISK FACTOR; SCORING SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMELLING; SMELLING DISORDER; STRIATONIGRAL DEGENERATION; SUBSTANTIA NIGRA; TEGMENTUM; VAGUS NERVE;

EID: 11244260421     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/awh322     Document Type: Article

References (81)

1. Albin RL, Koeppe RA, Chervin RD, Consens FB, Wernette K, Frey KA, et al. Decreased striatal dopaminergic innervation in REM sleep behavior disorder. Neurology 2000; 55: 1410-2.
2. Ansari KA, Johnson A. Olfactory function in patients with Parkinson's disease. J Chronic Dis 1975; 28: 493-7.
3. Arnulf I, Bonnet A-M. Darmer P, Bejjani B-P, Seilhean D, Derenne J-P, et al. Hallucinations. REM sleep, and Parkinson's disease: a medical hypothesis. Neurology 2000; 55: 281-8.
4. Atlas Task Force of the American Sleep Disorders Association (ASDA) revised. The International Classification of Sleep Disorders-Diagnostic and Coding Manual. Rochester (MN): American Sleep Disorders Association; 1997, p. 177-80.
5. Benamer HT, Patterson J, Grosset DG, Booij J, de Bruin K, vanRoyen E, et al. Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group. Mov Disord 2000; 15: 503-10.
6. Benamer HT, Oertel WH, Patterson J, Hadley DM, Pogarell O, Hoeffken H, et al. Prospective study of presynaptic dopaminergic imaging in patients with mild parkinsonism and tremor disorders: part 1. Baseline and 3-month observations. Mov Disord 2003; 18: 977-84.
7. Berendse HC, Booij J, Francot CMJE, et al. Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell. Ann Neurol 2001; 50: 34-41.
8. Boeve BF, Silber JH, Ferman TJ, Kokmen E, Smith GE, Ivnik RJ, et al. REM sleep behavior disorder and degenerative dementia. Neurology 1998; 51: 363-70.
9. Boeve BF, Silber MH, Ferman TJ, Lucas JA, Parisi JE. Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. Mov Disord 2001; 16: 622-30.
10. Bonuccelli U, Maremmani C, Piccini P, Del Dotto P, Nocita G, Muratorio A. Parkinson's disease and progressive supranuclear palsy: differences in performance of an odour test. In: Proceedings, 10th International Symposium on Parkinson's Disease, Tokyo; 1991.
11. Braak H, Braak E, Yilmazer D, de Vos RAI, Jansen ENH, Bohl J. Pattern of brain destruction in Parkinson's and Alzheimer's diseases. J Neural Transm 1996; 103: 455-90.
12. Braak H, Sandmann-Keil D, Gai WP, Braak E. Extensive axonal Lewy neuntes in Parkinson's disease: a novel pathological feature revealed by alpha-synuclein immunohistochemistry. Neurosci Lett 1999; 265: 67-9.
13. Braak H, Rub U, Sandmann-Keil D, Gai WP, de Vos RAI, Jansen ENH. et al. Parkinson's disease: affection of brainstem nuclei controlling premotor and motor neurons of the somatomotor system. Acta Neuropathol 2000; 99: 489-95.
14. Braak H, Del Tredici K, Rub U, de Vos RAI, Jansen Steur ENH, Braak E. Staging of pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003; 24: 197-211.
15. Bramerson A, Johansson L, Ek L, Nordin S, Bende M. Prevalence of olfactory dysfunction: the Skovde population-based study. Laryngoskope 2004; 114: 733-7.
16. Comella CL, Nardine TM, Diederich NJ, Stebbins GT. Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson's disease. Neurology 1998; 51: 526-9.
17. Daum RF, Sekinger B, Kobal G, Lang CJ. Olfactory testing with 'Sniffin' Sticks' for clinical diagnosis of Parkinson's disease. Nervenarzt 2000; 71: 643-50.
18. Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF, et al. Smell and taste disorders: A study of 750 patients from the University of Pennsylvania Smell and Taste Center (1981-1986). Arch Otolaryngol Head Neck Surg 1991; 177.
