25-Hydroxycholesterol, 7β-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages

Free Radical Research

Volumn 41, Issue 3, 2007, Pages 260-266

  Erridge, Clett ^a   Webb, David ^b   Spickett, Corinne ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Atherosclerosis; Inflammation; Oxysterols; Toll like receptors

Indexed keywords

25 HYDROXYCHOLESTEROL; 7 OXOCHOLESTEROL; 7BETA HYDROXYCHOLESTEROL; I KAPPA B ALPHA; INTERLEUKIN 8; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR ALPHA; 25-HYDROXYCHOLESTEROL; 7-KETOCHOLESTEROL; CHOLEST 5 EN 3 BETA,7 ALPHA DIOL; CHOLEST-5-EN-3 BETA,7 ALPHA-DIOL; CHOLESTEROL DERIVATIVE; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TLR6 PROTEIN, HUMAN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; UPREGULATION; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIUM CELL; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; METABOLISM;

CELLS, CULTURED; EPITHELIAL CELLS; HUMANS; HYDROXYCHOLESTEROLS; INTERLEUKIN-8; KETOCHOLESTEROLS; MACROPHAGES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 6; TOLL-LIKE RECEPTORS; TRANSFECTION; UP-REGULATION;

EID: 33947106449     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760601070091     Document Type: Article

References (35)

1. Greaves, DR and Channon, KM (2002) Inflammation and immune responses in atherosclerosis. Trends Immunol, 23, pp. 535-541.
2. Ross, R. (1999) Atherosclerosis is an inflammatory disease. Am Heart J, 138, pp. S419-S420.
3. Bjorkbacka, H., Kunjathoor, VV, Moore, KJ, Koehn, S.,; Ordija, CM, Lee, MA, Means, T., Halmen, K., Luster, AD, Golenbock, DT and Freeman, MW (2004) Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signalling pathways. Nat Med, 10, pp. 416-421.
4. Michelson, KS, Wong, MH, Shah, PK, Zhang, W., Yano, J., Doherty, TM, Akira, S., Rajavashisth and Arditi, M. (2004) Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci USA, 101, pp. 10679-10684.
5. Mullick, AE, Tobias, PS and Curtiss, LK (2005) Modulation of atherosclerosis in mice by Toll-like receptor 2. J Clin Invest, 115, pp. 3149-3156.
6. Underhill, DM and Ozinsky, A. (2002) Toll-like receptors: Key mediators of microbe detection. Curr Opin Immunol, 14, pp. 103-110.
7. Kiechl, S., Lorenz, E., Reindl, M., Wiedermann, CJ, Oberhollenzer, F., Bonora, E., Willeit, J. and Schwartz, DA (2002) Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med, 347, pp. 185-192.
8. Ameziane, N., Beillat, T., Verpillat, P., Chollet-Martin, S., Aumont, MC, Seknadji, P., Lamotte, M., Lebret, D., Ollivier, V. and de Prost, D. (2003) Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler Thromb Vasc Biol, 23, pp. 61-64.
9. Edfeldt, K., Swedenborg, J., Hansson, GK and Yan, Z. (2002) Expression of Toll-like receptors in human atherosclerotic lesions: A possible pathway for plaque activation. Circulation, 105, pp. 1158-1160.
10. Barath, P., Fishbein, MC, Cao, J., Berenson, J., Helfant, RH and Forrester, JS (1990) Detection and localisation of tumor necrosis factor in human atheroma. Am J Cardiol, 65, pp. 297-302.
11. Brand, K., Page, S., Rogler, G., Bartsch, A., Brandl, R., Knuechel, R., Page, M., Kaltschmidt, C., Baeuerle, PA and Neumeier, D. (1996) Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. J Clin Invest, 97, pp. 1715-1722.
12. Watson, AD, Leitinger, N., Navab, M., Faull, KF, Horkko, S., Witztum, JL, Palinski, W., Schwenke, D., Salomon, RG, Sha, W., Subbanagounder, G., Fogelman, AM and Berliner, JA (1997) Structural identification by mass spectrometry of oxidised phospholipids in minimally oxidised low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J Biol Chem, 272, pp. 13597-13607.
13. Brown, AJ and Jessup, W. (1999) Oxysterols and atherosclerosis. Atherosclerosis, 142, pp. 1-28.
14. Brown, AJ, Leong, SL, Dean, RT and Jessup, W. (1997) 7-hydroperoxycholesterol and its products in oxidised low density lipoprotein and human atherosclerotic plaque. J Lipid Res, 38, pp. 1730-1745.
15. Liu, Y., Hulten, LM and Wiklund, O. (1997) Macrophages isolated from human atherosclerotic plaques produce IL-8, and oxysterols may have a regulatory function for IL-8 production. Arterioscler Thromb Vasc Biol, 17, pp. 317-323.
16. Rydberg, EK, Salomonsson, L., Hult LM, Norén K., Bondjers, G., Wiklund, O., Björnheden, T. and Ohlsson, BG (2003) Hypoxia increases 25-hydroxycholesterol-induced interleukin-8 protein secretion in human macrophages. Atherosclerosis, 170, pp. 245-252.
17. Walton, KA, Hsieh, X., Gharavi, N., Wang, S., Wang, G., Yeh, M., Cole, AL and Berliner, JA (2003) Receptors involved in the oxidised 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8: A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein. J Biol Chem, 278, pp. 29661-29668.
18. Erridge, C., Webb, DJ and Spickett, CM (2006) Toll-like receptor 4 signalling is neither sufficient nor required for oxidised phospholipid mediated induction of interleukin-8 expression. Atherosclerosis
19. Miller, YI, Viriyakosol, S., Binder, CJ, Feramisco, JR, Kirkland, TN and Witztum, JL (2003) Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2 and inhibits phagocytosis of apoptotic cells. J Biol Chem, 278, pp. 1561-1568.
20. Miller, YI, Viriyakosol, S., Worrall, DS, Boullier, A., Butler, S. and Witztum, JL (2005) Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol, 25, pp. 1213-1219.
21. Leonarduzzi, G., Gamba, P., Sottero, B., Kadl, A., Robbesyn, F., Calogero, RA, Biasi, F., Chiarpotto, E., Leitinger, N., Sevanian, A. and Poli, G. (2005) Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells. Free Radic Biol Med, 39, pp. 1152-1161.
22. Landis, MS, Patel, HV and Capone, JP (2002) Oxysterol activators of liver x receptor and 9-cis-retinoic acid promote steps in the synthesis and secretion of tumor necrosis factor-α from human monocytes. J Biol Chem, 277, pp. 4713-4721.
23. Rosklint, T., Ohlsson, BG, Wiklund, O., Norén, K. and Hultén, LM (2002) Oxysterols induce interleukin-1 beta production in human macrophages. Eur J Clin Invest, 32, pp. 35-42.
24. Russell, DW (2000) Oxysterol biosynthetic enzymes. Biochim Biophys Acta, 1529, pp. 126-135.
25. Schroepfer, GJ (2000) Oxysterols: Modulators of cholesterol metabolism and other processes. Physiol Rev, 80, pp. 361-554.
26. Brown, A., Dean, R. and Jessup, W. (1996) Free and esterified oxysterol: Formation during copper-oxidation of low density lipoprotein and uptake by macrophages. J Lipid Res, 37, pp. 320-335.
27. Hirschfeld, M., Weis, JH, Vogel, SN and Weis, JJ (2000) Cutting edge: Repurification of lipopolysaccharide eliminates signalling through both human and murine Toll-like receptor 2. J Immunol, 165, pp. 618-622.
28. Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdorfer, B., Giese, T., Endres, S. and Hartmann, G. (2002) Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol, 168, pp. 4531-4537.
29. Ozinsky, A., Underhill, DM, Fontenot, JD, Hajjar, AM, Smith, KD, Wilson, CB, Schroeder, L. and Aderem, A. (2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by co-operation between Toll-like receptors. Proc Natl Acad Sci USA, 97, pp. 13766-13771.
30. Reape, TJ and Groot, PHE (1999) Chemokines and atherosclerosis. Atherosclerosis, 147, pp. 213-225.
31. Boekholdt, SM, Peters, RJ, Hack, CE, Day, NE, Luben, R., Bingham, SA, Wareham, NJ, Reitsma, PH and Khaw, KT (2004) IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: The EPIC-Norfolk prospective population study. Arterioscler Thromb Vasc Biol, 24, pp. 1503-1508.
32. Boisvert, WA, Santiago, R., Curtiss, LK and Terkeltaub, RA (1998) A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J Clin Invest, 101, pp. 353-363.
33. Aiello, RJ, Bourassa, PA, Lindsey, S., Weng, W., Natoli, E., Rollins, BJ and Milos, PM (1999) Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol, 19, pp. 1518-1525.
34. Akashi, S., Nagai, Y., Ogata, H., Oikawa, M., Fukase, K., Kusumoto, S., Kawasaki, K., Nishijima, M., Hayashi, S., Kimoto, M. and Miyake, K. (2001) Human MD-2 confers on mouse Toll-like receptor 4 species specific lipopolysaccharide recognition. Int Immunol, 13, pp. 1595-1599.
35. Hajjar, AM, Ernst, RK, Tsai, JH, Wilson, CB and Miller, SI (2003) Human Toll-like receptor 4 recognises host-specific LPS modifications. Nat Immunol, 3, pp. 354-359.