Splice variants but not mutations of DNA polymerase β are common in bladder cancer

Cancer Research

Volumn 62, Issue 11, 2002, Pages 3251-3256

  Thompson, Tracy E ^a   Taylor, Jack A ^a   Risinger, John I ^b   Rogan, Peter K ^c  

^a Genetic Epidemiology and Omics Research   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA DIRECTED DNA POLYMERASE BETA; GENOMIC DNA; MESSENGER RNA;

ALTERNATIVE RNA SPLICING; ARTICLE; BLADDER CANCER; BLADDER TUMOR; CHROMOSOME 8P; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SEQUENCE; EXCISION REPAIR; EXON; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR CLONING; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; SOMATIC MUTATION;

ALTERNATIVE SPLICING; CARCINOMA, TRANSITIONAL CELL; DNA POLYMERASE BETA; DNA, COMPLEMENTARY; DNA, NEOPLASM; EXONS; GENE DELETION; HUMANS; POINT MUTATION; POLYMORPHISM, GENETIC; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 0036606302     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. A genetic system to identify DNA polymerase β mutator mutants
2. Chromosomal location of the human gene for DNA polymerase β
3. Cytogenetic analysis of 57 primary prostatic adenocarcinomas
4. Chromosomal study demonstrating the clonal evolution and metastatic origin of a metachronous colorectal carcinoma
5. Cytogenetic studies in primary gastric cancer
6. Loss of heterozygosity from the short arm of chromosome 8 is an early event in breast cancers
7. Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer
8. Specific chromosome aberration in human renal cell carcinoma
9. Deletion mapping of chromosome 8 in cancers of the urinary bladder using restriction fragment length polymorphisms and microsatellite polymorphisms
10. Allelotype of human bladder cancer
11. Loss of heterozygosity in 8p is associated with microinvasion in colorectal carcinoma
12. Loss of heterozygosity from the short arm of chromosome 8 is associated with invasive behavior in breast cancer
13. DNA polymerase β gene mutation in human prostate cancer
14. DNA polymerase β gene mutations in human bladder cancer
15. DNA polymerase β mutations in human colorectal cancer
16. The human DNA polymerase β gene structure. Evidence of alternative splicing in gene expression
17. p53 mutations in bladder tumors from arylamine-exposed workers
18. Identification of novel mRNA isoforms for human DNA polymerase β
19. Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites
20. Human β-polymerase gene. Structure of the 5′-flanking region and active promoter
21. High throughput and economical mutation detection and RFLP analysis using a mini-method for DNA preparation from whole blood and acrylamide gel electrophoresis
22. Information analysis of human splice site mutations
23. Using information content and base frequencies to distinguish mutations from genetic polymorphisms in splice junction recognition sites
24. Information content of individual genetic sequences
25. Splice-site mutations in atherosclerosis candidate genes: Relating individual information to phenotype
26. Mutation analysis of 8p genes POLB and PPP2CB in bladder cancer
27. Variant forms of DNA polymerase β in primary lung carcinomas
28. Exon recognition in vertebrate splicing
29. A comparison of expressed sequence tags (ESTs) to human genomic sequences
30. Cells deficient in DNA polymerase β are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage
31. Identification of mutations in DNA polymerase β mRNAs from patients with Wemer syndrome
32. Alternative splicing of DNA polymerase β mRNA is not tumor-specific
33. Defective DNA repair genes in a primary culture of human renal cell carcinoma
34. Alteration of hMSH2 and DNA polymerase β genes in breast carcinomas and fibroadenomas
35. Polymorphisms in the human DNA polymerase β gene
36. Identification of exon sequences involved in splice site selection
37. A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers
38. Changes in pre-mRNA splicing factors during neural differentiation in P19 embryonal carcinoma cells
39. A novel isoform ratio switch of the polypyrimidine tract binding protein
40. CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line
41. Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis
42. Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins
43. A variant of DNA polymerase β acts as a dominant negative mutant
44. Mammalian base excision repair and DNA polymerase β