Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair

Genes and Development

Volumn 16, Issue 15, 2002, Pages 1872-1883

  Prakash, Satya ^a   Prakash, Louise ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; DNA BINDING PROTEIN; DNA POLYMERASE; RAD18 PROTEIN; RAD6 PROTEIN; REACTIVE OXYGEN METABOLITE; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG;

CRYSTAL STRUCTURE; DNA DAMAGE; DNA REPLICATION; DNA SYNTHESIS; EUKARYOTE; MUTAGENESIS; POLYMERIZATION; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; ULTRAVIOLET RADIATION;

ANIMALS; ARCHAEAL PROTEINS; BACTERIAL PROTEINS; BASE PAIR MISMATCH; DNA; DNA DAMAGE; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI PROTEINS; EUKARYOTIC CELLS; HUMANS; MICE; MODELS, MOLECULAR; NEOPLASTIC SYNDROMES, HEREDITARY; NUCLEIC ACID CONFORMATION; PROKARYOTIC CELLS; PROTEIN CONFORMATION; PROTEINS; PYRIMIDINE DIMERS; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY; XERODERMA PIGMENTOSUM;

EUKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036682979     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1009802     Document Type: Review

References (82)

1. Site and strand specificity of UVB mutagenesis in the SUP4-o gene of yeast
2. Quantitative measurement of translesion replication in human cells: Evidence for bypass of abasic sites by a replicative DNA polymerase
3. Specific complex formation between yeast RAD6 and RAD18 proteins: A potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites
4. Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities
5. Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro
6. Sulfolobus solfataricus P2 DNA polymerae IV (Dpo4): An archael DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic polη
7. Sunlight and the onset of skin cancer
8. UV-induced mutation hotspots occur at DNA damage hotspots
9. Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells
10. Mutation spectra in supF: Approaches to elucidating sequence context effects
11. Determination of pyrimidine dimer unwinding angle by measurement of DNA electrophoretic mobility
12. Replication fork bypass of a pyrimidine dimer blocking leading strand DNA synthesis
13. Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution
14. Fidelity mechanisms in DNA replication
15. Structure of Taq polymerase with DNA at the polymerase active site
16. Disruption of the Rev31-encoded catalytic subunit of polymerase ζ in mice results in early embryonic lethality
17. The T-T pyrimidine (6-4) pyrimidinone UV photoproduct is much less mutagenic in yeast than in Escherichia coli
18. Biochemical basis of DNA replication fidelity
19. 6-methylguanine by yeast and human DNA polymerase η
20. Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η
21. Physical and functional interactions of human DNA polymerase η with PCNA
22. Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA
23. Interaction with PCNA is essential for yeast DNA polymerase η function
24. Roles of yeast DNA polymerases δ and ζ and of Rev1 in the bypass of abasic sites
25. Inefficient bypass of an abasic site by DNA polymerase η
26. Yeast Rev1 protein is a G template-specific DNA polymerase
27. Stimulation of DNA synthesis activity of human DNA polymerase K by PCNA
28. Ribozyme- catalyzed and nonenzymatic reactions of phosphate diesters: Rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom
29. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair
30. Yeast DNA repair protein RAD5 that promotes instability of simple repetitive sequences is a DNA-dependent ATPase
31. hRAD30 mutations in the variant form of xeroderma pigmentosum
32. Efficient by- pass of a thymine-thymine dimer by yeast DNA polymerase, Polη
33. The human DINB1 gene encodes the DNA polymerase Polθ
34. Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions
35. Fidelity of human DNA polymerase η
36. Role of DNA polymerase η in the bypass of a (6-4) TT photoproduct
37. The (6-4) photoproduct of thymine-thymine induces targeted substitution mutations in mammalian cells
38. Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal
39. Contrasting structural impacts induced by cis-syn cyclobutane dimer and (6-4) adduct in DNA duplex decamers: Implication in mutagenesis and repair activity
40. Acidic residues critical for the activity and biological function of yeast DNA polymerase η
41. NMR structural studies of the ionizing radiation adduct 7-hydro- 8-oxodeoxyguanosine (-8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-oxo-7H-dG(syn) · dA(anti) alignment at lesion site
42. Kinetic mechanism of DNA polymerase I (Klenow)
43. Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity
44. DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiae
45. Solution structure of a DNA decamer duplex containing the stable 3′ T. G base pair of the pyrimidine(6-4)pyrimidone photoproduct [(6-4) adduct]: Implications for the highly specific 3′ T → C transition of the (6-4) adduct
46. Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation
47. 6-ethenodeoxyadenosine
48. Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: Structural basis for nucleotide incorporation
49. Crystal structure of a Y-family DNA polymerase in action: A mechanism for error-prone and lesion-bypass replication
50. X-Ray structure of a DNA decamer containing 7,8- dihydro-8-oxoguanine
51. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
52. A specific partner for abasic damage in DNA
53. Low fidelity DNA synthesis by human DNA polymerase η
54. Crystal structure of a DNA duplex containing 8-hydroxydeoxyguanine-adenine base pairs
55. Base mispair extension kinetics. Comparison of DNA polymerase α and reverse transcriptase
56. 2-guanine adducts of 1,3-butadiene metabolites
57. Deoxycytidyl transferase activity of yeast REV1 protein
58. Thymine-thymine dimer bypass by yeast DNA polymerase ζ
59. Discrimination between translesion synthesis and template switching during bypass replication of thymine dimers in duplex DNA
60. The Y-family of DNA polymerases
61. Pre-steady state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant
62. Structure of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP
63. Comparison between DNA melting themodynamics and DNA polymerase fidelity
64. Specificity of the yeast rev3Δ antimutator and REV3 dependency of the mutator resulting from a defect (rad1Δ) in nucleotide excision repair
65. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
66. Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus
67. Pyrene nucleotide as a mechanistic probe: Evidence for a transient abasic site-like intermediate in the bypass of dipyrimidine photoproducts by T7 DNA polymerase
68. Roles of E. coli DNA polymerase IV and V in lesion-targeted and untargeted SOS mutagenesis
69. Requirement of RAD5 and MMS2 for post replication repair of UV-damaged DNA in Saccharomyces cerevisiae
70. Structure of the catalytic core of S. cerevisiae DNA polymerase η: Implications for translesion DNA synthesis
71. Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage
72. Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproducts
73. Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase η
74. Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase η
75. Mismatch extension ability of yeast and human DNA polymerase η
76. Yeast DNA polymerase η utilizes an induced fit mechanism of nucleotide incorporation
77. Humn DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini
78. Ultraviolet hypermutability of a shuttle vector propagated in xeroderma pigmentosum variant cells
79. Disruption of the developmentally regulated Rev31 gene causes embryonic lethality
80. An induced-fit kinetic mechanism for DNA replication fidelity: Direct measurement by single-turnover kinetics
81. Requirement of DNA polymerase η for error-free bypass of UV- induced CC and TC photoproducts
82. Crystal structure of a DinB lesion bypass DNA polymerase catalytic fragment reveals a classic polymerase catalytic domain