19. Del Tredici K, Rub U, de Vos RAI, Bohl JRE, Braak H. Where does Parkinson disease pathology begin in the brain? J Neuropathol Exp Neurol 2002; 61: 413-26.
20. Doty RL, Shaman P, Applebaum SL, Giberson R, Sikorsky L, Rosenberg L. Smell identification ability: changes with age. Science 1984; 266: 1441-3.
21. Doty RL, Deems DA, Stellar S. Olfactory dysfunction in parkinsonism: a general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 1988; 38: 1237-44.
22. Doty RL, Sing A, Tetrud JW, Langston JW. Lack of major olfactory dysfunction in MPTP-induced parkinsonism. Ann Neurol 1992a; 32: 87-100.
23. Doty RL, Stern MB, Pfeiffer C, Gollomp SM, Hurtig HI. Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1992b; 55: 138-42.
24. Doty RL, Golbe LI, McKeown DA, Stern MB, Lehrach CM, Crawford D. Olfactory testing differentiates between progressive supranuclear palsy and idiopathic Parkinson's disease. Neurology 1993; 43: 962-5.
25. Double KL, Rowe DB, Hayes M, Chan DKY, Blackie J, Corbett A, et al. Identifying the pattern of olfactory deficits in Parkinson's disease using the brief smell identification test. Arch Neurol 2003; 60.
26. Eisensehr I, Linke R, Noachtar S, Schwarz J, Gildehaus FJ, Tatsch K. Reduced striatal dopamine transporter in idiopathic rapid eye movement sleep behavior disorder. Brain 2000; 123: 1155-60.
27. Eisensehr I, Linke R, Tatsch K, Kharraz B, Gildehaus JF, Wetter TC, et al. Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporter. IPT and IBZM SPECT imaging in subclinical and clinically manifest idiopathic REM sleep behavior disorder, Parkinson's disease, and controls. Sleep 2003; 26: 507-12.
28. Fahn S, Elton RL, Committee UD. Unified Parkinson's Disease Rating Scale. In: Fahn S, Marsden CD and Goldstein M, editors. Recent developments in Parkinson's disease. II. New York: Macmillan; 1987. p. 153-63.
29. Ferini-Strambi L, Di Gioia MR, Castronovo V, Oldani A, Zucconi M, Cappa SF. Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD)-does the idiopathic form really exist? Neurology 2004; 62: 41-5.
30. Ferman TJ, Boeve BF, Smith GE, Silber MH, Kokmen E, Petersen RC, et al. REM sleep behavior disorder and dementia: Cognitive differences when compared with AD. Neurology 1999; 52: 951-7.
31. Folstein MF, Folstein SE, McHugh PR. 'Mini-Mental State'. A practical guide for grading the cognitive state of patients for the clinician. J Psychiatry Res 1975; 12: 189-98.
32. Forno LS, Langston JW, DeLanney LE, Irwin I, Ricaurte GA. Locus coeruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann Neurol 1986; 20: 49-55.
33. Gagnon J-F, Bedard M-A, Fantini ML, Petit D, Panisset M, Rompre S, et al. REM sleep behavior disorder and REM sleep without atonia in Parkinson's disease. Neurology 2002; 59: 585-9.
34. German DC, Dubach M, Askari S, Apeciale SG, Bowden D, M. 1-methyl-4-phenyl-1,2,3.6-tetrahydropyridine-induced Parkinsonian syndrome in Macaca fascicularis: which midbrain dopaminergic neurons are lost? Neuroscience 1988; 24: 161-74.
35. Halliday GM, Li YW, Blumbergs PC, Joh TH, Cotton RGH, Howe PRC, et al. Neuropathology of immunohistochemically identified brainstem neurons in Parkinson's disease. Ann Neurol 1990; 27: 373-85.
36. Hawkes CH. Olfaction in neurodegenerative disorders. Mov Disord 2003; 18: 364-72.
37. Hawkes CH, Shepard BC. Olfactory evoked responses and identification tests in neurological disease. Ann N Y Acad Sci 1998; 855.
