Recent progress in the biology, chemistry and structural biology of DNA glycosylases

BioEssays

Volumn 23, Issue 3, 2001, Pages 270-281

  Schärer, Orlando D ^a   Jiricny, Josef ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA GLYCOSYLTRANSFERASE; GLYCOSIDASE;

AMINO ACID SEQUENCE; ANIMAL; BASE MISPAIRING; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DNA DAMAGE; DNA REPAIR; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; BASE PAIR MISMATCH; BINDING SITES; DNA; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; N-GLYCOSYL HYDROLASES; PROTEIN STRUCTURE, SECONDARY;

ZIZIPHUS MAURITIANA;

EID: 0035111895     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-1878(200103)23:3<270::AID-BIES1037>3.0.CO;2-J     Document Type: Review

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4. Reconstitution of the DNA base excision-repair pathway
5. Reconstitution of DNA base excision-repair with purified human proteins: Interaction between DNA polymerase beta and the XRCC1 protein
6. Second pathway for completion of human DNA base excision-repair: Reconstitution with purified proteins and requirement for DNase IV (FEN1)
7. Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps
8. Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon
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10. Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair
11. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway
12. Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1
13. DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination
14. The type of DNA glycosylase determines the base excision repair pathway in mammalian cells
15. Unified catalytic mechanism for DNA glycosylases
16. Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase
17. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication
18. Post-replicative base excision repair in replication foci
19. Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors
20. Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase
21. Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells
22. A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase
23. 3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase
24. The role of the Escherichia coli mug protein in the removal of uracil and 3,N(4)-ethenocytosine from DNA
25. Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase
26. 5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex
27. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
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31. MutT-related error avoidance mechanism for DNA synthesis
32. Mutagenesis by 8-oxoguanine: An enemy within
33. Repair of oxidatively damaged guanine in Saccharomyces cerevisiae by an alternative pathway
34. MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae
35. Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III
36. Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III
37. Excision of products of oxidative DNA base damage by human NTH1 protein
38. Saccnaromyces cerevisiae Ntg1p and Ntg2p: Broad specificity N- glycosylases for the repair of oxidative DNA damage in the nucleus and mitochondria
39. The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast
40. 3-methyladenine DNA glycosylases: Structure, function, and biological importance
41. Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene
42. Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage
43. Mitochondrial DNA repair pathways
44. Mutagenic deamination of cytosine residues in DNA
45. Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA
46. Life without DNA repair
47. Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase
48. Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4- ethenocytosine or 8-oxoguanine
49. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
50. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice
51. Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing
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54. Crystal structure and mutational analysis of human uracil-DNA glycosylase: Structural basis for specificity and catalysis
55. A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA
56. Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects
57. Crystal structure of a G:T/U mismatch-specific DNA glycosylase: Mismatch recognition by complementary-strand interactions
58. Crystal structure of a thwarted mismatch glycosylase DNA repair complex
59. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
60. Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure
61. MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily
62. Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: Mechanisms for nucleotide flipping and base excision
63. Structural basis for the excision repair of alkylation-damaged DNA
64. Three-dimensional structure of a DNA repair enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli
65. DNA bending and a flip-out mechanism for base excision by the helix- hairpin-helix DNA glycosylase, Escherichia coli AIKA
66. Atomic model of a pyrimidine dimer excision repair enzyme complexed with a DNA substrate: Structural basis for damaged DNA recognition
67. Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily
68. Chemical approaches toward understanding base excision DNA repair
69. Chemistry of glyeosylases and endonucleases involved in base-excision repair
70. DNA containing a chemically reduced apurinic site is a high affinity ligand for the E. coli formamidopyrimidine-DNA glycosylase
71. Specific binding of a designed pyrrolidine abasic site analog to multiple DNA glycosylases
72. AP site structural determinants for Fpg specific recognition
73. Unusually strong binding of a designed transition-state analog to a base-excision DNA repair protein
74. A designed inhibitor of base-excision DNA repair
75. Investigation of the mechanisms of DNA binding of the human G/T glycosylase using designed inhibitors
76. Substrate recognition by Escherichia coli MutY using substrate analogs
77. Hhal methyltransferase flips its target base out of the DNA helix
78. The Crystal structure of Haelli methyltransferase convalently complexed to DNA: An extrahelical cytosine and rearranged base pairing
79. Excision of cytosine and thymine from DNA by mutants of human uracil- DNA glycosylase
80. DNA Repair Enzymes
81. Release of normal bases from intact DNA by a native DNA repair enzyme
82. Generation of a strong mutator phenotype in yeast by imbalanced base excision repair
83. Imbalanced base excision repair increases spontaneous mutation and alkylation sensitivity in Escherichia coli
84. Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase
85. Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: Electrophilic catalysis of uracil expulsion by a neutral histidine 187
86. Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis
87. Mechanisms of enzymatic glycoside hydrolysis
88. Snapshots along an enzymatic reaction coordinate: Analysis of a retaining beta-glycoside hydrolase
89. Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG