DEN1 is a dual function protease capable of processing the c terminus of Nedd8 and deconjugating hyper-neddylated CUL1

Journal of Biological Chemistry

Volumn 278, Issue 31, 2003, Pages 28882-28891

  Wu, Kenneth ^a   Yamoah, Kosj ^a   Dolios, Georgia ^a   Gan Erdene, Tudeviin ^b   Tan, Peilin ^a   Chen, Angus ^a   Lee, Chee Gun ^c   Wei, Ning ^d   Wilkinson, Keith D ^b   Wang, Rong ^a   Pan, Zhen Qiang ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYST SELECTIVITY; CHEMICAL BONDS; CHEMICAL MODIFICATION; CLONING; ENZYME KINETICS; HYDROLYSIS;

UBIQUITINATION;

ENZYMES;

CULLIN 1; DEN1 PROTEASE; LIGASE; NEDD8 PROTEIN; PROTEINASE; REGULATOR PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ISOLATION; ENZYME SUBUNIT; HUMAN; HUMAN CELL; HYDROLYSIS; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; REACTION ANALYSIS; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; CELL CYCLE PROTEINS; CULLIN PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; UBIQUITIN; UBIQUITINS;

EID: 0043208977     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302888200     Document Type: Article

References (41)

1. Osaka, F., Saeki, M., Katayama, S., Aida, N., Toh-E, A., Kominami, K., Toda, T., Suzuki, T., Chiba, T., Tanaka, K., and Kato, S. (2000) EMBO J. 19, 3475-3484
2. Tateishi, K., Omata, M., Tanaka, K., and Chiba, T. (2001) J. Cell Biol. 155, 571-579
3. Ou, C. Y., Lin, Y. F., Chen, Y. J., and Chien, C. T. (2002) Genes Dev. 16, 2403-2414
4. Hori, T., Osaka, F., Chiba, T., Miyamoto, C., Okabayashi, K., Shimbara, N., Kato, S., and Tanaka, K. (1999) Oncogene 18, 6829-6834
5. Hochstrasser, M. (1998) Genes Dev. 12, 901-907
6. Gong, L., and Yeh, E. T. (1999) J. Biol. Chem. 274, 12036-12042
7. Kamura, T., Conrad, M. N., Yan, Q., Conaway, R. C., and Conaway, J. W. (1999) Genes Dev. 13, 2928-2933
8. Read, M. A., Brownell, J. E., Gladysheva, T. B., Hottelet, M., Parent, L. A., Coggins, M. B., Pierce, J. W., Podust, V. N., Luo, R. S., Chau, V., and Palombella, V. J. (2000) Mol. Cell. Biol. 20, 2326-2333
9. Podust, V. N., Brownell, J. E., Gladysheva, T. B., Luo, R. S., Wang, C., Coggins, M. B., Pierce, J. W., Lightcap, E. S., and Chau, V. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4579-4584
10. Tan, P., Fuchs, S. Y., Chen, A., Wu, K., Gomez, C., Ronai, Z., and Pan, Z.-Q. (1999) Mol. Cell 3, 527-533
11. Ohta, T., Michel, J. J., Schottelius, A. J., and Xiong, Y. (1999) Mol. Cell 3, 535-541
12. Wu, K., Fuchs, S. Y., Chen, A., Tan, P., Gomez, C., Ronai, Z., and Pan, Z.-Q. (2000) Mol. Cell. Biol. 20, 1382-1393
13. Ohh, M., Kim, W. Y., Moslehi, J. J., Chen, Y., Chau, V., Read, M. A., and Kaelin, W. G., Jr. (2002) EMBO Rep. 3, 177-182
14. Conaway, R. C., Brower, C. S., and Conaway, J. W. (2002) Science 296, 1254-1258
15. Wu, K., Chen, A., and Pan, Z.-Q. (2000) J. Biol. Chem. 275, 32317-32324
16. Wu, K., Chen, A., Tan, P., and Pan, Z.-Q. (2002) J. Biol. Chem. 277, 516-527
17. Lyapina, S., Cope, G., Shevchenko, A., Serino, G., Tsuge, T., Zhou, C., Wolf, D. A., Wei, N., Shevchenko, A., and Deshaies, R. J. (2001) Science 292, 1382-1385
