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Volumn 20, Issue , 2004, Pages 695-723

Signaling pathways in intestinal development and cancer

Author keywords

BMP; Hedgehog; LKB; Notch; TGF beta; Wnt

Indexed keywords

APC PROTEIN; BONE MORPHOGENETIC PROTEIN; K RAS PROTEIN; NOTCH RECEPTOR; PROTEINASE ACTIVATED RECEPTOR; RAF PROTEIN; SONIC HEDGEHOG PROTEIN; WNT PROTEIN;

EID: 8444220513     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.20.010403.092805     Document Type: Review
Times cited : (448)

References (184)
  • 3
    • 0035444798 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: The 'RASCAL II' study
    • Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, et al. 2001. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br. J. Cancer 85:692-96
    • (2001) Br. J. Cancer , vol.85 , pp. 692-696
    • Andreyev, H.J.1    Norman, A.R.2    Cunningham, D.3    Oates, J.4    Dix, B.R.5
  • 4
    • 0033606972 scopus 로고    scopus 로고
    • Notch signalling controls pancreatic cell differentiation
    • Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, et al. 1999. Notch signalling controls pancreatic cell differentiation. Nature 400:877-81
    • (1999) Nature , vol.400 , pp. 877-881
    • Apelqvist, A.1    Li, H.2    Sommer, L.3    Beatus, P.4    Anderson, D.J.5
  • 5
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-Tsakonas S, Rand MD, Lake RJ. 1999. Notch signaling: cell fate control and signal integration in development. Science 284:770-76
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 6
    • 0033195998 scopus 로고    scopus 로고
    • Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    • Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JJ, et al. 1999. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat. Cell Biol. 1:260-66
    • (1999) Nat. Cell Biol. , vol.1 , pp. 260-266
    • Ashcroft, G.S.1    Yang, X.2    Glick, A.B.3    Weinstein, M.4    Letterio, J.J.5
  • 7
    • 0038614742 scopus 로고    scopus 로고
    • Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
    • Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, et al. 2003. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J. 22:3062-72
    • (2003) EMBO J. , vol.22 , pp. 3062-3072
    • Baas, A.F.1    Boudeau, J.2    Sapkota, G.P.3    Smit, L.4    Medema, R.5
  • 8
    • 1542777034 scopus 로고    scopus 로고
    • Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
    • Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, et al. 2004. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 116:457-66
    • (2004) Cell , vol.116 , pp. 457-466
    • Baas, A.F.1    Kuipers, J.2    Van Der Wel, N.N.3    Batlle, E.4    Koerten, H.K.5
  • 9
    • 2942729619 scopus 로고    scopus 로고
    • LKB1 tumor suppressor protein: PARtaker in cell polarity
    • In press
    • Baas AF, Smit L, Clevers HC. 2004. LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends Cell Biol. In press
    • (2004) Trends Cell Biol.
    • Baas, A.F.1    Smit, L.2    Clevers, H.C.3
  • 10
    • 0034096436 scopus 로고    scopus 로고
    • Stem cells: The intestinal stem cell as a paradigm
    • Bach SP, Renehan AG, Potten CS. 2000. Stem cells: the intestinal stem cell as a paradigm. Carcinogenesis 21:469-76
    • (2000) Carcinogenesis , vol.21 , pp. 469-476
    • Bach, S.P.1    Renehan, A.G.2    Potten, C.S.3
  • 11
    • 0037068461 scopus 로고    scopus 로고
    • Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
    • Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, et al. 2002. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419:162-67
    • (2002) Nature , vol.419 , pp. 162-167
    • Bardeesy, N.1    Sinha, M.2    Hezel, A.F.3    Signoretti, S.4    Hathaway, N.A.5
  • 12
    • 0001360371 scopus 로고
    • Regulation of intestinal epithelial-cell growth by transforming growth-factor type-beta
    • Barnard JA, Beauchamp RD, Coffey RJ, Moses HL. 1989. Regulation of intestinal epithelial-cell growth by transforming growth-factor type-beta. Proc. Natl. Acad. Sci. USA 86:1578-82
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 1578-1582
    • Barnard, J.A.1    Beauchamp, R.D.2    Coffey, R.J.3    Moses, H.L.4
  • 13
    • 0037376416 scopus 로고    scopus 로고
    • An overview of the Notch signalling pathway
    • Baron M. 2003. An overview of the Notch signalling pathway. Semin. Cell Dev. Biol. 14:113-19
    • (2003) Semin. Cell Dev. Biol. , vol.14 , pp. 113-119
    • Baron, M.1
  • 14
    • 18644376279 scopus 로고    scopus 로고
    • Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB
    • Batlle E, Henderson JT, Beghtel H, van den Born MM, Sancho E, et al. 2002. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 111:251-63
    • (2002) Cell , vol.111 , pp. 251-263
    • Batlle, E.1    Henderson, J.T.2    Beghtel, H.3    Van Den Born, M.M.4    Sancho, E.5
  • 15
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman DM, Karhadkar SS, Maitra A, Montes DO, Gerstenblith MR, et al. 2003. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425:846-51
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3    Montes, D.O.4    Gerstenblith, M.R.5
  • 16
    • 0034644526 scopus 로고    scopus 로고
    • Linking colorectal cancer to Wnt signaling
    • Bienz M, Clevers H. 2000. Linking colorectal cancer to Wnt signaling. Cell 103:311-20
    • (2000) Cell , vol.103 , pp. 311-320
    • Bienz, M.1    Clevers, H.2
  • 17
    • 0028837742 scopus 로고
    • Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
    • Bitgood MJ, McMahon AP. 1995. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev. Biol. 172:126-38
    • (1995) Dev. Biol. , vol.172 , pp. 126-138
    • Bitgood, M.J.1    McMahon, A.P.2
  • 18
    • 0032897996 scopus 로고    scopus 로고
    • Clonal analysis of mouse intestinal epithelial progenitors
    • Bjerknes M, Cheng H. 1999. Clonal analysis of mouse intestinal epithelial progenitors. Gastroenterology 116:7-14
    • (1999) Gastroenterology , vol.116 , pp. 7-14
    • Bjerknes, M.1    Cheng, H.2
  • 19
    • 0034604110 scopus 로고    scopus 로고
    • Mechanisms of disease: Role of transforming growth factor beta in human disease
    • Blobe GC, Schiemann WP, Lodish HF. 2000. Mechanisms of disease: role of transforming growth factor beta in human disease. N. Engl. J. Med. 342:1350-58
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 22
    • 0034080251 scopus 로고    scopus 로고
    • Gut instincts: Thoughts on intestinal epithelial stem cells
    • Booth C, Potten CS. 2000. Gut instincts: thoughts on intestinal epithelial stem cells. J. Clin. Invest 105:1493-99
    • (2000) J. Clin. Invest. , vol.105 , pp. 1493-1499
    • Booth, C.1    Potten, C.S.2
  • 23
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL. 1989. ras oncogenes in human cancer: a review. Cancer Res. 49:4682-89
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 24
