The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia- dependent aortic aneurysm

Nature Medicine

Volumn 10, Issue 9, 2004, Pages 966-973

  Zhao, Lei ^a   Moos, Michael P W ^b   Gräbner, Rolf ^b   Pédrono, Frédérique ^a,c   Fan, Jinjin ^a   Kaiser, Brigitte ^b   John, Nicole ^b   Schmidt, Sandra ^b   Spanbroek, Rainer ^b   Lötzer, Katharina ^b   Huang, Li ^d   Cui, Jisong ^d   Rader, Daniel J ^a   Evans, Jilly F ^d   Habenicht, Andreas J R ^b   Funk, Colin D ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c QUEEN S UNIVERSITY   (Canada)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; AUTACOID; CHOLIC ACID; GELATINASE A; LEUKOTRIENE; LEUKOTRIENE D4; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2;

ADVENTITIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ANEURYSM; ARTERY WALL; ARTICLE; ATHEROGENIC DIET; ATHEROSCLEROSIS; BIOSYNTHESIS; CARDIOVASCULAR DISEASE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENE EXPRESSION; HEART INFARCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERLIPIDEMIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MOUSE; MOUSE STRAIN; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROKE;

ANALYSIS OF VARIANCE; ANIMALS; AORTIC ANEURYSM, ABDOMINAL; ARACHIDONATE 5-LIPOXYGENASE; BLOTTING, WESTERN; CARRIER PROTEINS; CHEMOKINE CCL2; CHEMOKINES, CXC; CHOLATES; CONNECTIVE TISSUE; CYTOKINES; DIET, ATHEROGENIC; DNA PRIMERS; GENE EXPRESSION REGULATION; HISTOLOGICAL TECHNIQUES; HUMANS; HYPERLIPIDEMIAS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOTRIENE D4; LEUKOTRIENES; MACROPHAGE INFLAMMATORY PROTEIN-1; MACROPHAGES; MATRIX METALLOPROTEINASE 2; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PATHOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

ANIMALIA; SIGANUS;

EID: 4644301666     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1099     Document Type: Article

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