Inflammation-related gene expression by lipid oxidation-derived products in the progression of atherosclerosis

Free Radical Biology and Medicine

Volumn 52, Issue 1, 2012, Pages 19-34

  Leonarduzzi, Gabriella ^a   Gamba, Paola ^a   Gargiulo, Simona ^a   Biasi, Fiorella ^a   Poli, Giuseppe ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Aldehydes; Atherosclerosis; Cell signaling; Core aldehydes; Free radicals; Inflammation; Leukotrienes; Oxidized LDL; Oxidized phospholipids; Oxysterols; Prostanoids

Indexed keywords

ARACHIDONIC ACID; ICOSANOID; LIPOXYGENASE; MEMBRANE PHOSPHOLIPID; PROSTAGLANDIN SYNTHASE;

ARTERY INTIMA; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; GENE EXPRESSION; HUMAN; INFLAMMATION; LIPID OXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW;

ANIMALS; ATHEROSCLEROSIS; BLOOD VESSELS; EICOSANOIDS; ENDOTHELIUM, VASCULAR; FREE RADICALS; GENE EXPRESSION; HUMANS; INFLAMMATION; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MICE; MICE, TRANSGENIC; OXIDATION-REDUCTION; PLAQUE, ATHEROSCLEROTIC; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84655169879     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.09.031     Document Type: Review

References (280)

1. J.L. Witztum, and D. Steinberg The oxidative modification hypothesis of atherosclerosis: does it hold for humans? Trends Cardiovasc. Med. 11 2001 93 102 (Pubitemid 33070331)
2. A. Tedgui, and Z. Mallat Cytokines in atherosclerosis: pathogenic and regulatory pathways Physiol. Rev. 86 2006 515 581
3. G.K. Hansson Inflammation, atherosclerosis, and coronary artery disease N. Engl. J. Med. 352 2005 1685 1695
4. P. Libby, P.M. Ridker, and G.K. Hansson Leducq Transatlantic Network on Atherothrombosis: Inflammation in atherosclerosis: from pathophysiology to practice J. Am. Coll. Cardiol. 54 2009 2129 2138
5. A. Fougerat, S. Gayral, N. Malet, F. Briand-Mesange, M. Breton-Douillon, and M. Laffargue Phosphoinositide 3-kinases and their role in inflammation: potential clinical targets in atherosclerosis? Clin. Sci. (London) 116 2009 791 804
6. P. Libby, P.M. Ridker, and G.K. Hansson Progress and challenges in translating the biology of atherosclerosis Nature 473 2011 317 325
7. C.L. Speyer, and P.A. Ward Role of endothelial chemokines and their receptors during inflammation J. Invest. Surg. 24 2011 18 27
8. J.E. McLaren, D.R. Michael, T.G. Ashlin, and D.P. Ramji Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy Prog. Lipid Res. 50 2011 331 347
9. D. Steinberg Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime Nat. Med. 8 2002 1211 1217 (Pubitemid 35373551)
10. D. Steinberg Hypercholesterolemia and inflammation in atherogenesis: two sides of the same coin Mol. Nutr. Food Res. 49 2005 995 998 (Pubitemid 41735560)
11. A.C. Cave, A.C. Brewer, A. Narayanapanicker, R. Ray, D.J. Grieve, S. Walker, and A.M. Shah NADPH oxidases in cardiovascular health and disease Antioxid. Redox Signal. 8 2006 691 728 (Pubitemid 44043102)
12. J.A. Berliner, and J.W. Heinecke The role of oxidized lipoproteins in atherogenesis Free Radic. Biol. Med. 20 1996 707 727 (Pubitemid 26105783)
13. L. Badimon, R.F. Storey, and G. Vilahur Update on lipids, inflammation and atherothrombosis Thromb. Haemost. 105 Suppl. 1 2011 S34 S42
14. G. Leonarduzzi, M.C. Arkan, H. Başaǧa, E. Chiarpotto, A. Sevanian, and G. Poli Lipid oxidation products in cell signaling Free Radic. Biol. Med. 28 2000 1370 1378 (Pubitemid 30621481)
15. C. Mazière, and J.C. Mazière Activation of transcription factors and gene expression by oxidized low-density lipoprotein Free Radic. Biol. Med. 46 2009 127 137
16. K.G. Birukov Oxidized lipids: the two faces of vascular inflammation Curr. Atheroscler. Rep. 8 2006 223 231 (Pubitemid 43676326)
17. G.J. Schroepfer Jr. Oxysterols: modulators of cholesterol metabolism and other processes Physiol. Rev. 80 2000 361 554 (Pubitemid 30060568)
18. G. Leonarduzzi, B. Sottero, and G. Poli Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects J. Nutr. Biochem. 13 2002 700 710 (Pubitemid 35463198)
19. S. Gill, R. Chow, and A.J. Brown Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised Prog. Lipid Res. 47 2008 391 404
20. W.L. Smith, and R.C. Murphy Oxidized lipids formed non-enzymatically by reactive oxygen species J. Biol. Chem. 283 2008 15513 15514
21. A.J. Brown, and W. Jessup Oxysterols: sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis Mol. Aspects Med. 30 2009 111 122
22. G. Poli, B. Sottero, S. Gargiulo, and G. Leonarduzzi Cholesterol oxidation products in the vascular remodeling due to atherosclerosis Mol. Aspects Med. 30 2009 180 189
23. B. Sottero, P. Gamba, S. Gargiulo, G. Leonarduzzi, and G. Poli Cholesterol oxidation products and disease: an emerging topic of interest in medicinal chemistry Curr. Med. Chem. 16 2009 685 705
24. A. Otaegui-Arrazola, M. Menéndez-Carreño, D. Ansorena, and I. Astiasarán Oxysterols: a world to explore Food Chem. Toxicol. 48 2010 3289 3303
25. V.M. Olkkonen, and R. Hynynen Interactions of oxysterols with membranes and proteins Mol. Aspects Med. 30 2009 123 133
26. N. Shibata, and C.K. Glass Macrophages, oxysterols and atherosclerosis Circ. J. 74 2010 2045 2051
27. D. Töröcsik, A. Szanto, and L. Nagy Oxysterol signaling links cholesterol metabolism and inflammation via the liver X receptor in macrophages Mol. Aspects Med. 30 2009 134 152
28. G. Leonarduzzi, P. Gamba, B. Sottero, A. Kadl, F. Robbesyn, R.A. Calogero, F. Biasi, E. Chiarpotto, N. Leitinger, A. Sevanian, and G. Poli Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells Free Radic. Biol. Med. 39 2005 1152 1161 (Pubitemid 41407710)
29. S. Gargiulo, B. Sottero, P. Gamba, E. Chiarpotto, G. Poli, and G. Leonarduzzi Plaque oxysterols induce unbalanced up-regulation of matrix metalloproteinase-9 in macrophagic cells through redox-sensitive signaling pathways: implications regarding the vulnerability of atherosclerotic lesions Free Radic. Biol. Med. 51 2011 844 855
30. G. Leonarduzzi, S. Gargiulo, P. Gamba, M.G. Perrelli, I. Castellano, A. Sapino, B. Sottero, and G. Poli Molecular signaling operated by a diet-compatible mixture of oxysterols in up-regulating CD36 receptor in CD68 positive cells Mol. Nutr. Food Res. 54 Suppl. 1 2010 S31 S41
31. C. Prunet, T. Montange, A. Véjux, A. Laubriet, J.F. Rohmer, J.M. Riedinger, A. Athias, S. Lemaire-Ewing, D. Néel, J.M. Petit, E. Steinmetz, R. Brenot, P. Gambert, and G. Lizard Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients Cytometry A 69 2006 359 373 (Pubitemid 44651349)
32. A.J. Muslin MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets Clin. Sci. (London) 115 2008 203 218
33. Y. Liu, L.M. Hultén, and O. Wiklund Macrophages isolated from human atherosclerotic plaques produce IL-8, and oxysterols may have a regulatory function for IL-8 production Arterioscler. Thromb. Vasc. Biol. 17 1997 317 323 (Pubitemid 27098190)
34. E.K. Rydberg, L. Salomonsson, L.M. Hultén, K. Norén, G. Bondjers, O. Wiklund, T. Björnheden, and B.G. Ohlsson Hypoxia increases 25-hydroxycholesterol-induced interleukin-8 protein secretion in human macrophages Atherosclerosis 170 2003 245 252 (Pubitemid 37377796)
35. S. Lemaire-Ewing, C. Prunet, T. Montange, A. Vejux, A. Berthier, G. Bessède, L. Corcos, P. Gambert, D. Néel, and G. Lizard Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols Cell Biol. Toxicol. 21 2005 97 114 (Pubitemid 41253203)
36. C. Erridge, D.J. Webb, and C.M. Spickett 25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages Free Radic. Res. 41 2007 260 266 (Pubitemid 46404468)
37. S. Lemaire-Ewing, A. Berthier, M.C. Royer, E. Logette, L. Corcos, A. Bouchot, S. Monier, C. Prunet, M. Raveneau, C. Rébé, C. Desrumaux, G. Lizard, and D. Néel 7beta-Hydroxycholesterol and 25- hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent Cell Biol. Toxicol. 25 2009 127 139
38. B. Bai, K. Yamamoto, H. Sato, H. Sugiura, and T. Tanaka Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon carcinoma cell line (Caco-2) Inflammation 29 2005 141 146 (Pubitemid 44897911)
