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Volumn 31, Issue 19, 2011, Pages 6963-6971

Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE;

EID: 79956317900     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6513-10.2011     Document Type: Article
Times cited : (151)

References (62)
  • 7
    • 0033560729 scopus 로고    scopus 로고
    • Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory βalpha subunit
    • Bryant JC, Westphal RS, Wadzinski BE (1999) Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory βalpha subunit. Biochem J 339:241-246.
    • (1999) Biochem J , vol.339 , pp. 241-246
    • Bryant, J.C.1    Westphal, R.S.2    Wadzinski, B.E.3
  • 9
    • 17844406856 scopus 로고    scopus 로고
    • Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
    • Chen L, Feany MB (2005) Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat Neurosci 8:657-663.
    • (2005) Nat Neurosci , vol.8 , pp. 657-663
    • Chen, L.1    Feany, M.B.2
  • 11
    • 33947621993 scopus 로고    scopus 로고
    • Assessing nest building in mice
    • Deacon RM (2006) Assessing nest building in mice. Nat Protoc 1:1117-1119.
    • (2006) Nat Protoc , vol.1 , pp. 1117-1119
    • Deacon, R.M.1
  • 12
    • 0032924712 scopus 로고    scopus 로고
    • Nutritional and occupational factors influencing the risk of Parkinson's disease: A casecontrol study in southeastern Sweden
    • Fall PA, Fredrikson M, Axelson O, Granérus AK (1999) Nutritional and occupational factors influencing the risk of Parkinson's disease: a casecontrol study in southeastern Sweden. Mov Disord 14:28-37.
    • (1999) Mov Disord , vol.14 , pp. 28-37
    • Fall, P.A.1    Fredrikson, M.2    Axelson, O.3    Granérus, A.K.4
  • 16
    • 50549085408 scopus 로고    scopus 로고
    • Neuroinflammation and oxidation/nitration of α-synuclein linked to dopaminergic neurodegeneration
    • Gao HM, Kotzbauer PT, Uryu K, Leight S, Trojanowski JQ, Lee VM (2008) Neuroinflammation and oxidation/nitration of α-synuclein linked to dopaminergic neurodegeneration. J Neurosci 28:7687-7698.
    • (2008) J Neurosci , vol.28 , pp. 7687-7698
    • Gao, H.M.1    Kotzbauer, P.T.2    Uryu, K.3    Leight, S.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 17
    • 0035409575 scopus 로고    scopus 로고
    • Alpha-synuclein and neurodegenerative diseases
    • Goedert M (2001) Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci 2:492-501.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 492-501
    • Goedert, M.1
  • 19
    • 61849088424 scopus 로고    scopus 로고
    • Tau phosphorylation: The therapeutic challenge for neurodegenerative disease
    • Hanger DP, Anderton BH, Noble W (2009) Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends Mol Med 15:112-119.
    • (2009) Trends Mol Med , vol.15 , pp. 112-119
    • Hanger, D.P.1    Anderton, B.H.2    Noble, W.3
  • 20
    • 0036323447 scopus 로고    scopus 로고
    • MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction
    • Harada A, Teng J, Takei Y, Oguchi K, Hirokawa N (2002) MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. J Cell Biol 158:541-549.
    • (2002) J Cell Biol , vol.158 , pp. 541-549
    • Harada, A.1    Teng, J.2    Takei, Y.3    Oguchi, K.4    Hirokawa, N.5
  • 21
    • 9544227379 scopus 로고    scopus 로고
    • Diet and Parkinson's disease. II: A possible role for the past intake of specific nutrients. Results from a self-administered food-frequency questionnaire in a case-control study
    • Hellenbrand W, Boeing H, Robra BP, Seidler A, Vieregge P, Nischan P, Joerg J, Oertel WH, Schneider E, Ulm G (1996) Diet and Parkinson's disease. II: A possible role for the past intake of specific nutrients. Results from a self-administered food-frequency questionnaire in a case-control study. Neurology 47:644-650.
    • (1996) Neurology , vol.47 , pp. 644-650
    • Hellenbrand, W.1    Boeing, H.2    Robra, B.P.3    Seidler, A.4    Vieregge, P.5    Nischan, P.6    Joerg, J.7    Oertel, W.H.8    Schneider, E.9    Ulm, G.10
  • 23
    • 34548702649 scopus 로고    scopus 로고
    • Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies
    • Ishii A, Nonaka T, Taniguchi S, Saito T, Arai T, Mann D, Iwatsubo T, Hisanaga S, Goedert M, Hasegawa M (2007) Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: implication for alpha-synucleinopathies. FEBS Lett 581:4711-4717.
    • (2007) FEBS Lett , vol.581 , pp. 4711-4717
    • Ishii, A.1    Nonaka, T.2    Taniguchi, S.3    Saito, T.4    Arai, T.5    Mann, D.6    Iwatsubo, T.7    Hisanaga, S.8    Goedert, M.9    Hasegawa, M.10
  • 24
    • 0034008852 scopus 로고    scopus 로고
    • Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation
    • Kanda S, Bishop JF, Eglitis MA, Yang Y, Mouradian MM (2000) Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation. Neuroscience 97:279-284.
    • (2000) Neuroscience , vol.97 , pp. 279-284
    • Kanda, S.1    Bishop, J.F.2    Eglitis, M.A.3    Yang, Y.4    Mouradian, M.M.5
  • 25
    • 1342327361 scopus 로고    scopus 로고
    • C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites
    • Kao G, Tuck S, Baillie D, Sundaram MV (2004) C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites. Development 131:755-765.
    • (2004) Development , vol.131 , pp. 755-765
    • Kao, G.1    Tuck, S.2    Baillie, D.3    Sundaram, M.V.4
  • 27
    • 0021884476 scopus 로고
    • Neonatal frontal lesions in hamsters impair species-typical behaviors and reduce brain weight and neocortical thickness
    • Kolb B, Whishaw IQ (1985) Neonatal frontal lesions in hamsters impair species-typical behaviors and reduce brain weight and neocortical thickness. Behav Neurosci 99:691-706.
    • (1985) Behav Neurosci , vol.99 , pp. 691-706
    • Kolb, B.1    Whishaw, I.Q.2
  • 28
    • 18744373008 scopus 로고    scopus 로고
    • A versatile method for the quantitative determination of β-N-alkanoyl-5-hydroxytryptamides in roasted coffee
    • Lang R, Hofmann T (2005) A versatile method for the quantitative determination of β-N-alkanoyl-5-hydroxytryptamides in roasted coffee. Eur Food Res Technol 220:638-643.
    • (2005) Eur Food Res Technol , vol.220 , pp. 638-643
    • Lang, R.1    Hofmann, T.2
  • 29
    • 0027184102 scopus 로고
    • Protein phosphatase 2A catalytic subunit is methylesterified at its carboxyl terminus by a novel methyltransferase
    • Lee J, Stock J (1993) Protein phosphatase 2A catalytic subunit is methylesterified at its carboxyl terminus by a novel methyltransferase. J Biol Chem 268:19192-19195.
    • (1993) J Biol Chem , vol.268 , pp. 19192-19195
    • Lee, J.1    Stock, J.2
  • 30
    • 0029952559 scopus 로고    scopus 로고
    • A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain
    • Lee J, Chen Y, Tolstykh T, Stock J (1996) A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain. Proc Natl Acad Sci U S A 93:6043-6047.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6043-6047
    • Lee, J.1    Chen, Y.2    Tolstykh, T.3    Stock, J.4
  • 31
    • 27644478606 scopus 로고    scopus 로고
    • Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
    • Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22:1942-1950.
    • (2005) Eur J Neurosci , vol.22 , pp. 1942-1950
    • Liu, F.1    Grundke-Iqbal, I.2    Iqbal, K.3    Gong, C.X.4
  • 32
    • 34848843828 scopus 로고    scopus 로고
    • Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit
    • Longin S, Zwaenepoel K, Louis JV, Dilworth S, Goris J, Janssens V (2007) Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit. J Biol Chem 282:26971-26980.
