4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK

Toxicology and Applied Pharmacology

Volumn 242, Issue 2, 2010, Pages 191-198

  Lee, Seung J ^a,b   Kim, Chae E ^a,b   Yun, Mi R ^a,b   Seo, Kyo W ^a,b   Park, Hye M ^a,b   Yun, Jung W ^a,b   Shin, Hwa K ^b   Bae, Sun S ^a,b   Kim, Chi D ^a,b  

^a School of Medicine   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

4 Hydroxynonenal; 5 Lipoxygenase; Leukotriene; Macrophages; MMP 9

Indexed keywords

2 (2,6 DIHYDROXYHEXYL) 6 (3 HYDROXY 1,5 UNDECADIENYL)PYRIDINE; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 4 HYDROXYNONENAL; ALPHA PENTYL 3 (2 QUINOLYLMETHOXY)BENZYL ALCOHOL; ARACHIDONATE 5 LIPOXYGENASE; GELATINASE B; LEUKOTRIENE B4; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ALDEHYDES; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; BASE SEQUENCE; DNA PRIMERS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MACROPHAGES, PERITONEAL; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

MURINAE;

EID: 71049193819     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.10.007     Document Type: Article

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