SUMO Modification of Huntingtin and Huntington's Disease Pathology

Science

Volumn 304, Issue 5667, 2004, Pages 100-104

  Steffan, Joan S ^a   Agrawal, Namita ^b   Pallos, Judit ^b   Rockabrand, Erica ^a   Trotman, Lloyd C ^c   Slepko, Natalia ^b   Illes, Katalin ^a   Lukacsovich, Tamas ^b   Zhu, Ya Zhen ^a   Cattaneo, Elena ^d   Pandolfi, Pier Paolo ^c   Thompson, Leslie Michels ^a   Marsh, J Lawrence ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEGRADATION; DISEASES; PROTEINS;

PATHOGENIC FRAGMENT; PATHOGENIC PROTEIN;

PATHOLOGY;

HUNTINGTIN; LYSINE; POLYGLUTAMINE; PROTEIN; PROTEIN HTTEX1P; SUMO 1 PROTEIN; SUMO PROTEIN; UNCLASSIFIED DRUG; HD PROTEIN, HUMAN; HDH PROTEIN, RAT; HYBRID PROTEIN; NERVE PROTEIN; NUCLEAR PROTEIN; PROLINE; UBIQUITIN;

MEDICINE;

ARTICLE; CONTROLLED STUDY; DROSOPHILA; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; ANIMAL; CELL LINE; CELL NUCLEUS; CHEMISTRY; CORPUS STRIATUM; CYTOLOGY; CYTOPLASM; GENE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HELA CELL; METABOLISM; MUTATION; NERVE CELL; PATHOLOGY; PROMOTER REGION; RAT; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL LINE; CELL NUCLEUS; CORPUS STRIATUM; CYTOPLASM; DROSOPHILA; GENES, MDR; HELA CELLS; HUMANS; HUNTINGTON DISEASE; LYSINE; MUTATION; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PROLINE; PROMOTER REGIONS (GENETICS); RATS; RECOMBINANT FUSION PROTEINS; SUMO-1 PROTEIN; TRANSCRIPTION, GENETIC; TRANSFECTION; UBIQUITIN;

EID: 11144353613     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1092194     Document Type: Article

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45. We thank M. Nevels, A. Dejean, G. David, R. De-Pinho, D. Bohmann, J. Palvimo, E. Stanbridge, B. Blumberg, M. Tabb, and R. Evans for their generous gifts of plasmids; E. Wanker for the antibody to Huntingtin; and D. A. Keys and C. Johnson for helpful discussions. This work was supported by a Cure HD Initiative of the Hereditary Disease Foundation (L.M.T. and J.L.M.), Coalition for the Cure of the Huntington's Disease Society of America (L.M.T.), NIH awards HD36081 and HD36049 (J.L.M.), and Human Frontiers Science Program grant (L.M.T.). This work was made possible in part through access to the Optical Biology Shared Resource of the Cancer Center Support Grant (CA62203) at the University of California, Irvine and the National Drosophila Stock Center in Bloomington, IN. J.L.M. and L.M.T. are members of the scientific advisory board of EnVivo Corporation.