Role of myeloperoxidase in the neutrophil-induced oxidation of low density lipoprotein as studied by myeloperoxidase-knockout mouse

Journal of Biochemistry

Volumn 127, Issue 6, 2000, Pages 971-976

  Noguchi, Noriko ^a   Nakano, Kazumi ^a   Aratani, Yasuaki ^b   Koyama, Hideki ^b   Kodama, Tatsuhiko ^a   Niki, Etsuo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

LDL; Lipid peroxidation; MPO knockout mouse; Myeloperoxidase; Neutrophil

Indexed keywords

ALPHA TOCOPHEROL; CHOLESTEROL ESTER; HYDROPEROXIDE; LOW DENSITY LIPOPROTEIN; MYELOPEROXIDASE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLCHOLINE; SUPEROXIDE DISMUTASE; TYROSINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; KNOCKOUT MOUSE; LIPID PEROXIDATION; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATION;

ANIMALIA;

EID: 0033937863     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022713     Document Type: Article

References (35)

1. Steinberg, D., Parthasarathy, S., Carew, T.E., Khoo, J.C., and Witztum, J.L. (1989) Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320, 915-924
2. Parthasarathy, S. and Rankin, S.M. (1992) The role of oxidized LDL in atherogenesis. Prog. Lipid Res. 31, 127-143
3. Heinecke, J.W. (1987) Free radical modification of low-density lipoprotein: mechanisms and biological consequences. Free Radical Biol. Med. 3, 65-73
4. Jurgens, G., Hoff, H.F., Chisolm, G.M., and Esterbauer, H. (1987) Modification of human serum low density lipoprotein by oxidation-characterization and pathophysiological implications. Chem. Phys. Lipid. 45, 315-336
5. Steinbrecher, U.P., Zhang, H.F., and Lougheed, M. (1990) Role of oxidatively modified LDL in atherosclerosis. Free Radical Biol Med. 9, 155-168
6. Witztum, J.L. and Steinberg, D. (1991) Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 88, 1785-1792
7. Penn, M.S. and Chisolm, G.M. (1994) Oxidized lipoproteins, altered cell function and atherosclerosis. Atherosclerosis 108, suppl. S21-S29
8. Berliner, J.A. and Heinecke, J.W. (1996) The role of oxidized lipoproteins in atherogenesis. Free Radical Biol. Med. 20, 707-727
9. Ames, B.N., Shigenaga, M.K., and Hagan, T.M. (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 90, 7915-7922
10. Stadtman, E.R. (1992) Protein oxidation and aging. Science 257, 1220-1224
11. Baynes, J.W. (1991) Role of oxidative stress in development of complications in diabetes. Diabetes 40, 405-412
12. Kuhn, H., Belkner, J., Zaiss, S., Fahrenklemper, T., and Wohlfeil, S. (1994) Involvement of 15-lipoxygenase in early stages of atherogenesis J. Exp. Med. 179, 1903-1911
13. Gordon, A.F., Armand, J.M., Edwin, L.B., and Heinecke, J.W. (1993) Oxidative tyrosylation of high density lipoprotein by peroxidase enhances cholesterol removal from cultured fobroblasts and macrophages foam cells. Proc. Natl. Acad. Sci. USA 90, 6631-6635
14. Daugherty, A., Dunn, J.L., Rateri, D.L., and Heinecke, J.W. (1994) Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. J. Clin. Invest. 94, 437-444
15. Hazell, L.J., Armol, L., Flfoers, L., Waeg, G., Malle, E., and Stocker, R. (1996) Presence of hypochlorite-modified proteins in human atherosclerotic lesions. J. Clin. Invest. 97, 1535-1544
16. Hazen, S. and Heinecke, J.W. (1997) 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. J. Clin. Invest. 99, 2075-2081
17. Leewenburg, C., Rasmussen, J.E., Hsu, F.F., Mueller, D.M., Pennathur, S., and Heinecke, J.W. (1997) Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human atherosclerotic plaques. J. Biol. Chem. 272, 3520-3526
18. Beckman, J. and Crow, J.P. (1993) Pathological implications of nitric oxide, superoxide and peroxynitrite formation. Biochem. Soc. Trans. 21, 330-334
19. Aratani, Y., Koyama, H., Nyui, S., Suzuki, K., Kura, F., and Maeda, N. (1999) Severe impiarment in early host defence against Canadida albica in mice deficient in myeloperoxidase. Infect. Immun. 67, 1828-1836
20. Chance, B. and Maehly, A.C. (1955) Assay of catalases and peroxidases in Methods in Enzymology (Sidney, P.C. and Nathan, O.K., eds.) Vol. 2, pp. 764-775, Academic Press, New York
21. Fridovich, I. (1985) Cytochrome c in Hand Book of Methods for Oxygen Radical Research (Greemwald, R.A., ed.) pp. 121-122, CRC Press, Boca Raton, FL
22. Ramos, P., Gieseg, S.P., Schuster, B., and Esterbauer H. (1995) Effect of temperature and phase transition on oxidation resistance of low density lipoprotein. J. Lipid Res. 36, 2113-2128
23. Yamamoto, Y. (1994) Chemiluminescence-based high-performance liquid chromatography assay of lipid hydroperoxides in Methods in Enzymology (Packer, L., ed.) Vol. 233, pp. 319-324, Academic Press, New York
24. Noguchi, N. and Niki E. (1994) Apolipoprotein B protein oxidation in low-density lipoproteins in Methods in Enzymology (Packer, L., ed.) Vol. 233, pp. 490-494, Academic Press, New York
25. Savenkova, M.L., Mueller DM., and Heinecke JW. (1994) Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein. J. Biol. Chem. 269, 20394-20400
26. Hiramatsu, K., Rosen, H., Heinecke, J.W., Wolfbauer., G., and Chait, A. (1987) Superoxide initiates oxidation of low density lipoprotein by human monocytes. Arteriosclerosis 7, 55-60
27. Beckman, J. (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87, 1620-1624
28. Byun, J., Mueller D.M., Fabjan, J.S., and Heinecke, J.W. (1999) Nitrogen dioxide radical generated by the myeloperoxidase-hydrogen peroxide-nitrite system promotes lipid peroxidation of low density lipoprotein. FEBS Lett. 455, 243-246
29. Hazen, S.L., Zhang, R., Shen, Z., Wu, W., Podrez, E.A., MacPherson, J.C., Schmitt, D., Mitra, S.N., Mukhopadhyay, C., Chen, Y., Cohen, P.A., Hoff, H.F., and Abu-Soud, H.M. (1999) Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes. Pathways for monocyte-mediated protein nitration and lipid peroxidation in vivo. Circ. Reg. 85, 950-958
30. Chisolm, G.M., Hazen, S.L., Fox, P.L., and Cathcart, M.K. (1999) The oxidation of lipoproteins by monocytes-macrophages. J. Biol. Chem. 274, 25959-25962
31. Kapiotis, S., Sengoelge, G., Hermann, M., Held, I., Seelos, C., and Gmeiner, B.M. (1997) Paracetamol catalyzes myeloperoxidase-initiated lipid oxidation in LDL. Arterioscl. Thromb. Vasc. Biol. 17, 2855-2860
32. Hazen, S.L., Heller, J., Hsu, F.F., d'Avignon, A., and Heinecke, J.W. (1999) Synthesis, isolation, and characterization of the adduct formed in the reaction of p-hydroxyphenylacetaldehyde with the amino headgroup of phosphatidylethanolamine and phosphatidylserine. Chem. Res. Toxicol. 12, 19-27
33. Hazell, L.J., van den Berg, J.M., and Stocker, R. (1994) Oxidation of low density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation. Biochem. J. 302, 297-304
34. Hawkins, C.L. and Davis, M.J. (1998) Hypochlorite-induced damage to proteins: formation of nitrogen-centred radicals from lysine residues and their role in protein fragmentation. Biochem. J. 332, 617-625
35. Hawkins, C.L. and Davis, M.J. (1999) Hypochlorite-induced oxidation of proteins in plasma: formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation. Biochem. J. 340, 539-548