Oxidized phospholipids in control of inflammation and endothelial barrier

Translational Research

Volumn 153, Issue 4, 2009, Pages 166-176

  Fu, Panfeng ^a   Birukov, Konstantin G ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 PALMITOYL 2 (5 OXOVALEROYL) SN GLYCERO PHOSPHOCHOLINE; 1 PALMITOYL 2 (5,6 EPOXYEPOXYCYCLOPENTENONE) SN GLYCERO 3 PHOSPHOCHOLINE; 1 PALMITOYL 2 (5,6 EPOXYISOPROSTANE) SN GLYCERO 3 PHSPHOCHOLINE; 1 PALMITOYL 2 ARACHIDONOYL SN GLYCERO 3 PHOSPHORYLCHOLINE; 1 PALMITOYL 2 GLUTAROYL SN GLYCERO 3 PHOSPHOCHOLINE; 5 HYDROXY 8 OXO 6 OCTENOYLPHOSPHOCHOLINE; BUTAPROST; CYTOKINE; G PROTEIN COUPLED RECEPTOR; PAXILLIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHOSPHOLIPID; SCAVENGER RECEPTOR; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANTIINFLAMMATORY ACTIVITY; CELL ACTIVATION; DRUG MECHANISM; ENDOTHELIUM CELL; HUMAN; LIPID OXIDATION; LUNG ENDOTHELIUM; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; REVIEW; THROMBOGENESIS; UPREGULATION;

EID: 62349112779     PISSN: 19315244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trsl.2008.12.005     Document Type: Review

References (77)