    • (2007) J Biol Chem , vol.282 , pp. 26971-26980
    • Longin, S.1    Zwaenepoel, K.2    Louis, J.V.3    Dilworth, S.4    Goris, J.5    Janssens, V.6
  • 37
    • 0033553570 scopus 로고    scopus 로고
    • A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A
    • Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC (1999) A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. J Biol Chem 274:14382-14391.
    • (1999) J Biol Chem , vol.274 , pp. 14382-14391
    • Ogris, E.1    Du, X.2    Nelson, K.C.3    Mak, E.K.4    Yu, X.X.5    Lane, W.S.6    Pallas, D.C.7
  • 39
    • 0042924399 scopus 로고    scopus 로고
    • Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits
    • Palop JJ, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L (2003) Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc Natl Acad Sci U S A 100:9572-9577.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9572-9577
    • Palop, J.J.1    Jones, B.2    Kekonius, L.3    Chin, J.4    Yu, G.Q.5    Raber, J.6    Masliah, E.7    Mucke, L.8
  • 40
    • 0034714204 scopus 로고    scopus 로고
    • Synucleins are a novel class of substrates for G protein-coupled receptor kinases
    • Pronin AN, Morris AJ, Surguchov A, Benovic JL (2000) Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem 275:26515-26522.
    • (2000) J Biol Chem , vol.275 , pp. 26515-26522
    • Pronin, A.N.1    Morris, A.J.2    Surguchov, A.3    Benovic, J.L.4
  • 41
    • 0036605566 scopus 로고    scopus 로고
    • Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters
    • Rockenstein E, Mallory M, Hashimoto M, Song D, Shults CW, Lang I, Masliah E (2002) Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res 68:568-578.
    • (2002) J Neurosci Res , vol.68 , pp. 568-578
    • Rockenstein, E.1    Mallory, M.2    Hashimoto, M.3    Song, D.4    Shults, C.W.5    Lang, I.6    Masliah, E.7
  • 45
    • 33846979780 scopus 로고    scopus 로고
    • Differential expression of the B'β regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis
    • Saraf A, Virshup DM, Strack S (2007) Differential expression of the B'β regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. J Biol Chem 282:573-580.
    • (2007) J Biol Chem , vol.282 , pp. 573-580
    • Saraf, A.1    Virshup, D.M.2    Strack, S.3
  • 46
    • 0035863784 scopus 로고    scopus 로고
    • The serine/threonine phosphatase, PP2A: Endogenous regulator of inflammatory cell signaling
    • Shanley TP, Vasi N, Denenberg A, Wong HR (2001) The serine/threonine phosphatase, PP2A: endogenous regulator of inflammatory cell signaling. J Immunol 166:966-972.
    • (2001) J Immunol , vol.166 , pp. 966-972
    • Shanley, T.P.1    Vasi, N.2    Denenberg, A.3    Wong, H.R.4
  • 47
    • 1842510667 scopus 로고    scopus 로고
    • Altered expression levels of the protein phosphatase 2A AB alpha C enzyme are associated with Alzheimer disease pathology
    • Sontag E, Luangpirom A, Hladik C, Mudrak I, Ogris E, Speciale S, White CL 3rd (2004a) Altered expression levels of the protein phosphatase 2A AB alpha C enzyme are associated with Alzheimer disease pathology. J Neuropathol Exp Neurol 63:287-301.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 287-301
    • Sontag, E.1    Luangpirom, A.2    Hladik, C.3    Mudrak, I.4    Ogris, E.5    Speciale, S.6    White III, C.L.7
  • 48
    • 5644293035 scopus 로고    scopus 로고
    • Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis
    • Sontag E, Hladik C, Montgomery L, Luangpirom A, Mudrak I, Ogris E, White CL 3rd (2004b) Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J Neuropathol Exp Neurol 63:1080-1091.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 1080-1091
    • Sontag, E.1    Hladik, C.2    Montgomery, L.3    Luangpirom, A.4    Mudrak, I.5    Ogris, E.6    White III, C.L.7
  • 51
    • 34447275978 scopus 로고    scopus 로고
    • Small-molecule inhibitors of ser/thr protein phosphatases: Specificity, use and common forms of abuse
    • Swingle M, Ni L, Honkanen RE (2007) Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. Methods Mol Biol 365:23-38.