39. M. Moreau, I. Brocheriou, L. Petit, E. Ninio, M.J. Chapman, and M. Rouis Interleukin-8 mediates downregulation of tissue inhibitor of metalloproteinase-1 expression in cholesterol-loaded human macrophages: relevance to stability of atherosclerotic plaque Circulation 99 1999 420 426 (Pubitemid 29051269)
40. P. Palozza, R. Simone, A. Catalano, G. Monego, A. Barini, M.C. Mele, N. Parrone, S. Trombino, N. Picci, and F.O. Ranelletti Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression J. Nutr. Biochem. 22 2011 259 268
41. T. Rosklint, B.G. Ohlsson, O. Wiklund, K. Norén, and L.M. Hultén Oxysterols induce interleukin-1beta production in human macrophages Eur. J. Clin. Invest. 32 2002 35 42 (Pubitemid 36228381)
42. G. Lizard, S. Lemaire, S. Monier, S. Gueldry, D. Néel, and P. Gambert Induction of apoptosis and of interleukin-1beta secretion by 7beta-hydroxycholesterol and 7-ketocholesterol: partial inhibition by Bcl-2 overexpression FEBS Lett. 419 1997 276 280 (Pubitemid 28010826)
43. S. Lemaire, G. Lizard, S. Monier, C. Miguet, S. Gueldry, F. Volot, P. Gambert, and D. Néel Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol FEBS Lett. 440 1998 434 439 (Pubitemid 29052329)
44. S.C. Sung, K. Kim, K.A. Lee, K.H. Choi, S.M. Kim, Y.H. Son, Y.S. Moon, S.K. Eo, and B.Y. Rhim 7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells J. Vasc. Res. 46 2009 36 44
45. U. Ikeda, T. Ito, and K. Shimada Interleukin-6 and acute coronary syndrome Clin. Cardiol. 24 2001 701 704 (Pubitemid 33027552)
46. M.S. Landis, H.V. Patel, and J.P. Capone Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes J. Biol. Chem. 277 2002 4713 4721 (Pubitemid 34968502)
47. Y. Feng, G.F. Schreiner, S. Chakravarty, D.Y. Liu, and A.H. Joly Inhibition of the mitogen activated protein kinase, p38 alpha, prevents proinflammatory cytokine induction by human adherent mononuclear leukocytes in response to lipid loading Atherosclerosis 158 2001 331 338 (Pubitemid 32913642)
48. M.I. Dushkin, O.M. Khoshchenko, E.N. Kudinova, and Y.S. Schwartz Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages Bull. Exp. Biol. Med. 141 2006 233 235 (Pubitemid 43792715)
49. J. Dulak, A. Józkowicz, W. Dichtl, H. Alber, S.P. Schwarzacher, O. Pachinger, and F. Weidinger Vascular endothelial growth factor synthesis in vascular smooth muscle cells is enhanced by 7-ketocholesterol and lysophosphatidylcholine independently of their effect on nitric oxide generation Atherosclerosis 159 2001 325 332 (Pubitemid 33127246)
50. G. Leonarduzzi, A. Sevanian, B. Sottero, M.C. Arkan, F. Biasi, E. Chiarpotto, H. Basaga, and G. Poli Up-regulation of the fibrogenic cytokine TGF-beta1 by oxysterols: a mechanistic link between cholesterol and atherosclerosis FASEB J. 15 2001 1619 1621
51. R. Kraemer, K.B. Pomerantz, J. Joseph-Silverstein, and D.P. Hajjar Induction of basic fibroblast growth factor mRNA and protein synthesis in smooth muscle cells by cholesteryl ester enrichment and 25-hydroxycholesterol J. Biol. Chem. 268 1993 8040 8045 (Pubitemid 23120385)
52. N. Tamasawa, H. Murakami, J. Matsui, K. Yamato, G. JingZhi, T. Imaizumi, K. Fujimoto, H. Yoshida, K. Satoh, and T. Suda An oxidized derivative of cholesterol increases the release of soluble vascular cell adhesion molecule-1 from human umbilical vein endothelial cells in culture Biochim. Biophys. Acta 1531 2001 178 187 (Pubitemid 32452423)
53. G. Romeo, J.V. Frangioni, and A. Kazlauskas Profilin acts downstream of LDL to mediate diabetic endothelial cell dysfunction FASEB J. 18 2004 725 727
54. Y. Naito, M. Shimozawa, H. Manabe, N. Nakabe, K. Katada, S. Kokura, N. Yoshida, H. Ichikawa, T. Kon, and T. Yoshikawa Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species Eur. J. Pharmacol. 546 2006 11 18 (Pubitemid 44331840)
55. Y. Naito, M. Shimozawa, M. Kuroda, N. Nakabe, H. Manabe, K. Katada, S. Kokura, H. Ichikawa, N. Yoshida, N. Noguchi, and T. Yoshikawa Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules Atherosclerosis 180 2005 19 25
56. G.R. Romeo, and A. Kazlauskas Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1 J. Biol. Chem. 283 2008 9595 9605
57. M.J. Duran, S.V. Pierre, P. Lesnik, G. Pieroni, M. Bourdeaux, F. Dignat-Georges, J. Sampol, and J.M. Maixent 7-Ketocholesterol inhibits Na,K-ATPase activity by decreasing expression of its α1-subunit and membrane fluidity in human endothelial cells Cell Mol. Biol. (Noisy-le-grand) 56 2010 OL1434 OL1441 (Suppl.)
58. G. Leonarduzzi, P. Gamba, S. Gargiulo, B. Sottero, A. Kadl, F. Biasi, E. Chiarpotto, N. Leitinger, G. Vendemiale, G. Serviddio, and G. Poli Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixture Aging Cell 7 2008 375 382 (Pubitemid 351663906)
59. B. Fuhrman, A. Partoush, N. Volkova, and M. Aviram Ox-LDL induces monocyte-to-macrophage differentiation in vivo: possible role for the macrophage colony stimulating factor receptor (M-CSF-R) Atherosclerosis 196 2008 598 607
60. Y.I. Miller, S.H. Choi, L. Fang, and R. Harkewicz Toll-like receptor-4 and lipoprotein accumulation in macrophages Trends Cardiovasc. Med. 19 2009 227 232
61. S. Kiechl, E. Lorenz, M. Reindl, C.J. Wiedermann, F. Oberhollenzer, E. Bonora, J. Willeit, and D.A. Schwartz Toll-like receptor 4 polymorphisms and atherogenesis N. Engl. J. Med. 347 2002 185 192 (Pubitemid 34764822)
62. A. Vejux, E. Kahn, F. Ménétrier, T. Montange, J. Lherminier, J.M. Riedinger, and G. Lizard Cytotoxic oxysterols induce caspase-independent myelin figure formation and caspase-dependent polar lipid accumulation Histochem. Cell Biol. 127 2007 609 624 (Pubitemid 46879054)
63. A. Vejux, L. Malvitte, and G. Lizard Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis Braz. J. Med. Biol. Res. 41 2008 545 556
64. E. Orsó, M. Grandl, and G. Schmitz Oxidized LDL-induced endolysosomal phospholipidosis and enzymatically modified LDL-induced foam cell formation determine specific lipid species modulation in human macrophages Chem. Phys. Lipids 164 2011 479 487
65. C. Miguet-Alfonsi, C. Prunet, S. Monier, G. Bessède, S. Lemaire-Ewing, A. Berthier, F. Ménétrier, D. Néel, P. Gambert, and G. Lizard Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals Biochem. Pharmacol. 64 2002 527 541 (Pubitemid 34874856)
66. A. Vejux, S. Guyot, T. Montange, J.M. Riedinger, E. Kahn, and G. Lizard Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis J. Nutr. Biochem. 20 2009 45 61
67. I. Tabas Macrophage death and defective inflammation resolution in atherosclerosis Nat. Rev. Immunol. 10 2010 36 46
68. V. Antonio, B. Janvier, A. Brouillet, M. Andreani, and M. Raymondjean Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells Biochem. J. 376 Pt 2 2003 351 360 (Pubitemid 38010519)
69. S.R. Panini, L. Yang, A.E. Rusinol, M.S. Sinensky, J.V. Bonventre, and C.C. Leslie Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol J. Lipid Res. 42 2001 1678 1686 (Pubitemid 33020101)
70. N.E. Freeman, A.E. Rusinol, M. Linton, D.L. Hachey, S. Fazio, M.S. Sinensky, and D. Thewke Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages J. Lipid Res. 46 2005 1933 1943 (Pubitemid 41248490)
71. E.R. Wohlfeil, and W.B. Campbell 25-Hydroxycholesterol enhances eicosanoid production in cultured bovine coronary artery endothelial cells by increasing prostaglandin G/H synthase-2 Biochim. Biophys. Acta 1345 1997 109 120 (Pubitemid 27105908)
72. 2 + signals and inhibit the phosphorylation of endothelial NO synthase and cytosolic phospholipase A2 Biochem. J. 380 Pt 2 2004 533 539 (Pubitemid 38796451)
73. P.L. Liao, Y.W. Cheng, C.H. Li, Y.L. Lo, and J.J. Kang Cholesterol-3-beta, 5-alpha, 6-beta-triol induced PI(3)K-Akt-eNOS-dependent cyclooxygenase-2 expression in endothelial cells Toxicol. Lett. 190 2009 172 178
74. M.C. Englund, A.L. Karlsson, O. Wiklund, G. Bondjers, and B.G. Ohlsson 25-Hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages Atherosclerosis 158 2001 61 71 (Pubitemid 32735468)
75. M. Napolitano, and E. Bravo Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages Eur. J. Clin. Invest. 35 2005 482 490 (Pubitemid 41153202)
