Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species

European Journal of Pharmacology

Volumn 546, Issue 1-3, 2006, Pages 11-18

  Naito, Yuji ^a   Shimozawa, Makoto ^a   Manabe, Hikori ^a   Nakabe, Nami ^a   Katada, Kazuhiro ^a   Kokura, Satoshi ^a   Yoshida, Norimasa ^a   Ichikawa, Hiroshi ^b   Kon, Tatsuya ^a,c   Yoshikawa, Toshikazu ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY   (Japan)

^c Central Research Development Laboratory Fancl Corporation   (Japan)

Author keywords

7 Ketocholesterol; Adhesion molecule; Calcium channel blocker; Endothelial cell; Reactive oxygen species

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 7 OXOCHOLESTEROL; AZELNIDIPINE; CALCIUM CHANNEL BLOCKING AGENT; CARBON; DICHLORODIHYDROFLUORESCEIN DIACETATE; HYDROXYL RADICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NIFEDIPINE; OXIDIZED LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANTIOXIDANT ACTIVITY; AORTA; ARTICLE; ATHEROSCLEROSIS; CELL ADHESION; CONTROLLED STUDY; DRUG MECHANISM; ELECTRON SPIN RESONANCE; ENDOTHELIUM CELL; ENZYME IMMUNOASSAY; FLUORESCENCE MICROSCOPY; FLUOROMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INFLAMMATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

AORTA; AZETIDINECARBOXYLIC ACID; BIPHENYL COMPOUNDS; CALCIUM CHANNEL BLOCKERS; CELL ADHESION; CELL MEMBRANE; CYCLIC N-OXIDES; DIHYDROPYRIDINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; FLUORESCEINS; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION; HUMANS; HYDRAZINES; INDICATORS AND REAGENTS; INFLAMMATION; KETOCHOLESTEROLS; MONOCYTES; NF-KAPPA B P50 SUBUNIT; NIFEDIPINE; PICRATES; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33748304270     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.07.030     Document Type: Article

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