Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts

DNA Repair

Volumn 4, Issue 6, 2005, Pages 714-724

  King, Nicole M ^a   Nikolaishvili Feinberg, Nana ^a   Bryant, Miriam F ^a   Luche, Douglas D ^a,d   Heffernan, Timothy P ^a,e   Simpson, Dennis A ^a   Hanaoka, Fumio ^b   Kaufmann, William K ^a,c   Cordeiro Stone, Marila ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

DNA polymerase eta; Mutagenesis; Spontaneous mutation rate; Translesion synthesis; Ultraviolet light; Xeroderma pigmentosum variant

Indexed keywords

DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE ETA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MESSENGER RNA; PLATINUM; PYRIMIDINE; UNCLASSIFIED DRUG;

ARTICLE; CELL IMMORTALIZATION; CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; DIPLOIDY; DNA REPAIR; FIBROBLAST; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MOLECULAR CLONING; MUTAGENESIS; PRIORITY JOURNAL; RETROVIRUS; ULTRAVIOLET RADIATION; WILD TYPE; XERODERMA PIGMENTOSUM;

BLOTTING, WESTERN; CAFFEINE; CELL LINE, TRANSFORMED; DIPLOIDY; DNA REPAIR; DNA-DIRECTED DNA POLYMERASE; ECDYSTERONE; FIBROBLASTS; FRAMESHIFT MUTATION; GENE DOSAGE; GENETIC COMPLEMENTATION TEST; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; KINETICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ULTRAVIOLET RAYS; VARIATION (GENETICS); XERODERMA PIGMENTOSUM;

EID: 19344375950     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2005.04.002     Document Type: Article

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