Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1

Journal of Biological Chemistry

Volumn 283, Issue 15, 2008, Pages 9595-9605

  Romeo, Giulio R ^a,b   Kazlauskas, Andrius ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BLOOD VESSEL PROSTHESES; BLOOD VESSELS; DISEASE CONTROL; GENE EXPRESSION; SELF ASSEMBLY; SUGAR (SUCROSE);

BINDING PROTEINS; DIABETIC RATS; ENDOTHELIAL DYSFUNCTIONS; FLANKING REGIONS; LUCIFERASE REPORTER ASSAYS; MOLECULAR BASES; OXYSTEROL; PROATHEROGENIC PROTEINS; PROFILIN; RESPONSE ELEMENTS; TRANSCRIPTIONAL MECHANISMS; VASCULAR DISEASES;

ENDOTHELIAL CELLS;

7 OXOCHOLESTEROL; BINDING PROTEIN; LUCIFERASE; OXYSTEROL; OXYSTEROL BINDING PROTEIN 1; PROFILIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; 7-KETOCHOLESTEROL; CHOLESTEROL DERIVATIVE; JAK2 PROTEIN, RAT; JANUS KINASE 2; OXYSTEROL RECEPTOR; STAT3 PROTEIN, RAT; STEROID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY ENDOTHELIUM; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DIABETES MELLITUS; DNA FLANKING REGION; ENDOTHELIUM; ENDOTHELIUM CELL; GENE EXPRESSION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION; ANIMAL; AORTA; ATHEROSCLEROSIS; BIOSYNTHESIS; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; PROMOTER REGION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; AORTA; ATHEROSCLEROSIS; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; JANUS KINASE 2; KETOCHOLESTEROLS; MALE; PROFILINS; PROMOTER REGIONS (GENETICS); RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, STEROID; STAT3 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 44349141839     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M710092200     Document Type: Article

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