76. O.S. Kim, C.S. Lee, E.H. Joe, and I. Jou Oxidized low density lipoprotein suppresses lipopolysaccharide-induced inflammatory responses in microglia: oxidative stress acts through control of inflammation Biochem. Biophys. Res. Commun. 342 2006 9 18 (Pubitemid 43247353)
77. A. Castrillo, S.B. Joseph, S.A. Vaidya, M. Haberland, A.M. Fogelman, G. Cheng, and P. Tontonoz Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism Mol. Cell 12 2003 805 816 (Pubitemid 37352775)
78. S.B. Joseph, A. Castrillo, B.A. Laffitte, D.J. Mangelsdorf, and P. Tontonoz Reciprocal regulation of inflammation and lipid metabolism by liver X receptors Nat. Med. 9 2003 213 219 (Pubitemid 36227724)
79. R. Geyeregger, M. Zeyda, and T.M. Stulnig Liver X receptors in cardiovascular and metabolic disease Cell. Mol. Life Sci. 63 2006 524 539
80. P.A. Edwards, M.A. Kennedy, and P.A. Mak LXRs: oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis Vasc. Pharmacol. 38 2002 249 256 (Pubitemid 36398270)
81. S.A. Khan, and J.P. Vanden Heuvel Role of nuclear receptors in the regulation of gene expression by dietary fatty acids J. Nutr. Biochem. 14 2003 554 567 (Pubitemid 37239008)
82. T.J. Berrodin, Q. Shen, E.M. Quinet, M.R. Yudt, L.P. Freedman, and S. Nagpal Identification of 5α,6α-epoxycholesterol as a novel modulator of liver X receptor activity Mol. Pharmacol. 78 2010 1046 1058
83. X. Fu, J.G. Menke, Y. Chen, G. Zhou, K.L. MacNaul, S.D. Wright, C.P. Sparrow, and E.G. Lund 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells J. Biol. Chem. 276 2001 38378 38387
84. A. Castrillo, S.B. Joseph, C. Marathe, D.J. Mangelsdorf, and P. Tontonoz Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages J. Biol. Chem. 278 2003 10443 10449 (Pubitemid 36800310)
85. S.B. Joseph, E. McKilligin, L. Pei, M.A. Watson, A.R. Collins, B.A. Laffitte, M. Chen, G. Noh, J. Goodman, G.N. Hagger, J. Tran, T.K. Tippin, X. Wang, A.J. Lusis, W.A. Hsueh, R.E. Law, J.L. Collins, T.M. Willson, and P. Tontonoz Synthetic LXR ligand inhibits the development of atherosclerosis in mice Proc. Natl. Acad. Sci. U. S. A. 99 2002 7604 7609 (Pubitemid 34568738)
86. F. Morello, E. Saglio, A. Noghero, D. Schiavone, T.A. Williams, A. Verhovez, F. Bussolino, F. Veglio, and P. Mulatero LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms Atherosclerosis 207 2009 38 44
87. W. Huang, S. Ghisletti, V. Perissi, M.G. Rosenfeld, and C.K. Glass Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint Mol. Cell 35 2009 48 57
88. S. Ogawa, J. Lozach, K. Jepsen, D. Sawka-Verhelle, V. Perissi, R. Sasik, D.W. Rose, R.S. Johnson, M.G. Rosenfeld, and C.K. Glass A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation Proc. Natl. Acad. Sci. U. S. A. 101 2004 14461 14466 (Pubitemid 39346771)
89. S. Ghisletti, W. Huang, S. Ogawa, G. Pascual, M.E. Lin, T.M. Willson, M.G. Rosenfeld, and C.K. Glass Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma Mol. Cell 25 2007 57 70 (Pubitemid 46049061)
90. N. Noguchi, K. Nakano, Y. Aratani, H. Koyama, T. Kodama, and E. Niki Role of myeloperoxidase in the neutrophil-induced oxidation of low density lipoprotein as studied by myeloperoxidase-knockout mouse J. Biochem. 127 2000 971 976 (Pubitemid 30430150)
91. S. Ghosh, B. Zhao, J. Bie, and J. Song Macrophage cholesteryl ester mobilization and atherosclerosis Vasc. Pharmacol. 52 2010 1 10
92. L. Kritharides, W. Jessup, J. Gifford, and R.T. Dean A method for defining the stages of low-density lipoprotein oxidation by the separation of cholesterol- and cholesteryl ester-oxidation products using HPLC Anal. Biochem. 213 1993 79 89 (Pubitemid 23250620)
93. 2*- free radicals or by copper FEBS Lett. 451 1999 103 108 (Pubitemid 29231931)
94. R. Harkewicz, K. Hartvigsen, F. Almazan, E.A. Dennis, J.L. Witztum, and Y.I. Miller Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein J. Biol. Chem. 283 2008 10241 10251
95. I. Jedidi, M. Couturier, P. Thérond, M. Gardès-Albert, A. Legrand, R. Barouki, D. Bonnefont-Rousselot, and M. Aggerbeck Cholesteryl ester hydroperoxides increase macrophage CD36 gene expression via PPARα Biochem. Biophys. Res. Commun. 351 2006 733 738 (Pubitemid 44780858)
96. C. Degirolamo, G.S. Shelness, and L.L. Rudel LDL cholesteryl oleate as a predictor for atherosclerosis: evidence from human and animal studies on dietary fat J. Lipid Res. 50 2009 S434 S439 (Suppl.)
97. H. Kamido, A. Kuksis, L. Marai, and J.J. Myher Lipid ester-bound aldehydes among copper-catalyzed peroxidation products of human plasma lipoproteins J. Lipid Res. 36 1995 1876 1886
98. G. Hoppe, A. Ravandi, D. Herrera, A. Kuksis, and H.F. Hoff Oxidation products of cholesteryl linoleate are resistant to hydrolysis in macrophages, form complexes with proteins, and are present in human atherosclerotic lesions J. Lipid Res. 38 1997 1347 1360 (Pubitemid 27332562)
99. B. Karten, H. Boechzelt, P.M. Abuja, M. Mittelbach, and W. Sattler Macrophage-enhanced formation of cholesteryl ester-core aldehydes during oxidation of low density lipoprotein J. Lipid Res. 40 1999 1240 1253 (Pubitemid 29328527)
100. J. Huber, H. Boechzelt, B. Karten, M. Surboeck, V.N. Bochkov, B.R. Binder, W. Sattler, and N. Leitinger Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathway Arterioscler. Thromb. Vasc. Biol. 22 2002 581 586 (Pubitemid 34408737)
101. Y. Kawai, A. Saito, N. Shibata, M. Kobayashi, S. Yamada, T. Osawa, and K. Uchida Covalent binding of oxidized cholesteryl esters to protein: implications for oxidative modification of low density lipoprotein and atherosclerosis J. Biol. Chem. 278 2003 21040 21049 (Pubitemid 36806415)
102. B. Sottero, P. Gamba, M. Longhi, F. Robbesyn, P.M. Abuja, R.J. Schaur, G. Poli, and G. Leonarduzzi Expression and synthesis of TGFbeta1 is induced in macrophages by 9-oxononanoyl cholesterol, a major cholesteryl ester oxidation product Biofactors 24 2005 209 216 (Pubitemid 41750544)
103. S. Gargiulo, P. Gamba, B. Sottero, F. Biasi, E. Chiarpotto, G. Serviddio, G. Vendemiale, G. Poli, and G. Leonarduzzi The core-aldehyde 9-oxononanoyl cholesterol increases the level of transforming growth factor beta1-specific receptors on promonocytic U937 cell membranes Aging Cell 8 2009 77 87
104. H. Østerbauer, R.J. Schaur, and H. Zollner Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Free Radic. Biol. Med. 11 1991 81 128 (Pubitemid 121003917)
105. E. Niki, Y. Yoshida, Y. Saito, and N. Noguchi Lipid peroxidation: mechanisms, inhibition, and biological effects Biochem. Biophys. Res. Commun. 338 2005 668 676 (Pubitemid 41540614)
106. E. Niki Lipid peroxidation: physiological levels and dual biological effects Free Radic. Biol. Med. 47 2009 469 484
107. C. Schneider An update on products and mechanisms of lipid peroxidation Mol. Nutr. Food Res. 53 2009 315 321
108. F. Guéraud, M. Atalay, N. Bresgen, A. Cipak, P.M. Eckl, L. Huc, I. Jouanin, W. Siems, and K. Uchida Chemistry and biochemistry of lipid peroxidation products Free Radic. Res. 44 2010 1098 1124
109. D.R. Petersen, and J.A. Doorn Reactions of 4-hydroxynonenal with proteins and cellular targets Free Radic. Biol. Med. 37 2004 937 945 (Pubitemid 39164576)
110. G. Aldini, I. Dalle-Donne, R.M. Facino, A. Milzani, and M. Carini Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls Med. Res. Rev. 27 2007 817 868 (Pubitemid 350035121)
111. A. Catalá Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions Chem. Phys. Lipids 157 2009 1 11
112. G. Poli, R.J. Schaur, W.G. Siems, and G. Leonarduzzi 4-Hydroxynonenal: a membrane lipid oxidation product of medicinal interest Med. Res. Rev. 28 2008 569 631 (Pubitemid 351842143)
113. Y. Riahi, G. Cohen, O. Shamni, and S. Sasson Signaling and cytotoxic functions of 4-hydroxyalkenals Am. J. Physiol. Endocrinol. Metab. 299 2010 879 886
114. H.J. Forman Reactive oxygen species and alpha, beta-unsaturated aldehydes as second messengers in signal transduction Ann. N. Y. Acad. Sci. 1203 2010 35 44
115. Usatyuk, P.V.; Natarajan, V. Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function. Microvasc. Res. (in press); 2011.
