Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells

Genes and Development

Volumn 15, Issue 2, 2001, Pages 158-172

  Kannouche, Patricia ^a   Broughton, Bernard C ^a   Volker, Marcel ^b   Hanaoka, Fumio ^c   Mullenders, Leon H F ^b   Lehmann, Alan R ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

DNA polymerase; DNA replication; Foci; Translesion synthesis; UV radiation; Xeroderma pigmentosum

Indexed keywords

DNA POLYMERASE;

ARTICLE; CELL CYCLE S PHASE; DNA DAMAGE; DNA REPLICATION; DNA TEMPLATE; ENZYME ACTIVITY; ENZYME LOCALIZATION; EXCISION REPAIR; FIBROBLAST; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; ULTRAVIOLET RADIATION; XERODERMA PIGMENTOSUM;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE, TRANSFORMED; CELL NUCLEUS; DNA; DNA DAMAGE; DNA PRIMERS; DNA REPAIR; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN STRUCTURE, TERTIARY; RAD51 RECOMBINASE; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; ULTRAVIOLET RAYS; VARIATION (GENETICS); XERODERMA PIGMENTOSUM;

EID: 0035862988     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.187501     Document Type: Article

References (41)

1. Survey of radiosensitivity in a variety of human cell strains
2. The influence of caffeine on cell survival in excision-proficient and excision-deficient xeroderma pigmentosum and normal human cell strains following ultraviolet light irradiation
3. Specific complex formation between yeast RAD6 and RAD18 proteins: A potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites
4. Xeroderma pigmentosum and related disorders: Defects in DNA repair and transcription
5. Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: Association with DNA replication sites
6. Mutations in the xeroderma pigmentosum group D DNA repair gene in patients with trichothiodystrophy
7. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1
8. Increased ultraviolet sensitivity and chromosomal instability related to p53 function in the xeroderma pigmentosum variant
9. Replication fork bypass of a pyrimidine dimer blocking leading strand DNA synthesis
10. Impaired translesion synthesis in xeroderma pigmentosum extracts
11. Molecular mechanism of nucleotide excision repair
12. Ultraviolet-light irradiation of mouse L cells: Effects on cells in the DNA synthesis phase
13. Bypass of a site-specific cis-syn thymine dimer in an SV40 vector during in vitro replication by HeLa and XPV cell-free extracts
14. Coping with replication "train wrecks" in Escherichia coli using Pol V, Pol II and RecA proteins
15. Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes
16. hRAD30 mutations in the variant form of xeroderma pigmentosum
17. Efficient by-pass of a thymine-thymine dimer by yeast DNA polymerase, Polη
18. Fidelity of human DNA polymerase η
19. Inhibition of DNA replication by ionizing radiation is mediated by a trans-acting factor
20. Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation
21. Abnormal kinetics of DNA synthesis in ultraviolet light-irradiated cells from patients with Cockayne's syndrome
22. Inaugural article: Polymerase η deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair
23. Highly mutagenic replication by DNA polymerase V (UmuC) provides a mechanistic basis for SOS untargeted mutagenesis
24. Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
25. The human XPV (xeroderma pigmentosum variant) gene encodes human polymerase η
26. Accurate translesion synthesis by human DNA polymerase η
27. Low fidelity DNA synthesis by human DNA polymerase-η
28. Abnormal, error-prone bypass of photoproducts by xeroderma pigmentosum variant cell extracts results in extreme strand bias for the kinds of mutations induced by UV light
29. The N-terminal domain of human DNA ligase I contains the nuclear localization signal and directs the enzyme to sites of DNA replication
30. DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: Identification of a common targeting mechanism for the assembly of replication factories
31. Simultaneous establishment of monoclonal antibodies specific for either cyclobutane pyrimidine dimer or (6′-4′) photoproduct from the same mouse immunized with ultraviolet-irradiated DNA
32. Post-replicative base excision repair in replication foci
33. Nuclear export of proteins: The role of nuclear retention
34. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
35. Defective bypass replication of a leading strand cyclobutane thymine dimer in xeroderma pigmentosum variant cell extracts
36. Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens
37. A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair
38. Polη, a remarkably error-prone human DNA polymerase
39. Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells
40. A plethora of lesion-replicating DNA polymerases
41. Specificity of DNA lesion bypass by the yeast DNA polymerase η