    • 0141753981 scopus 로고    scopus 로고
    • MO25 alpha/beta interact with STRAD alpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
    • Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, et al. 2003. MO25 alpha/beta interact with STRAD alpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J. 22:5102-14
    • (2003) EMBO J. , vol.22 , pp. 5102-5114
    • Boudeau, J.1    Baas, A.F.2    Deak, M.3    Morrice, N.A.4    Kieloch, A.5
  • 25
    • 1842581909 scopus 로고    scopus 로고
    • Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
    • Brajenovic M, Joberty G, Kuster B, Bouwmeester T, Drewes G. 2004. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J. Biol. Chem. 279:12804-11
    • (2004) J. Biol. Chem. , vol.279 , pp. 12804-12811
    • Brajenovic, M.1    Joberty, G.2    Kuster, B.3    Bouwmeester, T.4    Drewes, G.5
  • 26
    • 0028221943 scopus 로고
    • Mutation in the DNA mismatch repair gene homolog Hmlh1 is associated with hereditary nonpolyposis colon-cancer
    • Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, et al. 1994. Mutation in the DNA mismatch repair gene homolog Hmlh1 is associated with hereditary nonpolyposis colon-cancer. Nature 368:258-61
    • (1994) Nature , vol.368 , pp. 258-261
    • Bronner, C.E.1    Baker, S.M.2    Morrison, P.T.3    Warren, G.4    Smith, L.G.5
  • 27
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: A common theme in animal development
    • Cadigan KM, Nusse R. 1997. Wnt signaling: a common theme in animal development. Genes Dev. 11:3286-305
    • (1997) Genes Dev. , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 29
    • 0028905406 scopus 로고
    • Familial adenomatous polyposis: Desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444
    • Caspari R, Olschwang S, Friedl W, Mandl M, Boisson C, et al. 1995. Familial adenomatous polyposis: desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444. Hum. Mol. Genet. 4:337-40
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 337-340
    • Caspari, R.1    Olschwang, S.2    Friedl, W.3    Mandl, M.4    Boisson, C.5
  • 30
    • 0346337126 scopus 로고    scopus 로고
    • Aberrant crypt foci as microscopic precursors of colorectal cancer
    • Cheng L, Lai MD. 2003. Aberrant crypt foci as microscopic precursors of colorectal cancer. World J. Gastroenterol. 9:2642-49
    • (2003) World J. Gastroenterol. , vol.9 , pp. 2642-2649
    • Cheng, L.1    Lai, M.D.2
  • 31
    • 0030852842 scopus 로고    scopus 로고
    • Bi-transgenic mice reveal that K-rasVal12 augments a p53-independent apoptosis when small intestinal villus enterocytes reenter the cell cycle
    • Coopersmith CM, Chandrasekaran C, McNevin MS, Gordon JI. 1997. Bi-transgenic mice reveal that K-rasVal12 augments a p53-independent apoptosis when small intestinal villus enterocytes reenter the cell cycle. J. Cell Biol. 138:167-79
    • (1997) J. Cell Biol. , vol.138 , pp. 167-179
    • Coopersmith, C.M.1    Chandrasekaran, C.2    McNevin, M.S.3    Gordon, J.I.4
  • 32
    • 0032934979 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
    • Datto MB, Frederick JP, Pan LH, Borton AJ, Zhuang Y, Wang XF. 1999. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol. Cell. Biol. 19:2495-504
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2495-2504
    • Datto, M.B.1    Frederick, J.P.2    Pan, L.H.3    Borton, A.J.4    Zhuang, Y.5    Wang, X.F.6
  • 34
    • 0033535504 scopus 로고    scopus 로고
    • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
    • De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, et al. 1999. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398:518-22
    • (1999) Nature , vol.398 , pp. 518-522
    • De Strooper, B.1    Annaert, W.2    Cupers, P.3    Saftig, P.4    Craessaerts, K.5
  • 35
    • 0034530165 scopus 로고    scopus 로고
    • Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis
    • Dunker N, Krieglstein K. 2000. Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis. Eur. J. Biochem. 267:6982-88
    • (2000) Eur. J. Biochem. , vol.267 , pp. 6982-6988
    • Dunker, N.1    Krieglstein, K.2
  • 36
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    • Echelard Y, Epstein DJ, St Jacques B, Shen L, Mohler J, et al. 1993. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75:1417-30
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St Jacques, B.3    Shen, L.4    Mohler, J.5
  • 37
    • 0033565626 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 suppresses non-metastatic colon cancer at an early stage of tumorigenesis
    • Engle SJ, Hoying JB, Boivin GP, Ormsby I, Gartside PS, Doetschman T. 1999. Transforming growth factor beta 1 suppresses non-metastatic colon cancer at an early stage of tumorigenesis. Cancer Res. 59:3379-86
    • (1999) Cancer Res. , vol.59 , pp. 3379-3386
    • Engle, S.J.1    Hoying, J.B.2    Boivin, G.P.3    Ormsby, I.4    Gartside, P.S.5    Doetschman, T.6
  • 38
    • 0037112436 scopus 로고    scopus 로고
    • Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice
    • Engle SJ; Ormsby I, Pawlowski S, Boivin GP, Croft J, et al. 2002. Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice. Cancer Res 62:6362-66
    • (2002) Cancer Res. , vol.62 , pp. 6362-6366
    • Engle, S.J.1    Ormsby, I.2    Pawlowski, S.3    Boivin, G.P.4    Croft, J.5
  • 39
    • 16044369574 scopus 로고    scopus 로고
    • MADR2 maps to 18q21 and encodes a TGF beta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
    • Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, et al. 1996. MADR2 maps to 18q21 and encodes a TGF beta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86:543-52
    • (1996) Cell , vol.86 , pp. 543-552
    • Eppert, K.1    Scherer, S.W.2    Ozcelik, H.3    Pirone, R.4    Hoodless, P.5
  • 40
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. 1990. A genetic model for colorectal tumorigenesis. Cell 61:759-67
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 41
    • 0028567875 scopus 로고
    • A targeted chain-termination mutation in the mouse APC gene results in multiple intestinal tumors
    • Fodde R, Edelmann W, Yang K, van Leeuwen C, Carlson C, et al. 1994. A targeted chain-termination mutation in the mouse APC gene results in multiple intestinal tumors. Proc. Natl. Acad. Sci. USA 91:8969-73
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8969-8973
    • Fodde, R.1    Edelmann, W.2    Yang, K.3    Van Leeuwen, C.4    Carlson, C.5
  • 42
    • 0035070046 scopus 로고    scopus 로고
    • Mutations in the APC tumour suppressor gene cause chromosomal instability
    • Fodde R, Kuipers J, Rosenberg C, Smits R, Kielman M, et al. 2001a. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat. Cell Biol. 3:433-38
    • (2001) Nat. Cell Biol. , vol.3 , pp. 433-438
    • Fodde, R.1    Kuipers, J.2    Rosenberg, C.3    Smits, R.4    Kielman, M.5
  • 43
    • 0035496104 scopus 로고    scopus 로고
    • APC, signal transduction and genetic instability in colorectal cancer
    • Fodde R, Smits R, Clevers H. 2001b. APC, signal transduction and genetic instability in colorectal cancer. Nat. Rev. Cancer 1:55-67
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 55-67
    • Fodde, R.1    Smits, R.2    Clevers, H.3
  • 44
    • 0023262990 scopus 로고
    • Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
    • Forrester K, Almoguera C, Han K, Grizzle WE, Perucho M. 1987. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 327:298-303
    • (1987) Nature , vol.327 , pp. 298-303
    • Forrester, K.1    Almoguera, C.2    Han, K.3    Grizzle, W.E.4    Perucho, M.5
  • 49
    • 0023222358 scopus 로고
    • Nevoid basal-cell carcinoma syndrome
    • Gorlin RJ. 1987. Nevoid basal-cell carcinoma syndrome. Medicine 66:98-113
    • (1987) Medicine , vol.66 , pp. 98-113
    • Gorlin, R.J.1
  • 50
    • 0033555627 scopus 로고    scopus 로고
    • Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers
    • Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, et al. 1999. Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res. 59:320-24
    • (1999) Cancer Res. , vol.59 , pp. 320-324
    • Grady, W.M.1    Myeroff, L.L.2    Swinler, S.E.3    Rajput, A.4    Thiagalingam, S.5
  • 51
    • 0025938038 scopus 로고
    • Identification and characterization of the familial adenomatous polyposis coli gene
    • Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, et al. 1991. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66:589-600
    • (1991) Cell , vol.66 , pp. 589-600
    • Groden, J.1    Thliveris, A.2    Samowitz, W.3    Carlson, M.4    Gelbert, L.5
  • 52
    • 0022977531 scopus 로고
    • Hereditary gastrointestinal polyposis syndromes
    • Haggitt RC, Reid BJ. 1986. Hereditary gastrointestinal polyposis syndromes. Am. J. Surg. Pathol. 10:871-87
    • (1986) Am. J. Surg. Pathol. , vol.10 , pp. 871-887
    • Haggitt, R.C.1    Reid, B.J.2
  • 53
    • 15844386165 scopus 로고    scopus 로고
    • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    • Hahn H, Wicking C, Zaphiropoulous PG, Gailani MR, Shanley S, et al. 1996. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85:841-51
    • (1996) Cell , vol.85 , pp. 841-851
    • Hahn, H.1    Wicking, C.2    Zaphiropoulous, P.G.3    Gailani, M.R.4    Shanley, S.5
  • 54
    • 0037542854 scopus 로고    scopus 로고
    • Ras proteins: Different signals from different locations
    • Hancock JF. 2003. Ras proteins: different signals from different locations. Nat. Rev. Mol. Cell Biol. 4:373-84
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 373-384
    • Hancock, J.F.1
  • 55
    • 0033230616 scopus 로고    scopus 로고
    • Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    • Harada N, Tamai Y, Ishikawa T, Sauer B, Takaku K, Oshima M, Taketo MM. 1999. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J. 18:5931-42
    • (1999) EMBO J. , vol.18 , pp. 5931-5942
    • Harada, N.1    Tamai, Y.2    Ishikawa, T.3    Sauer, B.4    Takaku, K.5    Oshima, M.6    Taketo, M.M.7
  • 58
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, et al. 2003. Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2:28
    • (2003) J. Biol. , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5
  • 59
    • 0029940608 scopus 로고    scopus 로고
    • Epithelial cell migration in the intestine
    • Heath JP. 1996. Epithelial cell migration in the intestine. Cell Biol. Int. 20:139-46
    • (1996) Cell Biol. Int. , vol.20 , pp. 139-146
    • Heath, J.P.1
  • 60
    • 0032495530 scopus 로고    scopus 로고
    • A serine/threonine kinase gene defective in Peutz-Jegheus syndrome
    • Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, et al. 1998. A serine/threonine kinase gene defective in Peutz-Jegheus syndrome. Nature 391:184-47
    • (1998) Nature , vol.391 , pp. 184-247
    • Hemminki, A.1    Markie, D.2    Tomlinson, I.3    Avizienyte, E.4    Roth, S.5
  • 61
    • 0031012344 scopus 로고    scopus 로고
    • Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis
    • Hemminki A, Tomlinson I, Markie D, Jarvinen H, Sistonen P, et al. 1997. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat. Genet. 15:87-90
    • (1997) Nat. Genet. , vol.15 , pp. 87-90
    • Hemminki, A.1    Tomlinson, I.2    Markie, D.3    Jarvinen, H.4    Sistonen, P.5
  • 62
    • 0029964159 scopus 로고    scopus 로고
    • Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system
    • Hermiston ML, Wong MH, Gordon JI. 1996. Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system. Genes Dev. 10:985-96
    • (1996) Genes Dev. , vol.10 , pp. 985-996
    • Hermiston, M.L.1    Wong, M.H.2    Gordon, J.I.3
  • 63
    • 0032406286 scopus 로고    scopus 로고
    • Molecular mechanisms of enteroendocrine differentiation
    • Hocker M, Wiedenmann B. 1998. Molecular mechanisms of enteroendocrine differentiation. Ann. NY Acad. Sci. 859:160-74
    • (1998) Ann. NY Acad. Sci. , vol.859 , pp. 160-174
    • Hocker, M.1    Wiedenmann, B.2
  • 64
    • 0024535843 scopus 로고
    • Differential sensitivity of subclasses of human-colon carcinoma cell-lines to the growth inhibitory effects of transforming growth factor-beta-1
    • Hoosein NM, McKnight MK, Levine AE, Mulder KM, Childress KE, et al. 1989. Differential sensitivity of subclasses of human-colon carcinoma cell-lines to the growth inhibitory effects of transforming growth factor-beta-1. Exp. Cell Res. 181:442-53
    • (1989) Exp. Cell Res. , vol.181 , pp. 442-453
    • Hoosein, N.M.1    McKnight, M.K.2    Levine, A.E.3    Mulder, K.M.4    Childress, K.E.5
  • 65
    • 0034972978 scopus 로고    scopus 로고
    • Germline mutations of the gene encoding bone morphogenetic protein receptor IA in juvenile polyposis
    • Howe JR, Bair JL, Sayed MG, Anderson ME, Mitros FA, et al. 2001. Germline mutations of the gene encoding bone morphogenetic protein receptor IA in juvenile polyposis. Nat. Genet. 28:184-87
    • (2001) Nat. Genet. , vol.28 , pp. 184-187
    • Howe, J.R.1    Bair, J.L.2    Sayed, M.G.3    Anderson, M.E.4    Mitros, F.A.5
  • 68
    • 0037220169 scopus 로고    scopus 로고
    • TP53 mutation in colorectal cancer
    • Iacopetta B. 2003. TP53 mutation in colorectal cancer. Hum. Mutat. 21:271-76
    • (2003) Hum. Mutat. , vol.21 , pp. 271-276
    • Iacopetta, B.1
  • 69
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham PW, McMahon AP. 2001. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15:3059-87
    • (2001) Genes Dev. , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 70
    • 0030987867 scopus 로고    scopus 로고
    • A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria
    • Jacoby RF, Schlack S, Cole CE, Skarbek M, Harris C, Meisner LF. 1997. A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria. Gastroenterology 112:1398-403
    • (1997) Gastroenterology , vol.112 , pp. 1398-1403
    • Jacoby, R.F.1    Schlack, S.2    Cole, C.E.3    Skarbek, M.4    Harris, C.5    Meisner, L.F.6
  • 71
    • 0037365636 scopus 로고    scopus 로고
    • Murine models of colorectal cancer: Studying the role of oncogenic K-ras
    • Janssen KP. 2003. Murine models of colorectal cancer: studying the role of oncogenic K-ras. Cell Mol. Life Sci. 60:495-506
    • (2003) Cell Mol. Life Sci. , vol.60 , pp. 495-506
    • Janssen, K.P.1
  • 72
    • 0036328995 scopus 로고    scopus 로고
    • Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice
    • Janssen KP, el Marjou F, Pinto D, Sastre X, Rouillard D, et al. 2002. Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. Gastroenterology 123:492-504
    • (2002) Gastroenterology , vol.123 , pp. 492-504
    • Janssen, K.P.1    El Marjou, F.2    Pinto, D.3    Sastre, X.4    Rouillard, D.5
  • 73
    • 7144256236 scopus 로고    scopus 로고
    • Morphology of sporadic colorectal cancer with DNA replication errors
    • Jass JR, Do KA, Simms LA, lino H, Wynter C, et al. 1998. Morphology of sporadic colorectal cancer with DNA replication errors. Gut 42:673-79
    • (1998) Gut , vol.42 , pp. 673-679
    • Jass, J.R.1    Do, K.A.2    Simms, L.A.3    Lino, H.4    Wynter, C.5
  • 75
    • 0031974516 scopus 로고    scopus 로고
    • Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
    • Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, et al. 1998. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat. Genet. 18:38-44
    • (1998) Nat. Genet. , vol.18 , pp. 38-44
    • Jenne, D.E.1    Reimann, H.2    Nezu, J.3    Friedel, W.4    Loff, S.5
  • 76
    • 0037011171 scopus 로고    scopus 로고
    • Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium
    • Jenny M, Uhl C, Roche C, Duluc I, Guillermin V, et al. 2002. Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J. 21:6338-47
    • (2002) EMBO J. , vol.21 , pp. 6338-6347
    • Jenny, M.1    Uhl, C.2    Roche, C.3    Duluc, I.4    Guillermin, V.5
  • 78
    • 0037173013 scopus 로고    scopus 로고
    • Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis
    • Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, et al. 2002. Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc. Natl. Acad. Sci. USA 99:8903-8
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 8903-8908
    • Jishage, K.1    Nezu, J.2    Kawase, Y.3    Iwata, T.4    Watanabe, M.5
  • 79
    • 0035953550 scopus 로고    scopus 로고
    • Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
    • Johnson L, Mercer K, Greenbaum D, Bronson RT, Crowley D, et al. 2001. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410:1111-16
    • (2001) Nature , vol.410 , pp. 1111-1116
    • Johnson, L.1    Mercer, K.2    Greenbaum, D.3    Bronson, R.T.4    Crowley, D.5
  • 80
    • 15844381336 scopus 로고    scopus 로고
    • Human homolog of patched, a candidate gene for the basal cell nevus syndrome
    • Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, et al. 1996. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272:1668-71
    • (1996) Science , vol.272 , pp. 1668-1671
    • Johnson, R.L.1    Rothman, A.L.2    Xie, J.3    Goodrich, L.V.4    Bare, J.W.5
  • 82
    • 0027363255 scopus 로고
    • Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia
    • Kim SH, Roth KA, Moser AR, Gordon JI. 1993. Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia. J. Cell Biol. 123:877-93
    • (1993) J. Cell Biol. , vol.123 , pp. 877-893
    • Kim, S.H.1    Roth, K.A.2    Moser, A.R.3    Gordon, J.I.4
  • 83
    • 0033966897 scopus 로고    scopus 로고
    • New mouse models of congenital anorectal malformations
    • Kimmel SG, Mo R, Hui CC, Kim PC. 2000. New mouse models of congenital anorectal malformations. J. Pediatr. Surg. 35:227-30
    • (2000) J. Pediatr. Surg. , vol.35 , pp. 227-230
    • Kimmel, S.G.1    Mo, R.2    Hui, C.C.3    Kim, P.C.4
  • 85
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler KW, Vogelstein B. 1996. Lessons from hereditary colorectal cancer. Cell 87:159-70
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 86
    • 0034669031 scopus 로고    scopus 로고
    • A common enzyme connects notch signaling and Alzheimer's disease
    • Kopan R, Goate A. 2000. A common enzyme connects notch signaling and Alzheimer's disease. Genes Dev. 14:2799-806
    • (2000) Genes Dev. , vol.14 , pp. 2799-2806
    • Kopan, R.1    Goate, A.2
  • 87
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    • Korinek V, Barker N, Moerer P, van Donselaar E, Huls G, et al. 1998. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 19:379-83
    • (1998) Nat. Genet. , vol.19 , pp. 379-383
    • Korinek, V.1    Barker, N.2    Moerer, P.3    Van Donselaar, E.4    Huls, G.5
  • 89
    • 0023115518 scopus 로고
    • Effects of growth-factors on an intestinal epithelial-cell line - Transforming growth-factor-beta inhibits proliferation and stimulates differentiation
    • Kurokowa M, Lynch K, Podolsky DK. 1987. Effects of growth-factors on an intestinal epithelial-cell line - transforming growth-factor-beta inhibits proliferation and stimulates differentiation. Biochem. Biophys. Res. Comm. 142:775-82
    • (1987) Biochem. Biophys. Res. Comm. , vol.142 , pp. 775-782
    • Kurokowa, M.1    Lynch, K.2    Podolsky, D.K.3
  • 90
    • 0027145633 scopus 로고
    • Mutations of a mutS homolog in hereditary nonpolyposis nolorectalnancer
    • Leach FS, Nicolaides NC, Papadopoulos N, Liu B, et al. 1993. Mutations of a mutS homolog in hereditary nonpolyposis nolorectalnancer. Cell 75:1215-25
    • (1993) Cell , vol.75 , pp. 1215-1225
    • Leach, F.S.1    Nicolaides, N.C.2    Papadopoulos, N.3    Liu, B.4
  • 91
    • 0025354907 scopus 로고
    • Genetic-analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps
    • Leppert M, Burt R, Hughes JP, Samowitz W, Nakamura Y, et al. 1990. Genetic-analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps. N. Engl. J. Med. 322:904-8
    • (1990) N. Engl. J. Med. , vol.322 , pp. 904-908
    • Leppert, M.1    Burt, R.2    Hughes, J.P.3    Samowitz, W.4    Nakamura, Y.5
  • 92
    • 0028859671 scopus 로고
    • Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
    • Liu B, Nicolaides NC, Markowitz S, Willson JKV, Parsons RE, et al. 1995. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat. Genet. 9:48-55
    • (1995) Nat. Genet. , vol.9 , pp. 48-55
    • Liu, B.1    Nicolaides, N.C.2    Markowitz, S.3    Willson, J.K.V.4    Parsons, R.E.5
  • 93
    • 0033780630 scopus 로고    scopus 로고
    • Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling
    • Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, et al. 2000. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. Nat. Genet. 26:146-47
    • (2000) Nat. Genet. , vol.26 , pp. 146-147
    • Liu, W.1    Dong, X.2    Mai, M.3    Seelan, R.S.4    Taniguchi, K.5
  • 94
    • 12144287284 scopus 로고    scopus 로고
    • LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    • Lizcano JM, Goransson O, Toth R, Deak M, Morrice NA, et al. 2004. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 23:833-43
    • (2004) EMBO J. , vol.23 , pp. 833-843
    • Lizcano, J.M.1    Goransson, O.2    Toth, R.3    Deak, M.4    Morrice, N.A.5
  • 95
    • 0037422027 scopus 로고    scopus 로고
    • Genomic medicine - Hereditary colorectal cancer
    • Lynch HT, de la Chapelle A. 2003. Genomic medicine - hereditary colorectal cancer. N. Engl. J. Med. 348:919-32
    • (2003) N. Engl. J. Med. , vol.348 , pp. 919-932
    • Lynch, H.T.1    De La Chapelle, A.2
  • 96
  • 97
    • 0029066689 scopus 로고
    • Inactivation of the type-II TGF-beta receptor in colon-cancer cells with microsatellite instability
    • Markowitz S, Wang J, Myeroff L, Parsons R, Sun LZ, et al. 1995. Inactivation of the type-II TGF-beta receptor in colon-cancer cells with microsatellite instability. Science 268:1336-38
    • (1995) Science , vol.268 , pp. 1336-1338
    • Markowitz, S.1    Wang, J.2    Myeroff, L.3    Parsons, R.4    Sun, L.Z.5
  • 98
    • 0036007425 scopus 로고    scopus 로고
    • The intestinal epithelial stem cell
    • Marshman E, Booth C, Potten CS. 2002. The intestinal epithelial stem cell. BioEssays 24:91-98
    • (2002) BioEssays , vol.24 , pp. 91-98
    • Marshman, E.1    Booth, C.2    Potten, C.S.3
  • 99
    • 0037461735 scopus 로고    scopus 로고
    • A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
    • Martin SG, St Johnston D. 2003. A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 421:379-84
    • (2003) Nature , vol.421 , pp. 379-384
    • Martin, S.G.1    St Johnston, D.2
  • 100
    • 0031278322 scopus 로고    scopus 로고
    • Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
    • Miyaki M, Konishi M, Tanaka K, Kikuchi-Yanoshita R, Muraoka M, et al. 1997. Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. Nat. Genet. 17:271-72
    • (1997) Nat. Genet. , vol.17 , pp. 271-272
    • Miyaki, M.1    Konishi, M.2    Tanaka, K.3    Kikuchi-Yanoshita, R.4    Muraoka, M.5
  • 102
    • 0026894053 scopus 로고
    • Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
    • Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, et al. 1992. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum. Mol. Genet. 1:229-33
    • (1992) Hum. Mol. Genet. , vol.1 , pp. 229-233
    • Miyoshi, Y.1    Nagase, H.2    Ando, H.3    Horii, A.4    Ichii, S.5
  • 103
    • 0034880142 scopus 로고    scopus 로고
    • Anorectal malformations caused by defects in sonic hedgehog signaling
    • Mo R, Kim JH, Zhang J, Chiang C, Hui CC, Kim PC. 2001. Anorectal malformations caused by defects in sonic hedgehog signaling. Am. J. Pathol. 159:765-74
    • (2001) Am. J. Pathol. , vol.159 , pp. 765-774
    • Mo, R.1    Kim, J.H.2    Zhang, J.3    Chiang, C.4    Hui, C.C.5    Kim, P.C.6
  • 104
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, et al. 1997. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275:1787-90
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5
  • 105
    • 0025015168 scopus 로고
    • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    • Moser AR, Pitot HC, Dove WF. 1990. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247:322-24
    • (1990) Science , vol.247 , pp. 322-324
    • Moser, A.R.1    Pitot, H.C.2    Dove, W.F.3
  • 106
    • 0029125021 scopus 로고
    • Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation
    • Moser AR, Shoemaker AR, Connelly CS, Clipson L, Gould KA, et al. 1995. Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation. Dev. Dyn. 203:422-33
    • (1995) Dev. Dyn. , vol.203 , pp. 422-433
    • Moser, A.R.1    Shoemaker, A.R.2    Connelly, C.S.3    Clipson, L.4    Gould, K.A.5
  • 107
    • 0034671686 scopus 로고    scopus 로고
    • Notch signaling: From the outside in
    • Mumm JS, Kopan R. 2000. Notch signaling: from the outside in. Dev. Biol. 228:151-65
    • (2000) Dev. Biol. , vol.228 , pp. 151-165
    • Mumm, J.S.1    Kopan, R.2
  • 108
    • 0028987249 scopus 로고
    • Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein
    • Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P. 1995. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. USA 92:3046-50
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3046-3050
    • Munemitsu, S.1    Albert, I.2    Souza, B.3    Rubinfeld, B.4    Polakis, P.5
  • 109
    • 0027146559 scopus 로고
    • Mutations of the APC (adenomatous polyposis coli) gene
    • Nagase H, Nakamura Y. 1993. Mutations of the APC (adenomatous polyposis coli) gene. Hum. Mutat. 2:425-34
    • (1993) Hum. Mutat. , vol.2 , pp. 425-434
    • Nagase, H.1    Nakamura, Y.2
  • 110
    • 0030886674 scopus 로고    scopus 로고
    • Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice
    • Naya FJ, Huang HP, Qiu YH, Mutoh H, Demayo FJ, et al. 1997. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice. Genes Dev. 11:2323-34
    • (1997) Genes Dev. , vol.11 , pp. 2323-2334
    • Naya, F.J.1    Huang, H.P.2    Qiu, Y.H.3    Mutoh, H.4    Demayo, F.J.5
  • 111
    • 0027933070 scopus 로고
    • Mutations of 2 pms homologs in hereditary nonpolyposis colon-cancer
    • Nicolaides NC, Papadopoulos N, Liu B, Wei YF, Carter KC, et al. 1994. Mutations of 2 pms homologs in hereditary nonpolyposis colon-cancer. Nature 371:75-80
    • (1994) Nature , vol.371 , pp. 75-80
    • Nicolaides, N.C.1    Papadopoulos, N.2    Liu, B.3    Wei, Y.F.4    Carter, K.C.5
  • 112
    • 0041699964 scopus 로고    scopus 로고
    • Expression of Musashi-1 in human normal colon crypt cells: A possible stem cell marker of human colon epithelium
    • Nishimura S, Wakabayashi N, Toyoda K, Kashima K, Mitsufuji S. 2003. Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epithelium. Dig. Dis. Sci. 48:1523-29
    • (2003) Dig. Dis. Sci. , vol.48 , pp. 1523-1529
    • Nishimura, S.1    Wakabayashi, N.2    Toyoda, K.3    Kashima, K.4    Mitsufuji, S.5
  • 113
    • 0031468110 scopus 로고    scopus 로고
    • Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa
    • Nucci MR, Robinson CR, Longo P, Campbell P, Hamilton SR. 1997. Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa. Hum. Pathol. 28:1396-407
    • (1997) Hum. Pathol. , vol.28 , pp. 1396-1407
    • Nucci, M.R.1    Robinson, C.R.2    Longo, P.3    Campbell, P.4    Hamilton, S.R.5
  • 114
    • 0036778132 scopus 로고    scopus 로고
    • Hedgehog signal transduction: Recent findings
    • Nybakken K, Perrimon N. 2002. Hedgehog signal transduction: recent findings. Curr. Opin. Genet. Dev. 12:503-11
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 503-511
    • Nybakken, K.1    Perrimon, N.2
  • 115
    • 0029047954 scopus 로고
    • Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
    • Oshima M, Oshima H, Kitagawa K, Kobayashi M, Itakura C, Taketo M. 1995. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc. Natl. Acad. Sci. USA 92:4482-86
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4482-4486
    • Oshima, M.1    Oshima, H.2    Kitagawa, K.3    Kobayashi, M.4    Itakura, C.5    Taketo, M.6
  • 117
    • 0345059765 scopus 로고    scopus 로고
    • Hedgehog signalling in cancer formation and maintenance
    • Pasca dM, Hebrok M. 2003. Hedgehog signalling in cancer formation and maintenance. Nat. Rev. Cancer 3:903-11
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 903-911
    • Pasca, D.M.1    Hebrok, M.2
  • 118
    • 0037829660 scopus 로고    scopus 로고
    • Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
    • Pinto D, Gregorieff A, Beghtel H, Clevers H. 2003. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 17:1709-13
    • (2003) Genes Dev. , vol.17 , pp. 1709-1713
    • Pinto, D.1    Gregorieff, A.2    Beghtel, H.3    Clevers, H.4
  • 119
    • 0033054464 scopus 로고    scopus 로고
    • The oncogenic activation of beta-catenin
    • Polakis P. 1999. The oncogenic activation of beta-catenin. Curr. Opin. Genet. Dev. 9:15-21
    • (1999) Curr. Opin. Genet. Dev. , vol.9 , pp. 15-21
    • Polakis, P.1
  • 121
    • 0032578019 scopus 로고    scopus 로고
    • Stem cells in gastrointestinal epithelium: Numbers, characteristics and death
    • Potten CS. 1998. Stem cells in gastrointestinal epithelium: numbers, characteristics and death. Philos. Trans. R. Soc. London Ser. B 353:821-30
    • (1998) Philos. Trans. R. Soc. London Ser. B , vol.353 , pp. 821-830
    • Potten, C.S.1
  • 122
    • 0012872309 scopus 로고    scopus 로고
    • Identification of a putative intestinal stem cell and early lineage marker; musashi-1
    • Potten CS, Booth C, Tudor GL, Booth D, Brady G, et al. 2003. Identification of a putative intestinal stem cell and early lineage marker; musashi-1. Differentiation 71:28-41
    • (2003) Differentiation , vol.71 , pp. 28-41
    • Potten, C.S.1    Booth, C.2    Tudor, G.L.3    Booth, D.4    Brady, G.5
  • 123
    • 0025641727 scopus 로고
    • Stem cells: Attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt
    • Potten CS, Loeffler M. 1990. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110:1001-20
    • (1990) Development , vol.110 , pp. 1001-1020
    • Potten, C.S.1    Loeffler, M.2
  • 124
    • 0036591968 scopus 로고    scopus 로고
    • Intestinal stem cells protect their genome by selective segregation of template DNA strands
    • Potten CS, Owen G, Booth D. 2002. Intestinal stem cells protect their genome by selective segregation of template DNA strands. J. Cell Sci. 115:2381-88
    • (2002) J. Cell Sci. , vol.115 , pp. 2381-2388
    • Potten, C.S.1    Owen, G.2    Booth, D.3
  • 125
    • 0038079684 scopus 로고    scopus 로고
    • Bottom-up histogenesis of colorectal adenomas: Origin in the monocryptal adenoma and initial expansion by crypt fission
    • Preston SL, Wong WM, Chan AO, Poulsom R, Jeffery R, et al. 2003. Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission. Cancer Res. 63:3819-25
    • (2003) Cancer Res. , vol.63 , pp. 3819-3825
    • Preston, S.L.1    Wong, W.M.2    Chan, A.O.3    Poulsom, R.4    Jeffery, R.5
  • 128
    • 0033916281 scopus 로고    scopus 로고
    • Hedgehog signals regulate multiple aspects of gastrointestinal development
    • Ramalho-Santos M, Melton DA, McMahon AP. 2000. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127:2763-72
    • (2000) Development , vol.127 , pp. 2763-2772
    • Ramalho-Santos, M.1    Melton, D.A.2    McMahon, A.P.3
  • 129
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino N, Yamamoto H, lonov Y, Li Y, Sawai H, et al. 1997. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275:967-69
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Lonov, Y.3    Li, Y.4    Sawai, H.5
  • 131
    • 0026609311 scopus 로고
    • Intestinal brush-border-associated enzymes: Co-ordinated expression in colorectal cancer
    • Real FX, Xu M, Vila MR, de Bolos C. 1992. Intestinal brush-border- associated enzymes: co-ordinated expression in colorectal cancer. Int. J. Cancer 51:173-81
    • (1992) Int. J. Cancer , vol.51 , pp. 173-181
    • Real, F.X.1    Xu, M.2    Vila, M.R.3    De Bolos, C.4
  • 132
    • 0032426346 scopus 로고    scopus 로고
    • Early patterning of the C. elegans embryo
    • Rose LS, Kemphues KJ. 1998. Early patterning of the C. elegans embryo. Annu. Rev. Genet. 32:521-45
    • (1998) Annu. Rev. Genet. , vol.32 , pp. 521-545
    • Rose, L.S.1    Kemphues, K.J.2
  • 133
    • 0025164013 scopus 로고
    • Spatial differentiation of the intestinal epithelium: Analysis of enteroendocrine cells containing immunoreactive serotonin, secretin, and substance P in normal and transgenic mice
    • Roth KA, Gordon JI. 1990. Spatial differentiation of the intestinal epithelium: analysis of enteroendocrine cells containing immunoreactive serotonin, secretin, and substance P in normal and transgenic mice. Proc. Natl. Acad. Sci. USA 87:6408-12
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6408-6412
    • Roth, K.A.1    Gordon, J.I.2
  • 134
    • 0029664368 scopus 로고    scopus 로고
    • Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    • Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P. 1996. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272:1023-26
    • (1996) Science , vol.272 , pp. 1023-1026
    • Rubinfeld, B.1    Albert, I.2    Porfiri, E.3    Fiol, C.4    Munemitsu, S.5    Polakis, P.6
  • 137
    • 0023780022 scopus 로고
    • Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine
    • Schmidt GH, Winton DJ, Ponder BA. 1988. Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine. Development 103:785-90
    • (1988) Development , vol.103 , pp. 785-790
    • Schmidt, G.H.1    Winton, D.J.2    Ponder, B.A.3
  • 138
    • 0036947013 scopus 로고    scopus 로고
    • Expression of Notch pathway components in fetal and adult mouse small intestine
    • Schroder N, Gossler A. 2002. Expression of Notch pathway components in fetal and adult mouse small intestine. Gene Expr. Patterns 2:247-50
    • (2002) Gene Expr. Patterns , vol.2 , pp. 247-250
    • Schroder, N.1    Gossler, A.2
  • 139
    • 0026660392 scopus 로고
    • Enteric defensins: Antibiotic peptide components of intestinal host defense
    • Selsted ME, Miller SI, Henschen AH, Ouellette AJ. 1992. Enteric defensins: antibiotic peptide components of intestinal host defense. J. Cell. Biol. 118:929-36
    • (1992) J. Cell. Biol. , vol.118 , pp. 929-936
    • Selsted, M.E.1    Miller, S.I.2    Henschen, A.H.3    Ouellette, A.J.4
  • 140
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi YG, Massagué J. 2003. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113:685-700
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.G.1    Massagué, J.2
  • 143
    • 0034640112 scopus 로고    scopus 로고
    • The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole
    • Shulman JM, Benton R, St Johnston D. 2000. The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole. Cell 101:377-88
    • (2000) Cell , vol.101 , pp. 377-388
    • Shulman, J.M.1    Benton, R.2    St Johnston, D.3
  • 145
    • 0031936192 scopus 로고    scopus 로고
    • Apc1638N: A mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts
    • Smits R, van der Houven van Oordt, Luz A, Zurcher C, Jagmohan-Changur S, et al. 1998. Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. Gastroenterology 114:275-83
    • (1998) Gastroenterology , vol.114 , pp. 275-283
    • Smits, R.1    Van Der Houven Van Oordt2    Luz, A.3    Zurcher, C.4    Jagmohan-Changur, S.5
  • 146
    • 0023278941 scopus 로고
    • Chromosome-5 allele loss in human colorectal carcinomas
    • Solomon E, Voss R, Hall V, Bodmer WF, Jass JR, et al. 1987. Chromosome-5 allele loss in human colorectal carcinomas. Nature 328:616-19
    • (1987) Nature , vol.328 , pp. 616-619
    • Solomon, E.1    Voss, R.2    Hall, V.3    Bodmer, W.F.4    Jass, J.R.5
  • 147
    • 0027724691 scopus 로고
    • Alleles of the Apc gene - An attenuated form of familial polyposis
    • Spirio L, Olschwang S, Groden J, Robertson M, Samowitz W, et al. 1993. Alleles of the Apc gene - an attenuated form of familial polyposis. Cell 75:951-57
    • (1993) Cell , vol.75 , pp. 951-957
    • Spirio, L.1    Olschwang, S.2    Groden, J.3    Robertson, M.4    Samowitz, W.5
  • 149
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St. Jacques B, Hammerschmidt M, McMahon AP. 1999. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 13:2072-86
    • (1999) Genes Dev. , vol.13 , pp. 2072-2086
    • St. Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 150
    • 0037417893 scopus 로고    scopus 로고
    • Molecular features of adult mouse small intestinal epithelial progenitors
    • Stappenbeck TS, Mills JC, Gordon JI. 2003. Molecular features of adult mouse small intestinal epithelial progenitors. Proc. Natl. Acad. Sci. USA 100:1004-9
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1004-1009
    • Stappenbeck, T.S.1    Mills, J.C.2    Gordon, J.I.3
  • 151
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, et al. 1992. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256:668-70
    • (1992) Science , vol.256 , pp. 668-670
    • Su, L.K.1    Kinzler, K.W.2    Vogelstein, B.3    Preisinger, A.C.4    Moser, A.R.5
  • 152
    • 0034071348 scopus 로고    scopus 로고
    • The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium
    • Sukegawa A, Narita T, Kameda T, Saitoh K, Nohno T, et al. 2000. The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. Development 127:1971-80
    • (2000) Development , vol.127 , pp. 1971-1980
    • Sukegawa, A.1    Narita, T.2    Kameda, T.3    Saitoh, K.4    Nohno, T.5
  • 153
    • 0029808666 scopus 로고    scopus 로고
    • Somatic alterations of the DPC4 gene in human colorectal cancers in vivo
    • Takagi Y, Kohmura H, Futamura M, Kida H, Tanemura H, et al. 1996. Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. Gastroenterology 111:1369-72
    • (1996) Gastroenterology , vol.111 , pp. 1369-1372
    • Takagi, Y.1    Kohmura, H.2    Futamura, M.3    Kida, H.4    Tanemura, H.5
  • 155
    • 0032489508 scopus 로고    scopus 로고
    • Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
    • Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, Taketo MM. 1998. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell 92:645-56
    • (1998) Cell , vol.92 , pp. 645-656
    • Takaku, K.1    Oshima, M.2    Miyoshi, H.3    Matsui, M.4    Seldin, M.F.5    Taketo, M.M.6
  • 156
    • 0037102191 scopus 로고    scopus 로고
    • No effects of Smad2 (Madh2) null mutation on malignant progression of intestinal polyps in Apc(Delta 716) knockout mice
    • Takaku K, Wrana JL, Robertson EJ, Taketo MM. 2002. No effects of Smad2 (Madh2) null mutation on malignant progression of intestinal polyps in Apc(Delta 716) knockout mice. Cancer Res. 62:4558-61
    • (2002) Cancer Res. , vol.62 , pp. 4558-4561
    • Takaku, K.1    Wrana, J.L.2    Robertson, E.J.3    Taketo, M.M.4
  • 157
    • 0034751732 scopus 로고    scopus 로고
    • The rasH2 transgenic mouse: Nature of the model and mechanistic studies on tumorigenesis
    • Tamaoki N. 2001. The rasH2 transgenic mouse: nature of the model and mechanistic studies on tumorigenesis. Toxicol. Pathol. 29(Suppl.):81-89
    • (2001) Toxicol. Pathol. , vol.29 , Issue.SUPPL. , pp. 81-89
    • Tamaoki, N.1
  • 159
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau SN, Bren G, Schaid D. 1993. Microsatellite instability in cancer of the proximal colon. Science 260:816-19
    • (1993) Science , vol.260 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 160
    • 0033775722 scopus 로고    scopus 로고
    • A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation
    • Tomancak P, Piano F, Riechmann V, Gunsalus KC, Kemphues KJ, Ephrussi A. 2000. A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation. Nat. Cell Biol. 2:458-60
    • (2000) Nat. Cell Biol. , vol.2 , pp. 458-460
    • Tomancak, P.1    Piano, F.2    Riechmann, V.3    Gunsalus, K.C.4    Kemphues, K.J.5    Ephrussi, A.6
  • 161
    • 0023390121 scopus 로고
    • The crypt cycle. Crypt and villus production in the adult intestinal epithelium
    • Totafurno J, Bjerknes M, Cheng H. 1987. The crypt cycle. Crypt and villus production in the adult intestinal epithelium. Biophys. J. 52:279-94
    • (1987) Biophys. J. , vol.52 , pp. 279-294
    • Totafurno, J.1    Bjerknes, M.2    Cheng, H.3
  • 162
    • 0023619575 scopus 로고
    • A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants
    • Trahey M, McCormick F. 1987. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238:542-45
    • (1987) Science , vol.238 , pp. 542-545
    • Trahey, M.1    McCormick, F.2
  • 163
    • 18644373146 scopus 로고    scopus 로고
    • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, et al. 2002. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111:241-50
    • (2002) Cell , vol.111 , pp. 241-250
    • Van De Wetering, M.1    Sancho, E.2    Verweij, C.3    De Lau, W.4    Oving, I.5
  • 165
    • 6844252957 scopus 로고    scopus 로고
    • Germline mutations in the 3′ part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli
    • van der Luijt RB, Meera KP, Vasen HF, Breukel C, Tops CM, et al. 1996. Germline mutations in the 3 part of APC exon 15 do not result in truncated pro′teins and are associated with attenuated adenomatous polyposis coli. Hum. Genet. 98:727-34
    • (1996) Hum. Genet. , vol.98 , pp. 727-734
    • Van Der Luijt, R.B.1    Meera, K.P.2    Vasen, H.F.3    Breukel, C.4    Tops, C.M.5
  • 166
    • 13144307115 scopus 로고    scopus 로고
    • Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
    • Veigl ML, Kasturi L, Olechnowicz J, Ma AH, Lutterbaugh JD, et al. 1998. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc. Natl. Acad. Sci. USA 95:8698-702
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8698-8702
    • Veigl, M.L.1    Kasturi, L.2    Olechnowicz, J.3    Ma, A.H.4    Lutterbaugh, J.D.5
  • 168
    • 0032893658 scopus 로고    scopus 로고
    • Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence
    • Wang ZJ, Ellis I, Zauber P, Iwama T, Marchese C, et al. 1999. Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence. J. Pathol. 188:9-13
    • (1999) J. Pathol. , vol.188 , pp. 9-13
    • Wang, Z.J.1    Ellis, I.2    Zauber, P.3    Iwama, T.4    Marchese, C.5
  • 169
    • 0034090975 scopus 로고    scopus 로고
    • The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry
    • Watts JL, Morton DG, Bestman J, Kemphues KJ. 2000. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development 127:1467-75
    • (2000) Development , vol.127 , pp. 1467-1475
    • Watts, J.L.1    Morton, D.G.2    Bestman, J.3    Kemphues, K.J.4
  • 170
    • 0034023371 scopus 로고    scopus 로고
    • Functions of mammalian Smad genes as revealed by targeted gene disruption in mice
    • Weinstein M, Yang X, Deng C. 2000. Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. Cytokine Growth Factor Rev. 11:49-58
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 49-58
    • Weinstein, M.1    Yang, X.2    Deng, C.3
  • 171
    • 0023837466 scopus 로고
    • Localization of villin, a cytoskeletal protein specific to microvilli, in human ileum and colon and in colonic neoplasms
    • West AB, Isaac CA, Carboni JM, Morrow JS, Mooseker MS, Barwick KW. 1988. Localization of villin, a cytoskeletal protein specific to microvilli, in human ileum and colon and in colonic neoplasms. Gastroenterology 94:343-52
    • (1988) Gastroenterology , vol.94 , pp. 343-352
    • West, A.B.1    Isaac, C.A.2    Carboni, J.M.3    Morrow, J.S.4    Mooseker, M.S.5    Barwick, K.W.6
  • 172
    • 0037309324 scopus 로고    scopus 로고
    • Sonic hedgehog in normal and neoplastic proliferation: Insight gained from human tumors and animal models
    • Wetmore C. 2003. Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models. Curr. Opin. Genet. Dev. 13:34-42
    • (2003) Curr. Opin. Genet. Dev. , vol.13 , pp. 34-42
    • Wetmore, C.1
  • 173
    • 0030014340 scopus 로고    scopus 로고
    • Type II TGF beta receptor expression in intestinal cell lines and in the intestinal tract
    • Winesett MP, Ramsey GW, Barnard JA. 1996. Type II TGF beta receptor expression in intestinal cell lines and in the intestinal tract. Carcinogenesis 17:989-95
    • (1996) Carcinogenesis , vol.17 , pp. 989-995
    • Winesett, M.P.1    Ramsey, G.W.2    Barnard, J.A.3
  • 175
    • 0035011886 scopus 로고    scopus 로고
    • Hamartomatous polyposis syndromes: Molecular genetics, neoplastic risk, and surveillance recommendations
    • Wirtzfeld DA, Petrelli NJ, Rodriguez-Bigas MA. 2001. Hamartomatous polyposis syndromes: molecular genetics, neoplastic risk, and surveillance recommendations. Ann. Surg. Oncol. 8:319-27
    • (2001) Ann. Surg. Oncol. , vol.8 , pp. 319-327
    • Wirtzfeld, D.A.1    Petrelli, N.J.2    Rodriguez-Bigas, M.A.3
  • 176
    • 11144355129 scopus 로고    scopus 로고
    • Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits alphsbeta production and alters lymphopoiesis and intestinal cell differentiation
    • Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, et al. 2004. Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits alphsbeta production and alters lymphopoiesis and intestinal cell differentiation. J. Biol. Chem. 279:12876-82
    • (2004) J. Biol. Chem. , vol.279 , pp. 12876-12882
    • Wong, G.T.1    Manfra, D.2    Poulet, F.M.3    Zhang, Q.4    Josien, H.5
  • 178
    • 0034611611 scopus 로고    scopus 로고
    • Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
    • Xu XL, Brodie SG, Yang X, Im YH, Parks WT, et al. 2000. Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. Oncogene 19:1868-74
    • (2000) Oncogene , vol.19 , pp. 1868-1874
    • Xu, X.L.1    Brodie, S.G.2    Yang, X.3    Im, Y.H.4    Parks, W.T.5
  • 179
    • 0035824487 scopus 로고    scopus 로고
    • Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    • Yang Q, Bermingham NA, Finegold MJ, Zoghbi HY. 2001. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 294:2155-58
    • (2001) Science , vol.294 , pp. 2155-2158
    • Yang, Q.1    Bermingham, N.A.2    Finegold, M.J.3    Zoghbi, H.Y.4
  • 180
    • 0035903028 scopus 로고    scopus 로고
    • Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
    • Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, et al. 2001. Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science 293:1323-26
    • (2001) Science , vol.293 , pp. 1323-1326
    • Ylikorkala, A.1    Rossi, D.J.2    Korsisaari, N.3    Luukko, K.4    Alitalo, K.5
  • 181
    • 0032478143 scopus 로고    scopus 로고
    • Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells
    • Zhou SB, Buckhaults P, Zawel L, Bunz F, Riggins G, et al. 1998. Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells. Proc. Natl. Acad. Sci. USA 95:2412-16
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2412-2416
    • Zhou, S.B.1    Buckhaults, P.2    Zawel, L.3    Bunz, F.4    Riggins, G.5
  • 182
    • 0034829630 scopus 로고    scopus 로고
    • Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes
    • Zhou XP, Woodford-Richens K, Lehtonen R, Kurose K, Aldred M, et al. 2001. Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Am. J. Hum. Genet. 69:704-11
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 704-711
    • Zhou, X.P.1    Woodford-Richens, K.2    Lehtonen, R.3    Kurose, K.4    Aldred, M.5
  • 183
    • 0032544448 scopus 로고    scopus 로고
    • Smad3 mutant mice develop metastatic colorectal cancer
    • Zhu YA, Richardson JA, Parada LF, Graff JM. 1998. Smad3 mutant mice develop metastatic colorectal cancer. Cell 94:703-14
    • (1998) Cell , vol.94 , pp. 703-714
    • Zhu, Y.A.1    Richardson, J.A.2    Parada, L.F.3    Graff, J.M.4
  • 184
    • 0037862003 scopus 로고    scopus 로고
    • New intracellular components of bone morphogenetic protein/Smad signaling cascades
    • Zwijsen A, Verschueren K, Huylebroeck D. 2003. New intracellular components of bone morphogenetic protein/Smad signaling cascades. FEBS Lett. 546:133-39
    • (2003) FEBS Lett. , vol.546 , pp. 133-139
    • Zwijsen, A.1    Verschueren, K.2    Huylebroeck, D.3


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