Recognition of phosphodegron motifs in human cyclin E by the SCF Fbw7 ubiquitin ligase

Journal of Biological Chemistry

Volumn 279, Issue 48, 2004, Pages 50110-50119

  Ye, Xin ^a   Nalepa, Grzegorz ^a,d   Welcker, Markus ^e   Kessler, Benedikt M ^a   Spooner, Eric ^a   Qin, Jun ^d   Elledge, Stephen J ^a,b,c   Clurman, Bruce E ^e   Harper, J Wade ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b LABORATORY FOR MOLECULAR MEDICINE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASM; DEGRADATION ASSAY; PHOSPHODEGRON MOTIFS;

BIOASSAY; BIODEGRADATION; DISSOCIATION; POLYPEPTIDES; PROTEINS; REDUCTION;

CELLS;

ALANINE; CYCLIN E; PHOSPHOPEPTIDE; PROTEIN SUBUNIT; SERINE; THREONINE; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE SCF FBW7; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; HUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION;

AMINO ACID MOTIFS; BINDING SITES; CYCLIN E; HUMANS; MASS SPECTROMETRY; PEPTIDE MAPPING; PHOSPHORYLATION; SKP CULLIN F-BOX PROTEIN LIGASES; THREONINE;

EID: 9644279589     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409226200     Document Type: Article

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