1. Yoshimi N., Ikura Y., Sugama Y., et al. Oxidized phosphatidylcholine in alveolar macrophages in idiopathic interstitial pneumonias. Lung 183 (2005) 109-121
2. Nakamura T., Henson P.M., and Murphy R.C. Occurrence of oxidized metabolites of arachidonic acid esterified to phospholipids in murine lung tissue. Anal Biochem 262 15 (1998) 23-32
3. Subbanagounder G., Leitinger N., Schwenke D.C., et al. Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position. Arterioscler Thromb Vasc Biol 20 (2000) 2248-2254
4. Watson A.D., Leitinger N., Navab M., et al. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J Biol Chem 23 (1997) 13597-13607
5. Huber J., Vales A., Mitulovic G., et al. Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions. Arterioscler Thromb Vasc Biol 22 (2002) 101-107
6. Chang M.K., Binder C.J., Miller Y.I., et al. Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J Exp Med 200 (2004) 1359-1370
7. Hiltunen T.P., Gough P.J., Greaves D.R., Gordon S., and Yla-Herttuala S. Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor. Atherosclerosis 154 (2001) 415-419
8. Lee H., Shi W., Tontonoz P., et al. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circ Res 87 (2000) 516-521
9. Subbanagounder G., Wong J.W., Lee H., et al. Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta. J Biol Chem 277 (2002) 7271-7281
10. Birukov K.G., Bochkov V.N., Birukova A.A., et al. Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. Circ Res 95 (2004) 892-901
11. Leitinger N., Tyner T.R., Oslund L., et al. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. Proc Natl Acad Sci U S A 96 (1999) 12010-12015
12. Parhami F., Fang Z.T., Yang B., Fogelman A.M., and Berliner J.A. Stimulation of Gs and inhibition of Gi protein functions by minimally oxidized LDL. Arterioscler Thromb Vasc Biol 15 (1995) 2019-2024
13. Kabarowski J.H., Zhu K., Le L.Q., Witte O.N., and Xu Y. Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A. Science 293 (2001) 702-705
14. Lum H., Qiao J., Walter R.J., et al. Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells. Am J Physiol 285 (2003) H1786-H1789
15. Zhu K., Baudhuin L.M., Hong G., et al. Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. J Biol Chem 276 (2001) 41325-41335
16. Tomura H., Mogi C., Sato K., and Okajima F. Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors. Cell Signal 17 (2005) 1466-1476
17. Anliker B., and Chun J. Cell surface receptors in lysophospholipid signaling. Semin Cell Dev Biol 15 (2004) 457-465
18. Marathe G.K., Davies S.S., Harrison K.A., et al. Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. J Biol Chem 274 (1999) 28395-28404
19. Mao Y.J., Wang L., and Wang W.J. Effect of ginkgolide B on the function of rat aorta smooth cells and U937 cells stimulated by oxLDL. Yao Xue Xue Bao 41 (2006) 36-40
20. Beaudeux J.L., Said T., Ninio E., et al. Activation of PAF receptor by oxidised LDL in human monocytes stimulates chemokine releases but not urokinase-type plasminogen activator expression. Clin Chim Acta 344 (2004) 163-171
21. Birukova A.A., Chatchavalvanich S., Oskolkova O., Bochkov V.N., and Birukov K.G. Signaling pathways involved in OxPAPC-induced pulmonary endothelial barrier protection. Microvasc Res 73 (2007) 173-181
22. Oskolkova O.V., Afonyushkin T., Leitner A., et al. ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response. Blood 112 (2008) 330-339
23. Li R., Mouillesseaux K.P., Montoya D., et al. Identification of prostaglandin E2 receptor subtype 2 as a receptor activated by OxPAPC. Circ Res 98 (2006) 642-650
24. Davies S.S., Pontsler A.V., Marathe G.K., et al. Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists. J Biol Chem 276 (2001) 16015-16023
25. Delerive P., Furman C., Teissier E., Fruchart J., Duriez P., and Staels B. Oxidized phospholipids activate PPARalpha in a phospholipase A2-dependent manner. FEBS Lett 471 (2000) 34-38
26. Podrez E.A., Poliakov E., Shen Z., et al. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. J Biol Chem 277 (2002) 38503-38516
27. Boullier A., Gillotte K.L., Horkko S., et al. The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein. J Biol Chem 275 (2000) 9163-9169
28. Gillotte-Taylor K., Boullier A., Witztum J.L., Steinberg D., and Quehenberger O. Scavenger receptor class B type I as a receptor for oxidized low density lipoprotein. J Lipid Res 42 (2001) 1474-1482
29. Kar N.S., Ashraf M.Z., Valiyaveettil M., and Podrez E.A. Mapping and characterization of the binding site for specific oxidized phospholipids and oxidized low density lipoprotein of scavenger receptor CD36. J Biol Chem 283 (2008) 8765-8771
30. Walton K.A., Hsieh X., Gharavi N., et al. Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein. J Biol Chem 278 (2003) 29661-29666
31. Yeh M., Cole A.L., Choi J., et al. Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products. Circ Res 95 (2004) 780-788
32. Brame C.J., Boutaud O., Davies S.S., et al. Modification of proteins by isoketal-containing oxidized phospholipids. J Biol Chem 279 (2004) 13447-13451
33. Gugiu B.G., Mouillesseaux K., Duong V., et al. Protein targets of oxidized phospholipids in endothelial cells. J Lipid Res 49 (2008) 510-520
34. Gargalovic P.S., Gharavi N.M., Clark M.J., et al. The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol 26 (2006) 2490-2496
35. Henriksen T., Mahoney E.M., and Steinberg D. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proc Natl Acad Sci U S A 78 (1981) 6499-6503
36. Cole A.L., Subbanagounder G., Mukhopadhyay S., Berliner J.A., and Vora D.K. Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway. Arterioscler Thromb Vasc Biol 23 (2003) 1384-1390
37. Huber J., Furnkranz A., Bochkov V.N., et al. Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase. J Lipid Res 47 (2006) 1054-1062
38. Bochkov V.N. Inflammatory profile of oxidized phospholipids. Thromb Haemost 97 (2007) 348-354
39. Bochkov V.N., and Leitinger N. Anti-inflammatory properties of lipid oxidation products. J Mol Med 81 (2003) 613-626