    • (2007) Methods Mol Biol , vol.365 , pp. 23-38
    • Swingle, M.1    Ni, L.2    Honkanen, R.E.3
  • 53
    • 75949087271 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
    • Tansey MG, Goldberg MS (2010) Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiol Dis 37:510-518.
    • (2010) Neurobiol Dis , vol.37 , pp. 510-518
    • Tansey, M.G.1    Goldberg, M.S.2
  • 54
    • 58149380755 scopus 로고    scopus 로고
    • Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease
    • Theodore S, Cao S, McLean PJ, Standaert DG (2008) Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease. J Neuropathol Exp Neurol 67:1149-1158.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 1149-1158
    • Theodore, S.1    Cao, S.2    McLean, P.J.3    Standaert, D.G.4
  • 55
    • 0034331359 scopus 로고    scopus 로고
    • Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits
    • Tolstykh T, Lee J, Vafai S, Stock JB (2000) Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits. EMBO J 19:5682-5691.
    • (2000) EMBO J , vol.19 , pp. 5682-5691
    • Tolstykh, T.1    Lee, J.2    Vafai, S.3    Stock, J.B.4
  • 56
    • 77956385203 scopus 로고    scopus 로고
    • Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models
    • van Eersel J, Ke YD, Liu X, Delerue F, Kril JJ, Götz J, Ittner LM (2010) Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A 107:13888-13893.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13888-13893
    • van Eersel, J.1    Ke, Y.D.2    Liu, X.3    Delerue, F.4    Kril, J.J.5    Götz, J.6    Ittner, L.M.7
  • 57
    • 0034331296 scopus 로고    scopus 로고
    • Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo
    • Wu J, Tolstykh T, Lee J, Boyd K, Stock JB, Broach JR (2000) Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo. EMBO J 19:5672-5681.
    • (2000) EMBO J , vol.19 , pp. 5672-5681
    • Wu, J.1    Tolstykh, T.2    Lee, J.3    Boyd, K.4    Stock, J.B.5    Broach, J.R.6
  • 59
    • 41149175685 scopus 로고    scopus 로고
    • Structural mechanism of demethylation and inactivation of protein phosphatase 2A
    • Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y (2008) Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell 133:154-163.
    • (2008) Cell , vol.133 , pp. 154-163
    • Xing, Y.1    Li, Z.2    Chen, Y.3    Stock, J.B.4    Jeffrey, P.D.5    Shi, Y.6
  • 60
    • 10944243102 scopus 로고    scopus 로고
    • Role of alpha-synuclein in presynaptic dopamine recruitment
    • Yavich L, Tanila H, Vepsäläinen S, Jäkälä P (2004) Role of alpha-synuclein in presynaptic dopamine recruitment. J Neurosci 24:11165-11170.
    • (2004) J Neurosci , vol.24 , pp. 11165-11170
    • Yavich, L.1    Tanila, H.2    Vepsäläinen, S.3    Jäkälä, P.4
  • 61
    • 0035177048 scopus 로고    scopus 로고
    • Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Bα regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen
    • Yu XX, Du X, Moreno CS, Green RE, Ogris E, Feng Q, Chou L, McQuoid MJ, Pallas DC (2001) Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Bα regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. Mol Biol Cell 12:185-199.
    • (2001) Mol Biol Cell , vol.12 , pp. 185-199
    • Yu, X.X.1    Du, X.2    Moreno, C.S.3    Green, R.E.4    Ogris, E.5    Feng, Q.6    Chou, L.7    McQuoid, M.J.8    Pallas, D.C.9
  • 62
    • 69249100506 scopus 로고    scopus 로고
    • PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated β-catenin dephosphorylation
    • Zhang W, Yang J, Liu Y, Chen X, Yu T, Jia J, Liu C (2009) PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated β-catenin dephosphorylation. J Biol Chem 284:22649-22656.
    • (2009) J Biol Chem , vol.284 , pp. 22649-22656
    • Zhang, W.1    Yang, J.2    Liu, Y.3    Chen, X.4    Yu, T.5    Jia, J.6    Liu, C.7


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