Biological relevance of DNA polymerase beta and translesion synthesis polymerases to cancer and its treatment

Current Molecular Pharmacology

Volumn 5, Issue 1, 2012, Pages 54-67

  Nicolay, Nils H ^a,b   Helleday, Thomas ^a,c   Sharma, Ricky A ^a,d  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c STOCKHOLM UNIVERSITY   (Sweden)

^d NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

Author keywords

Base excision repair; Cisplatin; DNA damage repair; DNA polymerase; Oxaliplatin; Radiotherapy; Translesion synthesis

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; BLEOMYCIN; CARBOPLATIN; CELL EXTRACT; CHLORMETHINE; CISPLATIN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA DIRECTED DNA POLYMERASE BETA; DNA DIRECTED DNA POLYMERASE ETA; DNA POLYMERASE; DNA POLYMERASE REV1; DOUBLE STRANDED DNA; GLYCOSIDE; LITHOCHOLIC ACID; MASTICADIENONIC ACID; MELPHALAN; MESSENGER RNA; NSC 666715; NUCLEOTIDYLTRANSFERASE INHIBITOR; OXALIPLATIN; SUGAR PHOSPHATE; TEMOZOLOMIDE; TRANSLESION SYNTHESIS POLYMERASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CELL CYCLE S PHASE; CELL SURVIVAL; CHROMOSOME ABERRATION; CRYSTALLIZATION; DISEASE ASSOCIATION; DNA CONFORMATION; DNA CROSS LINKING; DNA DAMAGE; DNA PURIFICATION; DNA REPLICATION; DNA STRUCTURE; DNA SYNTHESIS; DOWN REGULATION; DRUG SENSITIVITY; DRUG SYNTHESIS; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME INHIBITION; EXCISION REPAIR; FIBROBLAST; GENE MAPPING; GENE OVEREXPRESSION; GENE TARGETING; GLIOBLASTOMA; HUMAN; HYDROLYSIS KINETICS; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; LUNG NON SMALL CELL CANCER; MOLECULAR WEIGHT; MOLECULARLY TARGETED THERAPY; MUTAGENESIS; NEOPLASM; NONHUMAN; OXIDATION KINETICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; REDUCTION KINETICS; UPREGULATION;

ANTINEOPLASTIC AGENTS; DNA POLYMERASE BETA; DNA REPAIR; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; HUMANS; NEOPLASMS; NUCLEAR PROTEINS; NUCLEOTIDYLTRANSFERASES;

EID: 84855827214     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467211205010054     Document Type: Article

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