Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system

Journal of Biological Chemistry

Volumn 284, Issue 15, 2009, Pages 9796-9803

  Iwata, Atsushi ^a   Nagashima, Yu ^a   Matsumoto, Lumine ^a   Suzuki, Takahiro ^b   Yamanaka, Tomoyuki ^c   Date, Hidetoshi ^a   Deoka, Ken ^a   Nukina, Nobuyuki ^c   Tsuji, Shoji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; CELL DEATH; CELL PROLIFERATION; DEGRADATION; MACHINERY; MAMMALS; NEURODEGENERATIVE DISEASES;

AUTOSOMAL DOMINANTS; CELLULAR TOXICITIES; DEGRADATION KINETICS; HUNTINGTON DISEASE; NUCLEAR INCLUSIONS; PROTEIN AGGREGATES; PROTEIN QUALITY CONTROL; UBIQUITIN-PROTEASOME SYSTEM;

PROTEINS;

POLYGLUTAMINE; PROTEASOME; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; PEPTIDE; SACCHAROMYCES CEREVISIAE PROTEIN; SAN1 PROTEIN, S CEREVISIAE; UHRF2 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL CULTURE; CELL NUCLEUS; CELL NUCLEUS INCLUSION BODY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DATA ANALYSIS; DEGENERATIVE DISEASE; DEGRADATION KINETICS; HUNTINGTON CHOREA; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MAMMAL CELL; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; CHEMISTRY; HELA CELL; HUMAN; KINETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

MAMMALIA;

CELL NUCLEUS; CELLS, CULTURED; CYTOPLASM; HELA CELLS; HUMANS; KINETICS; NEURODEGENERATIVE DISEASES; NEURONS; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 65649121163     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809739200     Document Type: Article

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