116. G. Poli, and R.J. Schaur 4-Hydroxynonenal in the pathomechanisms of oxidative stress IUBMB Life 50 2000 315 321 (Pubitemid 32289090)
117. K. Uchida 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress Prog. Lipid Res. 42 2003 318 343 (Pubitemid 36411689)
118. C. Schneider, N.A. Porter, and A.R. Brash Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation J. Biol. Chem. 283 2008 15539 15543
119. M.U. Dianzani 4-Hydroxynonenal from pathology to physiology Mol. Aspects Med. 24 2003 263 272
120. G. Leonarduzzi, F. Robbesyn, and G. Poli Signaling kinases modulated by 4-hydroxynonenal Free Radic. Biol. Med. 37 2004 1694 1702 (Pubitemid 39445371)
121. P.V. Usatyuk, N.L. Parinandi, and V. Natarajan Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins J. Biol. Chem. 281 2006 35554 35566 (Pubitemid 46036589)
122. Y.M. Go, P.J. Halvey, J.M. Hansen, M. Reed, J. Pohl, and D.P. Jones Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesion Am. J. Pathol. 171 2007 1670 1681 (Pubitemid 350158327)
123. K. Uchida A lipid-derived endogenous inducer of COX-2: a bridge between inflammation and oxidative stress Mol. Cells 25 2008 347 351
124. S.P. Annangudi, Y. Deng, X. Gu, W. Zhang, J.W. Crabb, and R.G. Salomon Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE Chem. Res. Toxicol. 21 2008 1384 1395
125. M.R. Yun, D.S. Im, S.J. Lee, J.W. Woo, K.W. Hong, S.S. Bae, and C.D. Kim 4-Hydroxynonenal contributes to macrophage foam cell formation through increased expression of class A scavenger receptor at the level of translation Free Radic. Biol. Med. 45 2008 177 183
126. T. Ishii, K. Itoh, E. Ruiz, D.S. Leake, H. Unoki, M. Yamamoto, and G.E. Mann Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal Circ. Res. 94 2004 609 616 (Pubitemid 38387743)
127. S. Numazawa, M. Ishikawa, A. Yoshida, S. Tanaka, and T. Yoshida Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress Am. J. Physiol. Cell Physiol. 285 2003 C334 C342
128. R.C. Siow, T. Ishii, and G.E. Mann Modulation of antioxidant gene expression by 4-hydroxynonenal: atheroprotective role of the Nrf2/ARE transcription pathway Redox Rep. 12 2007 11 15 (Pubitemid 46210347)
129. M. Tanito, M.P. Agbaga, and R.E. Anderson Upregulation of thioredoxin system via Nrf2-antioxidant responsive element pathway in adaptive-retinal neuroprotection in vivo and in vitro Free Radic. Biol. Med. 42 2007 1838-1850 (Pubitemid 46754760)
130. M. Nitti, C. Domenicotti, C. d'Abramo, S. Assereto, D. Cottalasso, E. Melloni, G. Poli, F. Biasi, U.M. Marinari, and M.A. Pronzato Activation of PKC-β isoforms mediates HNE-induced MCP-1 release by macrophages Biochem. Biophys. Res. Commun. 294 2002 547 552 (Pubitemid 34694043)
131. G. Leonarduzzi, A. Scavazza, F. Biasi, E. Chiarpotto, S. Camandola, S. Vogel, R. Dargel, and G. Poli The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis FASEB J. 11 1997 851 857 (Pubitemid 27371894)
132. E. Chiarpotto, C. Allasia, F. Biasi, G. Leonarduzzi, F. Ghezzo, G. Berta, G. Bellomo, G. Waeg, and G. Poli Down-modulation of nuclear localisation and pro-fibrogenic effect of 4-hydroxy-2,3-nonenal by thiol- and carbonyl-reagents Biochim. Biophys. Acta 1584 2002 1 8 (Pubitemid 35223224)
133. E. Chiarpotto, L. Castello, G. Leonarduzzi, F. Biasi, and G. Poli Role of 4-hydroxy-2,3-nonenal in the pathogenesis of fibrosis Biofactors 24 2005 229 236 (Pubitemid 41750546)
134. S.J. Lee, K.W. Seo, M.R. Yun, S.S. Bae, W.S. Lee, K.W. Hong, and C.D. Kim 4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt/NF-κB signaling pathways Free Radic. Biol. Med. 45 2008 1487 1492
135. S.J. Lee, C.E. Kim, K.W. Seo, and C.D. Kim HNE-induced 5-LO expression is regulated by NF-κB/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages Cardiovasc. Res. 88 2010 352 359
136. S. Page, C. Fischer, B. Baumgartner, M. Haas, U. Kreusel, G. Loidl, M. Hayn, H.W. Ziegler-Heitbrock, D. Neumeier, and K. Brand 4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis J. Biol. Chem. 274 1999 11611 11618
137. Y. Hattori, S. Hattori, and K. Kasai 4-Hydroxynonenal prevents NO production in vascular smooth muscle cells by inhibiting nuclear factor-kappaB-dependent transcriptional activation of inducible NO synthase Arterioscler. Thromb. Vasc. Biol. 21 2001 1179 1183 (Pubitemid 34215147)
138. H. Minekura, T. Kumagai, Y. Kawamoto, F. Nara, and K. Uchida 4-Hydroxy-2-nonenal is a powerful endogenous inhibitor of endothelial response Biochem. Biophys. Res. Commun. 282 2001 557 561 (Pubitemid 32917907)
139. B. Donath, C. Fischer, S. Page, S. Prebeck, N. Jilg, M. Weber, C. da Costa, D. Neumeier, T. Miethke, and K. Brand Chlamydia pneumoniae activates IKK/I kappa B-mediated signaling, which is inhibited by 4-HNE and following primary exposure Atherosclerosis 165 2002 79 88 (Pubitemid 35223170)
140. S. Camandola, A. Scavazza, G. Leonarduzzi, F. Biasi, E. Chiarpotto, A. Azzi, and G. Poli Biogenic 4-hydroxy-2-nonenal activates transcription factor AP-1 but not NF-kappa B in cells of the macrophage lineage Biofactors 6 1997 173 179 (Pubitemid 27487822)
141. J. Ruef, M. Moser, C. Bode, W. Kübler, and M.S. Runge 4-Hydroxynonenal induces apoptosis, NF-kappaB-activation and formation of 8-isoprostane in vascular smooth muscle cells Basic Res. Cardiol. 96 2001 143 150 (Pubitemid 32236783)
142. J. Ruef, G.N. Rao, F. Li, C. Bode, C. Patterson, A. Bhatnagar, and M.S. Runge Induction of rat aortic smooth muscle cell growth by the lipid peroxidation product 4-hydroxy-2-nonenal Circulation 97 1998 1071 1078
143. M. Parola, G. Robino, F. Marra, M. Pinzani, G. Bellomo, G. Leonarduzzi, P. Chiarugi, S. Camandola, G. Poli, G. Waeg, P. Gentilini, and M.U. Dianzani HNE interacts directly with JNK isoforms in human hepatic stellate cells J. Clin. Invest. 102 1998 1942 1950 (Pubitemid 29001840)
144. A. Negre-Salvayre, O. Vieira, I. Escargueil-Blanc, and R. Salvayre Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity Mol. Aspects Med. 24 2003 251 261 (Pubitemid 36945025)
145. N. Auge, V. Garcia, F. Maupas-Schwalm, T. Levade, R. Salvayre, and A. Negre-Salvayre Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways Arterioscler. Thromb. Vasc. Biol. 22 2002 1990 1995 (Pubitemid 36025204)
146. C. Vindis, I. Escargueil-Blanc, K. Uchida, M. Elbaz, R. Salvayre, and A. Negre-Salvayre Lipid oxidation products and oxidized low-density lipoproteins impair platelet-derived growth factor receptor activity in smooth muscle cells: implication in atherosclerosis Redox Rep. 12 2007 96 100 (Pubitemid 46210365)
147. H. Kakishita, and Y. Hattori Vascular smooth muscle cell activation and growth by 4-hydroxynonenal Life Sci. 69 2001 689 697 (Pubitemid 32673627)
148. T.J. Lee, J.T. Lee, S.K. Moon, C.H. Kim, J.W. Park, and T.K. Kwon Age-related differential growth rate and response to 4-hydroxynonenal in mouse aortic smooth muscle cells Int. J. Mol. Med. 17 2006 29 35
149. S. Akiba, S. Kumazawa, H. Yamaguchi, N. Hontani, T. Matsumoto, T. Ikeda, M. Oka, and T. Sato Acceleration of matrix metalloproteinase-1 production and activation of platelet-derived growth factor receptor beta in human coronary smooth muscle cells by oxidized LDL and 4-hydroxynonenal Biochim. Biophys. Acta 1763 2006 797 804 (Pubitemid 44205278)
150. S.J. Lee, C.E. Kim, M.R. Yun, K.W. Seo, H.M. Park, J.W. Yun, H.K. Shin, S.S. Bae, and C.D. Kim 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK Toxicol. Appl. Pharmacol. 242 2010 191 198
151. K.W. Seo, S.J. Lee, C.E. Kim, M.R. Yun, H.M. Park, J.W. Yun, S.S. Bae, and C.D. Kim Participation of 5-lipoxygenase-derived LTB(4) in 4-hydroxynonenal-enhanced MMP-2 production in vascular smooth muscle cells Atherosclerosis 208 2010 56 61
152. K.S. Kilgore, and A.N. Billin PPARbeta/delta ligands as modulators of the inflammatory response Curr. Opin. Investig. Drugs 9 2008 463 469 (Pubitemid 351677899)
153. C. Fürnsinn, T.M. Willson, and B. Brunmair Peroxisome proliferator-activated receptor-delta, a regulator of oxidative capacity, fuel switching and cholesterol transport Diabetologia 50 2007 8 17 (Pubitemid 46035846)
154. L. Cheng, G. Ding, Q. Qin, Y. Huang, W. Lewis, N. He, R.M. Evans, M.D. Schneider, F.A. Brako, Y. Xiao, Y.E. Chen, and Q. Yang Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy Nat. Med. 10 2004 1245 1250 (Pubitemid 39540443)
155. U. Risérus, D. Sprecher, T. Johnson, E. Olson, S. Hirschberg, A. Liu, Z. Fang, P. Hegde, D. Richards, L. Sarov-Blat, J.C. Strum, S. Basu, J. Cheeseman, B.A. Fielding, S.M. Humphreys, T. Danoff, N.R. Moore, P. Murgatroyd, S. O'Rahilly, P. Sutton, T. Willson, D. Hassall, K.N. Frayn, and F. Karpe Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men Diabetes 57 2008 332 339
156. E.K. Long, and M.J. Picklo Sr. Trans-4-hydroxy-2-hexenal, a product of n-3 fatty acid peroxidation: make some room HNE... Free Radic Biol. Med. 49 2010 1 8
157. J.Y. Lee, J.H. Je, K.J. Jung, B.P. Yu, and H.Y. Chung Induction of endothelial iNOS by 4-hydroxyhexenal through NF-κB activation Free Radic. Biol. Med. 37 2004 539 548 (Pubitemid 38901086)
158. J.Y. Lee, J.H. Je, D.H. Kim, S.W. Chung, Y. Zou, N.D. Kim, M. Ae Yoo, H. Suck Baik, B.P. Yu, and H.Y. Chung Induction of endothelial apoptosis by 4-hydroxyhexenal Eur. J. Biochem. 271 2004 1339 1347 (Pubitemid 38523303)
159. M.M. Anderson, S.L. Hazen, F.F. Hsu, and J.W. Heinecke Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein: a mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation. J. Clin. Invest. 99 1997 424 432 (Pubitemid 27414799)
160. J.F. Stevens, and C.S. Maier Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease Mol. Nutr. Food Res. 52 2008 7 25 (Pubitemid 351211799)
161. Y.S. Park, and N. Taniguchi Acrolein induces inflammatory response underlying endothelial dysfunction: a risk factor for atherosclerosis Ann. N. Y. Acad. Sci. 1126 2008 185 189 (Pubitemid 351589296)
162. T.E. O'Toole, Y.T. Zheng, J. Hellmann, D.J. Conklin, O. Barski, and A. Bhatnagar Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages Toxicol. Appl. Pharmacol. 236 2009 194 201
163. G.O. Fruhwirth, A. Loidl, and A. Hermetter Oxidized phospholipids: from molecular properties to disease Biochim. Biophys. Acta 1772 2007 718 736 (Pubitemid 46891216)
164. H.P. Deigner, and A. Hermetter Oxidized phospholipids: emerging lipid mediators in pathophysiology Curr. Opin. Lipidol. 19 2008 289 294 (Pubitemid 351653568)
165. N. Leitinger The role of phospholipid oxidation products in inflammatory and autoimmune diseases: evidence from animal models and in humans Subcell. Biochem. 49 2008 325 350
166. V.N. Bochkov, O.V. Oskolkova, K.G. Birukov, A.L. Levonen, C.J. Binder, and J. Stöckl Generation and biological activities of oxidized phospholipids Antioxid. Redox Signal. 12 2010 1009 1059
167. V.N. Bochkov Inflammatory profile of oxidized phospholipids Thromb. Haemost. 97 2007 348 354 (Pubitemid 46437795)
168. P. Fu, and K.G. Birukov Oxidized phospholipids in control of inflammation and endothelial barrier Transl. Res. 153 2009 166 176
169. A.D. Watson, N. Leitinger, M. Navab, K.F. Faull, S. Hörkkö, J.L. Witztum, W. Palinski, D. Schwenke, R.G. Salomon, W. Sha, G. Subbanagounder, A.M. Fogelman, and J.A. Berliner Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo J. Biol. Chem. 272 1997 13597 13607 (Pubitemid 27224791)
170. G. Subbanagounder, N. Leitinger, D.C. Schwenke, J.W. Wong, H. Lee, C. Rizza, A.D. Watson, K.F. Faull, A.M. Fogelman, and J.A. Berliner Determinants of bioactivity of oxidized phospholipids: specific oxidized fatty acyl groups at the sn-2 position Arterioscler. Thromb. Vasc. Biol. 20 2000 2248 2254
171. J.A. Berliner, G. Subbanagounder, N. Leitinger, A.D. Watson, and D. Vora Evidence for a role of phospholipid oxidation products in atherogenesis Trends Cardiovasc. Med. 11 2001 142 147 (Pubitemid 33070338)
172. N. Leitinger, T.R. Tyner, L. Oslund, C. Rizza, G. Subbanagounder, H. Lee, P.T. Shih, N. Mackman, G. Tigyi, M.C. Territo, J.A. Berliner, and D.K. Vora Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils Proc. Natl. Acad. Sci. U. S. A. 96 1999 12010 12015 (Pubitemid 29502849)
173. A.L. Cole, G. Subbanagounder, S. Mukhopadhyay, J.A. Berliner, and D.K. Vora Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway Arterioscler. Thromb. Vasc. Biol. 23 2003 1384 1390 (Pubitemid 36994526)
174. R. Li, K.P. Mouillesseaux, D. Montoya, D. Cruz, N. Gharavi, M. Dun, L. Koroniak, and J.A. Berliner Identification of prostaglandin E2 receptor subtype 2 as a receptor activated by OxPAPC Circ. Res. 98 2006 642 650
175. D.K. Vora, Z.T. Fang, S.M. Liva, T.R. Tyner, F. Parhami, A.D. Watson, T.A. Drake, M.C. Territo, and J.A. Berliner Induction of P-selectin by oxidized lipoproteins: separate effects on synthesis and surface expression Circ. Res. 80 1997 810 818 (Pubitemid 27230055)
176. A. Furnkranz, A. Schober, V.N. Bochkov, P. Bashtrykov, G. Kronke, A. Kadl, B.R. Binder, C. Weber, and N. Leitinger Oxidized phospholipids trigger atherogenic inflammation in murine arteries Arterioscler. Thromb. Vasc. Biol. 25 2005 633 638 (Pubitemid 40315690)
177. -/- mouse arteries via upregulation of P-selectin Free Radic. Biol. Med. 44 2008 452 463
178. E.A. Podrez, T.V. Byzova, M. Febbraio, R.G. Salomon, Y. Ma, M. Valiyaveettil, E. Poliakov, M. Sun, P.J. Finton, B.R. Curtis, J. Chen, R. Zhang, R.L. Silverstein, and S.L. Hazen Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype Nat. Med. 13 2007 1086 1095 (Pubitemid 47517507)
179. A. Asai, F. Okajima, K. Nakagawa, D. Ibusuki, K. Tanimura, Y. Nakajima, M. Nagao, M. Sudo, T. Harada, T. Miyazawa, and S. Oikawa Phosphatidylcholine hydroperoxide-induced THP-1 cell adhesion to intracellular adhesion molecule-1 J. Lipid Res. 50 2009 957 965
180. A. Asai, F. Okajima, Y. Nakajima, M. Nagao, K. Nakagawa, T. Miyazawa, and S. Oikawa Involvement of Rac GTPase activation in phosphatidylcholine hydroperoxide-induced THP-1 cell adhesion to ICAM-1 Biochem. Biophys. Res. Commun. 406 2011 273 277
181. J.A. Berliner, and A.D. Watson A role for oxidized phospholipids in atherosclerosis N. Engl. J. Med. 353 2005 9 11 (Pubitemid 41007802)
182. S. Reddy, S. Hama, V. Grijalva, K. Hassan, R. Mottahedeh, G. Hough, D.J. Wadleigh, M. Navab, and A.M. Fogelman Mitogen-activated protein kinase phosphatase 1 activity is necessary for oxidized phospholipids to induce monocyte chemotactic activity in human aortic endothelial cells J. Biol. Chem. 276 2001 17030 17035
183. ++/NFAT Blood 99 2002 199 206
184. K.G. Birukov, N. Leitinger, V.N. Bochkov, and J.G. Garcia Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins Microvasc. Res. 67 2004 18 28 (Pubitemid 38050220)
185. P.S. Gargalovic, M. Imura, B. Zhang, N.M. Gharavi, M.J. Clark, J. Pagnon, W.P. Yang, A. He, A. Truong, S. Patel, S.F. Nelson, S. Horvath, J.A. Berliner, T.G. Kirchgessner, and A.J. Lusis Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids Proc. Natl. Acad. Sci. U. S. A. 103 2006 12741 12746 (Pubitemid 44298631)
186. O.V. Oskolkova, T. Afonyushkin, A. Leitner, E. von Schlieffen, P.S. Gargalovic, A.J. Lusis, B.R. Binder, and V.N. Bochkov ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response Blood 112 2008 330 339
187. M. Yeh, N.M. Gharavi, J. Choi, X. Hsieh, E. Reed, K.P. Mouillesseaux, A.L. Cole, S.T. Reddy, and J.A. Berliner Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT) 3 pathway J. Biol. Chem. 279 2004 30175 30181 (Pubitemid 38937941)
188. N.M. Gharavi, J.A. Alva, K.P. Mouillesseaux, C. Lai, M. Yeh, W. Yeung, J. Johnson, W.L. Szeto, L. Hong, M. Fishbein, L. Wei, L.M. Pfeffer, and J.A. Berliner Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo J. Biol. Chem. 282 2007 31460 31468 (Pubitemid 350044874)
189. S. Pégorier, D. Stengel, H. Durand, M. Croset, and E. Ninio Oxidized phospholipid: POVPC binds to platelet-activating-factor receptor on human macrophages. Implications in atherosclerosis Atherosclerosis 188 2006 433 443 (Pubitemid 44301144)
190. H. Lee, W. Shi, P. Tontonoz, S. Wang, G. Subbanagounder, C.C. Hedrick, S. Hama, C. Borromeo, R.M. Evans, J.A. Berliner, and L. Nagy Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells Circ. Res. 87 2000 516 521
191. G. Subbanagounder, J.W. Wong, H. Lee, K.F. Faull, E. Miller, J.L. Witztum, and J.A. Berliner Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis: formation of these oxidized phospholipids in response to interleukin-1beta J. Biol. Chem. 277 2002 7271 7281 (Pubitemid 34953120)
192. J. Huber, A. Fürnkranz, V.N. Bochkov, M.K. Patricia, H. Lee, C.C. Hedrick, J.A. Berliner, B.R. Binder, and N. Leitinger Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase J. Lipid Res. 47 2006 1054 1062 (Pubitemid 43764701)
193. M.K. Patricia, R. Natarajan, A.N. Dooley, F. Hernandez, J.L. Gu, J.A. Berliner, J.J. Rossi, J.L. Nadler, R.S. Meidell, and C.C. Hedrick Adenoviral delivery of a leukocyte-type 12 lipoxygenase ribozyme inhibits effects of glucose and platelet-derived growth factor in vascular endothelial and smooth muscle cells Circ. Res. 88 2001 659 665 (Pubitemid 32378134)
194. E.A. Podrez, E. Poliakov, Z. Shen, R. Zhang, Y. Deng, M. Sun, P.J. Finton, L. Shan, B. Gugiu, P.L. Fox, H.F. Hoff, R.G. Salomon, and S.L. Hazen Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36 J. Biol. Chem. 277 2002 38503 38516 (Pubitemid 35154709)
195. V.N. Bochkov, M. Philippova, O. Oskolkova, A. Kadl, A. Furnkranz, E. Karabeg, T. Afonyushkin, F. Gruber, J. Breuss, A. Minchenko, D. Mechtcheriakova, P. Hohensinner, K. Rychli, J. Wojta, T. Resink, P. Erne, B.R. Binder, and N. Leitinger Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions Circ. Res. 99 2006 900 908 (Pubitemid 44556390)
196. M. Lucerna, A. Zernecke, R. de Nooijer, S.C. de Jager, I. Bot, C. van der Lans, I. Kholova, E.A. Liehn, T.J. van Berkel, S. Yla-Herttuala, C. Weber, and E.A. Biessen Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment Blood 109 2007 122 129 (Pubitemid 46053052)
197. A. Zimman, K.P. Mouillesseaux, T. Le, N.M. Gharavi, A. Ryvkin, T.G. Graeber, T.T. Chen, A.D. Watson, and J.A. Berliner Vascular endothelial growth factor receptor 2 plays a role in the activation of aortic endothelial cells by oxidized phospholipids Arterioscler. Thromb. Vasc. Biol. 27 2007 332 338 (Pubitemid 46143048)
198. N.M. Gharavi, N.A. Baker, K.P. Mouillesseaux, W. Yeung, H.M. Honda, X. Hsieh, M. Yeh, E.J. Smart, and J.A. Berliner Role of endothelial nitric oxide synthase in the regulation of SREBP activation by oxidized phospholipids Circ. Res. 98 2006 768 776
199. S. Lee, N.M. Gharavi, H. Honda, I. Chang, B. Kim, N. Jen, R. Li, A. Zimman, and J.A. Berliner A role for NADPH oxidase 4 in the activation of vascular endothelial cells by oxidized phospholipids Free Radic. Biol. Med. 47 2009 145 151
200. A. Landar, J.W. Zmijewski, D.A. Dickinson, C. Le Goffe, M.S. Johnson, G.L. Milne, G. Zanoni, G. Vidari, J.D. Morrow, and V.M. Darley-Usmar Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species Am. J. Physiol. Heart Circ. Physiol. 290 2006 1777 1787
201. C.E. Romanoski, N. Che, F. Yin, N. Mai, D. Pouldar, M. Civelek, C. Pan, S. Lee, L. Vakili, W.P. Yang, P. Kayne, I.N. Mungrue, J.A. Araujo, J.A. Berliner, and A.J. Lusis Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1 Circ. Res. 109 2011 e27 e41
202. R. Li, W. Chen, R. Yanes, S. Lee, and J.A. Berliner OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids J. Lipid Res. 48 2007 709 715 (Pubitemid 46397474)
203. R. Li, K.P. Mouillesseaux, D. Montoya, D. Cruz, N. Gharavi, M. Dun, L. Koroniak, and J.A. Berliner Identification of prostaglandin E2 receptor subtype 2 as a receptor activated by OxPAPC Circ. Res. 98 2006 642 650
204. D. Cruz, A.D. Watson, C.S. Miller, D. Montoya, M.T. Ochoa, P.A. Sieling, M.A. Gutierrez, M. Navab, S.T. Reddy, J.L. Witztum, A.M. Fogelman, T.H. Rea, D. Eisenberg, J. Berliner, and R.L. Modlin Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy J. Clin. Invest. 118 2008 2917 2928
205. H.K. Jyrkkänen, E. Kansanen, M. Inkala, A.M. Kivelä, H. Hurttila, S.E. Heinonen, G. Goldsteins, S. Jauhiainen, S. Tiainen, H. Makkonen, O. Oskolkova, T. Afonyushkin, J. Koistinaho, M. Yamamoto, V.N. Bochkov, S. Ylä-Herttuala, and A.L. Levonen Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo Circ. Res. 103 2008 1 9
206. G. Krönke, V.N. Bochkov, J. Huber, F. Gruber, S. Blüml, A. Fürnkranz, A. Kadl, B.R. Binder, and N. Leitinger Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein J. Biol. Chem. 278 2003 51006 51014 (Pubitemid 38020334)
207. A.V. Pontsler, A. St Hilaire, G.K. Marathe, G.A. Zimmerman, and T.M. McIntyre Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein J. Biol. Chem. 277 2002 13029 13036 (Pubitemid 34952671)
208. N.A. Pidkovka, O.A. Cherepanova, T. Yoshida, M.R. Alexander, R.A. Deaton, J.A. Thomas, N. Leitinger, and G.K. Owens Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro Circ. Res. 101 2007 792 801 (Pubitemid 350287194)
209. S.R. Johnstone, J. Ross, M.J. Rizzo, A.C. Straub, P.D. Lampe, N. Leitinger, and B.E. Isakson Oxidized phospholipid species promote in vivo differential cx43 phosphorylation and vascular smooth muscle cell proliferation Am. J. Pathol. 175 2009 916 924
210. O.A. Cherepanova, N.A. Pidkovka, O.F. Sarmento, T. Yoshida, Q. Gan, E. Adiguzel, M.P. Bendeck, J. Berliner, N. Leitinger, and G.K. Owens Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration Circ. Res. 104 2009 609 618
211. T. Afonyushkin, O.V. Oskolkova, M. Philippova, T.J. Resink, P. Erne, B.R. Binder, and V.N. Bochkov Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways Arterioscler. Thromb. Vasc. Biol. 30 2010 1007 1013
212. K.G. Birukov, V.N. Bochkov, A.A. Birukova, K. Kawkitinarong, A. Rios, A. Leitner, A.D. Verin, G.M. Bokoch, N. Leitinger, and J.G. Garcia Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac Circ. Res. 95 2004 892 901 (Pubitemid 39435004)
213. J. Qiao, F. Huang, R.P. Naikawadi, K.S. Kim, T. Said, and H. Lum Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4 Am. J. Physiol. Lung Cell. Mol. Physiol. 291 2006 91 101
214. A.A. Birukova, P. Fu, S. Chatchavalvanich, D. Burdette, O. Oskolkova, V.N. Bochkov, and K.G. Birukov Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium Am. J. Physiol. Lung Cell. Mol. Physiol. 292 2007 924 935
215. A.A. Birukova, I. Malyukova, V. Poroyko, and K.G. Birukov Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids Am. J. Physiol. Lung Cell. Mol. Physiol. 293 2007 199 211
216. A. Zimman, S.S. Chen, E. Komisopoulou, B. Titz, R. Martínez-Pinna, A. Kafi, J.A. Berliner, and T.G. Graeber Activation of aortic endothelial cells by oxidized phospholipids: a phosphoproteomic analysis J. Proteome Res. 9 2010 2812 2824
217. G. Schmitz, and K. Ruebsaamen Metabolism and atherogenic disease association of lysophosphatidylcholine Atherosclerosis 208 2010 10 18
218. S. Lavi, J.P. McConnell, C.S. Rihal, A. Prasad, V. Mathew, L.O. Lerman, and A. Lerman Local production of lipoprotein-associated phospholipase A2 and lysophosphatidylcholine in the coronary circulation: association with early coronary atherosclerosis and endothelial dysfunction in humans Circulation 115 2007 2715 2721 (Pubitemid 46842787)
219. 2 + signaling via the platelet-activating factor receptor in macrophages Am. J. Physiol. 272 1997 17 24
220. Q. Jing, S.M. Xin, W.B. Zhang, P. Wang, Y.W. Qin, and G. Pei Lysophosphatidylcholine activates p38 and p42/44 mitogen-activated protein kinases in monocytic THP-1 cells, but only p38 activation is involved in its stimulated chemotaxis Circ. Res. 87 2000 52 59 (Pubitemid 30456935)
221. Y.H. Huang, L. Schäfer-Elinder, R. Wu, H.E. Claesson, and J. Frostegård Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism Clin. Exp. Immunol. 116 1999 326 331 (Pubitemid 29219732)
222. C.G. Radu, L.V. Yang, M. Riedinger, M. Au, and O.N. Witte T cell chemotaxis to lysophosphatidylcholine through the G2A receptor Proc. Natl. Acad. Sci. U. S. A. 101 2004 245 250 (Pubitemid 38084235)
223. L.V. Yang, C.G. Radu, L. Wang, M. Riedinger, and O.N. Witte Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A Blood 105 2005 1127 1134 (Pubitemid 40170885)
224. N. Aiyar, J. Disa, Z. Ao, H. Ju, S. Nerurkar, R.N. Willette, C.H. Macphee, D.G. Johns, and S.A. Douglas Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells Mol. Cell. Biochem. 295 2007 113 120 (Pubitemid 46157993)
225. K.E. Olofsson, L. Andersson, J. Nilsson, and H. Björkbacka Nanomolar concentrations of lysophosphatidylcholine recruit monocytes and induce proinflammatory cytokine production in macrophages Biochem. Biophys. Res. Commun. 370 2008 348 352
226. M. Tan, F. Hao, X. Xu, G.M. Chisolm, and M.Z. Cui Lysophosphatidylcholine activates a novel PKD2-mediated signaling pathway that controls monocyte migration Arterioscler. Thromb. Vasc. Biol. 29 2009 1376 1382
227. T. Schilling, and C. Eder Non-selective cation channel activity is required for lysophosphatidylcholine-induced monocyte migration J. Cell. Physiol. 221 2009 325 334
228. D. Praticò Prostanoid and isoprostanoid pathways in atherogenesis Atherosclerosis 201 2008 8 16
229. 2-isoprostanes in inflammation and oxidative stress related pathology Mol. Cells 30 2010 383 391
230. K. Yuhki, F. Kojima, H. Kashiwagi, J. Kawabe, T. Fujino, S. Narumiya, and F. Ushikubi Roles of prostanoids in the pathogenesis of cardiovascular diseases: novel insights from knockout mouse studies Pharmacol. Ther. 129 2011 195 205
231. G. Riccioni, M. Bäck, and V. Capra Leukotrienes and atherosclerosis Curr. Drug Targets 11 2010 882 887
232. M. Hersberger Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins Clin. Chem. Lab. Med. 48 2010 1063 1073
233. C. Banfi, S. Colli, S. Eligini, L. Mussoni, and E. Tremoli Oxidized LDLs influence thrombotic response and cyclooxygenase 2. Prostaglandins Leukotrienes Essent Fatty Acids 67 2002 169 173
234. M.F. Linton, and S. Fazio Cyclooxygenase-2 and inflammation in atherosclerosis Curr. Opin. Pharmacol. 4 2004 116 123 (Pubitemid 38444045)
235. K. Uchida A lipid-derived endogenous inducer of COX-2: a bridge between inflammation and oxidative stress Mol. Cells 25 2008 347 351
236. J. Wittwer, and M. Hersberger The two faces of the 15-lipoxygenase in atherosclerosis. Prostaglandins Leukotrienes Essent Fatty Acids 77 2007 67 77 (Pubitemid 47539103)
237. A. Alfranca, M.A. Iñiguez, M. Fresno, and J.M. Redondo Prostanoid signal transduction and gene expression in the endothelium: role in cardiovascular diseases Cardiovasc. Res. 70 2006 446 456 (Pubitemid 44255556)
238. E. Ricciotti, and G.A. FitzGerald Prostaglandins and inflammation Arterioscler. Thromb. Vasc. Biol. 31 2011 986 1000
239. T. Ishizuka, K. Suzuki, M. Kawakami, T. Hidaka, Y. Matsuki, and H. Nakamura Thromboxane A2 receptor blockade suppresses intercellular adhesion molecule-1 expression by stimulated vascular endothelial cells Eur. J. Pharmacol. 312 1996 367 377 (Pubitemid 26323520)
240. T. Ishizuka, M. Kawakami, T. Hidaka, Y. Matsuki, M. Takamizawa, K. Suzuki, A. Kurita, and H. Nakamura Stimulation with thromboxane A2 (TXA2) receptor agonist enhances ICAM-1, VCAM-1 or ELAM-1 expression by human vascular endothelial cells Clin. Exp. Immunol. 112 1998 464 470 (Pubitemid 28267428)
241. H. Bayat, S. Xu, D. Pimentel, R.A. Cohen, and B. Jiang Activation of thromboxane receptor upregulates interleukin (IL)-1beta-induced VCAM-1 expression through JNK signaling Arterioscler. Thromb. Vasc. Biol. 28 2008 127 134
242. Y. Cheng, S.C. Austin, B. Rocca, B.H. Koller, T.M. Coffman, T. Grosser, J.A. Lawson, and G.A. FitzGerald Role of prostacyclin in the cardiovascular response to thromboxane A2 Science 296 2002 539 541 (Pubitemid 34408674)
243. J. Kawabe, K. Yuhki, M. Okada, T. Kanno, A. Yamauchi, N. Tashiro, T. Sasaki, S. Okumura, N. Nakagawa, Y. Aburakawa, N. Takehara, T. Fujino, N. Hasebe, S. Narumiya, and F. Ushikubi Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling Arterioscler. Thromb. Vasc. Biol. 30 2010 464 470
244. T. He, T. Lu, L.V. d'Uscio, C.F. Lam, H.C. Lee, and Z.S. Katusic Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells Circ. Res. 103 2008 80 88
245. Y. Huo, A. Schober, S.B. Forlow, D.F. Smith, M.C. Hyman, S. Jung, D.R. Littman, C. Weber, and K. Ley Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E Nat. Med. 9 2003 61 67 (Pubitemid 36098261)
246. S. Tole, A.M. Durkan, Y.W. Huang, G.Y. Liu, A. Leung, L.L. Jones, J.A. Taylor, and L.A. Robinson Thromboxane prostanoid receptor stimulation induces shedding of the transmembrane chemokine CX3CL1 yet enhances CX3CL1-dependent leukocyte adhesion Am. J. Physiol. Cell Physiol. 298 2010 1469 1480
247. T. Nawa, M.T. Nawa, Y. Cai, C. Zhang, I. Uchimura, S. Narumi, F. Numano, and S. Kitajima Repression of TNF-α-induced E-selectin expression by PPAR activators: involvement of transcriptional repressor LRF-1/ATF3 Biochem. Biophys. Res. Commun. 275 2000 406 411
248. N.G. Chen, and X. Han Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium Biochem. Biophys. Res. Commun. 282 2001 717 722 (Pubitemid 32924616)
249. K. Goya, M. Otsuki, X. Xu, and S. Kasayama Effects of the prostaglandin I2 analogue, beraprost sodium, on vascular cell adhesion molecule-1 expression in human vascular endothelial cells and circulating vascular cell adhesion molecule-1 level in patients with type 2 diabetes mellitus Metabolism 52 2003 192 198 (Pubitemid 36388842)
250. 2 inhibits PDGF-A and -B chain expression in human vascular endothelial cells independent of PPAR γ Biochem. Biophys. Res. Commun. 298 2002 128 132 (Pubitemid 35205397)
251. D. Santovito, A. Mezzetti, and F. Cipollone Cyclooxygenase and prostaglandin synthases: roles in plaque stability and instability in humans Curr. Opin. Lipidol. 20 2009 402 408
252. F. Cipollone, C. Prontera, B. Pini, M. Marini, M. Fazia, D. De Cesare, A. Iezzi, S. Ucchino, G. Boccoli, V. Saba, F. Chiarelli, F. Cuccurullo, and A. Mezzetti Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability Circulation 104 2001 921 927 (Pubitemid 32778044)
253. F. Cipollone, M. Fazia, A. Iezzi, B. Pini, C. Cuccurullo, M. Zucchelli, D. de Cesare, S. Ucchino, F. Spigonardo, M. De Luca, R. Muraro, R. Bei, M. Bucci, F. Cuccurullo, and A. Mezzetti Blockade of the angiotensin II type 1 receptor stabilizes atherosclerotic plaques in humans by inhibiting prostaglandin E2-dependent matrix metalloproteinase activity Circulation 109 2004 1482 1488 (Pubitemid 38420175)
254. 2 stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways Biochem. Biophys. Res. Commun. 286 2001 923 928 (Pubitemid 32924860)
255. M. Inoue, H. Itoh, T. Tanaka, T.H. Chun, K. Doi, Y. Fukunaga, N. Sawada, J. Yamshita, K. Masatsugu, T. Saito, S. Sakaguchi, M. Sone, K.I. Yamahara, T. Yurugi, and K. Nakao Oxidized LDL regulates vascular endothelial growth factor expression in human macrophages and endothelial cells through activation of peroxisome proliferator-activated receptor-gamma Arterioscler. Thromb. Vasc. Biol. 21 2001 560 566 (Pubitemid 32323389)
256. S. Gross, P. Tilly, D. Hentsch, J.L. Vonesch, and J.E. Fabre Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors J. Exp. Med. 204 2007 311 320 (Pubitemid 46294547)
257. K. Takayama, G. García-Cardena, G.K. Sukhova, J. Comander, M.A. Gimbrone Jr.; and P. Libby Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor J. Biol. Chem. 277 2002 44147 44154 (Pubitemid 36157844)
258. F. Cipollone, G. Cicolini, and M. Bucci Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives Pharmacol. Ther. 118 2008 161 180
259. P. Minuz, C. Fava, and A. Lechi Lipid peroxidation, isoprostanes and vascular damage Pharmacol. Rep. 58 2006 57 68
260. 2-isoprostanes as an indicator and risk factor for coronary heart disease Free Radic. Biol. Med. 50 2011 559 566
261. 2α-III: evidence from apolipoprotein E- and LDL receptor-deficient mice Circulation 112 2005 2867 2874 (Pubitemid 41641682)
262. M. Comporti, C. Signorini, B. Arezzini, D. Vecchio, B. Monaco, and C. Gardi F2-isoprostanes are not just markers of oxidative stress Free Radic. Biol. Med. 44 2008 247 256
263. 2 Thromb. Haemost. 87 2002 888 898 (Pubitemid 34516619)
264. A. Habib, and K.F. Badr Molecular pharmacology of isoprostanes in vascular smooth muscle cells Chem. Phys. Lipids 128 2004 69 73 (Pubitemid 38167377)
265. 2α stimulates endothelial cells to bind monocytes: differences from thromboxane-mediated endothelial activation FASEB J. 15 2001 1254 1256
266. H. Scholz, P. Aukrust, J.K. Damås, S. Tonstad, E.L. Sagen, S.O. Kolset, C. Hall, A. Yndestad, and B. Halvorsen 8-Isoprostane increases scavenger receptor A and matrix metalloproteinase activity in THP-1 macrophages, resulting in long-lived foam cells Eur. J. Clin. Invest. 34 2004 451 458 (Pubitemid 39049849)
267. M. Bäck Leukotriene signaling in atherosclerosis and ischemia Cardiovasc. Drugs Ther. 23 2009 41 48
268. C.D. Funk Prostaglandins and leukotrienes: advances in eicosanoid biology Science 294 2001 1871 1875 (Pubitemid 33101574)
269. K.E. Pedersen, B.S. Bochner, and B.J. Undem Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism J. Pharmacol. Exp. Ther. 281 1997 655 662 (Pubitemid 27203796)
270. L. Zhao, M.P. Moos, R. Gräbner, F. Pédrono, J. Fan, B. Kaiser, N. John, S. Schmidt, R. Spanbroek, K. Lötzer, L. Huang, J. Cui, D.J. Rader, J.F. Evans, A.J. Habenicht, and C.D. Funk The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm Nat. Med. 10 2004 966 973 (Pubitemid 39273738)
271. B. Uzonyi, K. Lötzer, S. Jahn, C. Kramer, M. Hildner, E. Bretschneider, D. Radke, M. Beer, R. Vollandt, J.F. Evans, C.D. Funk, and A.J. Habenicht Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells Proc. Natl. Acad. Sci. U. S. A. 103 2006 6326 6331
272. M. Bäck, D.X. Bu, R. Bränstrom, Y. Sheikine, Z.Q. Yan, and G.K. Hansson Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia Proc. Natl. Acad. Sci. U. S. A. 102 2005 17501 17506 (Pubitemid 41740895)
273. J. Moraes, J. Assreuy, C. Canetti, and C. Barja-Fidalgo Leukotriene B4 mediates vascular smooth muscle cell migration through αvβ3 integrin transactivation Atherosclerosis 212 2010 406 413
274. E. Sánchez-Galán, A. Gómez-Hernández, C. Vidal, J.L. Martín-Ventura, L.M. Blanco-Colio, B. Muñoz- García, L. Ortega, J. Egido, and J. Tuñón Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis Cardiovasc. Res. 81 2009 216 225
275. K.R. Chava, M. Karpurapu, D. Wang, M. Bhanoori, V. Kundumani-Sridharan, Q. Zhang, T. Ichiki, W.C. Glasgow, and G.N. Rao CREB-mediated IL-6 expression is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration Arterioscler. Thromb. Vasc. Biol. 29 2009 809 815
276. M.A. Reddy, S. Sahar, L.M. Villeneuve, L. Lanting, and R. Natarajan Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells Arterioscler. Thromb. Vasc. Biol. 29 2009 387 393
277. D.T. Bolick, A.W. Orr, A. Whetzel, S. Srinivasan, M.E. Hatley, M.A. Schwartz, and C.C. Hedrick 12/15-Lipoxygenase regulates intercellular adhesion molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaB Arterioscler. Thromb. Vasc. Biol. 25 2005 2301 2307 (Pubitemid 41552646)
278. H. Hlawaty, M.P. Jacob, L. Louedec, D. Letourneur, C. Brink, J.B. Michel, L. Feldman, and M. Bäck Leukotriene receptor antagonism and the prevention of extracellular matrix degradation during atherosclerosis and in-stent stenosis Arterioscler. Thromb. Vasc. Biol. 29 2009 518 524
279. K.W. Seo, S.J. Lee, C.E. Kim, M.R. Yun, H.M. Park, J.W. Yun, S.S. Bae, and C.D. Kim Participation of 5-lipoxygenase-derived LTB(4) in 4-hydroxynonenal-enhanced MMP-2 production in vascular smooth muscle cells Atherosclerosis 208 2010 56 61
280. F. Cipollone, A. Mezzetti, M.L. Fazia, C. Cuccurullo, A. Iezzi, S. Ucchino, F. Spigonardo, M. Bucci, F. Cuccurullo, S.M. Prescott, and D.M. Stafforini Association between 5-lipoxygenase expression and plaque instability in humans Arterioscler. Thromb. Vasc. Biol. 25 2005 1665 1670 (Pubitemid 41098938)