Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice

Gastroenterology

Volumn 123, Issue 2, 2002, Pages 492-504

  Janssen, KlausPeter ^a   Marjou, Fatima El ^a   Pinto, Daniel ^b   Sastre, Xavier ^c   Rouillard, Dany ^c   Fouquet, Coralie ^c   Soussi, Thierry ^c   Louvard, Daniel ^a   Robine, Sylvie ^a  

^a INSTITUT CURIE   (France)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; RAS PROTEIN;

ADENOCARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INVASION; CANCER STAGING; CARCINOGENESIS; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; INTESTINE EPITHELIUM; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

EID: 0036328995     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.34786     Document Type: Article

References (72)

1. Lessons from hereditary colorectal cancer
2. Mouse models for colorectal cancer
3. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
4. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors
5. Linking colorectal cancer to Wnt signaling
6. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
7. Meiotic pachytene arrest in MLH1-deficient mice
8. Smad3 mutant mice develop metastatic colorectal cancer
9. Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)K-γ
10. Tumour biology. Weakening link to colorectal cancer?
11. Bi-transgenic mice reveal that K-rasVal12 augments a p53-independent apoptosis when small intestinal villus enterocytes reenter the cell cycle
12. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
13. Prevalence of ras gene mutations in human colorectal cancers
14. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
15. A genetic model for colorectal tumorigenesis
16. Signalling networks that cause cancer
17. Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras
18. PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS
19. Understanding Ras: "It ain't over 'til it's over
20. Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia
21. Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
22. Epithelial cell growth and differentiation. IV. Controlled spatiotemporal expression of transgenes: New tools to study normal and pathological states
23. Regulatory sequences of the mouse Villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of small and large intestines
24. Human colon carcinoma Ki-ras2 oncogene and its corresponding proto-oncogene
25. Suppression of villin expression by antisense RNA impairs brush border assembly in polarized epithelial intestinal cells
26. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
27. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
28. Changes in villin synthesis and subcellular distribution during intestinal differentiation of HT29-18 clones
29. E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice
30. Aberrant crypts: Putative preneoplastic foci in human colonic mucosa
31. The mouse genome database (MGD): Integration nexus for the laboratory mouse
32. Clonal analysis of superficial depressed-type gastric carcinoma in humans
33. Molecular changes in the K-ras and APC genes in colorectal adenomas and carcinomas arising in the same patient
34. A simple p53 functional assay for screening cell lines, blood, and tumors
35. Transcriptional slippage of p53 gene enhanced by cellular damage in rat liver: Monitoring the slippage by a yeast functional assay
36. p53 mutation as a genetic trait of typical medullary breast carcinoma
37. Developmental regulation of villin gene expression in the epithelial cell lineages of mouse digestive and urogenital tracts
38. Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap
39. Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation, and morphological changes
40. Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade
41. Mechanisms underlying losses of heterozygosity in human colorectal cancer
42. Mutation detection by denaturing gradient gel electrophoresis (DGGE)
43. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene
44. Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis
45. Alteration of β-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients
46. Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation
47. Intestinal polyposis in mice with a dominant stable mutation of the β-catenin gene
48. Activation of extracellular signal-regulated kinase in human prostate cancer
49. Increased constitutive activity of mitogen-activated protein kinase and renaturable 85 kDa kinase in human-colorectal cancer
50. Regulation of cell death protease caspase-9 by phosphorylation
51. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
52. Multiple ras effector pathways contribute to G(1) cell cycle progression
53. Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells
54. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase
55. Transgenic activation of Ras in neurons promotes hypertrophy and protects from lesion-induced degeneration
56. APC mutations occur early during colorectal tumorigenesis
57. Colorectal cancer genetics. Closing the gap between genotype and phenotype
58. Attenuated familial adenomatous polyposis (AFAP). A phenotypically and genotypically distinctive variant of FAP
59. A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease
60. Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
61. Mutations of the Ki-ras, p53 and APC genes in adenocarcinomas of the human small intestine
62. Molecular determinants of dysplasia in colorectal lesions
63. Analysis of K-ras, APC β-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis
64. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
65. Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF
66. Loss of heterozygosity in spontaneous and X-ray-induced intestinal tumors arising in F1 hybrid min mice: Evidence for sequential loss of APC(+) and Dpc4 in tumor development
67. Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy
68. Apc1638N: A mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts
69. Ras enhances Myc protein stability
70. Identification of c-MYC as a target of the APC pathway
71. Deregulated β-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation