Hinge residue I174 Is critical for proper dNTP selection by DNA polymerase

Biochemistry

Volumn 49, Issue 11, 2010, Pages 2326-2334

  Yamtich, Jen ^a   Starcevic, Daniela ^a   Lauper, Julia ^a   Smith, Elenoe ^a   Shi, Idina ^a   Rangarajan, Sneha ^b   Jaeger, Joachim ^b   Sweasy, Joann B ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING POCKETS; DNA POLYMERASE; DNA REPAIR PATHWAYS; GAP FILLING; GENETIC SCREENS; GROUND-STATE BINDING; HYDROPHOBIC RESIDUES; KINETIC ANALYSIS; KINETIC PATHWAY; MOLECULAR DYNAMICS SIMULATIONS; POLYMERASE FIDELITY; PROTEIN DYNAMICS; SUB-DOMAINS; WILD TYPES;

AMINO ACIDS; DNA; GENES; GROUND STATE; HYDROPHOBICITY; MOLECULAR DYNAMICS; PHOSPHATASES; PROTEIN FOLDING; REPAIR;

POLYMERS;

AMINO ACID; DNA DIRECTED DNA POLYMERASE BETA; PARATHION; SERINE;

ARTICLE; GENE MUTATION; GENETIC SCREENING; GEOMETRY; KINETICS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; WILD TYPE;

ANIMALS; BASE PAIR MISMATCH; BASE SEQUENCE; DNA; DNA POLYMERASE BETA; ISOLEUCINE; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS; MUTATION; NUCLEOTIDES; PROTEIN CONFORMATION; PROTEIN FOLDING; RATS; SUBSTRATE SPECIFICITY;

EID: 77949519759     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi901735a     Document Type: Article

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