38. Hawkes CH, Shepard BC, Daniel SC. Olfactory dysfunction in Parkinson's disease. J Neurol Neurosurg Psychiatry 1997: 62: 436-46.
39. Hawkes CH, Shah M, Muhammed LJ, Findley LJ. Olfactory testing differentiates benign essential tremor from tremulous Parkinson's disease. Mov Disord 2004; 19: S446.
40. Hendricks JC, Bowker RM, Morrisson AR, Mann GL. Different behaviors during paradoxical sleep without atonia depend on pontine lesion site. Brain Res 1982; 239: 81-105.
41. Höffken H, Gerstner A, Oertel WH, Behr TM. Is the reliability of I-123-FP-CIT-SPECT dependent on reconstruction technique? Eur J Nucl Med 2001; 28: 1134.
42. Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G. Sniffing Sticks: olfactory performance assessed by the combined testing of odour identification, odour discrimination and olfactory threshold. Chem Senses 1997; 22: 39-52.
43. Jouvet M, Delorme JF. Locus coeruleus et sommeil paradoxical. C R Seances Soc Biol Fil 1965; 159: 895-9.
44. Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM, et al. Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odour identification, odour discrimination, and odour thresholds. Eur Arch Otorhinolaryngol 2000; 257: 205-11.
45. Lai YY, Siegel JM. Physiological and anatomical link between Parkinson-like disease and REM sleep behavior disorder. Mol Neurobiol 2003; 27: 137-51.
46. Lapierre O, Montplaisir J. Polysomnographic features of REM sleep behavior disorder: development of a scoring method. Neurology 1992; 42: 1371-4.
47. Mahowald MW, Schenk CH. REM sleep behavior disorder. In: Kryger MH, Roth T, editors. Principles and practice of sleep medicine. Philadelphia: Saunders; 1994. p. 574-88.
48. Mahowald MW, Schenk CH. REM sleep parasomnia. In: Kryger MH, Roth T, Dement WC, editors. Principles and practice of sleep medicine Philadelphia: Saunders; 2000. p. 724-41.
49. Markopoulou K, Larsen KW, Wszolek EK, Denson MA, Lang AE, Pfeiffer RF, et al. Olfactory dysfunction in familial parkinsonism. Neurology 1997; 49: 1262-7.
50. Mayer G, Kesper K, Peter H, Ploch T, Leinweber T, Peter JH. Comorbidity in narcoleptic patients. Dtsch Med Wochenschr 2002; 127: 1942-6.
51. Müller A, Reichmann H, Livermore A, Hummel T. Olfactory function in idiopathic Parkinson's disease (IPD): results from cross-sectional studies in IPD patients and long-term follow-up of de-novo IPD patients. J Neural Transm 2002; 109: 805-11.
52. Ohama E, Ikuta F. Parkinson's disease: distribution of Lewy bodies and monoamine neuron system. Acta Neuropathol 1976; 34: 311-9.
53. Olson EJ, Boeve BF, Silber MH. Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. Brain 2000; 123: 331-9.
54. Peyron G, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998; 18: 9996-10015.
55. Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000; 6: 991-7.
56. Plazzi G, Corsini R, Provini F, Pierangeli G, Martinelli P, Montagna P, et al. REM sleep behavior disorders in multiple system atrophy. Neurology 1997; 48: 1094-7.
57. Pompeiano O. Mechanisms responsible for spinal inhibition during synchronized sleep: experimental study. In: Guilleminault C, Dement WC, Passouant P, editors. Advances in sleep research New York: Spectrum Press; 1976, p. 411-49.
58. Quinn NP, Rossor MN, Marsden CD. Olfactory threshold in Parkinson's disease. J Neurol Neurosurg Psychiatry 1987; 50: 88-9.
59. Rechtschaffen A, Kales A. A manual of standardized terminology, techniques, and scoring system for sleep stages of human subjects. Los Angeles: UCLA Brain Information Service/Brain Research Institute, 1968.
60. Sakai K. Some anatomical and physiological properties of pontomesencephalic tegmental neurons with special reference to the PGO waves and postural atonia during paradoxical sleep in cat. In: Hobson JA, Brazier MAB, editors. The reticular formation revisited. New York: Raven Press; 1980, p. 427-47.
61. Sakai K. Anatomical and physiological basis of paradoxical sleep. In: McGinty DJ, Drucker-Colin R, Morrison AA, Parmeggiani PL, editors. Brain mechanisms of sleep. New York: Raven Press; 1985, p. 111-37.
62. Sakai K, Sastre JP, Danamori N. State-specific neurons in the pontomedullary reticular formation with special reference to the postural atonia during paradoxical sleep in cat. In: Pompeiano O, Marsan CA, editors. Brain mechanisms of perceptual awareness and purposeful behavior New York: Raven Press; 1981. p. 405-29.
63. Sanford LD, Morrison AR, Mann GL, Harris JS, Yoo L, Ross RJ. Sleep pattering and behaviour in cats with pontine lesions creating REM without atonia. J Sleep Res 1994; 3: 233-40.
64. Schenck CH, Mahowald MW. REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP. Sleep 2002; 25: 120-38.
65. Schenck CH, Hurwitz T, Mahowald MW. REM sleep behavior disorder: an update on a series of 96 patients and a review of the world literature. J Sleep Res 1993; 2: 224-31.
66. Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. [Published erratum appears in Neurology 1996; 46: 1787]. Neurology 1996; 46: 388-93.
67. Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. [Published erratum appears in Neurology 1996; 46: 1787]. Neurology 1996; 46: 388-93.
68. Schenck CH, Bundlie SR, Mahowald MW. REM behavior disorder (RBD): delayed emergence of parkinsonism and/or dementia in 65% of older men initially diagnosed with idiopathic RBD, and an analysis of the minimum & maximum tonic and/or phasic electromyographic abnormalities found during REM sleep. Sleep 2003; 26 (Suppl): 0794.M.
69. Schenkel E, Siegel JM. REM sleep without atonia after lesions of the medial medulla. Neurosci Lett 1989; 98: 159-65.
70. Schneider JS, Yuwiler A, Markham C. Production of a Parkinson-like syndrome in the cat with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): behavior, histology, and biochemistry. Exp Neurol 1986; 91: 293-307.
71. Shouse MN, Siegel JM. Pontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep. Brain Res 1992; 571.
72. Sobel N, Thomason ME, Stappen I, Tanner CM, Tetrad JW, Bower JM, et al. An impairment of sniffing contributes to the olfactory impairment in Parkinson's disease. Proc Natl Acad Sci USA 2001; 98: 4154-9.
73. Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich MS, et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000; 27: 469-74.
74. Tissingh G, Berendse HW, Bergmanns P, De Ward R, Drukarch B, Stoof JC, et al. Loss of olfaction in de novo and treated Parkinson's disease: possible implication for early diagnosis. Mov Disord 2001; 16: 41-6.
75. Trojanowski JQ, Lee VMY. Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies-implications for the pathogenesis of Parkinson's disease and Lewy body dementia. Arch Neurol 1998; 55: 151-2.
76. Turner RS, D'Amato CJ, Chervin RD, Blaivas M. The pathology of REM sleep behavior disorder with comorbid Lewy body dementia. Neurology 2000; 55: 1730-2.
77. Uchiyama M, Isse K, Tanaka K, Yokota N, Hamamoto M, Aida S, et al. Incidental Lewy body disease in a patient with REM sleep behavior disorders. Neurology 1995; 45: 709-12.
78. Wakabayashi K, Matsumoto K, Takayama K, Yoshimoto M, Takahashi H. NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease. Neurosci Lett 1997; 239: 45-8.
79. Ward CD, Hess WA, Calne DB. Olfactory impairment in Parkinson's disease. Neurology 1983; 33.
80. Wenning GK, Shephard B, Hawkes CH, Petruckevitch A, Lees A, Quinn NP. Olfactory function in atypical parkinsonian syndromes. Acta Neurol Scand 1995; 91: 247-50.
81. Zucco GM, Zaglis D, Wambsganss CS. Olfactory deficits in elderly subjects and Parkinson patients. Percept Mot Skills 1991; 73: 895-8.