18. Zhou, C., Seibert, V., Geyer, R., Rhee, E., Lyapina, S., Cope, G., Deshaies, R. J., and Wolf, D. A. (2001) BMC Biochemistry http://www.biomedcentral.com/1472-2091/2/7
19. Kawakami, T., Chiba, T., Suzuki, T., Iwai, K., Yamanaka, K., Minato, N., Suzuki, H., Shimbara, N., Hidaka, Y., Osaka, F., Omata, M., and Tanaka, K. (2001) EMBO J. 20, 4003-4012
20. Zheng, N., Schulman, B. A., Song, L., Miller, J. J., Jeffrey, P. D., Wang, P., Chu, C., Koepp, D. M., Elledge, S. J., Pagano, M., Conaway, R. C., Conaway, J. W., Harper, J. W., and Pavletich, N. P. (2002) Nature 416, 703-709
21. Skowyra, D., Koepp, D. M., Kamura, T., Conrad, M. N., Conaway, R. C., Conaway, J. W., Elledge, S. J., and Harper, J. W. (1999) Science 284, 662-665
22. Seol, J. H., Feldman, R. M., Zachariae, W., Shevchenko, A., Correll, C. C., Lyapina, S., Chi, Y., Galova, M., Claypool, J., Sandmeyer, S., Nasmyth, K., and Deshaies, R. J. (1999) Genes Dev. 13, 1614-1626
23. Chen, A., Wu, K., Fuchs, S. Y., Tan, P., Gomez, C., and Pan, Z.-Q. (2000) J. Biol. Chem. 275, 15432-15439
24. Liu, J., Furukawa, M., Matsumoto, T., and Xiong, Y. (2002) Mol. Cell 10, 1511-1518
25. Zheng, J., Yang, X., Harrell, J. M., Ryzhikov, S., Shim, E. H., Lykke-Andersen, K., Wei, N., Sun, H., Kobayashi, R., and Zhang, H. (2002) Mol. Cell 10, 1519-1526
26. Schwechheimer, C., Serino, G., Callis, J., Crosby, W. L., Lyapina, S., Deshaies, R. J., Gray, W. M., Estelle, M., and Deng, X. W. (2001) Science 292, 1379-1382
27. Chamovitz, D. A., and Glickman, M. (2002) Curr. Biol. 12, R232
28. Cope, G. A., Suh, G. S., Aravind, L., Schwarz, S. E., Zipursky, S. L., Koonin, E. V., and Deshaies, R. J. (2002) Science 298, 608-611
29. Wobbe, C. R., Dean, F., Weissbach, L., and Hurwitz, J. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 5710-5714
30. Dias, D. C., Dolios, G., Wang, R., and Pan, Z.-Q. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 16601-16606
31. Whitby, F. G., Xia, G., Pickart, C. M., and Hill, C. P. (1998) J. Biol. Chem. 273, 34983-34989
32. Cai, J., Uhlmann, F., Gibbs, E., Flores-Rozas, H., Lee, C. G., Phillips, B., Finkelstein, J., Yao, N., O'Donnell, M., and Hurwitz, J. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 12896-12901
33. Li, S. J., and Hochstrasser, M. (1999) Nature 398, 246-251
34. Wilkinson, K. D., and Hochstrasser, M. (1998) in Ubiquitin and the Biology of the Cell (Peters, J.-M., Harris, J. R., and Finley, D., eds) pp. 99-125, Plenum Publishing Corp., New York
35. Wada, H., Kito, K., Caskey, L. S., Yeh, E. T., and Kamitani, T. (1998) Biochem. Biophys. Res. Commun. 251, 688-692
36. Johnston, S. C., Larsen, C. N., Cook, W. J., Wilkinson, K. D., and Hill, C. P. (1997) EMBO J. 16, 3787-3796
37. Mossessova, E., and Lima, C. D. (2000) Mol. Cell 5, 865-876
38. Hu, M., Li, P., Li, M., Li, W., Yao, T., Wu, J. W., Gu, W., Cohen, R. E., and Shi, Y. (2002) Cell 111, 1041-1054
39. Yang, X., Menon, S., Lykke-Andersen, K., Tsuge, T., Xiao, D., Wang, X., Rodriguez-Suarez, R. J., Zhang, H., and Wei, N. (2002) Curr. Biol. 12, 667-672
40. Pickart, C. M., and Rose, I. A. (1985) J. Biol. Chem. 260, 7903-7910
41. Gan-Erdene, T., Kolli, N., Yin, L., Wu, K., Pan, Z.-Q., and Wilkinson, K. D. (2003) J. Biol. Chem. 278, 28892-28900