Cells deficient in DNA polymerase β are hypersensitive to alkylating agentinduced apoptosis and chromosomal breakage

Cancer Research

Volumn 59, Issue 7, 1999, Pages 1544-1551

  Ochs, Kirsten ^a   Sobol, Robert W ^b   Wilson, Samuel H ^b   Kaina, Bernd ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; CELL DNA; CISPLATIN; DIHYDROXYBENZO[A]PYRENE OXIDE; DNA DIRECTED DNA POLYMERASE BETA; MELPHALAN; METHYLNITRONITROSOGUANIDINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CHROMOSOME BREAKAGE; CONTROLLED STUDY; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; ENZYME DEFICIENCY; GENOTOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALKYLATING AGENTS; ANIMALS; APOPTOSIS; CHROMOSOME ABERRATIONS; DNA DAMAGE; DNA POLYMERASE BETA; DNA REPAIR; METHYL METHANESULFONATE; METHYLNITRONITROSOGUANIDINE; MICE; MICE, KNOCKOUT; NECROSIS;

EID: 0033118432     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Peto, R., Gray, R., Bantom, P., and Grosso, P. N-nitroso compounds: occurrence, biological effects and relevance to human cancer. IARC Sci. Publ., 57: 627-655, 1985.
2. Tew, K., Colvin, M., and Chabner, B. A. Alkylating agents. In: B. A. Chabner and D. L. Longo (eds.), Cancer Chemotherapy: Principles and Practice, Ed. 2. Philadelphia: J. B. Lippincott Co., 1995.
3. Singer, B., and Grunberger, D. Molecular Biology of Mutagens and Carcinogens. New York: Plenum Press, 1983.
4. 6-ethylguanine as molecular dosimeter for extrapolation from cells to the mouse. Environ. Health Perspect. 62: 163-169, 1985.
5. Natarajan, A. T., Simons, J. W. I. M., Vogel, E. W., and van Zeeland, A. A. Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells. A correlation with different ethylation products in DNA. Mutat. Res., 128: 31-40, 1984.
6. 6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents. Carcinogenesis (Lond.), 12: 1857-1867, 1991.
7. Engelward, B. P., Dreslin, A., Christensen, J., Huszar, D., Kurahara, C., and Samson, L. Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing. EMBO J., 15: 945-952, 1996.
8. 6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines. Environ. Mol. Mutagen., 22: 283-292, 1993.
9. Beranek, D. T. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res., 231: 11-30, 1990.
10. Friedberg, E. C., Walker, G. C., and Siede, W. DNA Repair and Mutagenesis, Washington, DC: ASM Press, 1995.
11. Dianov, G., Price, A., and Lindahl, T. Generation of single-nucleotide repair patches following excision of uracil residues from DNA. Mol. Cell. Biol., 12: 1605-1612, 1992.
12. Wilson, S. H. Gene regulation and structure-function studies of mammalian DNA polymerase β. In: P. R. a. W. Strauss, S. (ed.) The Eukaryotic Nucleus, Vol. 1, pp. 199-233. West Caldwell, NJ: Telford Press, 1990.
13. Singhal, R. K., and Wilson, S. H. Short gap-filling synthesis by DNA polymerase β is processive, J. Biol. Chem., 268: 15906-15911, 1993.
14. Matsumoto, Y., Kim, K., and Bogenhagen, D. F. Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair. Mol. Cell. Biol., 14: 6187-6197, 1994.
15. Singhal, R. K., Prasad, R., and Wilson, S. H. DNA polymerase b conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. J. Biol. Chem., 270: 949-957, 1995.
16. Matsumoto, Y., and Kim, K. Excision of deoxyribose phosphate residues by DNA polymerase β during DNA repair. Science (Washington DC), 269: 699-702, 1995.
17. Fornace, A. J., Jr., Zmudzka, B., Hollander, C., and Wilson, S. H. Induction of β-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells. Mol. Cell. Biol., 9: 851-853, 1989.
18. Oda, N., Levin, J. D., Spoonde, A. Y., Frank, E. G., Levine, A. S., Woodgate, R., and Ackerman, E. Arrested DNA replication in Xenopus and release by Escherichia coli mutagenesis proteins. Science (Washington DC), 272: 1644-1646, 1996.
19. Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., and Rajewsky, K. Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting. Science (Washington DC), 265: 103-106, 1994.
