Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 5, 2009, Pages 1811-1816

  Kimura, Takuma ^a   Takeuchi, Toshifumi ^a   Kumamoto Yonezawa, Yuko ^b   Ohashi, Eiji ^c   Ohmori, Haruo ^c   Masutani, Chikahide ^d   Hanaoka, Fumio ^e   Sugawara, Fumio ^a   Yoshida, Hiromi ^b   Mizushina, Yoshiyuki ^b  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e GAKUSHUIN UNIVERSITY   (Japan)

Author keywords

5 Methoxy 3(2H) furanone; Anti cancer agents; DNA polymerase ; Enzyme inhibitor; Penicilliol; Y Family DNA polymerases

Indexed keywords

4 (3 HYDROXYBUTANOYL) 2 (5 HYDROXYHEXA 1,3 DIEN 1 YL) 5 METHOXY 2 METHYLFURAN 3(2H) ONE; 4 (BUT 2 ENOYL) 2 (5 HYDROXYHEXA 1,3 DIEN 1 YL) 5 METHOXY 2 METHYLFURAN 3(2H) ONE; 5 METHOXY 3(2H) FURANONE DERIVATIVE; ANTINEOPLASTIC AGENT; DEOXYRIBONUCLEASE I; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE BETA; DNA DIRECTED DNA POLYMERASE DELTA; DNA DIRECTED DNA POLYMERASE EPSILON; DNA DIRECTED DNA POLYMERASE ETA; DNA DIRECTED DNA POLYMERASE GAMMA; DNA NUCLEOTIDYLEXOTRANSFERASE; DNA POLYMERASE; DNA POLYMERASE IOTA; DNA POLYMERASE KAPPA; DNA POLYMERASE LAMBDA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR; INOSINATE DEHYDROGENASE; PENICILLIOL A; PENICILLIOL B; POLYNUCLEOTIDE 5' HYDROXYL KINASE; RNA DIRECTED DNA POLYMERASE; RNA POLYMERASE; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; EUKARYOTE; FUNGUS; FUNGUS CULTURE; HUMAN; MAMMAL; NONHUMAN; PENICILLIUM DALEAE; SPECTROSCOPY;

ANIMALS; CATTLE; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LACTONES; MICE; PENICILLIUM;

BOVINAE; BRYOPHYTA; EUKARYOTA; FUNGI; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA; PENICILLIUM DALEAE;

EID: 61349196981     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.064     Document Type: Article

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