Adenoviral delivery of a leukocyte-type 12 lipoxygenase ribozyme inhibits effects of glucose and platelet-derived growth factor in vascular endothelial and smooth muscle cells

Circulation Research

Volumn 88, Issue 7, 2001, Pages 659-665

  Patricia, M K ^a   Natarajan, R ^a   Dooley, A N ^a   Hernandez, F ^a   Gu, J L ^a   Berliner, J A ^a   Rossi, J J ^a   Nadler, J L ^a   Meidell, R S ^a   Hedrick, C C ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

12 lipoxygenase; Adenovirus; Endothelium; Ribozyme; Vascular smooth muscle cells

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 12 LIPOXYGENASE; GLUCOSE; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR; RIBOZYME;

ADENOVIRUS; ANIMAL CELL; AORTA; ARTICLE; CELL ADHESION; CELL CULTURE; CELL MIGRATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; SWINE; VASCULAR ENDOTHELIUM; VIRUS RECOMBINANT;

EID: 0035853386     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh0701.088838     Document Type: Article

References (37)

1. Elevated glucose alters eicosanoid release from porcine aortic endothelial cells
2. Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells
3. A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease
4. 15-Hydroxy-5,8,11,13-eicosatetraenoic acid inhibits human vascular cyclooxygenase: Potential role in diabetic vascular disease
5. Enhancement of endogenous production of 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid in aortic smooth muscle cells by platelet-derived growth
6. Regulation of 12-lipoxygenase by cytokines in vascular smooth muscle cells
7. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase
8. Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
9. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice
10. Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice
11. A leukocyte type of 12-lipoxygenase is expressed in human vascular and mononuclear cells: Evidence for upregulation by angiotensin II
12. Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes
13. Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets
14. The therapeutic potential of ribozymes
15. Ribozyme-mediated inhibition of expression of leukocyte-type 12-lipoxygenase in porcine aortic vascular smooth muscle cells
16. Adenovirus-mediated expression of a ribozyme to c-myb mRNA inhibits smooth muscle cell proliferation and neointima formation in vivo
17. Adenovirus-mediated expression of ribozymes in mice
18. Immunosuppressive agents and endothelial repair: Prednisolone delays migration and cytoskeletal rearrangement in wounded porcine aortic monolayers
19. Vascular smooth muscle cells exhibit increased growth in response to elevated glucose
20. Modification of the Recalde method for the isolation of human monocytes
21. Platelet-derived growth factor BB mediated regulation of 12-lipoxygenase in porcine aortic smooth muscle cells
22. Specific action of the lipoxygenase pathway in mediating angiotensin II-induced aldosterone synthesis in isolated adrenal glomerulosa cells
23. Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells
24. Induction of monocyte binding to endothelial cells by MM-LDL: Role of lipoxygenase metabolites
25. Aortic smooth muscle cell migration caused by platelet-derived growth factor is mediated by lipoxygenase product(s) of arachidonic acid
26. Controlled, targeted, intracellular expression of ribozymes: Progress and problems
27. Glucose increases the synthesis of lipoxygenase-mediated metabolites of arachidonic acid in intact rat islets
28. Liver lipoxygenase arachidonic acid metabolites in streptozotocin-induced diabetes in rats
29. Pancreas lipoxygenase arachidonic acid metabolites production in streptozotocin-induced diabetes in rats
30. 15-Hydroxyeicosatetraenoic acid and diabetic endothelial dysfunction in rabbit aorta
31. Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism
32. Pancreatic islet arachidonic acid turnover and metabolism and insulin release in response to delta-9-tetrahydrocannabinol
33. Evidence that glucose increases monocyte binding to human aortic endothelial cells
34. Intimal alterations in rabbit aortas during the first 6 months of alloxan-induced diabetes
35. Lipoxygenase metabolites induced expression of adhesion molecules and transendothelial migration of monocyte-like HL-60 cells is linked to protein kinase C activation
36. In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung
37. Activation of mitogen-activated protein kinases by arachidonic acid and its metabolites in vascular smooth muscle cells