20. Xanthoudakis, S., Smeyne, R. J., Wallace, J. D., and Curran, T. The redox/DNA repair protein. Ref-1, is essential for early embryonic development in mice. Proc. Natl. Acad. Sci. USA, 93: 8919-8923, 1996.
21. Bentley, D., Selfridge, J., Millar, J. K., Samuel, K., Hole, N., Ansell, J. D., and Melton, D. W. DNA ligase 1 is required for fetal liver erythropoesis but is not essential for mammalian cell viability. Nat. Genet., 13: 489-491, 1996.
22. Sobol, R. W., Horton, J. K., Kühn, R., Gu, H., Singhai, R. K., Prasad, R., Rajewsky, K., and Wilson, S. H. Requirement of mammalian DNA polymerase-β in base-excision repair. Nature (Lond.), 379: 183-186, 1996.
23. 6-methylguanine DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs. Int. J. Cancer, 65: 506-512, 1996.
24. Ioannou, Y. A., and Chen, F. W. Quantitation of DNA fragmentation in apoptosis. Nucleic Acids Res., 24: 992-993, 1996.
25. Huschtscha, L. I., Jeitner, T. M., Andersson, C. E., Bartier, W. A., and Tattersall, M. H. N. Identification of apoptotic and necrotic human leukemic cells by flow cytometry. Exp. Cell Res., 212: 161-165, 1994.
26. Fraker, P. J., King, L. E., Lill-Elghanian, D., and Telford, W. G. Quantification of apoptotic events in pure and heterogeneous populations of cells using flow cytometer. Methods Cell Biol., 46: 57-76, 1995.
27. Vermes, I., Haanen, C., Steffens-Nakken, H., and Reutelingsberger, C. A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J. Immunol. Methods. 184: 39-51, 1995.
28. Kaina, B., Haas, S., and Kappes, H. A general role for c-Fos in cellular protection against DNA-damaging carcinogens and cytostatic drugs. Cancer Res., 57: 2721-2731, 1997.
29. + and methylation-tolerant mismatch repair compromised cells: facts and models. Mutat. Res., 381: 227-241, 1997.
30. 6-Alkylguanine DNA lesions trigger apoptosis. Carcinogenesis (Lond.), 19: 369-372, 1998.
31. Mitra, S., and Kaina, B. Regulation of repair of alkylation damage in mammalian genomes. Prog. Nucleic Acids Res. Mol. Biol., 44: 109-142, 1993.
32. Volkert, M. R. Adaptive response of Escherichia coli to alkylation damage. Environ. Mol. Mutagen., 11: 241-255, 1988.
33. Ono, Y., Futura, T., Ohmoto, T., Akiyama, K., and Seki, S. Stable expression in rat glioma cels of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme. APEX nucleasc. Mutat. Res., 315: 55-63, 1994.
34. Tomicic, M., Eschbach, E., and Kaina, B. Expression of yeast hut not human apurinic/apyrimidinic endonuelease renders Chinese hamster cells more resistant to DNA-damaging agents. Mutat. Res., 383: 155-165, 1997.
35. Boal, J. H., Ludemann, S. M., Ho, C. K., Engel, J., and Niemeyer, U. Direct detection of the intracellular formation of carboxyphosphamides using nuclear magnetic resonance spectroscopy. Arzneim. Forsch., 44: 84-93, 1994.
36. Crook, T. R., Souhami, R. L., Whyman, G. D., and McLean, A. E. Glutathione depiction as a determinant of sensitivity of human leukemia cells to cyclophosphamide. Cancer Res., 46: 5035-5038, 1986.
37. Dorr, R. T., Bowdan, G. T., Alberts, D. S., and Liddil, J. D. Interactions of milomycin C with mammalian DNA detected by alkaline elution. Cancer Res., 45: 3510-3516, 1985.
38. Tong, W. P., Kohn, K. W., and Ludlum, D. B. Modifications of DNA by different haloethylnitrosoureas. Cancer Res., 42: 4460-4464, 1992.
39. Pritsos, C. A., and Sartorelli, A. C. Generation of reactive oxygen radicals through bioactivation of mitomycin antibiotics. Cancer Res., 46: 3528-3532, 1986.
40. Chung, F. L., Krzeminsky, L. Wang, M., Chen, H. I., and Prokopczyk, B. Formation of the acrolein-derived 1, N2-propanodeoxyguanosine adducts in DNA upon reaction with 3-(N-carbethoxy-N-nitrosamino)propionaldehyde. Chem. Res. Toxicol., 7: 62-67, 1994.
41. Boerth, D. W., Eder, E., Hussain, S., and Hoffman, C. Structures of acrolein-guanine adducts: a semi-empirical self-consistent field and nuclear magnetic resonance spectral study. Chem. Res. Toxicol., 11: 284-294, 1998.