Plaque oxysterols induce unbalanced up-regulation of matrix metalloproteinase-9 in macrophagic cells through redox-sensitive signaling pathways: Implications regarding the vulnerability of atherosclerotic lesions

Free Radical Biology and Medicine

Volumn 51, Issue 4, 2011, Pages 844-855

  Gargiulo, Simona ^a   Sottero, Barbara ^a   Gamba, Paola ^a   Chiarpotto, Elena ^a   Poli, Giuseppe ^a   Leonarduzzi, Gabriella ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Atherosclerosis; Free radicals; Matrix metalloproteinases; Oxysterols; Reactive oxygen species; Signaling pathways

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIOXIDANT; DIPHENYLENEIODONIUM CHLORIDE; DIPHENYLIODONIUM SALT; DPI; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OXYSTEROL; PARTHENOLIDE; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROTENONE; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ADVANCED HUMAN CAROTID PLAQUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL STRAIN U937; CONTROLLED STUDY; DNA BINDING; DRUG EFFECT; EXPERIMENTAL MODEL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; MACROPHAGE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; ZYMOGRAPHY;

ANTIOXIDANTS; CELL LINE; HUMANS; MACROPHAGES; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; OXIDATION-REDUCTION; PLAQUE, ATHEROSCLEROTIC; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STEROLS; TRANSCRIPTION FACTOR AP-1; UP-REGULATION;

EID: 79960933719     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.05.030     Document Type: Article

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