40. Birukov K.G. Oxidized lipids: the two faces of vascular inflammation. Curr Atheroscler Rep 8 (2006) 223-231
41. Yeh M., Gharavi N.M., Choi J., et al. Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway. J Biol Chem 279 (2004) 30175-30181
42. Gharavi N.M., Baker N.A., Mouillesseaux K.P., et al. Role of endothelial nitric oxide synthase in the regulation of SREBP activation by oxidized phospholipids. Circ Res 98 (2006) 768-776
43. Gharavi N.M., Alva J.A., Mouillesseaux K.P., et al. Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo. J Biol Chem 282 (2007) 31460-31468
44. Bochkov V.N., Mechtcheriakova D., Lucerna M., et al. Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT. Blood 99 (2002) 199-206
45. Therond P., Abella A., Laurent D., et al. In vitro study of the cytotoxicity of isolated oxidized lipid low-density lipoproteins fractions in human endothelial cells: relationship with the glutathione status and cell morphology. Free Radic Biol Med 28 (2000) 585-596
46. Rouhanizadeh M., Hwang J., Clempus R.E., et al. Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine induces vascular endothelial superoxide production: implication of NADPH oxidase. Free Radic Biol Med 39 (2005) 1512-1522
47. Landar A., Zmijewski J.W., Dickinson D.A., et al. Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. Am J Physiol Heart Circ Physiol 290 (2006) H1777-H1787
48. Li R., Chen W., Yanes R., Lee S., and Berliner J.A. OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids. J Lipid Res. 48 (2007) 709-715
49. Ma Z., Li J., Yang L., et al. Inhibition of LPS- and CpG DNA-induced TNF-alpha response by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol 286 (2004) L808-L816
50. Nonas S., Miller I., Kawkitinarong K., et al. Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury. Am J Respir Crit Care Med 173 (2006) 1130-1138
51. Nonas S., Birukova A.A., Fu P., et al. Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo. Crit Care 12 (2008) R27
52. Li L., Wang X.P., and Wu K. The therapeutic effect of oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine in rodents with acute necrotizing pancreatitis and its mechanism. Pancreas 35 (2007) e27-e36
53. Bluml S., Kirchberger S., Bochkov V.N., et al. Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40. J Immunol 175 (2005) 501-508
54. Birukova A.A., Fu P., Chatchavalvanich S., et al. Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium. Am J Physiol Lung Cell Mol Physiol 292 (2007) L924-L935
55. Birukov K.G., Leitinger N., Bochkov V.N., and Garcia J.G. Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins. Microvasc Res 67 (2004) 18-28
56. Birukova A.A., Alekseeva E., Cokic I., Turner C.E., and Birukov K.G. Crosstalk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol 295 (2008) L593-L602
57. Birukova A.A., Malyukova I., Mikaelyan A., Fu P., and Birukov K.G. Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids. J Cell Physiol 211 (2007) 608-617
58. Beutler B. TLR4 as the mammalian endotoxin sensor. Curr Top Microbiol Immunol 270 (2002) 109-120
59. Pfeiffer A., Bottcher A., Orso E., et al. Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts. Eur J Immunol 31 (2001) 3153-3164
60. Poltorak A., He X., Smirnova I., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085-2088
61. Triantafilou M., Miyake K., Golenbock D.T., and Triantafilou K. Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J Cell Sci 115 (2002) 2603-2611
62. Guha M., and Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 13 (2001) 85-94
63. Hamilton T.A., Ma G.P., and Chisolm G.M. Oxidized low density lipoprotein suppresses the expression of tumor necrosis factor-alpha mRNA in stimulated murine peritoneal macrophages. J Immunol 144 (1990) 2343-2350
64. Eligini S., Brambilla M., Banfi C., et al. Oxidized phospholipids inhibit cyclooxygenase-2 in human macrophages via nuclear factor-kappaB/IkappaB- and ERK2-dependent mechanisms. Cardiovasc Res 55 (2002) 406-415
65. Bochkov V.N., Kadl A., Huber J., Gruber F., Binder B.R., and Leitinger N. Protective role of phospholipid oxidation products in endotoxin-induced tissue damage. Nature 419 (2002) 77-81
66. Engelmann B., Zieseniss S., Brand K., et al. Tissue factor expression of human monocytes is suppressed by lysophosphatidylcholine. Arterioscler Thromb Vasc Biol 19 (1999) 47-53
67. Walton K.A., Cole A.L., Yeh M., et al. Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2. Arterioscler Thromb Vasc Biol 23 (2003) 1197-1203
68. Ghersa P., Hooft van Huijsduijnen R., Whelan J., Cambet Y., Pescini R., and DeLamarter J.F. Inhibition of E-selectin gene transcription through a cAMP-dependent protein kinase pathway. J Biol Chem 269 (1994) 29129-29137
69. Rahman A., Anwar K.N., Minhajuddin M., et al. cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-kappaB activation and ICAM-1 expression in endothelial cells. Am J Physiol Lung Cell Mol Physiol 287 (2004) L1017-L1024
70. Fasshauer M., Klein J., Lossner U., and Paschke R. Isoproterenol is a positive regulator of the suppressor of cytokine signaling-3 gene expression in 3T3-L1 adipocytes. J Endocrinol 175 (2002) 727-733
71. Ishikawa K., Navab M., Leitinger N., Fogelman A.M., and Lusis A.J. Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL. J Clin Invest 100 (1997) 1209-1216
72. Otterbein L.E., Bach F.H., Alam J., et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 6 (2000) 422-428
73. Otterbein L.E., Zuckerbraun B.S., Haga M., et al. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med 9 (2003) 183-190
74. Pontsler A.V., St Hilaire A., Marathe G.K., Zimmerman G.A., and McIntyre T.M. Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein. J Biol Chem 277 (2002) 13029-13036
75. mai Y., Kuba K., Neely G.G., et al. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133 (2008) 235-249
76. Friedman P., Horkko S., Steinberg D., Witztum J.L., and Dennis E.A. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. J Biol Chem 277 (2002) 7010-7020
77. Kume N., Cybulsky M.I., and Gimbrone Jr. M.A. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest 90 (1992) 1138-1144